KEGG   Homo sapiens (human): 4122
Entry
4122              CDS       T01001                                 
Symbol
MAN2A2, MANA2X, alpha-MIIx
Name
(RefSeq) mannosidase alpha class 2A member 2
  KO
K01231  alpha-mannosidase II [EC:3.2.1.114]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00510  N-Glycan biosynthesis
hsa00513  Various types of N-glycan biosynthesis
hsa01100  Metabolic pathways
Module
hsa_M00075  N-glycan biosynthesis, complex type
Network
nt06015  N-Glycan biosynthesis
  Element
N00820  N-Glycan biosynthesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00510 N-Glycan biosynthesis
    4122 (MAN2A2)
   00513 Various types of N-glycan biosynthesis
    4122 (MAN2A2)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.2  Glycosylases
   3.2.1  Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
    3.2.1.114  mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
     4122 (MAN2A2)
SSDB
Motif
Pfam: Glyco_hydro_38N Glyco_hydro_38C Alpha-mann_mid Glyco_hydro_57 GapR_DNA-bd
Other DBs
NCBI-GeneID: 4122
NCBI-ProteinID: NP_006113
OMIM: 600988
HGNC: 6825
Ensembl: ENSG00000196547
UniProt: P49641
Position
15:90902382..90922585
AA seq 1150 aa
MKLKKQVTVCGAAIFCVAVFSLYLMLDRVQHDPTRHQNGGNFPRSQISVLQNRIEQLEQL
LEENHEIISHIKDSVLELTANAEGPPAMLPYYTVNGSWVVPPEPRPSFFSISPQDCQFAL
GGRGQKPELQMLTVSEELPFDNVDGGVWRQGFDISYDPHDWDAEDLQVFVVPHSHNDPGW
IKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNINVQKRAAVRRLVGN
GQLEIATGGWVMPDEANSHYFALIDQLIEGHQWLERNLGATPRSGWAVDPFGYSSTMPYL
LRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMMPFYSYDVPHTC
GPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVAERAALLLDQYRKKSQLFRSNVLL
VPLGDDFRYDKPQEWDAQFFNYQRLFDFFNSRPNLHVQAQFGTLSDYFDALYKRTGVEPG
ARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEVLYSLAAAHAR
RSGLAGRYPLSDFTLLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVNLKQVII
HAAHYLVLGDKETYHFDPEAPFLQVDDTRLSHDALPERTVIQLDSSPRFVVLFNPLEQER
FSMVSLLVNSPRVRVLSEEGQPLAVQISAHWSSATEAVPDVYQVSVPVRLPALGLGVLQL
QLGLDGHRTLPSSVRIYLHGRQLSVSRHEAFPLRVIDSGTSDFALSNRYMQVWFSGLTGL
LKSIRRVDEEHEQQVDMQVLVYGTRTSKDKSGAYLFLPDGEAKPYVPKEPPVLRVTEGPF
FSEVVAYYEHIHQAVRLYNLPGVEGLSLDISSLVDIRDYVNKELALHIHTDIDSQGIFFT
DLNGFQVQPRRYLKKLPLQANFYPMPVMAYIQDAQKRLTLHTAQALGVSSLKDGQLEVIL
DRRLMQDDNRGLGQGLKDNKRTCNRFRLLLERRTVGSEVQDSHSTSYPSLLSHLTSMYLN
APALALPVARMQLPGPGLRSFHPLASSLPCDFHLLNLRTLQAEEDTLPSAETALILHRKG
FDCGLEAKNLGFNCTTSQGKVALGSLFHGLDVVFLQPTSLTLLYPLASPSNSTDVYLEPM
EIATFRLRLG
NT seq 3453 nt   +upstreamnt  +downstreamnt
atgaagctgaaaaagcaggtgacagtgtgtggggctgccatcttctgtgtggcagtcttc
tcgctctacctcatgctggaccgagtgcaacacgatcccacccgacaccagaatggtggg
aacttcccccggagccaaatttctgtgctgcagaaccgcattgagcagctggagcagctt
ttggaggagaaccatgagattatcagccatatcaaggactccgtgctggagctgacagcc
aacgcagagggcccgcccgccatgctgccctactacacggtcaatggctcctgggtggtg
ccaccggagccccggcccagcttcttctccatctccccgcaggactgccagtttgctttg
gggggccggggtcagaagccagagctgcagatgctcactgtgtcggaggagctgccgttt
gacaacgtggatggtggtgtgtggaggcaaggcttcgacatctcctacgacccgcacgac
tgggatgctgaagacctgcaggtgtttgtggtgccccactctcacaatgacccaggctgg
atcaagacctttgacaagtactacacagagcagacccaacacatcctcaatagcatggtg
tctaagctgcaggaggacccccggcggcgcttcctctgggcagaggtctccttcttcgcc
aagtggtgggacaacatcaatgtccaaaagagagcggcagtccgaaggctggtgggaaac
