KEGG   Homo sapiens (human): 5198
Entry
5198              CDS       T01001                                 
Symbol
PFAS, FGAMS, FGAR-AT, FGARAT, GATD8, PURL
Name
(RefSeq) phosphoribosylformylglycinamidine synthase
  KO
K01952  phosphoribosylformylglycinamidine synthase [EC:6.3.5.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa01100  Metabolic pathways
Module
hsa_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    5198 (PFAS)
Enzymes [BR:hsa01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.5  Carbon-nitrogen ligases with glutamine as amido-N-donor
    6.3.5.3  phosphoribosylformylglycinamidine synthase
     5198 (PFAS)
SSDB
Motif
Pfam: GATase_5 AIRS_C FGAR-AT_N FGAR-AT_linker AIRS
Other DBs
NCBI-GeneID: 5198
NCBI-ProteinID: NP_036525
OMIM: 602133
HGNC: 8863
Ensembl: ENSG00000178921
UniProt: O15067 Q6P4B4 A8K9T9
Position
17:8247608..8270486
AA seq 1338 aa
MSPVLHFYVRPSGHEGAAPGHTRRKLQGKLPELQGVETELCYNVNWTAEALPSAEETKKL
MWLFGCPLLLDDVARESWLLPGSNDLLLEVGPRLNFSTPTSTNIVSVCRATGLGPVDRVE
TTRRYRLSFAHPPSAEVEAIALATLHDRMTEQHFPHPIQSFSPESMPEPLNGPINILGEG
RLALEKANQELGLALDSWDLDFYTKRFQELQRNPSTVEAFDLAQSNSEHSRHWFFKGQLH
VDGQKLVHSLFESIMSTQESSNPNNVLKFCDNSSAIQGKEVRFLRPEDPTRPSRFQQQQG
LRHVVFTAETHNFPTGVCPFSGATTGTGGRIRDVQCTGRGAHVVAGTAGYCFGNLHIPGY
NLPWEDPSFQYPGNFARPLEVAIEASNGASDYGNKFGEPVLAGFARSLGLQLPDGQRREW
IKPIMFSGGIGSMEADHISKEAPEPGMEVVKVGGPVYRIGVGGGAASSVQVQGDNTSDLD
FGAVQRGDPEMEQKMNRVIRACVEAPKGNPICSLHDQGAGGNGNVLKELSDPAGAIIYTS
RFQLGDPTLNALEIWGAEYQESNALLLRSPNRDFLTHVSARERCPACFVGTITGDRRIVL
VDDRECPVRRNGQGDAPPTPLPTPVDLELEWVLGKMPRKEFFLQRKPPMLQPLALPPGLS
VHQALERVLRLPAVASKRYLTNKVDRSVGGLVAQQQCVGPLQTPLADVAVVALSHEELIG
AATALGEQPVKSLLDPKVAARLAVAEALTNLVFALVTDLRDVKCSGNWMWAAKLPGEGAA
LADACEAMVAVMAALGVAVDGGKDSLSMAARVGTETVRAPGSLVISAYAVCPDITATVTP
DLKHPEGRGHLLYVALSPGQHRLGGTALAQCFSQLGEHPPDLDLPENLVRAFSITQGLLK
DRLLCSGHDVSDGGLVTCLLEMAFAGNCGLQVDVPVPRVDVLSVLFAEEPGLVLEVQEPD
LAQVLKRYRDAGLHCLELGHTGEAGPHAMVRVSVNGAVVLEEPVGELRALWEETSFQLDR
LQAEPRCVAEEERGLRERMGPSYCLPPTFPKASVPREPGGPSPRVAILREEGSNGDREMA
DAFHLAGFEVWDVTMQDLCSGAIGLDTFRGVAFVGGFSYADVLGSAKGWAAAVTFHPRAG
AELRRFRKRPDTFSLGVCNGCQLLALLGWVGGDPNEDAAEMGPDSQPARPGLLLRHNLSG
RYESRWASVRVGPGPALMLRGMEGAVLPVWSAHGEGYVAFSSPELQAQIEARGLAPLHWA
DDDGNPTEQYPLNPNGSPGGVAGICSCDGRHLAVMPHPERAVRPWQWAWRPPPFDTLTTS
PWLQLFINARNWTLEGSC
NT seq 4017 nt   +upstreamnt  +downstreamnt
atgtccccagtccttcacttctatgttcgtccctctggccatgagggggcagcccctgga
cacactcggaggaaactgcaagggaaactgccagagctgcagggcgtcgagactgaactg
tgctacaacgtgaactggacagctgaggccctccccagtgctgaggagacaaagaagctg
atgtggctgtttggttgccccttactgctggatgatgttgctcgggagtcctggctcctt
cctggctccaatgacctgctgctggaggtcgggcccaggctgaacttctccaccccaaca
tccaccaacatcgtgtcagtgtgccgcgccactgggctggggcctgtggatcgtgtggag
accacccggcgctaccggctctcgtttgcccaccccccgtcagctgaggtggaagccatt
gctctggctaccctgcacgaccggatgacagagcagcacttcccccatcccatccagagt
ttctcccctgagagcatgccggaacccctcaatggccctatcaatatactgggtgagggc
cggcttgcgctggagaaggccaaccaggagcttggtctggctttagactcttgggaccta
gacttctacaccaagcgcttccaggagctacagcggaacccgagcactgtggaggccttt
gacttggcgcagtccaatagcgagcacagccgacactggttcttcaagggccagctccac
gtggatgggcagaagctggtgcactcactgtttgagtccatcatgagcacccaggaatcc
tcgaaccccaacaacgtcctcaaattctgtgataacagcagtgcaatccagggaaaggaa
gtccgattcctacggcctgaggaccccacacggccaagccgcttccagcaacagcaaggg
ctgagacatgttgtcttcacagcagagactcacaactttcccacaggagtatgccccttt
agtggtgcaaccactggcacagggggccggattcgagatgtccagtgcacaggccgcggg
gcccacgtggtggctggcactgccggctattgctttggaaatctgcatattccaggttac
