KEGG   Homo sapiens (human): 51067
Entry
51067             CDS       T01001                                 
Symbol
YARS2, CGI-04, MLASA2, MT-TYRRS, TYRRS
Name
(RefSeq) tyrosyl-tRNA synthetase 2
  KO
K01866  tyrosyl-tRNA synthetase [EC:6.1.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00970  Aminoacyl-tRNA biosynthesis
Disease
H00898  Myopathy with lactic acidosis and sideroblastic anaemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   00970 Aminoacyl-tRNA biosynthesis
    51067 (YARS2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes [BR:hsa01007]
    51067 (YARS2)
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis [BR:hsa03016]
    51067 (YARS2)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    51067 (YARS2)
Enzymes [BR:hsa01000]
 6. Ligases
  6.1  Forming carbon-oxygen bonds
   6.1.1  Ligases forming aminoacyl-tRNA and related compounds
    6.1.1.1  tyrosine---tRNA ligase
     51067 (YARS2)
Amino acid related enzymes [BR:hsa01007]
 Aminoacyl-tRNA synthetase
  Class I (A)
   51067 (YARS2)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  Aminoacyl-tRNA synthetases (AARSs)
   Other AARSs
    51067 (YARS2)
 Prokaryotic type
    51067 (YARS2)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial transcription and translation factors
   Other mitochondrial DNA transcription and translation factors
    51067 (YARS2)
SSDB
Motif
Pfam: tRNA-synt_1b S4
Other DBs
NCBI-GeneID: 51067
NCBI-ProteinID: NP_001035526
OMIM: 610957
HGNC: 24249
Ensembl: ENSG00000139131
UniProt: Q9Y2Z4
Structure
Position
12:complement(32746544..32755897)
AA seq 477 aa
MAAPILRSFSWGRWSGTLNLSVLLPLGLRKAHSGAQGLLAAQKARGLFKDFFPETGTKIE
LPELFDRGTASFPQTIYCGFDPTADSLHVGHLLALLGLFHLQRAGHNVIALVGGATARLG
DPSGRTKEREALETERVRANARALRLGLEALAANHQQLFTDGRSWGSFTVLDNSAWYQKQ
HLVDFLAAVGGHFRMGTLLSRQSVQLRLKSPEGMSLAEFFYQVLQAYDFYYLFQRYGCRV
QLGGSDQLGNIMSGYEFINKLTGEDVFGITVPLITSTTGAKLGKSAGNAVWLNRDKTSPF
ELYQFFVRQPDDSVERYLKLFTFLPLPEIDHIMQLHVKEPERRGPQKRLAAEVTKLVHGR
EGLDSAKRCTQALYHSSIDALEVMSDQELKELFKEAPFSEFFLDPGTSVLDTCRKANAIP
DGPRGYRMITEGGVSINHQQVTNPESVLIVGQHILKNGLSLLKIGKRNFYIIKWLQL
NT seq 1434 nt   +upstreamnt  +downstreamnt
atggcggcgcccatcttgcggtccttttcctggggccggtggtctggtaccctaaatctc
tcagtattgttgcccttggggctgcgtaaggcccactcgggcgctcaggggttactggca
gcgcagaaggctcgaggtctgttcaaggacttcttcccggagacggggacgaaaatagag
ctcccagagctcttcgaccgtggcacggcgagttttccccaaaccatttactgtggcttc
gaccccacggcagactcgcttcatgtgggtcatctacttgcgctgctgggcctgtttcat
ttgcagcgagcgggccacaacgtgatcgcgctggtgggaggcgccacggcgcgcctggga
gacccgagcggccgtaccaaggaacgcgaggcgctggagacagagcgcgtgcgagccaac
gcgcgagctctgcgcctagggcttgaggccctggcggctaatcaccagcagcttttcact
gatgggcgctcctggggcagcttcactgtgctggacaactcggcctggtaccagaagcag
cacctggtggacttcctggcggcagtggggggtcacttccgcatggggacgctgctgagc
cggcagagcgtgcagctgcggctcaagagccccgagggcatgagcttggccgagttcttt
taccaggtgctccaggcctatgacttctattacctcttccagcgttatggatgcagggtc
cagctgggcggatctgatcaactaggcaacatcatgtccggatatgagttcatcaacaag
ttgactggagaagatgtatttggaatcaccgttcctctaattacaagtacaactggagca
aagctgggaaagtctgctggcaacgctgtttggctaaacagagataagacatctccattt
gaattgtatcaattctttgtcaggcaaccggacgattcagtggaaaggtacctgaagctg
ttcactttcctgccccttccagagattgatcatatcatgcagctgcatgtcaaagagcca
gaaaggcggggtcctcagaaacgactggcagcagaagtaacaaagcttgttcatggacga
gaaggattggattctgctaaaaggtgtacacaagccctttatcacagtagcatagatgca
ctggaggtcatgtctgatcaggagttaaaagagttgtttaaagaagctccattttctgaa
ttttttctcgatcctggaacaagtgtcctagatacttgccgcaaagcaaatgccattcca
gatggtccccgagggtatcgaatgataacagaaggcggagtcagcataaatcaccaacaa
gtaacaaatcctgagagtgttttaattgttggacaacatattctcaagaatggactttcc
ttacttaaaataggaaaaagaaatttctacattataaaatggcttcagttgtga

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Ontology (5)   
   KEGG BRITE (5)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (9)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (27)   
   RefSeq(nuc) (7)   
   GenBank (10)   
   EMBL (10)   
3D Structure (2)   
   PDB (2)   
Protein domain (2)   
   Pfam (2)   
All databases (61)   

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