KEGG   ORTHOLOGY: K01080Help
Entry
K01080                      KO                                     

Name
PLPP1_2_3
Definition
phosphatidate phosphatase [EC:3.1.3.4]
Pathway
ko00561  Glycerolipid metabolism
ko00564  Glycerophospholipid metabolism
ko00565  Ether lipid metabolism
ko00600  Sphingolipid metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko04072  Phospholipase D signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04975  Fat digestion and absorption
ko05231  Choline metabolism in cancer
Module
M00089  Triacylglycerol biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Lipid metabolism
   00561 Glycerolipid metabolism
    K01080  PLPP1_2_3; phosphatidate phosphatase
   00564 Glycerophospholipid metabolism
    K01080  PLPP1_2_3; phosphatidate phosphatase
   00565 Ether lipid metabolism
    K01080  PLPP1_2_3; phosphatidate phosphatase
   00600 Sphingolipid metabolism
    K01080  PLPP1_2_3; phosphatidate phosphatase
 Environmental Information Processing
  Signal transduction
   04072 Phospholipase D signaling pathway
    K01080  PLPP1_2_3; phosphatidate phosphatase
 Organismal Systems
  Immune system
   04666 Fc gamma R-mediated phagocytosis
    K01080  PLPP1_2_3; phosphatidate phosphatase
  Digestive system
   04975 Fat digestion and absorption
    K01080  PLPP1_2_3; phosphatidate phosphatase
 Human Diseases
  Cancers
   05231 Choline metabolism in cancer
    K01080  PLPP1_2_3; phosphatidate phosphatase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Lipid metabolism
    M00089  Triacylglycerol biosynthesis
     K01080  PLPP1_2_3; phosphatidate phosphatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.4  phosphatidate phosphatase
     K01080  PLPP1_2_3; phosphatidate phosphatase
BRITE hierarchy
Other DBs
RN: R02239 R04162 R06520 R06521 R06522
GO: 0008195
Genes
HSA: 8611(PLPP1) 8612(PLPP2) 8613(PLPP3)
PTR: 455525(PLPP2) 456884(PLPP3) 461869(PLPP1)
PPS: 100975594(PLPP3) 100975798(PLPP2) 100987060(PLPP1)
GGO: 101127981(PLPP2) 101137498(PLPP3) 101146159(PLPP1)
PON: 100442989(PLPP2) 100448168(PLPP1) 100455097(PLPP3)
NLE: 100580386 100581368(PLPP3) 100597096 100606664(PLPP1)
MCC: 706539(PLPP1) 715993(PLPP3) 721004(PLPP2)
MCF: 102126222(PLPP2) 102135864(PLPP3) 102145183(PLPP1)
CSAB: 103221500(PLPP1) 103224742(PLPP3) 103233553(PLPP2)
RRO: 104664269(PLPP3) 104673869(PLPP2) 104680488(PLPP1)
RBB: 108530983(PLPP1) 108531774(PLPP2) 108532937(PLPP3)
CJC: 100395846(PLPP3) 100401080(PLPP1) 100410546(PLPP2) 100410701 100410935
SBQ: 101033570(PPAP2A) 101041971 101048272(PPAP2B) 101052893(PPAP2C)
MMU: 19012(Plpp1) 50784(Plpp2) 67916(Plpp3)
