KEGG ORTHOLOGY: K01360

ORTHOLOGY: K01360

Entry

K01360                      KO

Symbol

PCSK2

Name

proprotein convertase subtilisin/kexin type 2 [EC:3.4.21.94]

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01360  PCSK2; proprotein convertase subtilisin/kexin type 2
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts
    K01360  PCSK2; proprotein convertase subtilisin/kexin type 2
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.94  proprotein convertase 2
     K01360  PCSK2; proprotein convertase subtilisin/kexin type 2
Peptidases and inhibitors [BR:ko01002]
Serine peptidases
  Family S8: subtilisin family
   K01360  PCSK2; proprotein convertase subtilisin/kexin type 2
Chaperones and folding catalysts [BR:ko03110]
Intramolecular chaperones
  Subtilisin family
   K01360  PCSK2; proprotein convertase subtilisin/kexin type 2

Genes

HSA:	5126(PCSK2)

PTR:	458106(PCSK2)

PPS:	100995237(PCSK2)

GGO:	101144581(PCSK2)

PON:	100171744(PCSK2)

NLE:	100606456(PCSK2)

HMH:	116461318(PCSK2)

MCC:	695730(PCSK2)

MCF:	102139968(PCSK2)

MTHB:

126929184

MNI:	105486861(PCSK2)

CSAB:

103214696(PCSK2)

CATY:

105582050(PCSK2)

PANU:

101018120(PCSK2)

TGE:	112633217(PCSK2)

MLEU:

105539280(PCSK2)

RRO:	104676602(PCSK2)

RBB:	108544396(PCSK2)

TFN:	117068427(PCSK2)

PTEH:

111546421(PCSK2)

CANG:

105526674(PCSK2)

CJC:	100410189(PCSK2)

SBQ:	101032326(PCSK2)

CIMI:

108292043(PCSK2)

CSYR:

103256179(PCSK2)

MMUR:

105868534(PCSK2)

LCAT:

123622882(PCSK2)

PCOQ:

105807145(PCSK2)

OGA:	100944687(PCSK2)

MMU:	18549(Pcsk2)

MCAL:

110284423(Pcsk2)

MPAH:

110317783(Pcsk2)

RNO:	25121(Pcsk2)

MCOC:

116091050(Pcsk2)

ANU:	117704080(Pcsk2)

MUN:	110548494(Pcsk2)

CGE:	100771130(Pcsk2)

MAUA:

106021024(Pcsk2)

PROB:

127221370(Pcsk2)

PLEU:

114709434(Pcsk2)

MORG:

121460161(Pcsk2)

MFOT:

126512047

AAMP:

119815398(Pcsk2)

NGI:	103747731(Pcsk2)

HGL:	101710029(Pcsk2)

CPOC:

100727607(Pcsk2)

CCAN:

109679472(Pcsk2)

DORD:

105993720(Pcsk2)

DSP:	122096086(Pcsk2)

PLOP:

125352316(Pcsk2)

NCAR:

124970768

MMMA:

107134363(Pcsk2)

OCU:

100358339

OPI:	101517360(PCSK2)

TUP:	102496906(PCSK2)

GVR:	103603908(PCSK2)

CFA:	485757(PCSK2)

CLUD:

112673545(PCSK2)

VVP:	112922736(PCSK2)

VLG:	121477688(PCSK2)

NPO:	129521699(PCSK2)

AML:	100484456(PCSK2)

UMR:	103680513(PCSK2)

UAH:	113258239(PCSK2)

UAR:	123797738(PCSK2)

ELK:

111141692

LLV:

125108857

MPUF:

101686940(PCSK2)

MNP:	132021712(PCSK2)

MLK:	131808137(PCSK2)

NVS:	122916283(PCSK2)

ORO:	101380258(PCSK2)

EJU:	114216413(PCSK2)

ZCA:	113938351(PCSK2)

MLX:	118011215(PCSK2)

NSU:	110590033(PCSK2)

LWW:	102736604(PCSK2)

FCA:	101098130(PCSK2)

PYU:	121012516(PCSK2)

PCOO:

112868923(PCSK2)

PBG:	122496591(PCSK2)

PVIV:

125162317(PCSK2)

LRUF:

124504157

PTG:	102951344(PCSK2)

PPAD:

109274692(PCSK2)

PUC:

125936834

AJU:

106967042

HHV:	120248232(PCSK2)

BTA:	281968(PCSK2)

BOM:	102280836(PCSK2)

BIU:	109568044(PCSK2)

BBUB:

102415434(PCSK2)

BBIS:

105003077(PCSK2)

CHX:	106503927(PCSK2)

OAS:	114117473 443027

BTAX:

128058040 128058509

ODA:	120868996(PCSK2)

