KEGG ORTHOLOGY: K00503

ORTHOLOGY: K00503

Entry

K00503                      KO

Symbol

DBH

Name

dopamine beta-monooxygenase [EC:1.14.17.1]

Pathway

map00350

Tyrosine metabolism

map01100

Metabolic pathways

Module

M00042

Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline

Reaction

R02535

dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)

Disease

H01005

Dopamine beta-hydroxylase deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K00503  DBH; dopamine beta-monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.17  With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.17.1  dopamine beta-monooxygenase
     K00503  DBH; dopamine beta-monooxygenase

Other DBs

GO:

0004500

Genes

HSA:

1621(DBH)

PTR:	464827(DBH)

PPS:	100985587(DBH)

GGO:	101154486(DBH)

PON:	100461514(DBH)

NLE:	100597609(DBH)

HMH:	116475831(DBH)

MCC:	574105(DBH)

MCF:	102139527(DBH)

MTHB:

126937138

MNI:	105471876(DBH)

CSAB:

103239676(DBH)

CATY:

105580523(DBH)

PANU:

101016746

TGE:	112608503(DBH)

MLEU:

105547818(DBH)

RRO:	104669786(DBH)

RBB:	108513277(DBH)

TFN:	117099202(DBH)

PTEH:

111523984(DBH)

CANG:

105503972(DBH)

CJC:	100406041(DBH)

SBQ:	101046079(DBH)

CIMI:

108292306(DBH)

CSYR:

103273377(DBH)

MMUR:

105880739(DBH)

LCAT:

123646086(DBH)

PCOQ:

105826696(DBH)

OGA:	100961448(DBH)

MMU:	13166(Dbh)

MCAL:

110290214(Dbh)

MPAH:

110319201(Dbh)

RNO:	25699(Dbh)

MCOC:

116089882(Dbh)

ANU:	117704073(Dbh)

MUN:	110557516(Dbh)

CGE:	100761411(Dbh)

MAUA:

101829122(Dbh)

PROB:

127221930(Dbh)

PLEU:

114684222(Dbh)

MORG:

121462939(Dbh)

MFOT:

126509477

AAMP:

119819746(Dbh)

NGI:	103742818(Dbh)

HGL:	101724312(Dbh)

CPOC:

100727873(Dbh)

CCAN:

109677868(Dbh)

DORD:

105995609(Dbh)

DSP:	122108906(Dbh)

PLOP:

125353283(Dbh)

NCAR:

124964227

MMMA:

107159145(Dbh)

OPI:	101531833(DBH)

TUP:	102468703(DBH)

GVR:	103596907(DBH)

CFA:	448806(DBH)

CLUD:

112677400(DBH)

VVP:	112906947(DBH)

VLG:	121473853(DBH)

NPO:	129517647(DBH)

AML:	100480347(DBH)

UMR:	103679922(DBH)

UAH:	113266575(DBH)

UAR:	123775689(DBH)

ELK:

111146214

LLV:

125083193

MPUF:

101687995(DBH)

MNP:	132024938(DBH)

MLK:	131812941(DBH)

NVS:	122916823(DBH)

ORO:	101362871(DBH)

EJU:	114201020(DBH)

ZCA:	113934884(DBH)

MLX:	118018100(DBH)

NSU:	110581632(DBH)

FCA:	101082957(DBH)

PYU:	121021226(DBH)

PCOO:

112860343(DBH)

PBG:	122474494(DBH)

PVIV:

125150068(DBH)

LRUF:

124522415

PTG:	102961078(DBH)

PPAD:

109258287(DBH)

PUC:

125923040

AJU:

106988258

HHV:	120247318(DBH)

BTA:	280758(DBH)

BOM:	102286194(DBH)

BIU:	109566610(DBH)

BBUB:

102409301(DBH)

BBIS:

104983329(DBH)

CHX:	102176244(DBH)

OAS:	114113851(DBH)

BTAX:

128056614(DBH)

ODA:	120852173(DBH)

CCAD:

122442339(DBH)

MBEZ:

129539725(DBH)

SSC:	733609(DBH)

CFR:	102523816(DBH)

CBAI:

105068611(DBH)

CDK:	105106327(DBH)

VPC:

102534249

BACU:

103001548(DBH)

BMUS:

118897084(DBH)

