KEGG   ORTHOLOGY: K00922Help
Entry
K00922                      KO                                     

Name
PIK3C
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Disease
H00027  
Ovarian cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   04015 Rap1 signaling pathway
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   04012 ErbB signaling pathway
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   04370 VEGF signaling pathway
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   04630 Jak-STAT signaling pathway
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   04668 TNF signaling pathway
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   04066 HIF-1 signaling pathway
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   04068 FoxO signaling pathway
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   04070 Phosphatidylinositol signaling system
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   04151 PI3K-Akt signaling pathway
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   04150 mTOR signaling pathway
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
  Cell growth and death
   04210 Apoptosis
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
  Cell communication
   04510 Focal adhesion
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   04650 Natural killer cell mediated cytotoxicity
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   04660 T cell receptor signaling pathway
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   04662 B cell receptor signaling pathway
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   04664 Fc epsilon RI signaling pathway
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   04666 Fc gamma R-mediated phagocytosis
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   04670 Leukocyte transendothelial migration
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   04062 Chemokine signaling pathway
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
  Endocrine system
   04910 Insulin signaling pathway
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   04915 Estrogen signaling pathway
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   04914 Progesterone-mediated oocyte maturation
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   04917 Prolactin signaling pathway
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   04921 Oxytocin signaling pathway
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   04919 Thyroid hormone signaling pathway
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
  Digestive system
   04973 Carbohydrate digestion and absorption
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
  Nervous system
   04725 Cholinergic synapse
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   04722 Neurotrophin signaling pathway
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
  Development
   04380 Osteoclast differentiation
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   05205 Proteoglycans in cancer
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   05203 Viral carcinogenesis
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   05210 Colorectal cancer
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   05212 Pancreatic cancer
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   05214 Glioma
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   05221 Acute myeloid leukemia
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   05220 Chronic myeloid leukemia
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   05218 Melanoma
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   05211 Renal cell carcinoma
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   05215 Prostate cancer
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   05213 Endometrial cancer
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   05222 Small cell lung cancer
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   05223 Non-small cell lung cancer
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   05166 HTLV-I infection
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   05162 Measles
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   05164 Influenza A
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   05161 Hepatitis B