CCAD:

122448749(PCSK2)

MBEZ:

129555341(PCSK2)

SSC:	445533(PCSK2)

CFR:	102511136(PCSK2)

CBAI:

105083143(PCSK2)

CDK:	105094118(PCSK2)

VPC:	102526288(PCSK2)

BACU:

103012983(PCSK2)

BMUS:

118881888(PCSK2)

LVE:	103076654(PCSK2)

OOR:	101276250(PCSK2)

DLE:	111184969 111185078

PCAD:

102978314(PCSK2)

PSIU:

116740293(PCSK2)

NASI:

112405362(PCSK2)

ECB:	100050755(PCSK2)

EPZ:	103561885(PCSK2)

EAI:	106823791(PCSK2)

MYB:	102239561(PCSK2)

MYD:	102759435(PCSK2)

MMYO:

118663794(PCSK2)

MLF:	102432827(PCSK2)

PKL:	118708055(PCSK2)

EFUS:

103285692(PCSK2)

MNA:	107536362(PCSK2)

DRO:	112304169(PCSK2)

SHON:

118984882(PCSK2)

AJM:	119061122(PCSK2)

PDIC:

114506917(PCSK2)

PHAS:

123814658(PCSK2)

MMF:	118619150(PCSK2)

PPAM:

129070888(PCSK2)

HAI:	109372764(PCSK2)

RFQ:	117016129(PCSK2)

PALE:

102879445(PCSK2)

PGIG:

120611881(PCSK2)

PVP:	105299493(PCSK2)

RAY:	107520753(PCSK2)

MJV:	108393766(PCSK2)

TOD:	119232326(PCSK2) 119242620

SARA:

101540743(PCSK2)

SETR:

126010749(PCSK2)

LAV:	100659343(PCSK2)

TMU:

101361430

ETF:	101640004(PCSK2)

DNM:	101416376(PCSK2)

MDO:	100033262(PCSK2)

GAS:	123234761(PCSK2)

SHR:	100925659(PCSK2)

AFZ:

127548466

PCW:	110208376(PCSK2)

OAA:	100085012(PCSK2)

GGA:	395136(PCSK2)

PCOC:

116235280(PCSK2)

MGP:	100548840(PCSK2)

CJO:	107310688(PCSK2)

TPAI:

128077852(PCSK2)

LMUT:

125689022(PCSK2)

NMEL:

110396263(PCSK2)

APLA:

101791329(PCSK2)

ACYG:

106048665(PCSK2)

CATA:

118251151(PCSK2)

AFUL:

116488002(PCSK2)

TGU:	100223337(PCSK2)

LSR:	110484895(PCSK2)

SCAN:

103822198(PCSK2)

PMOA:

120506870(PCSK2)

OTC:	121335864(PCSK2)

PRUF:

121358756(PCSK2)

GFR:	102034686(PCSK2)

FAB:	101808403(PCSK2)

OMA:	130251508(PCSK2)

PHI:	102111890(PCSK2)

PMAJ:

107202341(PCSK2)

CCAE:

111926118(PCSK2)

CCW:	104696571(PCSK2)

CBRC:

103617205(PCSK2)

ETL:	114058803(PCSK2)

ZAB:	102063514(PCSK2)

ACHL:

103809599(PCSK2)

SVG:	106863229(PCSK2)

MMEA:

130575246(PCSK2)

HRT:	120750420(PCSK2)

FPG:	101924281(PCSK2)

FCH:	102046561(PCSK2)

CLV:	102088621(PCSK2)

EGZ:	104122531(PCSK2)

NNI:	104022491(PCSK2)

PCRI:

104027279(PCSK2)

PLET:

104626782(PCSK2)

EHS:	104513798(PCSK2)

PCAO:

104047597(PCSK2)

ACUN:

113477999(PCSK2)

TALA:

104358328(PCSK2)

PADL:

103920513(PCSK2)

AFOR:

103901650(PCSK2)

ACHC:

115344536(PCSK2)

HALD:

104312650

HLE:	104836443(PCSK2)

AGEN:

126038426

GCL:

127014213

CCRI:

104164777(PCSK2)

MUI:	104536743(PCSK2)

BREG:

104632403(PCSK2)

FGA:	104077143(PCSK2)

GSTE:

104257903(PCSK2)

LDI:	104354308(PCSK2)

MNB:	103780818(PCSK2)

OHA:	104332924(PCSK2)

NNT:	104411689(PCSK2)

SHAB:

115609680(PCSK2)

DPUB:

104305994(PCSK2)

PGUU:

104463966(PCSK2)

ACAR:

104532040(PCSK2)

CPEA:

104390984(PCSK2)

AVIT:

104275039(PCSK2)