LVE:	103082302(DBH)

OOR:	101269198(DBH)

DLE:	111177039(DBH)

PCAD:

102990638(DBH)

PSIU:

116755116(DBH)

NASI:

112411311(DBH)

ECB:	791247(DBH)

EPZ:	103564043(DBH)

EAI:	106845350(DBH)

MYB:	102264141(DBH)

MYD:	102763656(DBH)

MMYO:

118666900(DBH)

PKL:	118708909(DBH)

EFUS:

103295991(DBH)

MNA:	107524669(DBH)

DRO:	112306436(DBH)

SHON:

118980160(DBH)

AJM:	119036119(DBH)

PDIC:

114508649(DBH)

PHAS:

123823386(DBH)

MMF:	118629977(DBH)

PPAM:

129079166(DBH)

HAI:	109381156(DBH)

RFQ:	117031624(DBH)

PALE:

102882740(DBH)

PGIG:

120618872(DBH)

PVP:	105308213(DBH)

RAY:	107506265(DBH)

MJV:	108398386(DBH)

TOD:	119231230(DBH)

SARA:

101549744(DBH)

SETR:

126009332(DBH)

LAV:	100675803(DBH)

TMU:

101344432

ETF:	101657053(DBH)

DNM:	101445626(DBH)

MDO:	100018814(DBH)

GAS:	123235192(DBH)

SHR:	100925655(DBH)

AFZ:

127547077

PCW:	110205374(DBH)

OAA:	100073905(DBH)

GGA:	395549(DBH)

PCOC:

116234079(DBH)

MGP:	100544779(DBH)

CJO:	107321868(DBH)

TPAI:

128073402(DBH)

LMUT:

125702511(DBH)

NMEL:

110406867(DBH)

APLA:

101793381(DBH)

ACYG:

106044068(DBH)

CATA:

118252230(DBH)

AFUL:

116497023(DBH)

TGU:	100224356(DBH)

LSR:	110477727(DBH)

SCAN:

103818963(DBH)

PMOA:

120512423(DBH)

OTC:	121337041(DBH)

PRUF:

121362449(DBH)

GFR:	102038113(DBH)

FAB:	101810825(DBH)

OMA:	130260260(DBH)

PHI:	102100810(DBH)

PMAJ:

107211985(DBH)

CCAE:

111937045(DBH)

CCW:	104688340(DBH)

CBRC:

103623244(DBH)

ETL:	114059130(DBH)

ZAB:	102067155(DBH)

ACHL:

103807315(DBH)

SVG:	106851290(DBH)

MMEA:

130576690(DBH)

HRT:	120761618(DBH)

FPG:	101923335(DBH)

FCH:	102048380(DBH)

CLV:	102097674(DBH)

EGZ:	104129357(DBH)

NNI:	104023198(DBH)

PCRI:

104028747(DBH)

PLET:

104623396(DBH)

EHS:	104510808(DBH)

PCAO:

104050609(DBH)

ACUN:

113486646(DBH)

TALA:

104360329(DBH)

PADL:

103915345(DBH)

AFOR:

103905336(DBH)

ACHC:

115335026(DBH)

HALD:

104321603(DBH)

HLE:	104833860(DBH)

AGEN:

126052377

GCL:

127023841

CCRI:

104163012(DBH)

CSTI:

104554872(DBH)

CMAC:

104487171(DBH)

MUI:	104541274(DBH)

BREG:

104638501(DBH)

FGA:	104080547(DBH)

GSTE:

104264786(DBH)

LDI:	104353407(DBH)

MNB:	103770274(DBH)

OHA:	104329486(DBH)

NNT:	104413882(DBH)

SHAB:

115617137(DBH)

DPUB:

104296410(DBH)

PGUU:

104462249(DBH)

ACAR:

104517771(DBH)

CPEA:

104389814(DBH)

AVIT:

104275314(DBH)

CVF:	104292827(DBH)

RTD:	128917489(DBH)

CUCA:

104066832(DBH)

TEO:	104375628(DBH)

BRHI:

104496129(DBH)

AAM:	106484479(DBH)

AROW:

112964327(DBH)

NPD:	112956064(DBH)

TGT:	104568108(DBH)

DNE:	112979868(DBH)

SCAM:

104138237(DBH)

