KEGG   Homo sapiens (human): 92935
Entry
92935             CDS       T01001                                 
Symbol
MARS2, COXPD25, MetRS, mtMetRS
Name
(RefSeq) methionyl-tRNA synthetase 2, mitochondrial
  KO
K01874  methionyl-tRNA synthetase [EC:6.1.1.10]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00450  Selenocompound metabolism
hsa00970  Aminoacyl-tRNA biosynthesis
hsa01100  Metabolic pathways
Disease
H00891  Combined oxidative phosphorylation deficiency
H01351  Spastic ataxia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00450 Selenocompound metabolism
    92935 (MARS2)
 09120 Genetic Information Processing
  09122 Translation
   00970 Aminoacyl-tRNA biosynthesis
    92935 (MARS2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes [BR:hsa01007]
    92935 (MARS2)
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis [BR:hsa03016]
    92935 (MARS2)
Enzymes [BR:hsa01000]
 6. Ligases
  6.1  Forming carbon-oxygen bonds
   6.1.1  Ligases forming aminoacyl-tRNA and related compounds
    6.1.1.10  methionine---tRNA ligase
     92935 (MARS2)
Amino acid related enzymes [BR:hsa01007]
 Aminoacyl-tRNA synthetase
  Class I (U)
   92935 (MARS2)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  Aminoacyl-tRNA synthetases (AARSs)
   Multi-aminoacyl-tRNA synthetase complex (MSC)
    92935 (MARS2)
 Prokaryotic type
   Other AARSs
    92935 (MARS2)
SSDB
Motif
Pfam: tRNA-synt_1g tRNA-synt_1 tRNA-synt_1e Anticodon_3 Anticodon_1 tRNA-synt_1f D123 PP1
Other DBs
NCBI-GeneID: 92935
NCBI-ProteinID: NP_612404
OMIM: 609728
HGNC: 25133
Ensembl: ENSG00000247626
UniProt: Q96GW9
Position
2:197705369..197708395
AA seq 593 aa
MLRTSVLRLLGRTGASRLSLLEDFGPRYYSSGSLSAGDDACDVRAYFTTPIFYVNAAPHI
GHLYSALLADALCRHRRLRGPSTAATRFSTGTDEHGLKIQQAAATAGLAPTELCDRVSEQ
FQQLFQEAGISCTDFIRTTEARHRVAVQHFWGVLKSRGLLYKGVYEGWYCASDECFLPEA
KVTQQPGPSGDSFPVSLESGHPVSWTKEENYIFRLSQFRKPLQRWLRGNPQAITPEPFHH
VVLQWLDEELPDLSVSRRSSHLHWGIPVPGDDSQTIYVWLDALVNYLTVIGYPNAEFKSW
WPATSHIIGKDILKFHAIYWPAFLLGAGMSPPQRICVHSHWTVCGQKMSKSLGNVVDPRT
CLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADALGGLLNRCTAKRINPSET
YPAFCTTCFPSEPGLVGPSVRAQAEDYALVSAVATLPKQVADHYDNFRIYKALEAVSSCV
RQTNGFVQRHAPWKLNWESPVDAPWLGTVLHVALECLRVFGTLLQPVTPSLADKLLSRLG
VSASERSLGELYFLPRFYGHPCPFEGRRLGPETGLLFPRLDQSRTWLVKAHRT
NT seq 1782 nt   +upstreamnt  +downstreamnt
atgctgcgaacgtccgtcctccgcctgctaggacgcacgggggctagtaggctgtctctc
ctggaggacttcggcccacgctactacagttcgggctccctcagtgccggcgatgatgct
tgtgatgtgcgcgcctacttcactacacccattttctacgtgaacgcggcgccgcacatc
gggcacctgtactcggcactactggcggacgccctatgccgccaccgtcgcctccgaggt
cccagcacggccgccacgcgattctccactggtaccgacgagcacgggctgaagattcag
caggcagcagctaccgcgggcctggccccgaccgagctgtgcgaccgagtctctgagcag
ttccagcagcttttccaggaggccggtatctcctgcacagatttcatccgcaccacggag
gcccggcaccgggtggctgtgcagcacttctggggggtgcttaagtcccgcggtctgctc
tacaagggcgtctatgaaggttggtattgcgcttccgacgagtgcttcctgcctgaggcc
aaggtcacccagcagccgggcccatcgggggattcgtttcctgtatctctcgagagcggg
catccagtctcctggaccaaggaagaaaactacattttcaggctttcccagttccggaag
ccactccagcggtggctgcggggcaaccctcaggcgatcacccccgaaccatttcatcac
gtagttcttcagtggctggacgaggagctgcccgacctgtccgtgtctcgcagaagtagc
cacttgcactggggcattccggtgcccggggatgattcgcagaccatctatgtatggctg
gatgccctggtcaactacctcactgtaattggctacccaaatgctgagttcaaatcttgg
tggccggccacctctcatatcataggtaaggacattctcaaattccatgccatctattgg
cctgccttcctgttaggggccggcatgagcccgccacagcgcatctgtgtccattcccac
tggacagtctgtggccaaaagatgtccaagagcttgggcaacgtggtggatcctaggact
tgccttaaccgctataccgtggatggcttccgctactttctccttcggcagggcgtcccc
aactgggactgtgactactatgatgaaaaggtggttaagttgctgaactccgagctggca
gatgccttgggaggtctcttgaaccgatgcactgccaaaagaataaatccttctgagacc
tacccagccttctgcactacctgcttccctagtgagccagggttggtggggccgtcagtt
cgtgctcaggcagaggattatgctctggtgagcgcagtggccactttgccaaagcaggta
gcagaccactatgataactttcggatatataaggctctggaggccgtgtccagctgtgtc
cggcaaactaatggttttgtccaaaggcatgcaccatggaagctgaactgggagagccca
gtggatgctccctggctgggtactgtgcttcatgtggccttggaatgtttgcgagtcttt
gggactttgctgcagcctgtcaccccaagcctagctgacaagctgctgtctaggctgggg
gtctctgcctcagagaggagtcttggagagctctatttcttgcctcgattctatggacat
ccatgcccttttgaagggaggaggctgggacctgaaactgggcttttgtttccaagacta
gaccagtccaggacttggctggtgaaagcccaccggacctag

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (17)   
   RefSeq(nuc) (1)   
   GenBank (8)   
   EMBL (8)   
Protein domain (8)   
   Pfam (8)   
All databases (70)   

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