KEGG   ORTHOLOGY: K01116Help
Entry
K01116                      KO                                     

Name
PLCG1
Definition
phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04064  NF-kappa B signaling pathway
ko04066  HIF-1 signaling pathway
ko04070  Phosphatidylinositol signaling system
ko04072  Phospholipase D signaling pathway
ko04360  Axon guidance
ko04370  VEGF signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko04660  T cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04670  Leukocyte transendothelial migration
ko04722  Neurotrophin signaling pathway
ko04750  Inflammatory mediator regulation of TRP channels
ko04919  Thyroid hormone signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05110  Vibrio cholerae infection
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05167  Kaposi's sarcoma-associated herpesvirus infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05214  Glioma
ko05223  Non-small cell lung cancer
ko05225  Hepatocellular carcinoma
ko05231  Choline metabolism in cancer
Module
M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04015 Rap1 signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04012 ErbB signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04370 VEGF signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04064 NF-kappa B signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04066 HIF-1 signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04020 Calcium signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04070 Phosphatidylinositol signaling system
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04072 Phospholipase D signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04660 T cell receptor signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04658 Th1 and Th2 cell differentiation
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04659 Th17 cell differentiation
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04664 Fc epsilon RI signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04666 Fc gamma R-mediated phagocytosis
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04670 Leukocyte transendothelial migration
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  Endocrine system
   04919 Thyroid hormone signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  Nervous system
   04722 Neurotrophin signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  Development
   04360 Axon guidance
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05231 Choline metabolism in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05206 MicroRNAs in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05205 Proteoglycans in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05225 Hepatocellular carcinoma
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05214 Glioma
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05223 Non-small cell lung cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  Infectious diseases
   05110 Vibrio cholerae infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05169 Epstein-Barr virus infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Lipid metabolism
    M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
     K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 Endocytosis
  Macropinocytosis
   Phospholipase C
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
BRITE hierarchy
Other DBs
RN: R03332 R03435 R10952
GO: 0004435
Genes
HSA: 5335(PLCG1)
PTR: 458253(PLCG1)
PPS: 100995010(PLCG1)
GGO: 101135199(PLCG1)
PON: 100450941(PLCG1)
NLE: 100591458(PLCG1)
MCC: 697069(PLCG1)
MCF: 102138726(PLCG1)
CSAB: 103245987(PLCG1)
RRO: 104672220(PLCG1)
RBB: 108519825(PLCG1)
CJC: 100397497(PLCG1)
SBQ: 101046976(PLCG1)
MMU: 18803(Plcg1)