ASN:	102377750(DBH)

AMJ:	102562465(DBH)

CPOO:

109313992(DBH)

GGN:	109293013(DBH)

PSS:	102455557(DBH)

CMY:	102935981(DBH)

CCAY:

125623615(DBH)

DCC:	119844211(DBH)

CPIC:

101944381(DBH)

TST:	117867238(DBH)

CABI:

116817450(DBH)

MRV:	120386832(DBH)

ACS:	100566843(dbh)

ASAO:

132763872(DBH)

PVT:	110089291(DBH)

SUND:

121936462(DBH)

PBI:	103050577(DBH)

PMUR:

107291028(DBH)

CTIG:

120314624(DBH)

TSR:	106552853(DBH)

PGUT:

117671327(DBH)

APRI:

131186228(DBH)

PTEX:

113448480(DBH)

NSS:	113426294(DBH)

VKO:	123035174(DBH)

PMUA:

114588914(DBH)

PRAF:

128406237(DBH)

ZVI:	118084255(DBH)

HCG:	128338782(DBH)

GJA:	107106563(DBH)

STOW:

125441929(DBH)

EMC:	129341924(DBH)

XLA:	108698178(dbh.L) 108699900(dbh.S)

XTR:	100492247(dbh)

NPR:	108792841(DBH)

RTEM:

120913857(DBH)

BBUF:

121009593(DBH)

BGAR:

122919306(DBH)

MUO:	115472054(DBH)

GSH:	117368390(DBH)

DRE:	30505(dbh)

SRX:	107713263 107744238

SANH:

107658656 107685164

SGH:	107595570(dbh) 107597665

CCAR:

109052532 109080215

CAUA:

113109649 113109662

CGIB:

127966274

PTET:

122352743(dbh)

LROH:

127171928(dbh)

OMC:	131548322(dbh)

PPRM:

120482193(dbh)

RKG:	130073531(dbh)

MAMB:

125257707(dbh)

CIDE:

127520887

MASI:

127433690

TROS:

130546436(dbh)

TDW:	130412074(dbh)

MANU:

129447255(dbh)

IPU:

108276829

IFU:	128620171 128620707(dbh)

PHYP:

113544042(dbh)

SMEO:

124393247(dbh)

TFD:	113653083(dbh)

TVC:	132863268(dbh)

AMEX:

103038160(dbh)

CMAO:

118824922(dbh)

EEE:	113576331(dbh)

CHAR:

105906021(dbh)

TRU:	101066621(dbh)

TFS:	130517645(dbh)

TNG:	GSTEN00024729G001

LCO:	104923914(dbh)

NCC:	104968179(dbh)

TBEN:

117476401(dbh)

CGOB:

115016923(dbh)

PGEO:

117455785(dbh)

GACU:

117534087(dbh)

EMAC:

134868709(dbh)

ELY:	117269510(dbh)

EFO:	125905776(dbh)

PLEP:

121960296(dbh)

SLUC:

116034955

ECRA:

117959052(dbh)

ESP:

116703934

PFLV:

114571332

GAT:	120832241(dbh)

PPUG:

119226520(dbh)

AFB:	129102695(dbh)

CLUM:

117740726(dbh)

PSWI:

130205805(dbh)

MSAM:

119882201 119914708(dbh)

SCHU:

122865195(dbh)

CUD:	121525273(dbh)

ALAT:

119030408(dbh)

MZE:	101464817(dbh)

ONL:	100708156(dbh)

OAU:	116335170(dbh)

OLA:	101157870(dbh)

OML:	112162907(dbh)

CSAI:

133455328(dbh)

XMA:	102218690(dbh)

XCO:	114149436(dbh)

XHE:	116724091(dbh)

PRET:

103473626(dbh)

PFOR:

103147866(dbh)

PLAI:

106948318(dbh)

PMEI:

106921879(dbh)

GAF:	122847123(dbh)

PPRL:

129366448(dbh)

CVG:	107088692(dbh)

CTUL:

119782614(dbh)

GMU:	124872393(dbh)

NFU:	107372400(dbh)

KMR:	108232649(dbh)

ALIM:

106514559(dbh)

NWH:	119424449(dbh) 119429221

AOCE:

111567020(dbh)

MCEP:

124996693(dbh)

CSEM:

103389065(dbh)