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   05160 Hepatitis C
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   05169 Epstein-Barr virus infection
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   05146 Amoebiasis
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   05145 Toxoplasmosis
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
   05142 Chagas disease (American trypanosomiasis)
    K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     K00922  PIK3C; phosphatidylinositol-4,5-bisphosphate 3-kinase
BRITE hierarchy
Other DBs
RN: 
GO: 
Genes
HSA: 
5290(PIK3CA) 5291(PIK3CB) 5293(PIK3CD) 5294(PIK3CG)
PTR: 
457922(PIK3CD) 460858(PIK3CA) 463649(PIK3CG) 471079(PIK3CB)
PPS: 
100988420(PIK3CG) 100989732(PIK3CD) 100990108(PIK3CB) 100990828(PIK3CA)
GGO: 
101143811(PIK3CA) 101146434(PIK3CD) 101152123(PIK3CB) 101153738(PIK3CG)
PON: 
100432846(PIK3CB) 100453085(PIK3CG) 100453779(PIK3CA)
MCC: 
698857(PIK3CG) 709959(PIK3CA) 716098(PIK3CB)
MCF: 
102122725(PIK3CA) 102142026(PIK3CB) 102143464(PIK3CD) 102146644(PIK3CG)
MMU: 
18706(Pik3ca) 18707(Pik3cd) 30955(Pik3cg) 74769(Pik3cb)
RNO: 
170911(Pik3ca) 298947(Pik3cg) 366508(Pik3cd) 85243(Pik3cb)
CGE: 
100689251(Pik3ca) 100689252(Pik3cb) 100765862(Pik3cg) 100769225(Pik3cd)
HGL: 
101707055(Pik3cg) 101711934(Pik3ca) 101712941(Pik3cd) 101715249(Pik3cb)
TUP: 
102472442 102483329(PIK3CA) 102500530(PIK3CD) 102502163(PIK3CB)
CFA: 
477085(PIK3CB) 483266(PIK3CG) 488084(PIK3CA) 489644(PIK3CD)
AML: 
FCA: 
101091892(PIK3CB) 101094274(PIK3CD) 101096215(PIK3CG) 101097413(PIK3CA)
BTA: 
282306(PIK3CA) 504531(PIK3CD) 517948(PIK3CB) 530001(PIK3CG)
BOM: 
102274461(PIK3CD) 102274553(PIK3CA) 102277419(PIK3CG) 102277548(PIK3CB)
PHD: 
102320516(PIK3CB) 102321231(PIK3CA) 102333324(PIK3CD) 102342662(PIK3CG)
CHX: 
102168391(PIK3CA) 102173256(PIK3CG) 102177551(PIK3CD) 102185042(PIK3CB)
SSC: 
100518131(PIK3CD) 100621789(PIK3CA) 100622663(PIK3CB) 396979(PIK3CG)
CFR: 
102503674(PIK3CG) 102518643(PIK3CD) 102519994(PIK3CB) 102523502(PIK3CA)
ECB: 
100050532(PIK3CG) 100051623(PIK3CD) 100051753(PIK3CB) 100058141(PIK3CA)
MYB: 
102239669(PIK3CA) 102241723(PIK3CG) 102252921(PIK3CD) 102260487(PIK3CB)
MDO: 
SHR: 
100925455(PIK3CG) 100929811 100932099(PIK3CA)
OAA: 
GGA: 
417706(PIK3CG) 419444(PIK3CD) 424826(PIK3CB) 424971(PIK3CA)
MGP: 
TGU: 
100219602 100224188(PIK3CD) 100229232(PIK3CG) 100229768(PIK3CA)
FAB: 
101811117(PIK3CG) 101811931(PIK3CD) 101814811(PIK3CA) 101821801(PIK3CB)
PHI: 
102099156(PIK3CA) 102102611(PIK3CG) 102103635(PIK3CD) 102106643(PIK3CB)
APLA: 
101796183(PIK3CA) 101796856(PIK3CG) 101800900(PIK3CB) 101802796(PIK3CD)
FPG: 
101910831(PIK3CG) 101911441(PIK3CA) 101919202(PIK3CD) 101923805(PIK3CB)
FCH: 
102049197(PIK3CA) 102049812(PIK3CD) 102051392(PIK3CG) 102057414(PIK3CB)
CLV: 
102083735(PIK3CB) 102084293(PIK3CA) 102090627(PIK3CG) 102095297(PIK3CD)
ASN: 
102372482(PIK3CB) 102381149(PIK3CG) 102387818(PIK3CA) 102388304(PIK3CD)
PSS: 
102448624(PIK3CA) 102459577(PIK3CD) 102460136 102461096(PIK3CB)
ACS: 
XTR: 
100144924(pik3ca) 100158519(pik3cg) 780390(pik3cb)
DRE: 
100002263(pik3cb) 394174(pik3cd) 406598(pik3cg) 561737 564261(pik3cg)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102350948(PIK3CA) 102351622(PIK3CD) 102353565(PIK3CG) 102359335(PIK3CB) 102362971
BFO: 
CIN: 
SPU: 
DME: 
Dmel_CG4141(Pi3K92E)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
551500(GB19635)
NVI: 
100115810(Pik3cb)
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CBR: 
CBG02868(Cbr-age-1)
BMY: 
LOA: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
SMO: 
MBR: 
MONBRDRAFT_18656(PI3K-CA_alpha)
DDI: 
DPP: 
DFA: 
DFA_06196(pikC) DFA_11886(pikA)
EHI: 
EHI_006130(83.t00026) EHI_095130(269.t00003)
EDI: 
ACAN: 
PTM: 
EHX: 
TCR: 
LIF: 
LDO: 
LMI: 
NGR: 
TVA: 
GLA: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Vanhaesebroeck B, Ali K, Bilancio A, Geering B, Foukas LC
  Title
Signalling by PI3K isoforms: insights from gene-targeted mice.
  Journal
Trends Biochem Sci 30:194-204 (2005)
Reference
PMID:9255069
  Authors
Vanhaesebroeck B, Leevers SJ, Panayotou G, Waterfield MD
  Title
Phosphoinositide 3-kinases: a conserved family of signal transducers.
  Journal
Trends Biochem Sci 22:267-72 (1997)

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