KEGG   ORTHOLOGY: K00502Help
Entry
K00502                      KO                                     

Name
TPH1_2
Definition
tryptophan 5-monooxygenase [EC:1.14.16.4]
Pathway
Tryptophan metabolism
Serotonergic synapse
Module
M00037  
Melatonin biosynthesis, tryptophan => serotonin => melatonin
Disease
H01646  
Major depressive disorder
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Amino acid metabolism
   00380 Tryptophan metabolism
    K00502  TPH1_2; tryptophan 5-monooxygenase
 Organismal Systems
  Nervous system
   04726 Serotonergic synapse
    K00502  TPH1_2; tryptophan 5-monooxygenase
KEGG modules [BR:ko00002]
 Pathway module
  Nucleotide and amino acid metabolism
   Aromatic amino acid metabolism
    M00037  Melatonin biosynthesis, tryptophan => serotonin => melatonin
     K00502  TPH1_2; tryptophan 5-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.16.4  tryptophan 5-monooxygenase
     K00502  TPH1_2; tryptophan 5-monooxygenase
BRITE hierarchy
Other DBs
RN: 
GO: 
Genes
HSA: 
121278(TPH2) 7166(TPH1)
PTR: 
466453(TPH1) 467070(TPH2)
PPS: 
100977344(TPH2) 103782654(TPH1)
GGO: 
101132108(TPH1) 101146582(TPH2)
PON: 
100459809(TPH2) 103891844(TPH1)
NLE: 
100588345(TPH2) 100601780(TPH1)
MCC: 
664730(TPH2) 695363(TPH1)
MCF: 
102124167(TPH2) 102145077(TPH1)
CSAB: 
103238730(TPH2) 103239320(TPH1)
RRO: 
104667637(TPH1) 104668095(TPH2)
CJC: 
100403096(TPH2) 100415029(TPH1)
SBQ: 
101051709(TPH2) 104652952(TPH1)
MMU: 
216343(Tph2) 21990(Tph1)
RNO: 
24848(Tph1) 317675(Tph2)
CGE: 
100763947(Tph2) 100767923(Tph1)
NGI: 
103734460(Tph1) 103735331(Tph2)
HGL: 
101710219(Tph1) 101714361(Tph2)
OCU: 
100009100(TPH1) 100101558(TPH1) 100344397(TPH2)
TUP: 
102481223(TPH2) 102487889(TPH1)
CFA: 
481165(TPH2) 611956(TPH1)
AML: 
100467699(TPH1) 100472165(TPH2)
UMR: 
103656892(TPH2) 103679407(TPH1)
FCA: 
101082165(TPH2) 101098575(TPH1)
PTG: 
102948910(TPH2) 102969936(TPH1)
BTA: 
100336620(TPH2) 781941(TPH1)
BOM: 
102269915(TPH1) 102275621(TPH2)
PHD: 
102324712(TPH2) 102328991(TPH1)
CHX: 
102174722(TPH2) 102184739(TPH1)
OAS: 
101113620(TPH1) 101120314(TPH2)
SSC: 
100511002(TPH1) 100627725(TPH2)
CFR: 
102512650(TPH2) 102522464(TPH1)
BACU: 
102997866(TPH1) 103006656(TPH2)
LVE: 
103083324(TPH1) 103087968(TPH2)
ECB: 
100009684(TPH2) 100056614(TPH1)
MYB: 
102241626(TPH2) 102244804(TPH1)
MYD: 
102753485(TPH2) 102767513(TPH1)
PALE: 
102882683(TPH1) 102891331(TPH2)
LAV: 
MDO: 
100011937(TPH2) 100020009(TPH1)
SHR: 
100915442(TPH1) 100923184(TPH2)
OAA: 
100090381(TPH1)
GGA: 
395799(TPH1) 408026(TPH2)
MGP: 
100303678(TPH2) 100549515(TPH1)
CJO: 
107310284(TPH2) 107314681(TPH1)
APLA: 
TGU: 
100228542(TPH2) 100229598(TPH1)
GFR: 
102036017(TPH2) 102041307(TPH1)
FAB: 
101817911(TPH2) 101820220(TPH1)
PHI: 
102103962(TPH2) 102106431(TPH1)
CCW: 
104685325(TPH1) 104698473(TPH2)
FPG: 
101914983(TPH1) 101918183(TPH2)
FCH: 
102052919(TPH2) 102057315(TPH1)
CLV: 
102092014(TPH2) 102095810(TPH1)
AAM: 
106488161(TPH2) 106497047(TPH1)
ASN: 
102376121(TPH2) 102380987(TPH1)
AMJ: 
102560538(TPH1) 102572294(TPH2)
PSS: 
102445658(TPH2) 102460535(TPH1)
CMY: 
ACS: 
100562860(tph1) 100564918(tph2)
PBI: 
GJA: 
107115340(TPH2) 107115550(TPH1)
XLA: 
387560(tph1.S)
XTR: 
100486097(tph2) 100497239(tph1)
DRE: 
352943(tph1a) 407712(tph2) 415103(tph1b)
TRU: 
446047(tph1) 446048(tph2)
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
102362567(TPH1) 102363250(TPH2)
CMK: 
103174831(tph1) 103185330(tph2)
BFO: 
CIN: 
SPU: 
SKO: 
100329006(tph-1)
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD13494(Dsim_GD13494)
DWI: 
DYA: 
Dyak_GE20982(dyak_GLEANR_4782)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
411200(Trh)
BIM: 
BTER: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
DPL: 
PXY: 
API: 
PHU: 
DPX: 
ISC: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
APRO: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Matthes S, Mosienko V, Bashammakh S, Alenina N, Bader M
  Title
Tryptophan hydroxylase as novel target for the treatment of depressive disorders.
  Journal
Pharmacology 85:95-109 (2010)

DBGET integrated database retrieval system