KEGG ORTHOLOGY: K01325

ORTHOLOGY: K01325

Entry

K01325                      KO

Symbol

KLK1_2

Name

tissue kallikrein [EC:3.4.21.35]

Pathway

map04614

Renin-angiotensin system

map04961

Endocrine and other factor-regulated calcium reabsorption

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09152 Endocrine system
   04614 Renin-angiotensin system
    K01325  KLK1_2; tissue kallikrein
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    K01325  KLK1_2; tissue kallikrein
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01325  KLK1_2; tissue kallikrein
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K01325  KLK1_2; tissue kallikrein
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.35  tissue kallikrein
     K01325  KLK1_2; tissue kallikrein
Peptidases and inhibitors [BR:ko01002]
Serine peptidases
  Family S1: chymotrypsin family
   K01325  KLK1_2; tissue kallikrein
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K01325  KLK1_2; tissue kallikrein

Genes

HSA:	3816(KLK1) 3817(KLK2)

PTR:	107969791(KLK1) 748637(KLK2)

PPS:	100967412(KLK2) 100995152(KLK1)

GGO:	101144843(KLK1)

PON:	100431610(KLK1) 100432729(KLK2)

NLE:	115836983(KLK1)

HMH:	116478138(KLK1)

MCC:	106994826(KLK1) 719436

MCF:

102135781

MTHB:

126943132 126943136

MNI:	105497139 105497145(KLK1)

CSAB:

103235100(KLK1) 103235106(KLK2)

CATY:

105595342(KLK1) 105595344

PANU:

101004790(KLK1) 101006181

TGE:	112612653 112613504(KLK2)

MLEU:

105528940(KLK2) 105528944(KLK1)

RRO:	104667242(KLK1)

RBB:	108532416(KLK1)

TFN:	117091647(KLK1)

PTEH:

111519950(KLK1) 111547903

CANG:

105514726(KLK1)

CJC:	100402463(KLK1) 100402826

SBQ:	101045013(KLK1) 101045648

CIMI:

108291947 108291980(KLK1) 108291981

CSYR:

103274723 103274726

MMUR:

105865551 105865552 105865567

LCAT:

123623765(KLK1) 123623766

PCOQ:

105809263(KLK1) 105809362

OGA:	100964111 100964738(KLK1)

MMU:	13646(Klk1b22) 13648(Klk1b9) 16612(Klk1) 16613(Klk1b11) 16616(Klk1b21) 16617(Klk1b24) 16618(Klk1b26) 16619(Klk1b27) 16622(Klk1b5) 16623(Klk1b1) 16624(Klk1b8) 18050(Klk1b3)

MCAL:

110288052 110288646 110288648 110288829 110297501 110298249 110298250 110298251 110298252 110298253 110298254 110298255 110298258 110298259 110298262 110298268

MPAH:

110315507 110315664 110315691 110315692 110315693 110318293 110318297 110318311 110318333 110318340 110318349

RNO:	100361452(Klk1c4) 24523(Klk1) 24594(Klk1b3) 24841(Klk1c2) 292855(Klk1c12) 292858(Klk1c10) 292866(Klk1c8) 292868(Klk1c9) 292872(Klk1c3) 408242(Klk1c6)

MCOC:

116100493 116100494 116101214 116101215 116101217 116102109 116102113

ANU:	117715292(Klk1)

MUN:	110539921 110539925

CGE:

100754155

MAUA:

106022386(Klk1)

PROB:

127213897

PLEU:

114684323(Klk1) 114684353

MORG:

121446057(Klk1)

MFOT:

126488198

AAMP:

119802928(Klk1)

NGI:	103743763(Klk1) 103743764

HGL:	101705888 101719001(Klk1)

CPOC:

100716976 100717627 100717905(Klk1)

CCAN:

109683867 109683868 109683884

DORD:

105994168 105994284(Klk1) 105994289 105994292

DSP:	122125573 122125633(Klk1) 122125638 122125650

PLOP:

125338534(Klk1) 125338541 125338543 125368107

NCAR:

124966706 124967234

MMMA:

107151706 107151708(Klk1)

OCU:

100101620

OPI:	105942447(KLK1)

TUP:	102489025(KLK1)

GVR:	103608034(KLK1)

CFA:	403942(KLK1) 403967(KLK2)