gggcagctggagattgcgacaggaggctgggtgatgccagatgaggccaattcccactac
tttgcattgattgaccagctcatcgaaggacaccagtggctggagagaaatcttggtgca
accccccgctctggctgggcagtggacccctttggatacagctccaccatgccttacctg
ctgcgccgtgccaacctcaccagcatgctgattcagagagtgcactatgccatcaagaag
cactttgctgccacccacagcctagagttcatgtggaggcagacatgggactcggactcc
agcacagacatcttctgtcacatgatgcccttctacagctatgacgtcccccatacctgt
ggcccagatcccaagatctgctgccaatttgatttcaaacgcctgcctggtgggcgcatc
aactgcccttggaaggtgccaccccgggccatcacagaggccaacgtggcagagagggca
gccctgcttctggaccaataccggaagaagtcccagctgttccgaagcaacgtcctcctg
gtgcctcttggagatgacttccgatatgacaagccccaggagtgggatgcccagttcttc
aactaccaacggctctttgacttcttcaacagcaggcctaacctccatgtgcaggcccag
tttggcactctttctgactattttgatgccctgtacaagaggacaggggtggagccaggg
gcccggcctccagggtttcctgtgctgagcggggatttcttctcctatgcggaccgggag
gatcattactggacaggctattacacttcccggcccttctacaagagcttagaccgagtc
ctggaagcccacctgcggggggcagaggttctgtacagcctggctgcagctcacgctcgc
cgctctggtctggctggccggtacccactgtctgatttcaccctcctgacggaagctcgg
cgcacattggggctcttccagcatcacgatgccatcactggcacggccaaggaggctgtg
gtggtggactatggggtcaggcttctgcgctcccttgtcaacctgaagcaggtcatcatt
catgcagcccactatctggtgctgggggacaaggagacctaccactttgaccctgaggcg
cccttcctccaagtggatgacactcgcttaagtcacgacgccctcccagagcgcacggtg
atccagctggattcctcgcccaggtttgtggtcctattcaacccactggaacaggagcga
ttcagcatggtgtccctgctggtcaactctccccgcgtgcgtgtcctttcggaggagggt
cagcccctggccgtgcagatcagcgcacactggagctctgccaccgaggcggtccctgac
gtctaccaggtgtctgtgcctgtccgcctgccagccctgggcctgggcgtgctgcagcta
cagctgggcctggatgggcaccgcacgctgccctcctctgtgcgcatctacctgcacggc
cggcagctgtccgtcagcaggcacgaagcgtttcctctccgtgtcattgactctggcacc
agcgacttcgccctcagcaaccgctacatgcaggtctggttctcaggccttactgggctc
ctcaagagcatccgaagggtggatgaggagcacgagcagcaggtggacatgcaggtcctt
gtctatggcacccgtacgtccaaagacaagagtggagcctacctcttcctgcccgatggc
gaggccaagccctacgtccccaaggagccccccgtgctgcgtgtcactgaaggccctttc
ttctcagaggtggttgcgtactatgagcacattcaccaggcggtccggctttacaatctg
ccaggggtggaggggctgtctctggacatatcatccctggtggacatccgggactacgtc
aacaaggagctggccctgcacatccatacagacatcgacagccagggtatcttcttcaca
gacctcaatggctttcaggtgcagccccgacggtatctgaagaagctccccctccaggcc
aacttctaccccatgccagtcatggcctatatccaggacgcacagaagcgcctcacgctg
cacactgcccaggccctgggtgtctctagcctcaaagatggccagctggaggtgatcttg
gaccggcggctgatgcaggatgacaaccggggcctaggccaagggctcaaggacaacaag
agaacctgcaaccgtttccgcctcctgctagagcggcgaaccgtgggcagtgaggtccaa
gatagccactctaccagctacccatccctcctcagccacctgacctccatgtacctgaac
gccccggcgctcgctctgcctgtagccaggatgcagctcccaggccctggtctgcgctca
tttcatcctctggcttcctcactgccctgtgacttccacctgctcaacctacgtacgctc
caggctgaggaggacaccctaccctcggcggagaccgcactcatcttacaccgcaagggt
tttgactgcggcctggaggccaagaacttgggcttcaactgcaccacaagccaaggcaag
gtagccctgggcagccttttccatggcctggatgtggtattccttcagccaacctccttg
acgttactgtaccctctggcctccccgtccaacagcactgacgtctatttggagcccatg
gagattgctacctttcgcctccgcttgggttag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Chemical substance (2)   
   KEGG COMPOUND (2)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (40)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (38)   
DNA sequence (75)   
   RefSeq(nuc) (41)   
   GenBank (17)   
   EMBL (17)   
Protein domain (5)   
   Pfam (5)   
All databases (147)   

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