KEGG   Homo sapiens (human): 5095
Entry
5095              CDS       T01001                                 
Symbol
PCCA
Name
(RefSeq) propionyl-CoA carboxylase subunit alpha
  KO
K01965  propionyl-CoA carboxylase alpha chain [EC:6.4.1.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00280  Valine, leucine and isoleucine degradation
hsa00630  Glyoxylate and dicarboxylate metabolism
hsa00640  Propanoate metabolism
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
Module
hsa_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA
Network
nt06024  Valine, leucine and isoleucine degradation
  Element
N00842  Propanoyl-CoA metabolism
Disease
H00175  Propionic acidemia
H01400  Secondary hyperammonemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00630 Glyoxylate and dicarboxylate metabolism
    5095 (PCCA)
   00640 Propanoate metabolism
    5095 (PCCA)
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    5095 (PCCA)
Enzymes [BR:hsa01000]
 6. Ligases
  6.4  Forming carbon-carbon bonds
   6.4.1  Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
    6.4.1.3  propionyl-CoA carboxylase
     5095 (PCCA)
SSDB
Motif
Pfam: CPSase_L_D2 Biotin_carb_N Biotin_carb_C PCC_BT Biotin_lipoyl Dala_Dala_lig_C Biotin_lipoyl_2 ATP-grasp RimK HlyD_3 ATP-grasp_5 HlyD_D23 ATPgrasp_ST GARS_A SLT_beta SnoaL_3 RnfC_N
Other DBs
NCBI-GeneID: 5095
NCBI-ProteinID: NP_000273
OMIM: 232000
HGNC: 8653
Ensembl: ENSG00000175198
UniProt: P05165
Structure
Position
13:100089093..100530435
AA seq 728 aa
MAGFWVGTAPLVAAGRRGRWPPQQLMLSAALRTLKHVLYYSRQCLMVSRNLGSVGYDPNE
KTFDKILVANRGEIACRVIRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKS
YLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIES
KLLAKKAEVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRD
GFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVV
EEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPV
TECITGLDLVQEMIRVAKGYPLRHKQADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQY
QEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRGVTH
NIALLREVIINSRFVKGDISTKFLSDVYPDGFKGHMLTKSEKNQLLAIASSLFVAFQLRA
QHFQENSRMPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSVEVDGSKLNVTSTWNLAS
PLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLAAELNKFMLEKVTEDTSS
VLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGKTGTVKSVHCQAGDTVGE
GDLLVELE
NT seq 2187 nt   +upstreamnt  +downstreamnt
atggcggggttctgggtcgggacagcaccgctggtcgctgccggacggcgtgggcggtgg
ccgccgcagcagctgatgctgagcgcggcgctgcggaccctgaagcatgttctgtactat
tcaagacagtgcttaatggtgtcccgtaatcttggttcagtgggatatgatcctaatgaa
aaaacttttgataaaattcttgttgctaatagaggagaaattgcatgtcgggttattaga
acttgcaagaagatgggcattaagacagttgccatccacagtgatgttgatgctagttct
gttcatgtgaaaatggcggatgaggctgtctgtgttggcccagctcccaccagtaaaagc
tacctcaacatggatgccatcatggaagccattaagaaaaccagggcccaagctgtacat
ccaggttatggattcctttcagaaaacaaagaatttgccagatgtttggcagcagaagat
gtcgttttcattggacctgacacacatgctattcaagccatgggcgacaagattgaaagc
aaattattagctaagaaagcagaggttaatacaatccctggctttgatggagtagtcaag
gatgcagaagaagctgtcagaattgcaagggaaattggctaccctgtcatgatcaaggcc
tcagcaggtggtggtgggaaaggcatgcgcattgcttgggatgatgaagagaccagggat
ggttttagattgtcatctcaagaagctgcttctagttttggcgatgatagactactaata
gaaaaatttattgataatcctcgtcatatagaaatccaggttctaggtgataaacatggg
aatgctttatggcttaatgaaagagagtgctcaattcagagaagaaatcagaaggtggtg
gaggaagcaccaagcatttttttggatgcggagactcgaagagcgatgggagaacaagct
gtagctcttgccagagcagtaaaatattcctctgctgggaccgtggagttccttgtggac
tctaagaagaatttttatttcttggaaatgaatacaagactccaggttgagcatcctgtc
acagaatgcattactggcctggacctagtccaggaaatgatccgtgttgctaagggctac
cctctcaggcacaaacaagctgatattcgcatcaacggctgggcagttgaatgtcgggtt
tatgctgaggacccctacaagtcttttggtttaccatctattgggagattgtctcagtac
caagaaccgttacatctacctggtgtccgagtggacagtggcatccaaccaggaagtgat
attagcatttattatgatcctatgatttcaaaactaatcacatatggctctgatagaact
gaggcactgaagagaatggcagatgcactggataactatgttattcgaggtgttacacat
aatattgcattacttcgagaggtgataatcaactcacgctttgtaaaaggagacatcagc
actaaatttctctccgatgtgtatcctgatggcttcaaaggacacatgctaaccaagagt
gagaagaaccagttattggcaatagcatcatcattgtttgtggcattccagttaagagca
caacattttcaagaaaattcaagaatgcctgttattaaaccagacatagccaactgggag
ctctcagtaaaattgcatgataaagttcataccgtagtagcatcaaacaatgggtcagtg
ttctcggtggaagttgatgggtcgaaactaaatgtgaccagcacgtggaacctggcttcg
cccttattgtctgtcagcgttgatggcactcagaggactgtccagtgtctttctcgagaa
gcaggtggaaacatgagcattcagtttcttggtacagtgtacaaggtgaatatcttaacc
agacttgccgcagaattgaacaaatttatgctggaaaaagtgactgaggacacaagcagt
gttctgcgttccccgatgcccggagtggtggtggccgtctctgtcaagcctggagacgcg
gtagcagaaggtcaagaaatttgtgtgattgaagccatgaaaatgcagaatagtatgaca
gctgggaaaactggcacggtgaaatctgtgcactgtcaagctggagacacagttggagaa
ggggatctgctcgtggagctggaatga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (5)   
   KEGG MODULE (2)   
Network (2)   
   KEGG NETWORK (2)   
Disease (4)   
   KEGG DISEASE (2)   
   OMIM (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (50)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (48)   
DNA sequence (95)   
   RefSeq(nuc) (57)   
   GenBank (19)   
   EMBL (19)   
3D Structure (3)   
   PDB (3)   
Protein domain (17)   
   Pfam (17)   
All databases (207)   

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