CLUD:

112645074(KLK1) 112645075

VVP:	112931184 112931507

VLG:	121475667 121484807

NPO:	129500105 129500627

AML:	100476682 100476932(KLK1) 117799551

UMR:	103657279(KLK1) 103657282

UAH:	113247288(KLK1) 113247344

UAR:	123778021(KLK1) 123778040

ELK:	111160671 111160724

LLV:	125089860 125089862

MPUF:

101690899 101692305(KLK1)

MNP:	132004729 132005283(KLK1)

MLK:	131817584(KLK1) 131817591

NVS:	122913862 122913865(KLK1)

ORO:	101375682 101382562

EJU:	114199586(KLK1) 114199592

ZCA:	113935385(KLK1) 113935397

MLX:	117997969 117998338(KLK1)

NSU:	110572972 110572982 110578655 123323730

LWW:	102751105(KLK1)

FCA:	101090062(KLK1) 101097936

PYU:	121018990(KLK1)

PCOO:

112850833

PBG:	122493807(KLK1)

PVIV:

125152590 125152739

LRUF:

124511698 124511770

PTG:	102963319(KLK1) 102963589

PPAD:

109252991 109252996(KLK1)

PUC:

125916128

AJU:	106989422 106989668

HHV:	120241686 120244551(KLK1)

BTA:	493738(KLK1)

BOM:	102283027(KLK1)

BIU:	109571921(KLK1)

BBUB:

102406481

BBIS:

104995754

CHX:

102177186

OAS:	100048991(KLK1)

BTAX:

128063377

ODA:	120872025(KLK1)

CCAD:

122421576(KLK1)

MBEZ:

129546491(KLK1)

SSC:	431673(KLK1)

CFR:	102515972(KLK1)

CBAI:

105062677

CDK:	105100157(KLK1)

VPC:	102528270(KLK1)

BACU:

103007165(KLK1)

BMUS:

118885121(KLK1) 118904290

LVE:	103081797(KLK1)

OOR:

101283477

DLE:	111181109(KLK1)

PCAD:

102980618

PSIU:

116743839

NASI:

112415494

ECB:	100034023(KLK1E2) 100147008(KLK1) 102147584 111775413

EAI:	106845317 106845494 123275590 123281043

MYB:	102251175(KLK1)

MYD:	102765308(KLK1)

MMYO:

118649263(KLK1)

EFUS:

103297602(KLK1)

MNA:	107531831(KLK1)

DRO:	112310143(KLK1)

AJM:	119052016(KLK1)

PDIC:

114511508(KLK1)

PHAS:

123830267(KLK1)

MMF:	118638349(KLK1)

PPAM:

129082971(KLK1)

HAI:	109390988(KLK1)

RFQ:	117016273 117019016 117035625(KLK1)

PALE:

102893946(KLK1) 102898477

PGIG:

120584017(KLK1)

PVP:	105307422(KLK1)

RAY:	107500469(KLK1)

MJV:	108397931(KLK1)

TOD:	119249652 119249656(KLK1)

SARA:

101548172 101548436 105942741

SETR:

126028039 126028043 126028631 126028632

LAV:	104845473 111749208

TMU:

101344800

ETF:

101656202

DNM:	101416554 101430451 101437536 111766066

OAA:	100087855(KLK1)

CTIG:

CSAI:

XHE:

PRET:

PFOR:

PMEI:

GAF:	122830864 122846929

GFS:

AMER:

BCOO:

FAS:

AGRG:

CCRN:

DVT:

TPAL:

OSN:

Reference

PMID:17006539

Authors

Gkika D, Topala CN, Chang Q, Picard N, Thebault S, Houillier P, Hoenderop JG, Bindels RJ

Title

Tissue kallikrein stimulates Ca(2+) reabsorption via PKC-dependent plasma membrane accumulation of TRPV5.

Journal

EMBO J 25:4707-16 (2006)
DOI:10.1038/sj.emboj.7601357

Sequence

[mmu:16612]

All links

Ontology (4)   
   KEGG BRITE (4)   
Pathway (4)   
   KEGG PATHWAY (4)   
Drug (3)   
   KEGG DRUG (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (324)   
   KEGG GENES (302)   
   RefGene (16)   
   OC (6)   
Literature (1)   
   PubMed (1)   
All databases (337)   

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