aatctgccctgggaggatccaagcttccagtatcctgggaattttgcccggcccctggag
gttgccattgaagccagtaatggagcttctgactatggcaacaagtttggggaaccagtg
ctggctggcttcgcccgctccttgggcctccagctcccagacggccagcggcgtgagtgg
atcaagcccatcatgtttagtgggggcattgggtccatggaagctgaccacataagcaag
gaggccccagagccaggcatggaagttgtaaaggttggaggtcccgtctacaggattgga
gttggaggtggagctgcttcatctgtgcaggtgcagggagataacaccagtgacctggac
tttggggctgtgcagcgaggagacccggagatggaacagaagatgaaccgtgtgatcagg
gcttgtgtggaggcccccaagggaaaccccatctgcagccttcatgatcagggcgctggt
ggcaatggcaatgtcctaaaagagctgagtgacccagctggagccatcatttacaccagc
cgcttccagcttggggacccaaccctgaatgccctggaaatctggggggctgagtaccag
gaatcaaatgctcttctgctgaggtcccccaaccgggacttcctgactcatgtcagtgcc
cgtgaacgttgcccggcttgcttcgtgggcaccatcactggagaccggagaatagtgctg
gtggacgatcgggagtgtcctgtcagaagaaatggccagggggatgcccccccgacaccc
ctgccaacccctgtggacctggagctcgaatgggtgctgggcaagatgcctcggaaggag
ttcttcctgcagaggaagccccccatgctgcagcctctggccttgcccccagggctgagc
gtgcaccaggctctggagagggttctgaggctgcccgccgtggccagcaagcgctacctc
accaataaggtggaccgctctgtgggaggcctggtggcccagcagcagtgcgtggggccc
ctgcaaactcctctggcagatgtagcggttgtggcactgagccatgaggagctcataggg
gctgccacagccttgggagaacagccagtcaagagcctgctggacccaaaagtcgccgcc
cggctggccgtggccgaagccctcaccaacctggtgtttgctctggtcactgacctccgg
gatgtgaagtgtagcgggaactggatgtgggcagccaagctcccaggggagggcgcagct
ttggcggatgcctgtgaggctatggtggcagtgatggcagccctgggtgtggcagtggat
ggtggcaaggactccctcagcatggctgctcgggttggcactgagaccgtgcgggctcct
gggtcactggtcatctcagcctatgccgtctgcccagacatcacagccactgtgacccca
gacctcaagcatcctgaagggagaggccatctgctctatgtggctctgagccctgggcag
caccggctcgggggcacagctctggcccagtgcttctcccagcttggggaacaccctcca
gacctggaccttcctgagaacttggtgcgggccttcagcatcactcaggggctgctgaaa
gaccgcctcctctgctcaggccacgatgtcagtgacggaggcctcgtcacatgcctgctg
gagatggcctttgctggaaattgcgggctacaggtggatgtgcctgtccccagggttgat
gtcctgtctgtgctgttcgctgaggagccaggcctcgtgctggaggtgcaggagccagac
ctggcccaggtgctgaagcgttaccgggatgctggcctccattgcctggagctgggccac
acaggcgaggccgggccccacgccatggtccgggtgtcagtgaacggggctgtggttctg
gaggagcctgttggggagctgcgagccctctgggaggagacgagtttccagctggaccgg
ctacaggcagagcctcgctgtgtggcagaggaggaacggggcctgagggagcggatgggg
cccagctattgcctgccccccacctttcccaaagcctccgtgccccgtgagcctggtggt
cccagcccccgagtcgccatcttgcgagaggagggcagtaatggagaccgggagatggcc
gatgccttccacttagctgggtttgaggtatgggacgtgaccatgcaggacctctgctct
ggggcaattgggctggacactttccgtggcgtggccttcgtgggcggcttcagctatgca
gatgtcctgggctctgccaaagggtgggcagctgctgtgacctttcatcccagggctggg
gctgagctgaggcgcttccggaagcggccagacaccttcagcctgggcgtgtgtaatggc
tgtcaactgctggctctgctcggctgggtgggaggcgaccccaatgaggatgctgcagag
atgggccctgactcccagccagcccggccaggccttctgctacgccacaacctgtctggg
cgctacgagtctcgctgggccagcgtgcgtgtggggcctgggccagccctgatgctgcga
gggatggagggcgccgtgctgcccgtgtggagtgcgcacggggaaggttacgtagcattt
tcttctccggaactccaagctcagattgaggccaggggcttggctccactgcactgggct
gatgatgacgggaaccccacagagcagtaccctctgaatcccaatgggtccccagggggc
gtggctggcatctgctcctgtgatggccgccacctggctgtcatgcctcaccctgagcgg
gccgttaggccttggcagtgggcatggcgaccccctccatttgatactctgaccacctcc
ccctggctccagctctttatcaatgcccgaaactggaccctggaagggagctgctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (2)   
   KEGG MODULE (1)   
Disease (1)   
   OMIM (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (16)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (12)   
DNA sequence (40)   
   RefSeq(nuc) (12)   
   GenBank (14)   
   EMBL (14)   
Protein domain (5)   
   Pfam (5)   
All databases (99)   

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