KEGG   ORTHOLOGY: K01080Help
Entry
K01080                      KO                                     

Name
PLPP1_2_3
Definition
phosphatidate phosphatase [EC:3.1.3.4]
Pathway
Glycerolipid metabolism
Glycerophospholipid metabolism
Ether lipid metabolism
Sphingolipid metabolism
Phospholipase D signaling pathway
Fc gamma R-mediated phagocytosis
Fat digestion and absorption
Choline metabolism in cancer
Module
M00089  
Triacylglycerol biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Lipid metabolism
   00561 Glycerolipid metabolism
    K01080  PLPP1_2_3; phosphatidate phosphatase
   00564 Glycerophospholipid metabolism
    K01080  PLPP1_2_3; phosphatidate phosphatase
   00565 Ether lipid metabolism
    K01080  PLPP1_2_3; phosphatidate phosphatase
   00600 Sphingolipid metabolism
    K01080  PLPP1_2_3; phosphatidate phosphatase
 Environmental Information Processing
  Signal transduction
   04072 Phospholipase D signaling pathway
    K01080  PLPP1_2_3; phosphatidate phosphatase
 Organismal Systems
  Immune system
   04666 Fc gamma R-mediated phagocytosis
    K01080  PLPP1_2_3; phosphatidate phosphatase
  Digestive system
   04975 Fat digestion and absorption
    K01080  PLPP1_2_3; phosphatidate phosphatase
 Human Diseases
  Cancers
   05231 Choline metabolism in cancer
    K01080  PLPP1_2_3; phosphatidate phosphatase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Lipid metabolism
    M00089  Triacylglycerol biosynthesis
     K01080  PLPP1_2_3; phosphatidate phosphatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.4  phosphatidate phosphatase
     K01080  PLPP1_2_3; phosphatidate phosphatase
BRITE hierarchy
Other DBs
Genes
HSA: 
8611(PLPP1) 8612(PLPP2) 8613(PLPP3)
PTR: 
455525(PLPP2) 456884(PLPP3) 461869(PLPP1)
PPS: 
100975594(PLPP3) 100975798(PLPP2) 100987060(PLPP1)
GGO: 
101127981(PLPP2) 101137498(PLPP3) 101146159(PLPP1)
PON: 
100442989(PLPP2) 100448168(PLPP1) 100455097(PLPP3)
NLE: 
MCC: 
706539(PLPP1) 715993(PLPP3) 721004(PLPP2)
MCF: 
102126222(PLPP2) 102135864(PLPP3) 102145183(PLPP1)
CSAB: 
103221500(PLPP1) 103224742(PLPP3) 103233553(PLPP2)
RRO: 
104664269(PLPP3) 104673869(PLPP2) 104680488(PLPP1)
CJC: 
SBQ: 
101033570(PPAP2A) 101041971 101048272(PPAP2B) 101052893(PPAP2C)
MMU: 
19012(Plpp1) 50784(Plpp2) 67916(Plpp3)
RNO: 
192270(Plpp3) 246115(Plpp2) 64369(Plpp1)
CGE: 
100771106(Plpp1) 100774295(Plpp2) 100774527(Plpp3)
NGI: 
103734095(Plpp3) 103737371(Plpp2) 103739918(Plpp1)
HGL: 
101699454(Plpp3) 101724889(Plpp1) 101725640(Plpp2)
CCAN: 
OCU: 
100008821(PLPP1) 100338249(PLPP3) 100351889(PLPP2)
TUP: 
102489550(PLPP2) 102499580(PLPP1) 102500387(PLPP3)
CFA: 
100856443(PLPP2) 479557(PLPP3) 607962(PLPP1)
AML: 
100475075(PLPP2) 100479871(PLPP1) 100481127(PLPP3)
UMR: 
103663676(PLPP1) 103670677(PLPP3) 103681620(PLPP2)
FCA: 
101088547(PLPP1) 101088986(PLPP2) 101095760(PLPP3)
PTG: 
102971478(PLPP1) 102971527(PLPP3) 102971652(PLPP2)
AJU: 
106975062(PLPP3) 106978113(PLPP2) 106987316(PLPP1)
BTA: 
101905992 504545(PLPP2) 617172(PLPP1) 617707(PLPP3)
BOM: 
102270713(PLPP3) 102277289(PLPP2) 102278931(PLPP1)
BIU: 
109556245(PLPP3) 109561957(PLPP2) 109574777(PLPP1)
PHD: 
CHX: 
102171567(PLPP3) 102181946(PLPP2) 102183913(PLPP1)
OAS: 
101102020(PLPP3) 101106938(PLPP2) 101108653 101115312(PLPP1)
SSC: 
100233200(PLPP2) 100512419(PLPP3) 100515451(PLPP1)
CFR: 
102507880(PLPP1) 102510542(PLPP3) 102514739 102517507(PLPP2)
BACU: 
102997391(PLPP1) 103007844(PLPP2) 103018691(PLPP3)
LVE: 
103068920(PLPP3) 103077334(PLPP1) 103089367(PLPP2)
ECB: 
100049896(PLPP3) 100062257(PLPP1) 100147309(PLPP2)
MYB: 
102248875(PLPP3) 102250749(PLPP1) 102258225(PLPP2) 106724446
MYD: 
