KEGG   ORTHOLOGY: K01116Help
Entry
K01116                      KO                                     

Name
PLCG1
Definition
phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
NF-kappa B signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
VEGF signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Inflammatory mediator regulation of TRP channels
Thyroid hormone signaling pathway
Vibrio cholerae infection
Epithelial cell signaling in Helicobacter pylori infection
Epstein-Barr virus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Module
M00130  
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04015 Rap1 signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04012 ErbB signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04370 VEGF signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04064 NF-kappa B signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04066 HIF-1 signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04020 Calcium signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04070 Phosphatidylinositol signaling system
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04660 T cell receptor signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04664 Fc epsilon RI signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04666 Fc gamma R-mediated phagocytosis
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04670 Leukocyte transendothelial migration
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  Endocrine system
   04919 Thyroid hormone signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  Nervous system
   04722 Neurotrophin signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05206 MicroRNAs in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05205 Proteoglycans in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05214 Glioma
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05223 Non-small cell lung cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  Infectious diseases
   05110 Vibrio cholerae infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05169 Epstein-Barr virus infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
KEGG pathway modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Lipid metabolism
    M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
     K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
BRITE hierarchy
Other DBs
RN: 
GO: 
Genes
HSA: 
5335(PLCG1)
PTR: 
458253(PLCG1)
PPS: 
100995010(PLCG1)
GGO: 
101135199(PLCG1)
PON: 
100450941(PLCG1)
MCC: 
697069(PLCG1)
MCF: 
102138726(PLCG1)
MMU: 
18803(Plcg1)
RNO: 
25738(Plcg1)
CGE: 
HGL: 
101705192(Plcg1)
TUP: 
102469651(PLCG1)
CFA: 
485874(PLCG1)
AML: 
FCA: 
101092925(PLCG1)
PTG: 
102952137(PLCG1)
BTA: 
281987(PLCG1)
BOM: 
102265099(PLCG1)
PHD: 
102324368(PLCG1)
CHX: 
102181878(PLCG1)
SSC: 
100152497(PLCG1)
CFR: 
102524452(PLCG1)
ECB: 
100070545(PLCG1)
MYB: 
102248243(PLCG1)
MYD: 
102756475(PLCG1)
PALE: 
102896228(PLCG1)
MDO: 
100032696(PLCG1)
SHR: 
100923119(PLCG1)
OAA: 
GGA: 
419175(PLCG1) 776273
MGP: 
TGU: 
FAB: 
PHI: 
102114427(PLCG1)
APLA: 
FPG: 
FCH: 
102057302(PLCG1)
CLV: 
ASN: 
PSS: 
CMY: 
ACS: 
XLA: 
398359(plcg1)
XTR: 
DRE: 
373867(plcg1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
Dpse_GA18024(Dpse_small-wing)
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
Dvir_GJ18791(Dvir_small-wing)
AGA: 
AAG: 
CQU: 
AME: 
551709(sl)
NVI: 
BMOR: 
100329155(PLCg)
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG18715(Cbr-plc-3)
BMY: 
LOA: 
TSP: 
NVE: 
HMG: 
AQU: 
100633163(Plcg1)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Suh PG, Park JI, Manzoli L, Cocco L, Peak JC, Katan M, Fukami K, Kataoka T, Yun S, Ryu SH
  Title
Multiple roles of phosphoinositide-specific phospholipase C isozymes.
  Journal
BMB Rep 41:415-34 (2008)
Reference
  Authors
Carpenter G, Ji Q
  Title
Phospholipase C-gamma as a signal-transducing element.
  Journal
Exp Cell Res 253:15-24 (1999)

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