KEGG ORTHOLOGY: K01368

ORTHOLOGY: K01368

Entry

K01368                      KO

Symbol

CTSS

Name

cathepsin S [EC:3.4.22.27]

Pathway

map04142

Lysosome

map04145

Phagosome

map04210

Apoptosis

map04612

Antigen processing and presentation

map05152

Tuberculosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K01368  CTSS; cathepsin S
   04142 Lysosome
    K01368  CTSS; cathepsin S
  09143 Cell growth and death
   04210 Apoptosis
    K01368  CTSS; cathepsin S
09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    K01368  CTSS; cathepsin S
09160 Human Diseases
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K01368  CTSS; cathepsin S
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01368  CTSS; cathepsin S
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts
    K01368  CTSS; cathepsin S
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.27  cathepsin S
     K01368  CTSS; cathepsin S
Peptidases and inhibitors [BR:ko01002]
Cysteine peptidases
  Family C1: papain family
   K01368  CTSS; cathepsin S
Chaperones and folding catalysts [BR:ko03110]
Intramolecular chaperones
  Papain family
   K01368  CTSS; cathepsin S

Genes

HSA:	1520(CTSS)

PTR:	457277(CTSS)

PPS:	100975000(CTSS)

GGO:	101141942(CTSS)

PON:	100432810(CTSS)

NLE:	100579205(CTSS)

HMH:	116469476(CTSS)

MCC:	708080(CTSS)

MCF:	102120796(CTSS)

MTHB:

126932352

MNI:	105497818(CTSS)

CSAB:

103247206(CTSS)

CATY:

105590202(CTSS)

PANU:

101021545(CTSS)

TGE:	112620366(CTSS)

MLEU:

105534752(CTSS)

RRO:	104681069(CTSS)

RBB:	108533262(CTSS)

TFN:	117075084(CTSS)

PTEH:

111543624(CTSS)

CANG:

105508849(CTSS)

CJC:	100409214(CTSS)

SBQ:	101044698(CTSS)

CIMI:

108316466(CTSS)

CSYR:

103251385(CTSS)

MMUR:

105873003(CTSS)

LCAT:

123633923(CTSS)

PCOQ:

105821963(CTSS)

OGA:	100950667(CTSS)

MMU:	13040(Ctss)

MCAL:

110290972(Ctss)

MPAH:

110320470(Ctss)

RNO:	50654(Ctss)

MCOC:

116093415(Ctss)

ANU:	117707492(Ctss)

MUN:	110543431(Ctss)

CGE:	100751823(Ctss)

MAUA:

101842997(Ctss)

PROB:

127232719(Ctss)

PLEU:

114682396(Ctss)

MORG:

121437918 121450702

MFOT:

126490028

AAMP:

119801374(Ctss)

NGI:	103729103(Ctss)

HGL:	101697008(Ctss)

CPOC:

100722492(Ctss)

CCAN:

109681200(Ctss)

DORD:

105984724(Ctss)

DSP:	122109432(Ctss)

PLOP:

125360057(Ctss)

NCAR:

124959416

MMMA:

107156835(Ctss)

OCU:

100101598

OPI:	101532461(CTSS)

TUP:	102469586(CTSS)

GVR:	103600306(CTSS)

CFA:	403400(CTSS)

CLUD:

112663998(CTSS)

VVP:	112907699(CTSS)

VLG:	121492130(CTSS)

NPO:	129501554(CTSS)

AML:	100483259(CTSS)

UMR:	103667539(CTSS)

UAH:	113246210(CTSS)

UAR:	123787738(CTSS)

ELK:

111162017

LLV:

125096876

MPUF:

101683261(CTSS)

MNP:	132001448(CTSS)

MLK:	131809393(CTSS)

NVS:	122900434(CTSS)

ORO:	101370623(CTSS)

EJU:	114197270(CTSS)

ZCA:	113912803(CTSS)

MLX:	118000310(CTSS)

NSU:	110578526(CTSS)

LWW:	102730297(CTSS)

FCA:	101083283(CTSS)

PYU:	121021050(CTSS)

PCOO:

112872170(CTSS)

PBG:	122481131(CTSS)

PVIV:

125159432(CTSS)

LRUF:

124514705

PTG:	102967913(CTSS)

PPAD:

109257065(CTSS)

PUC:

125912123

AJU:

106979853

HHV:	120241248(CTSS)

BTA:	327711(CTSS)

BOM:	102287237(CTSS)

BIU:	109555340(CTSS)

BBUB:

102408311(CTSS)

BBIS:

104987659(CTSS)

CHX:	102183747(CTSS)

OAS:	780472(CTSS)

BTAX:

128044918(CTSS)

ODA:	120855927(CTSS)

CCAD:

122434353(CTSS)

MBEZ:

129540962(CTSS)

SSC:	100153090(CTSS)

CFR:	102510939(CTSS)

CBAI:

105071741(CTSS)

VPC:	102544736(CTSS)

BACU:

103007667(CTSS)

BMUS:

118899772(CTSS)

LVE:	103074342(CTSS)

