KEGG   Homo sapiens (human): 10873
Entry
10873             CDS       T01001                                 
Symbol
ME3, NADP-ME
Name
(RefSeq) malic enzyme 3
  KO
K00029  malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) [EC:1.1.1.40]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00620  Pyruvate metabolism
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa03320  PPAR signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    10873 (ME3)
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    10873 (ME3)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.40  malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
     10873 (ME3)
SSDB
Motif
Pfam: Malic_M malic
Other DBs
NCBI-GeneID: 10873
NCBI-ProteinID: NP_001014811
OMIM: 604626
HGNC: 6985
Ensembl: ENSG00000151376
UniProt: Q16798 Q6TCH8
Structure
Position
11:complement(86434930..86672616)
AA seq 604 aa
MGAALGTGTRLAPWPGRACGALPRWTPTAPAQGCHSKPGPARPVPLKKRGYDVTRNPHLN
KGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQDRNEKL
FYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDNI
KAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRD
PLYIGLKHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCM
FNDDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKA
EATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGA
FTEQILRDMASFHERPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGK
TFIPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLST
IRDVSLRIAIKVLDYAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMN
VQTV
NT seq 1815 nt   +upstreamnt  +downstreamnt
atgggtgccgcgctggggacaggcacgcggctggctccctggccgggccgggcctgcggc
gccctcccgcgctggacacccaccgcgcccgcccaaggctgccactccaagcctggcccg
gcgcgccctgtgcccctgaagaagcgcggatacgatgtcaccaggaaccctcatctcaac
aaggggatggcctttacccttgaagaaaggctgcagcttggaatccacggcctaatcccg
ccctgctttctgagccaggacgtccagctcctccgaatcatgagatattacgagcggcag
cagagtgacctggacaagtacatcattctcatgacactccaagaccggaacgagaagctc
ttctaccgagtgctgacttcggacgtggagaagttcatgccaatcgtgtacacgcctacc
gtggggctggcctgtcagcactatggcctgactttccgcaggccccgtggactgttcatc
accattcatgacaaaggtcatcttgcaacaatgctgaattcttggccagaagacaatatt
aaggccgtggtggtgactgatggggagcgcatcctgggcctgggagacctgggctgctac
ggcatgggcatccctgtgggcaagctggccctgtacacggcatgcggaggggtgaacccg
cagcagtgcctccctgtgctgctggacgtcggcaccaacaatgaggagctgctcagagac
cctctgtacatcggcctgaaacaccagcgcgtgcacgggaaggcatacgatgacttgctg
gatgagttcatgcaggctgtgacagacaagtttggaataaattgcctcatccaatttgaa
gacttcgccaatgccaatgccttccgcctgctcaacaaataccgtaacaagtactgcatg
ttcaatgatgacatccaaggcacagcctccgttgctgtggcagggatcttggctgctctg
cgaatcaccaagaacaagctttccaatcacgtgtttgttttccaaggtgcaggcgaggca
gctatgggcattgcccacctccttgtcatggccctagagaaagaaggtgtaccgaaggca
gaggccacaagaaagatctggatggtggactctaaagggctcattgtcaaggggaggagc
cacctgaaccatgaaaaggagatgtttgcccaagaccatcctgaagtcaactccctggag
gaggtggtgaggctggtgaagcccacagccatcataggtgttgctgccatcgcaggagcc
ttcacggagcagattctgagggacatggcctccttccacgagcgccctatcatctttgcc
ctgagcaaccccaccagcaaggccgagtgcacggctgagaagtgctaccgggtcaccgag
ggccgagggatttttgccagtggaagtccttttaagagtgtgactctggaagatggcaag
accttcattcctgggcagggaaacaatgcttacgtgttccccggggtggcactgggagtc
atcgccggcgggatccggcacatcccagatgagatcttcctcctgacagcagagcaaatt
gcccaggaagtctctgagcagcatctgtcccaggggagactctacccaccactcagcacc
atccgagacgtgtctttgagaattgccatcaaagttctcgactacgcgtacaaacacaac
ctggcttcctactacccagagcctaaggacaaggaggcttttgtaagatccctggtctac
actccagactatgactcctttacactggacagctacacttggcccaaggaagccatgaat
gttcagacggtctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (4)   
   KEGG MODULE (2)   
Disease (1)   
   OMIM (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (20)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (17)   
DNA sequence (65)   
   RefSeq(nuc) (35)   
   GenBank (15)   
   EMBL (15)   
3D Structure (5)   
   PDB (5)   
Protein domain (2)   
   Pfam (2)   
All databases (125)   

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