RNO: 25738(Plcg1)
CGE: 100769697(Plcg1)
NGI: 103747244(Plcg1)
HGL: 101705192(Plcg1)
CCAN: 109683399(Plcg1)
OCU: 100349958(PLCG1)
TUP: 102469651(PLCG1)
CFA: 485874(PLCG1)
AML: 100480586(PLCG1)
UMR: 103669754(PLCG1)
ORO: 101380728(PLCG1)
FCA: 101092925(PLCG1)
PTG: 102952137(PLCG1)
AJU: 106974495(PLCG1)
BTA: 281987(PLCG1)
BOM: 102265099(PLCG1)
BIU: 109567698(PLCG1)
PHD: 102324368(PLCG1)
CHX: 102181878(PLCG1)
OAS: 101103341(PLCG1)
SSC: 100152497(PLCG1)
CFR: 102524452(PLCG1)
CDK: 105085024(PLCG1)
BACU: 103016663(PLCG1)
LVE: 103068930(PLCG1)
OOR: 101281412(PLCG1)
ECB: 100070545(PLCG1)
EPZ: 103562208(PLCG1)
EAI: 106834358(PLCG1)
MYB: 102248243(PLCG1)
MYD: 102756475(PLCG1)
HAI: 109379925(PLCG1)
RSS: 109456634(PLCG1)
PALE: 102896228(PLCG1)
LAV: 100677739(PLCG1)
TMU: 101359597
MDO: 100032696(PLCG1)
SHR: 100923119(PLCG1)
OAA: 100078757(PLCG1)
GGA: 419175(PLCG1) 776273
MGP: 100542272 100548670(PLCG1)
CJO: 107310620 107322901(PLCG1)
APLA: 101792010 101798692(PLCG1)
ACYG: 106042207 106043486(PLCG1)
TGU: 100220070(PLCG1) 100222362
GFR: 102032882(PLCG1) 102038983
FAB: 101806517(PLCG1) 101820005
PHI: 102100949 102114427(PLCG1)
PMAJ: 107200506 107213300(PLCG1)
CCW: 104687887(PLCG1) 104692596
FPG: 101912447(PLCG1) 101918282
FCH: 102046961 102057302(PLCG1)
CLV: 102098341(PLCG1) 102098590
EGZ: 104128859 104132170(PLCG1)
AAM: 106488145(PLCG1) 106494802
ASN: 102368895 102369875(PLCG1)
AMJ: 102563626(PLCG1) 102574067
PSS: 102459944(PLCG1) 102461099
CMY: 102944142(PLCG1) 102946940
CPIC: 101930905 101935550(PLCG1)
PVT: 110070157 110076765(PLCG1)
PBI: 103062888 103064933(PLCG1)
XLA: 108702812 108719445 398359(plcg1.L) 398360(plcg1.S)
XTR: 100496658 100496674(plcg1)
NPR: 108786812(PLCG1) 108789042
DRE: 373867(plcg1)
SANH: 107663201(plcg1) 107703619
IPU: 108275796(plcg1)
AMEX: 103023099(plcg1)
TRU: 101065481 101069039(plcg1)
LCO: 104925092(plcg1) 104927718
MZE: 101470576(plcg1) 101473405
OLA: 101163005(plcg1) 101167946
XMA: 102217766(plcg1) 102229810
PRET: 103463411 103467475(plcg1)
NFU: 107391021(plcg1) 107393039
CSEM: 103385539(plcg1) 103399890
LCF: 108877896(plcg1) 108879537
HCQ: 109514977(plcg1) 109524567
BPEC: 110164633(plcg1) 110172233
SASA: 106560399 106566556(plcg1)
ELS: 105011953 105013964(plcg1)
LCM: 102352804 102362442(PLCG1)
CIN: 100178711
SPU: 579102
APLC: 110980002
SKO: 100377901
DME: Dmel_CG4200(sl)
DPO: Dpse_GA18024(Dpse_small-wing)
DSI: Dsimw501_GD17281(Dsim_GD17281)
DVI: Dvir_GJ18791(Dvir_small-wing)
MDE: 101900328
AAG: 5564766
AME: 551709(sl)
BIM: 100748682
BTER: 100647687
AEC: 105144421
ACEP: 105624086
PBAR: 105431231
HST: 105188458
CFO: 105257806
LHU: 105673001
PGC: 109852947
NVI: 100123217
TCA: 660210
DPA: 109537047
NVL: 108561344
BMOR: 100329155(PLCg)
PMAC: 106717301
PRAP: 110998146
PXY: 105381166
API: 100166969
DNX: 107163682
ZNE: 110834677
TUT: 107359684
CEL: CELE_T01E8.3(plc-3)
CBR: CBG18715(Cbr-plc-3)
BMY: Bm1_42205
TSP: Tsp_10563
CRG: 105340725
MYI: 110450840
OBI: 106874041
EPA: 110244579
ADF: 107357605
HMG: 100212273
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Suh PG, Park JI, Manzoli L, Cocco L, Peak JC, Katan M, Fukami K, Kataoka T, Yun S, Ryu SH
  Title
Multiple roles of phosphoinositide-specific phospholipase C isozymes.
  Journal
BMB Rep 41:415-34 (2008)
Reference
  Authors
Carpenter G, Ji Q
  Title
Phospholipase C-gamma as a signal-transducing element.
  Journal
Exp Cell Res 253:15-24 (1999)
DOI:10.1006/excr.1999.4671
Reference
PMID:2167438
  Authors
Burgess WH, Dionne CA, Kaplow J, Mudd R, Friesel R, Zilberstein A, Schlessinger J, Jaye M
  Title
Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.
  Journal
Mol Cell Biol 10:4770-7 (1990)
DOI:10.1128/MCB.10.9.4770
  Sequence
[hsa:5335]

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