KEGG   ORTHOLOGY: K01080Help
Entry
K01080                      KO                                     

Name
PPAP2
Definition
phosphatidate phosphatase [EC:3.1.3.4]
Pathway
Glycerolipid metabolism
Glycerophospholipid metabolism
Ether lipid metabolism
Sphingolipid metabolism
Phospholipase D signaling pathway
Fc gamma R-mediated phagocytosis
Fat digestion and absorption
Choline metabolism in cancer
Module
M00089  
Triacylglycerol biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Lipid metabolism
   00561 Glycerolipid metabolism
    K01080  PPAP2; phosphatidate phosphatase
   00564 Glycerophospholipid metabolism
    K01080  PPAP2; phosphatidate phosphatase
   00565 Ether lipid metabolism
    K01080  PPAP2; phosphatidate phosphatase
   00600 Sphingolipid metabolism
    K01080  PPAP2; phosphatidate phosphatase
 Environmental Information Processing
  Signal transduction
   04072 Phospholipase D signaling pathway
    K01080  PPAP2; phosphatidate phosphatase
 Organismal Systems
  Immune system
   04666 Fc gamma R-mediated phagocytosis
    K01080  PPAP2; phosphatidate phosphatase
  Digestive system
   04975 Fat digestion and absorption
    K01080  PPAP2; phosphatidate phosphatase
 Human Diseases
  Cancers
   05231 Choline metabolism in cancer
    K01080  PPAP2; phosphatidate phosphatase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Lipid metabolism
    M00089  Triacylglycerol biosynthesis
     K01080  PPAP2; phosphatidate phosphatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.4  phosphatidate phosphatase
     K01080  PPAP2; phosphatidate phosphatase
BRITE hierarchy
Other DBs
Genes
HSA: 
8611(PLPP1) 8612(PLPP2) 8613(PLPP3)
PTR: 
455525(PLPP2) 456884(PLPP3) 461869(PLPP1)
PPS: 
100975594(PLPP3) 100975798(PLPP2) 100987060(PLPP1)
GGO: 
101127981(PLPP2) 101137498(PLPP3) 101146159(PLPP1)
PON: 
100442989(PLPP2) 100448168(PLPP1) 100455097(PLPP3)
NLE: 
MCC: 
706539(PLPP1) 715993(PLPP3) 721004(PLPP2)
MCF: 
102126222(PLPP2) 102135864(PLPP3) 102145183(PLPP1)
CSAB: 
103221500(PLPP1) 103224742(PLPP3) 103233553(PLPP2)
RRO: 
104664269(PLPP3) 104673869(PLPP2) 104680488(PLPP1)
CJC: 
SBQ: 
101033570(PPAP2A) 101041971 101048272(PPAP2B) 101052893(PPAP2C)
MMU: 
19012(Plpp1) 50784(Plpp2) 67916(Plpp3)
RNO: 
192270(Plpp3) 246115(Plpp2) 64369(Plpp1)
CGE: 
100771106(Plpp1) 100774295(Plpp2) 100774527(Plpp3)
NGI: 
103734095(Plpp3) 103737371(Plpp2) 103739918(Plpp1)
HGL: 
101699454(Plpp3) 101724889(Plpp1) 101725640(Plpp2)
OCU: 
100008821(PLPP1) 100338249(PLPP3) 100351889(PLPP2)
TUP: 
102489550(PLPP2) 102499580(PLPP1) 102500387(PLPP3)
CFA: 
100856443(PLPP2) 479557(PLPP3) 607962(PLPP1)
AML: 
100475075(PLPP2) 100479871(PLPP1) 100481127(PLPP3)
UMR: 
103663676(PLPP1) 103670677(PLPP3) 103681620(PLPP2)
FCA: 
101088547(PLPP1) 101088986(PLPP2) 101095760(PLPP3)
PTG: 
102971478(PLPP1) 102971527(PLPP3) 102971652(PLPP2)
AJU: 
106975062(PLPP3) 106978113(PLPP2) 106987316(PLPP1)
BTA: 
101905992 504545(PLPP2) 617172(PLPP1) 617707(PLPP3)
BOM: 
102270713(PLPP3) 102277289(PLPP2) 102278931(PLPP1)
PHD: 
CHX: 
102171567(PLPP3) 102181946(PLPP2) 102183913(PLPP1)
OAS: 
101102020(PLPP3) 101106938(PLPP2) 101108653 101115312(PLPP1)
SSC: 
100233200(PLPP2) 100512419(PLPP3) 100515451(PLPP1)
CFR: 
102507880(PLPP1) 102510542(PLPP3) 102514739 102517507(PLPP2)
BACU: 
102997391(PLPP1) 103007844(PLPP2) 103018691(PLPP3)
LVE: 
103068920(PLPP3) 103077334(PLPP1) 103089367(PLPP2)
ECB: 
100049896(PLPP3) 100062257(PLPP1) 100147309(PLPP2)
MYB: 
102248875(PLPP3) 102250749(PLPP1) 102258225(PLPP2) 106724446
MYD: 
102751980(PLPP1) 102752848 102758376(PLPP2) 102774584(PLPP3)
HAI: 
109374015(PLPP3) 109382141(PLPP1) 109390650(PLPP2)
PALE: 