POV:	109626136(dbh)

SSEN:

122758000(dbh)

HHIP:

117771598(dbh)

HSP:	118125929(dbh)

SMAU:

118284738(dbh)

LCF:

108879254

SDU:	111238762(dbh)

SLAL:

111666075(dbh)

XGL:	120806361(dbh)

HCQ:	109517071(dbh)

SSCV:

125980063

SBIA:

133490565(dbh)

PEE:	133414113(dbh)

PTAO:

133489895(dbh)

BPEC:

110174164(dbh)

MALB:

109963454(dbh)

BSPL:

114866790(dbh)

SJO:	128380399(dbh)

SASA:

106568424(dbh)

STRU:

115149420(dbh)

OTW:

112257386

OMY:	110536983(dbh)

OGO:

124000827

ONE:	115105985(dbh)

OKI:	109893630(dbh)

OKE:

118391620

SALP:

111980057

SNH:	120025633(dbh)

CCLU:

121573457

ELS:	105014776(dbh)

SFM:	108934136(dbh)

PKI:	111854168(dbh)

AANG:

118212852(dbh)

LOC:	102682868(dbh)

PSPA:

121303526 121307068

ARUT:

117422501(dbh)

PSEX:

120535438(dbh)

LCM:	102359119(DBH)

CMK:	103182970(dbh)

HOC:	132825774(dbh)

LERI:

129712113(dbh)

PMRN:

116955387(DBH)

BFO:

BBEL:

CIN:

SCLV:

SPU:	586320 752850

LPIC:

129278135 129278136

APLC:

110976390

SKO:

102804261

DME:	Dmel_CG1543(Tbh)

DER:

6551562

DSE:

6620197

DSI:	Dsimw501_GD16874(Dsim_Tbh)

DYA:	Dyak_GE15754

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI11219

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ019622

CPII:

120420172

CNS:

116347605

BCOO:

119067204

AME:	751102(Tbh)

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:	663011(TcTBH)

DPA:	109541252 109541259

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

100862766(Tbh)

BMAN:

114239450

MSEX:

115439887

DPL:	KGM_207724

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

TNL:

SLIU:

OFU:

PXY:	105395691 105397436

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:	126908822 126909213

BTAB:

109037049

DCI:	103510050 103516417

CLEC:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM211140

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_1839

DMK:

DPZ:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_H13N06.6(tbh-1)

CBR:	CBG_07714(Cbr-tbh-1)

CRQ:	GCK72_025527

HRO:	HELRODRAFT_64253

LGI:	LOTGIDRAFT_120180 LOTGIDRAFT_162200 LOTGIDRAFT_191156 LOTGIDRAFT_233457 LOTGIDRAFT_234237

PVUL:

126812196 126832242

PCAN:

112557427 112561909 112563147 112570230 112570414 112575465 112576338

BGT:	106066921 106077242 106078772

GAE:	121383804 121384141

HRF:	124114394 124138380 124142782 124142798 124148606 124151079

HRJ:	124253288 124257823 124266189 124270276 124275898 124284219 124284488 124289238

CRG:	105321753 105329831 105337151 105342404 105344230 105348387

CVN:	111125361 111127321 111133921

CANU:

128155514

OED:

125679743

MYI:	110442054 110447535 110447536 110450515 110452901 110454243 110454251 110455641 110456098 110456174 110467057 110467403

PMAX:

117316542 117316561 117316569 117316585 117319629 117321720 117321721 117321920 117321941 117334297 117334351 117334793 117335029

MCAF:

127728851

MMER:

123533077 123533930 123538847 123545778 123546293 123555574 123561327

RPHI:

DPOL:

OBI:

OSN:

LAK:	106150741 106165088 106173926 106180620 106181793

SMM:	Smp_163900

OVI:	T265_00912

» show all

Reference

PMID:3443096

Authors

Lamouroux A, Vigny A, Faucon Biguet N, Darmon MC, Franck R, Henry JP, Mallet J

Title

The primary structure of human dopamine-beta-hydroxylase: insights into the relationship between the soluble and the membrane-bound forms of the enzyme.

Journal

EMBO J 6:3931-7 (1987)
DOI:10.1002/j.1460-2075.1987.tb02734.x

Sequence

[hsa:1621]

DBGET integrated database retrieval system