102751980(PLPP1) 102752848 102758376(PLPP2) 102774584(PLPP3)
HAI: 
109374015(PLPP3) 109382141(PLPP1) 109390650(PLPP2)
RSS: 
109434075 109437060(PLPP2) 109453064(PLPP3) 109453442(PLPP1)
PALE: 
102879242(PLPP1) 102893849(PLPP3) 102895617(PLPP2)
LAV: 
100666604(PLPP2) 100668340(PLPP1) 100671563(PLPP3)
MDO: 
100025143(PLPP2) 100031858(PLPP1) 100032239(PLPP3)
SHR: 
100926398(PLPP3) 100927244(PLPP2) 100934490(PLPP1)
OAA: 
GGA: 
100858471(PLPP2) 424666(PLPP3) 427138(PLPP1)
MGP: 
100547177(PLPP3) 100551396(PLPP2)
CJO: 
107305985(PLPP1) 107317705(PLPP3) 107325607(PLPP2)
APLA: 
101799557(PLPP1) 101801518(PLPP2) 101802813(PLPP3)
TGU: 
100220959(PLPP1) 100227047(PLPP3) 105758944(PLPP2)
GFR: 
102031614(PLPP3) 102036933(PLPP1) 102043918(PLPP2)
FAB: 
101805764(PLPP1) 101813170(PLPP3) 101819263(PLPP2)
PHI: 
102101243(PLPP2) 102107198(PLPP1) 102111145(PLPP3)
CCW: 
104686671(PLPP1) 104695166(PLPP3) 104697003(PLPP2)
FPG: 
101914539(PLPP1) 101919468(PLPP3) 101924183(PLPP2)
FCH: 
102049189(PLPP3) 102049436(PLPP2) 102053348(PLPP1)
CLV: 
102083991(PLPP2) 102087921(PLPP3) 102096477(PLPP1)
AAM: 
ASN: 
102371394(PLPP3) 102383543 102384747(PLPP2) 102385252(PLPP1)
AMJ: 
102558172(PLPP1) 102561392 102571973(PLPP3) 109282348(PLPP2)
PSS: 
102452592(PLPP3) 102456134 102457256(PLPP1) 102460931(PLPP2)
CMY: 
102933032 102937547(PLPP1) 102939201(PLPP3) 102945370(PLPP2)
CPIC: 
101934148(PLPP1) 101945684(PLPP2) 101948636(PLPP3) 101949714
ACS: 
100552130(plpp3) 100552631(plpp2) 100557280 100562534(plpp1)
PBI: 
103049864(PLPP1) 103064697(PLPP3) 103064795(PLPP2) 103067987
GJA: 
107116100 107120510(PLPP1) 107120594(PLPP2) 107124049(PLPP3)
XLA: 
108703504 108711730 443680 443763(plpp2.S) 444206 447215(plpp3.S) 447319(plpp3.L) 735106(plpp1.L)
XTR: 
100135382 394722(plpp2) 496488(plpp1) 549612(plpp3)
DRE: 
335485(plpp2b) 557680(plpp3) 559124(ppap2d) 563806(plpp2a) 569053(plpp1a) 794598
IPU: 
TRU: 
TNG: 
LCO: 
MZE: 
OLA: 
XMA: 
CSEM: 
SASA: 
LCM: 
102349675 102352131(PLPP2) 102361613(PLPP1) 102365207(PLPP3)
CMK: 
103177820(plpp1) 103182070(plpp2) 103182773(plpp3) 103187548
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
Dmel_CG11425(CG11425) Dmel_CG11426(CG11426) Dmel_CG11437(CG11437) Dmel_CG11438(CG11438) Dmel_CG11440(laza) Dmel_CG8804(wun) Dmel_CG8805(wun2)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD10076(Dsim_GD10076) Dsimw501_GD10653(Dsim_GD10653) Dsimw501_GD12067(Dsim_GD12067) Dsimw501_GD15029(Dsim_GD15029) Dsimw501_GD15030(Dsim_GD15030) Dsimw501_GD15031(Dsim_GD15031) Dsimw501_GD15032(Dsim_GD15032)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
724942 727078(GB11827)
BIM: 
BTER: 
SOC: 
AEC: 
PBAR: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
PXY: 
API: 
PHU: 
DPX: 
ISC: 
CEL: 
CELE_F53C3.13(F53C3.13)
CBR: 
NAI: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
OVI: 
NVE: 
ADF: 
HMG: 
TAD: 
AQU: 
CVR: 
CME: 
GSL: 
TGO: 
FCY: 
TBR: 
LMA: 
TVA: 
FTW: 
FTL: 
FTH: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Carman GM, Han GS
  Title
Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis.
  Journal
J Biol Chem 284:2593-7 (2009)
DOI:10.1074/jbc.R800059200
Reference
  Authors
Brindley DN, Pilquil C, Sariahmetoglu M, Reue K
  Title
Phosphatidate degradation: phosphatidate phosphatases (lipins) and lipid phosphate phosphatases.
  Journal
Biochim Biophys Acta 1791:956-61 (2009)
DOI:10.1016/j.bbalip.2009.02.007
Reference
  Authors
Smyth SS, Sciorra VA, Sigal YJ, Pamuklar Z, Wang Z, Xu Y, Prestwich GD, Morris AJ
  Title
Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity.
  Journal
J Biol Chem 278:43214-23 (2003)
DOI:10.1074/jbc.M306709200
  Sequence
[hsa:8611]

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