RNO: 192270(Plpp3) 246115(Plpp2) 64369(Plpp1)
CGE: 100771106(Plpp1) 100774295(Plpp2) 100774527(Plpp3)
NGI: 103734095(Plpp3) 103737371(Plpp2) 103739918(Plpp1)
HGL: 101699454(Plpp3) 101724889(Plpp1) 101725640(Plpp2)
CCAN: 109678789 109679855 109686126(Plpp2) 109687259(Plpp3) 109691754(Plpp1)
OCU: 100008821(PLPP1) 100338249(PLPP3) 100351889(PLPP2)
TUP: 102489550(PLPP2) 102499580(PLPP1) 102500387(PLPP3)
CFA: 100856443(PLPP2) 479557(PLPP3) 607962(PLPP1)
AML: 100475075(PLPP2) 100479871(PLPP1) 100481127(PLPP3)
UMR: 103663676(PLPP1) 103670677(PLPP3) 103681620(PLPP2)
ORO: 101370883(PPAP2A) 101378709(PPAP2B) 101384673(PPAP2C)
FCA: 101088547(PLPP1) 101088986(PLPP2) 101095760(PLPP3)
PTG: 102971478(PLPP1) 102971527(PLPP3) 102971652(PLPP2)
AJU: 106975062(PLPP3) 106978113(PLPP2) 106987316(PLPP1)
BTA: 101905992 504545(PLPP2) 617172(PLPP1) 617707(PLPP3)
BOM: 102270713(PLPP3) 102277289(PLPP2) 102278931(PLPP1)
BIU: 109556245(PLPP3) 109561957(PLPP2) 109574777(PLPP1)
CHX: 102171567(PLPP3) 102181946(PLPP2) 102183913(PLPP1)
OAS: 101102020(PLPP3) 101106938(PLPP2) 101108653 101115312(PLPP1)
SSC: 100233200(PLPP2) 100512419(PLPP3) 100515451(PLPP1)
CFR: 102507880(PLPP1) 102510542(PLPP3) 102514739 102517507(PLPP2)
CDK: 105087144(PLPP1) 105092818(PLPP3) 105093401(PLPP2)
BACU: 102997391(PLPP1) 103007844(PLPP2) 103018691(PLPP3)
LVE: 103068920(PLPP3) 103077334(PLPP1) 103089367(PLPP2)
OOR: 101269638(PPAP2B) 101281392(PPAP2C) 101285196(PPAP2A)
ECB: 100049896(PLPP3) 100062257(PLPP1) 100147309(PLPP2)
EAI: 106833476(PLPP3) 106843361(PLPP1) 106846459(PLPP2)
MYB: 102248875(PLPP3) 102250749(PLPP1) 102258225(PLPP2) 106724446
MYD: 102751980(PLPP1) 102752848 102758376(PLPP2) 102774584(PLPP3)
HAI: 109374015(PLPP3) 109382141(PLPP1) 109390650(PLPP2)
RSS: 109434075 109437060(PLPP2) 109453064(PLPP3) 109453442(PLPP1)
PALE: 102879242(PLPP1) 102893849(PLPP3) 102895617(PLPP2)
LAV: 100666604(PLPP2) 100668340(PLPP1) 100671563(PLPP3)
MDO: 100025143(PLPP2) 100031858(PLPP1) 100032239(PLPP3)
OAA: 100083232(PLPP1) 100084258 100087743 100090109(PPAP2B)
GGA: 100858471(PLPP2) 424666(PLPP3) 427138(PLPP1)
MGP: 100547177(PLPP3) 100551396(PLPP2)
CJO: 107305985(PLPP1) 107317705(PLPP3) 107325607(PLPP2)
APLA: 101799557(PLPP1) 101801518(PLPP2) 101802813(PLPP3)
ACYG: 106032990(PPAP2B) 106035619(PPAP2A) 106049096(PPAP2C)
TGU: 100220959(PLPP1) 100227047(PLPP3) 105758944(PLPP2)
GFR: 102031614(PLPP3) 102036933(PLPP1) 102043918(PLPP2)
FAB: 101805764(PLPP1) 101813170(PLPP3) 101819263(PLPP2)
PHI: 102101243(PLPP2) 102107198(PLPP1) 102111145(PLPP3)
PMAJ: 107207902(PLPP3) 107215342(PLPP2) 107216077(PLPP1)
CCW: 104686671(PLPP1) 104695166(PLPP3) 104697003(PLPP2)
