| Entry |
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| Symbol |
PHGDH, 3-PGDH, 3PGDH, HEL-S-113, NLS, NLS1, PDG, PGAD, PGD, PGDH, PHGDHD, SERA
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| Name |
(RefSeq) phosphoglycerate dehydrogenase
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| KO |
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| Organism |
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| Pathway |
| hsa00260 | Glycine, serine and threonine metabolism |
| hsa00270 | Cysteine and methionine metabolism |
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| Module |
| hsa_M00020 | Serine biosynthesis, glycerate-3P => serine |
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| Network |
nt06033 Glycine, serine and arginine metabolism |
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| Element |
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| Disease |
| H01079 | 3-Phosphoglycerate dehydrogenase (3-PGDH) deficiency |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
26227 (PHGDH)
00270 Cysteine and methionine metabolism
26227 (PHGDH)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:hsa04147]
26227 (PHGDH)
Enzymes [BR:hsa01000]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.95 phosphoglycerate dehydrogenase
26227 (PHGDH)
1.1.1.399 2-oxoglutarate reductase
26227 (PHGDH)
Exosome [BR:hsa04147]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
26227 (PHGDH)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| Position |
1:119711934..119744215
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| AA seq |
533 aa
MAFANLRKVLISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVT
ADVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQ
IPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISP
EVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIV
DEGALLRALQSGQCAGAALDVFTEEPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIA
VQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEALGTLMRAWAGSPKGTIQVITQG
TSLKNAGNCLSPAVIVGLLKEASKQADVNLVNAKLLVKEAGLNVTTSHSPAAPGEQGFGE
CLLAVALAGAPYQAVGLVQGTTPVLQGLNGAVFRPEVPLRRDLPLLLFRTQTSDPAMLPT
MIGLLAEAGVRLLSYQTSLVSDGETWHVMGISSLLPSLEAWKQHVTEAFQFHF |
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| NT seq |
1602 nt +upstreamnt +downstreamnt
atggcttttgcaaatctgcggaaagtgctcatcagtgacagcctggacccttgctgccgg
aagatcttgcaagatggagggctgcaggtggtggaaaagcagaaccttagcaaagaggag
ctgatagcggagctgcaggactgtgaaggccttattgttcgctctgccaccaaggtgacc
gctgatgtcatcaacgcagctgagaaactccaggtggtgggcagggctggcacaggtgtg
gacaatgtggatctggaggccgcaacaaggaagggcatcttggttatgaacacccccaat
gggaacagcctcagtgccgcagaactcacttgtggaatgatcatgtgcctggccaggcag
attccccaggcgacggcttcgatgaaggacggcaaatgggagcggaagaagttcatggga
acagagctgaatggaaagaccctgggaattcttggcctgggcaggattgggagagaggta
gctacccggatgcagtcctttgggatgaagactatagggtatgaccccatcatttcccca
gaggtctcggcctcctttggtgttcagcagctgcccctggaggagatctggcctctctgt
gatttcatcactgtgcacactcctctcctgccctccacgacaggcttgctgaatgacaac
acctttgcccagtgcaagaagggggtgcgtgtggtgaactgtgcccgtggagggatcgtg
gacgaaggcgccctgctccgggccctgcagtctggccagtgtgccggggctgcactggac
gtgtttacggaagagccgccacgggaccgggccttggtggaccatgagaatgtcatcagc
tgtccccacctgggtgccagcaccaaggaggctcagagccgctgtggggaggaaattgct
gttcagttcgtggacatggtgaaggggaaatctctcacgggggttgtgaatgcccaggcc
cttaccagtgccttctctccacacaccaagccttggattggtctggcagaagctctgggg
acactgatgcgagcctgggctgggtcccccaaagggaccatccaggtgataacacaggga
acatccctgaagaatgctgggaactgcctaagccccgcagtcattgtcggcctcctgaaa
gaggcttccaagcaggcggatgtgaacttggtgaacgctaagctgctggtgaaagaggct
ggcctcaatgtcaccacctcccacagccctgctgcaccaggggagcaaggcttcggggaa
tgcctcctggccgtggccctggcaggcgccccttaccaggctgtgggcttggtccaaggc
actacgcctgtactgcaggggctcaatggagctgtcttcaggccagaagtgcctctccgc
agggacctgcccctgctcctattccggactcagacctctgaccctgcaatgctgcctacc
atgattggcctcctggcagaggcaggcgtgcggctgctgtcctaccagacttcactggtg
tcagatggggagacctggcacgtcatgggcatctcctccttgctgcccagcctggaagcg
tggaagcagcatgtgactgaagccttccagttccacttctaa |
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