CVF:	104283269(PCSK2)

RTD:	128907412(PCSK2)

CUCA:

104055448(PCSK2)

BRHI:

104499218(PCSK2)

AAM:	106496400(PCSK2)

AROW:

112961092(PCSK2)

NPD:	112945085(PCSK2)

TGT:	104564754(PCSK2)

DNE:	112989352(PCSK2)

SCAM:

104143481(PCSK2)

ASN:	102373017(PCSK2)

AMJ:	102576051(PCSK2)

CPOO:

109319520(PCSK2)

GGN:	109296915(PCSK2)

PSS:	102463058(PCSK2)

CMY:	102939591(PCSK2)

CCAY:

125633454(PCSK2)

DCC:	119853688(PCSK2)

CPIC:

101951129(PCSK2)

TST:	117874087(PCSK2)

CABI:

116840008(PCSK2)

MRV:	120401432(PCSK2)

ACS:	100564235(pcsk2)

ASAO:

132780445(PCSK2)

PVT:	110088789(PCSK2)

SUND:

121919837(PCSK2)

PBI:	103053916(PCSK2)

PMUR:

107283169(PCSK2)

CTIG:

120310661

TSR:	106542372(PCSK2)

PGUT:

117674425(PCSK2)

APRI:

131197647(PCSK2)

PTEX:

113444230(PCSK2)

NSS:	113412708(PCSK2)

VKO:	123035864(PCSK2)

PMUA:

114593687(PCSK2)

PRAF:

128409983(PCSK2)

ZVI:	118082473(PCSK2)

HCG:	128339967(PCSK2)

GJA:	107116988(PCSK2)

STOW:

125438196

EMC:	129343477(PCSK2)

XLA:	373675(pcsk2.L) 444586(pcsk2.S)

XTR:	100036632(pcsk2)

NPR:	108793310(PCSK2)

RTEM:

120937785(PCSK2)

BBUF:

120999305(PCSK2)

BGAR:

122935639(PCSK2)

MUO:	115465689(PCSK2)

GSH:	117358024(PCSK2)

DRE:	100004460(pcsk2)

SRX:	107719546(pcsk2) 107727889

SANH:

107699156 107701967

SGH:	107561970 107573254

CCAR:

109065357(pcsk2)

CAUA:

113057406 113113092

CGIB:

127969646 128026550

PTET:

122335481 122335483(pcsk2)

LROH:

127174793(pcsk2)

OMC:	131552783(pcsk2)

PPRM:

120492369(pcsk2)

RKG:	130103842(pcsk2)

MAMB:

125277521(pcsk2)

CIDE:

127525198

MASI:

127412310 127413928

TROS:

130559111(pcsk2)

TDW:	130432213(pcsk2)

MANU:

129416255(pcsk2)

IPU:

108262286

IFU:	128605267(pcsk2)

PHYP:

113542135(pcsk2)

SMEO:

124403240(pcsk2)

TFD:	113655412(pcsk2)

TVC:	132847004(pcsk2)

AMEX:

103033370(pcsk2) 103039520

CMAO:

118810137(pcsk2)

EEE:	113585930(pcsk2)

CHAR:

105892728(pcsk2)

TRU:	101068590(pcsk2) 101070282

TFS:	130534025(pcsk2)

TNG:	GSTEN00016397G001

LCO:	104930725(pcsk2)

NCC:	104955826(pcsk2)

TBEN:

117499911(pcsk2)

CGOB:

115020186(pcsk2)

PGEO:

117459288(pcsk2)

GACU:

117560906(pcsk2)

EMAC:

134858378(pcsk2)

ELY:	117248386(pcsk2)

EFO:	125903111(pcsk2)

PLEP:

121954547(pcsk2)

SLUC:

116055069(pcsk2)

ECRA:

117960430(pcsk2)

ESP:	116705553(pcsk2)

PFLV:

114572158(pcsk2)

GAT:	120820648(pcsk2)

PPUG:

119214010(pcsk2)

AFB:	129092246(pcsk2)

CLUM:

117744078(pcsk2)

PSWI:

130207080(pcsk2)

MSAM:

119917635(pcsk2)

SCHU:

122884577(pcsk2)

CUD:	121510697(pcsk2)

ALAT:

119033989(pcsk2)

MZE:	101470601(pcsk2)

ONL:	100534405(pcsk2)

OAU:	116333735(pcsk2)

OLA:	100049241(pcsk2)

OML:	112161964(pcsk2)

CSAI:

133464056(pcsk2)

XMA:	102231965(pcsk2)

XCO:	114138283(pcsk2)

XHE:	116713436(pcsk2)

PRET:

103476807(pcsk2)

PFOR:

103133516(pcsk2)

