KEGG   ORTHOLOGY: K01313Help
Entry
K01313                      KO                                     

Name
F2
Definition
coagulation factor II (thrombin) [EC:3.4.21.5]
Pathway
Neuroactive ligand-receptor interaction
Complement and coagulation cascades
Regulation of actin cytoskeleton
Disease
H00223  
Inherited thrombophilia
H01254  
Congenital prothrombin deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K01313  F2; coagulation factor II (thrombin)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K01313  F2; coagulation factor II (thrombin)
 Organismal Systems
  Immune system
   04610 Complement and coagulation cascades
    K01313  F2; coagulation factor II (thrombin)
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.5  thrombin
     K01313  F2; coagulation factor II (thrombin)
Peptidases [BR:ko01002]
 Serine Peptidases
  Family S1: chymotrypsin family
   K01313  F2; coagulation factor II (thrombin)
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of hepatic cells
   K01313  F2; coagulation factor II (thrombin)
Cell adhesion molecules and their ligands [BR:ko04516]
 2. Integrin Family
  Beta3 integrins
   alpha IIb  beta 3
    ITGB3; integrin beta 3
     K01313 F2; coagulation factor II (thrombin)
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Coagulation and fibrinolysis
   K01313  F2; coagulation factor II (thrombin)
BRITE hierarchy
Genes
HSA: 
2147(F2)
PTR: 
451158(F2)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
712729(F2)
MCF: 
CSAB: 
RRO: 
RBB: 
CJC: 
SBQ: 
MMU: 
14061(F2)
RNO: 
29251(F2)
CGE: 
NGI: 
HGL: 
CCAN: 
OCU: 
TUP: 
CFA: 
AML: 
UMR: 
FCA: 
PTG: 
AJU: 
BTA: 
280685(F2)
BOM: 
BIU: 
PHD: 
CHX: 
OAS: 
SSC: 
CFR: 
CDK: 
BACU: 
LVE: 
ECB: 
EPZ: 
EAI: 
MYB: 
MYD: 
HAI: 
RSS: 
PALE: 
LAV: 
MDO: 
SHR: 
OAA: 
GGA: 
395306(F2)
MGP: 
CJO: 
APLA: 
ACYG: 
TGU: 
GFR: 
FAB: 
PHI: 
CCW: 
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
PSS: 
CMY: 
CPIC: 
ACS: 
PBI: 
GJA: 
XLA: 
443652(f2.L) 446352(f2.S)
XTR: 
548514(f2)
NPR: 
DRE: 
325881(f2)
SRX: 
SANH: 
SGH: 
IPU: 
TRU: 
446073(f2)
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
SASA: 
ELS: 
SFM: 
LCM: 
CMK: 
SKO: 
CRG: 
OBI: 
LAK: 
NVE: 
ADF: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:6326805
  Authors
MacGillivray RT, Davie EW
  Title
Characterization of bovine prothrombin mRNA and its translation product.
  Journal
Biochemistry 23:1626-34 (1984)
DOI:10.1021/bi00303a007
  Sequence
[bta:280685]
Reference
PMID:2856554
  Authors
Glenn KC, Frost GH, Bergmann JS, Carney DH
  Title
Synthetic peptides bind to high-affinity thrombin receptors and modulate thrombin mitogenesis.
  Journal
Pept Res 1:65-73 (1988)

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