FPG: 101914539(PLPP1) 101919468(PLPP3) 101924183(PLPP2)
FCH: 102049189(PLPP3) 102049436(PLPP2) 102053348(PLPP1)
CLV: 102083991(PLPP2) 102087921(PLPP3) 102096477(PLPP1)
EGZ: 104123890(PPAP2B) 104124383(PPAP2C) 104134698(PPAP2A)
ASN: 102371394(PLPP3) 102383543 102384747(PLPP2) 102385252(PLPP1)
AMJ: 102558172(PLPP1) 102561392 102571973(PLPP3) 109282348(PLPP2)
PSS: 102452592(PLPP3) 102456134 102457256(PLPP1) 102460931(PLPP2)
CMY: 102933032 102937547(PLPP1) 102939201(PLPP3) 102945370(PLPP2)
CPIC: 101934148(PLPP1) 101945684(PLPP2) 101948636(PLPP3) 101949714
ACS: 100552130(plpp3) 100552631(plpp2) 100557280 100562534(plpp1)
PVT: 110077116(PLPP3) 110079297(PLPP2) 110085398(PLPP1) 110091305
PBI: 103049864(PLPP1) 103064697(PLPP3) 103064795(PLPP2) 103067987
GJA: 107116100 107120510(PLPP1) 107120594(PLPP2) 107124049(PLPP3)
XLA: 108703504 108711730 443680 443763(plpp2.S) 444206 447215(plpp3.S) 447319(plpp3.L) 735106(plpp1.L)
XTR: 100135382 394722(plpp2) 496488(plpp1) 549612(plpp3)
NPR: 108788162(PLPP3) 108791241(PLPP2) 108791487 108796685(PLPP1)
DRE: 335485(plpp2b) 557680(plpp3) 559124(ppap2d) 563806(plpp2a) 569053(plpp1a) 794598
LCM: 102349675 102352131(PLPP2) 102361613(PLPP1) 102365207(PLPP3)
CMK: 103177820(plpp1) 103182070(plpp2) 103182773(plpp3) 103187548
CIN: 100177985
SPU: 576030
DME: Dmel_CG11425(CG11425) Dmel_CG11426(CG11426) Dmel_CG11437(CG11437) Dmel_CG11438(CG11438) Dmel_CG11440(laza) Dmel_CG8804(wun) Dmel_CG8805(wun2)
DSI: Dsimw501_GD10076(Dsim_GD10076) Dsimw501_GD10653(Dsim_GD10653) Dsimw501_GD12067(Dsim_GD12067) Dsimw501_GD15029(Dsim_GD15029) Dsimw501_GD15030(Dsim_GD15030) Dsimw501_GD15031(Dsim_GD15031) Dsimw501_GD15032(Dsim_GD15032)
AAG: 5569026
AME: 724942 727078(GB11827)
CEL: CELE_F53C3.13(plpp-1.1)
CBR: CBG18435
TSP: Tsp_06576
LAK: 106171462
SHX: MS3_00593
HMG: 100212885
AQU: 100632908
FTW: FTW_0252
FTL: FTL_1728
FTH: FTH_1667
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Carman GM, Han GS
  Title
Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis.
  Journal
J Biol Chem 284:2593-7 (2009)
DOI:10.1074/jbc.R800059200
Reference
  Authors
Brindley DN, Pilquil C, Sariahmetoglu M, Reue K
  Title
Phosphatidate degradation: phosphatidate phosphatases (lipins) and lipid phosphate phosphatases.
  Journal
Biochim Biophys Acta 1791:956-61 (2009)
DOI:10.1016/j.bbalip.2009.02.007
Reference
  Authors
Smyth SS, Sciorra VA, Sigal YJ, Pamuklar Z, Wang Z, Xu Y, Prestwich GD, Morris AJ
  Title
Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity.
  Journal
J Biol Chem 278:43214-23 (2003)
DOI:10.1074/jbc.M306709200
  Sequence
[hsa:8611]

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