PLAI:

106947443(pcsk2)

PMEI:

106915462(pcsk2)

GAF:	122842986(pcsk2)

PPRL:

129360133(pcsk2)

CVG:	107089286(pcsk2)

CTUL:

119790858(pcsk2)

GMU:	124859577(pcsk2)

NFU:	107376020(pcsk2)

KMR:	108245432(pcsk2)

ALIM:

106513600(pcsk2)

NWH:	119419217(pcsk2)

AOCE:

111575540(pcsk2)

MCEP:

125018824(pcsk2)

CSEM:

103387697(pcsk2)

POV:	109629655(pcsk2)

SSEN:

122781804(pcsk2)

HHIP:

117775550(pcsk2)

HSP:	118119407(pcsk2)

SMAU:

118284093(pcsk2)

LCF:

108897258

SDU:	111235221(pcsk2)

SLAL:

111670048(pcsk2)

XGL:	120796104(pcsk2)

HCQ:	109512729(pcsk2)

SSCV:

125978557

SBIA:

133510256(pcsk2)

PEE:	133409613(pcsk2)

PTAO:

133485983(pcsk2)

BPEC:

110157135(pcsk2)

MALB:

109960189(pcsk2)

BSPL:

114870766(pcsk2)

SJO:	128373131(pcsk2)

SASA:

106576998(pcsk2) 106607177(NEC2)

STRU:

115153213 115193769

OTW:	112253023(pcsk2) 112254478

OMY:	110502463 110528870(pcsk2)

OGO:	124038252 124041260(pcsk2)

ONE:	115113227 115135108

OKI:	109889940(pcsk2) 109899106

OKE:	118369712(pcsk2) 118400241

SALP:

111952031 111977791

SNH:	120017928(pcsk2) 120045675

CCLU:

121553379(pcsk2) 121570819

ELS:	105010665(pcsk2)

SFM:	108927161(pcsk2) 108933539

PKI:	111859393(pcsk2)

AANG:

118217939 118218362(pcsk2)

LOC:	102684877(pcsk2)

PSPA:

121316109 121317233

ARUT:

117403276 117972516

PSEX:

120516353(pcsk2)

LCM:	102352855(PCSK2)

CMK:	103177907(pcsk2)

RTP:	109916953(pcsk2)

CPLA:

122553106(pcsk2)

HOC:	132819532(pcsk2)

LERI:

129695066(pcsk2)

PMRN:

116939757(PCSK2)

LRJ:	133347050(PCSK2)

BFO:

118418937

BBEL:

109477140

CIN:	100181292(cipc2)

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:	100377458(PCSK2)

DME:	Dmel_CG6438(amon)

DER:

6555399

DSE:

6617074

DSI:	Dsimw501_GD18123(Dsim_GD18123)

DYA:	Dyak_GE10618

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI24730

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108354669 108358306

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

CQU:	CpipJ_CPIJ012757

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CFEL:

CCRN:

API:

DNX:	107161769 107161799

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:	111057277 111062474

HVI:

124371878

MQU:

128985528

PHU:	Phum_PHUM354430

FOC:	113203115 127749951

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_193075

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:	119453738 119464287

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_C51E3.7(egl-3)

CBR:	CBG_09536(Cbr-egl-3)

CRQ:	GCK72_017605

NAI:	NECAME_01697 NECAME_12953

BMY:	BM_BM2886(Bma-egl-3)

LOA:	LOAG_16369

TSP:	Tsp_03058 Tsp_03058a

HRO:	HELRODRAFT_96355

LGI:	LOTGIDRAFT_212426

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:	105337074 105340113

CVN:	111125728 111125730 111130394

CANU:

128157396 128175454 128185202 128186002

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

132725002 132725003 132731113 132734671 132737329 132745221 132745222 132755075

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_077980

SHX:	MS3_00006538(PCSK2)

OVI:	T265_05982

EGL:

EGR_08746

TVA:	TVAG_2v0221310 TVAG_2v0621030 TVAG_2v0621280 TVAG_2v0931330

LMIR:

NCTC12852_01159(prcA_4)

LBI:	LEPBI_I3281

LBF:

LBF_3168

» show all

Reference

PMID:23011353

Authors

Jonsson A, Isomaa B, Tuomi T, Eriksson JG, Groop L, Lyssenko V

Title

Effect of a common variant of the PCSK2 gene on reduced insulin secretion.

Journal

Diabetologia 55:3245-51 (2012)
DOI:10.1007/s00125-012-2728-5

Sequence

[hsa:5126]

All links

Ontology (4)   
   KEGG BRITE (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (3835)   
   KEGG GENES (684)   
   KEGG MGENES (512)   
   RefGene (2628)   
   OC (11)   
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