KEGG   Homo sapiens (human): 983Help
Entry
983               CDS       T01001                                 

Gene name
CDK1, CDC2, CDC28A, P34CDC2
Definition
(RefSeq) cyclin dependent kinase 1
  KO
K02087  cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04110  Cell cycle
hsa04114  Oocyte meiosis
hsa04115  p53 signaling pathway
hsa04218  Cellular senescence
hsa04540  Gap junction
hsa04914  Progesterone-mediated oocyte maturation
hsa05168  Herpes simplex infection
hsa05169  Epstein-Barr virus infection
hsa05203  Viral carcinogenesis
Module
hsa_M00693  Cell cycle - G2/M transition
Network
N00274  HCV NS5A binding to host-cell-protein
Drug target
Alvocidib (DG02041): D02880 D09868
Dinaciclib: D09604
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    983 (CDK1)
   04114 Oocyte meiosis
    983 (CDK1)
   04115 p53 signaling pathway
    983 (CDK1)
   04218 Cellular senescence
    983 (CDK1)
  Cellular community - eukaryotes
   04540 Gap junction
    983 (CDK1)
 Organismal Systems
  Endocrine system
   04914 Progesterone-mediated oocyte maturation
    983 (CDK1)
 Human Diseases
  Cancers
   05203 Viral carcinogenesis
    983 (CDK1)
  Infectious diseases
   05168 Herpes simplex infection
    983 (CDK1)
   05169 Epstein-Barr virus infection
    983 (CDK1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     983 (CDK1)
    2.7.11.23  [RNA-polymerase]-subunit kinase
     983 (CDK1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CMGC group
  CDK family
   983 (CDK1)
DNA replication proteins [BR:hsa03032]
 Eukaryotic Type
  DNA Replication Termination Factors
   Prevention of re-replication factors
    983 (CDK1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic Type
  Centrosome formation and ciliogenesis proteins
   Kinases and associated factors
    983 (CDK1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   983 (CDK1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr Haspin_kinase Kinase-like APH Kdo Seadorna_VP7 Choline_kinase
Motif
Other DBs
NCBI-GeneID: 983
NCBI-ProteinID: NP_001307847
OMIM: 116940
HGNC: 1722
Ensembl: ENSG00000170312
Vega: OTTHUMG00000018290
Pharos: P06493(Tchem)
UniProt: P06493
Structure
PDB: 

Jmol
Position
10q21.2
AA seq 297 aa AA seqDB search
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
NT seq 894 nt NT seq  +upstreamnt  +downstreamnt
atggaagattataccaaaatagagaaaattggagaaggtacctatggagttgtgtataag
ggtagacacaaaactacaggtcaagtggtagccatgaaaaaaatcagactagaaagtgaa
gaggaaggggttcctagtactgcaattcgggaaatttctctattaaaggaacttcgtcat
ccaaatatagtcagtcttcaggatgtgcttatgcaggattccaggttatatctcatcttt
gagtttctttccatggatctgaagaaatacttggattctatccctcctggtcagtacatg
gattcttcacttgttaagagttatttataccaaatcctacaggggattgtgttttgtcac
tctagaagagttcttcacagagacttaaaacctcaaaatctcttgattgatgacaaagga
acaattaaactggctgattttggccttgccagagcttttggaatacctatcagagtatat
acacatgaggtagtaacactctggtacagatctccagaagtattgctggggtcagctcgt
tactcaactccagttgacatttggagtataggcaccatatttgctgaactagcaactaag
aaaccacttttccatggggattcagaaattgatcaactcttcaggattttcagagctttg
ggcactcccaataatgaagtgtggccagaagtggaatctttacaggactataagaataca
tttcccaaatggaaaccaggaagcctagcatcccatgtcaaaaacttggatgaaaatggc
ttggatttgctctcgaaaatgttaatctatgatccagccaaacgaatttctggcaaaatg
gcactgaatcatccatattttaatgatttggacaatcagattaagaagatgtag

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