102879242(PLPP1) 102893849(PLPP3) 102895617(PLPP2)
LAV: 
100666604(PLPP2) 100668340(PLPP1) 100671563(PLPP3)
MDO: 
100025143(PLPP2) 100031858(PLPP1) 100032239(PLPP3)
SHR: 
100926398(PLPP3) 100927244(PLPP2) 100934490(PLPP1)
OAA: 
GGA: 
100858471(PLPP2) 424666(PLPP3) 427138(PLPP1)
MGP: 
100547177(PLPP3) 100551396(PLPP2)
CJO: 
107305985(PLPP1) 107317705(PLPP3) 107325607(PLPP2)
APLA: 
101799557(PLPP1) 101801518(PLPP2) 101802813(PLPP3)
TGU: 
100220959(PLPP1) 100227047(PLPP3) 105758944(PLPP2)
GFR: 
102031614(PLPP3) 102036933(PLPP1) 102043918(PLPP2)
FAB: 
101805764(PLPP1) 101813170(PLPP3) 101819263(PLPP2)
PHI: 
102101243(PLPP2) 102107198(PLPP1) 102111145(PLPP3)
CCW: 
104686671(PLPP1) 104695166(PLPP3) 104697003(PLPP2)
FPG: 
101914539(PLPP1) 101919468(PLPP3) 101924183(PLPP2)
FCH: 
102049189(PLPP3) 102049436(PLPP2) 102053348(PLPP1)
CLV: 
102083991(PLPP2) 102087921(PLPP3) 102096477(PLPP1)
AAM: 
ASN: 
102371394(PLPP3) 102383543 102384747(PLPP2) 102385252(PLPP1)
AMJ: 
102558172(PLPP1) 102561392 102571973(PLPP3) 109282348(PLPP2)
PSS: 
102452592(PLPP3) 102456134 102457256(PLPP1) 102460931(PLPP2)
CMY: 
102933032 102937547(PLPP1) 102939201(PLPP3) 102945370(PLPP2)
CPIC: 
101934148(PLPP1) 101945684(PLPP2) 101948636(PLPP3) 101949714
ACS: 
100552130(plpp3) 100552631(plpp2) 100557280 100562534(plpp1)
PBI: 
103049864(PLPP1) 103064697(PLPP3) 103064795(PLPP2) 103067987
GJA: 
107116100 107120510(PLPP1) 107120594(PLPP2) 107124049(PLPP3)
XLA: 
108703504 108711730 443680 443763(plpp2.S) 444206 447215(plpp3.S) 447319(plpp3.L) 735106(plpp1.L)
XTR: 
100135382 394722(plpp2) 496488(plpp1) 549612(plpp3)
DRE: 
335485(plpp2b) 557680(plpp3) 559124(ppap2d) 563806(plpp2a) 569053(plpp1a) 794598
IPU: 
TRU: 
TNG: 
LCO: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
102349675 102352131(PLPP2) 102361613(PLPP1) 102365207(PLPP3)
CMK: 
103177820(plpp1) 103182070(plpp2) 103182773(plpp3) 103187548
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD10076(Dsim_GD10076) Dsimw501_GD10653(Dsim_GD10653) Dsimw501_GD12067(Dsim_GD12067) Dsimw501_GD15029(Dsim_GD15029) Dsimw501_GD15030(Dsim_GD15030) Dsimw501_GD15031(Dsim_GD15031) Dsimw501_GD15032(Dsim_GD15032)
DWI: 
DYA: 
Dyak_GE19275(dyak_GLEANR_3048) Dyak_GE19504(dyak_GLEANR_3363) Dyak_GE19505(dyak_GLEANR_3364) Dyak_GE19506(dyak_GLEANR_3365) Dyak_GE19507(dyak_GLEANR_3366) Dyak_GE19508(dyak_GLEANR_3367) Dyak_GE22302(dyak_GLEANR_599) Dyak_GE23017(dyak_GLEANR_6782) Dyak_GE23018(dyak_GLEANR_6783) Dyak_GE23019(dyak_GLEANR_6784) Dyak_GE23020(dyak_GLEANR_6785)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
724942 727078(GB11827)
BIM: 
BTER: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
DPL: 
PXY: 
API: 
PHU: 
DPX: 
ISC: 
CEL: 
CELE_F53C3.13(F53C3.13)
CBR: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
NVE: 
ADF: 
HMG: 
TAD: 
AQU: 
MIS: 
CSL: 
CVR: 
APRO: 
CME: 
GSL: 
CCP: 
TGO: 
SPAR: 
TBR: 
LMA: 
NGR: 
TVA: 
FTW: 
FTL: 
FTH: 
VG: 
18263455(BA82_gp026) 3654979(EhV079)
 » show all
TaxonomyVtaxonomyKoalaUniProt
Reference
  Authors
Carman GM, Han GS
  Title
Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis.
  Journal
J Biol Chem 284:2593-7 (2009)
Reference
  Authors
Brindley DN, Pilquil C, Sariahmetoglu M, Reue K
  Title
Phosphatidate degradation: phosphatidate phosphatases (lipins) and lipid phosphate phosphatases.
  Journal
Biochim Biophys Acta 1791:956-61 (2009)
Reference
  Authors
Smyth SS, Sciorra VA, Sigal YJ, Pamuklar Z, Wang Z, Xu Y, Prestwich GD, Morris AJ
  Title
Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity.
  Journal
J Biol Chem 278:43214-23 (2003)
  Sequence
[hsa:8611]

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