OOR:	101269523(CTSS)

DLE:	111169766(CTSS)

PCAD:

102979785(CTSS)

PSIU:

116738968(CTSS)

NASI:

112411657(CTSS)

ECB:	100054948(CTSS)

EPZ:	103547636(CTSS)

EAI:	106846535(CTSS)

MYB:	102259811(CTSS)

MYD:	102771016(CTSS)

MMYO:

118672753(CTSS)

MLF:	102439661(CTSS)

PKL:	118727473(CTSS)

EFUS:

103298976(CTSS)

MNA:	107539106(CTSS)

DRO:	112313687(CTSS)

AJM:	119034681(CTSS)

PDIC:

114489220(CTSS)

PHAS:

123804406(CTSS)

MMF:	118637207 118637209 118637210

PPAM:

129076822(CTSS)

HAI:	109372254(CTSS)

RFQ:	117015222(CTSS)

PALE:

102884940(CTSS)

PGIG:

120585211(CTSS)

PVP:	105303820(CTSS)

RAY:	107498990(CTSS)

MJV:	108404026(CTSS)

TOD:	119236327(CTSS)

SARA:

101543601(CTSS)

SETR:

125997496(CTSS)

LAV:	100674232(CTSS)

TMU:

101340786

ETF:	101656344(CTSS)

DNM:	101441455(CTSS)

MDO:	100017406(CTSS)

GAS:	123247280(CTSS)

SHR:	100917184(CTSS)

AFZ:

127559107

PCW:	110220556(CTSS)

OAA:	100088270(CTSS)

GGA:	425657(CTSS)

PCOC:

116238445(CTSS)

MGP:	104914438(CTSS)

CJO:	107324540(CTSS)

TPAI:

128071898(CTSS)

LMUT:

125685833(CTSS)

NMEL:

110387850

APLA:

101794564(CTSS)

ACYG:

106049275(CTSS)

CATA:

118260448(CTSS)

AFUL:

116499813(CTSS)

TGU:	100223082(CTSS)

LSR:

110476808

SCAN:

103824795

PMOA:

120502604(CTSS)

OTC:	121335620(CTSS)

PRUF:

121353497

GFR:

102032358

FAB:	101815635(CTSS)

OMA:	130263435(CTSS)

PHI:	102107924(CTSS)

PMAJ:

107214698

CCAE:

111939529

CBRC:

103619621(CTSS)

ETL:	114072354 114072744

ACHL:

103808852(CTSS)

SVG:

106862353

HRT:	120764228(CTSS)

FPG:	101911722(CTSS)

FCH:	102055558(CTSS)

CLV:	102094330(CTSS)

EGZ:

104126881

NNI:	104014433 104014434

PCRI:

104025589(CTSS) 104037773

PLET:

104615368

PCAO:

104044828 104044829

ACUN:

113490571(CTSS)

TALA:

104366166 122152486 122152489 122152527

PADL:

AFOR:

ACHC:

HALD:

HLE:	104830534 104830575

AGEN:

126040215 126041273

GCL:	127027058 127027059

CCRI:

104168031 104168032

CSTI:

104562030(CTSS)

CMAC:

104476793 104476794

MUI:	104534231 104538170

BREG:

104632098(CTSS)

FGA:	104081458 104081459

GSTE:

104256108 104264334(CTSS)

LDI:	104347091(CTSS)

MNB:	103780570(CTSS)

OHA:	104338084(CTSS)

NNT:	104409361(CTSS)

SHAB:

115602671(CTSS)

PGUU:

104459482(CTSS)

ACAR:

104518069(CTSS)

CPEA:

104385233(CTSS)

CVF:	104285441 104285443

RTD:

128900892

CUCA:

104066019 104066024

TEO:	104373475(CTSS)

AAM:	106495149(CTSS)

AROW:

112972481 112972517

NPD:	112953003(CTSS)

TGT:	104573262(CTSS)

DNE:	112990058 112990083

SCAM:

104139547 104149055

ASN:	102373459 102384087(CTSS)

AMJ:	102562033(CTSS) 109283982

PSS:

102458936

CMY:	102947704 102947924 119564251

CCAY:

125625866 125625867

DCC:	119847717 119847844

CPIC:

101931018 101934688 101940635 101944372 101944639 101949655

TST:

117869840

CABI:

116817621 116817622 116817623 116817624

MRV:	120390630 120390631 120390632 120390633

ACS:	100560943(ctss)

ASAO:

132764183(CTSS)

PVT:	110081451(CTSS)

SUND:

121916254(CTSS)

PBI:	103053841(CTSS)

PMUR:

107292919(CTSS)

CTIG:

120317009(CTSS)

TSR:	106546304(CTSS)

PGUT:

117670137(CTSS)

APRI:

131186545

PTEX:

113449184(CTSS)

NSS:	113425694(CTSS)

VKO:	123032984(CTSS)

PMUA:

114586295(CTSS) 114588654

PRAF:

128403644(CTSS)

ZVI:	118076374(CTSS)

HCG:	128336905 128336952

GJA:	107120549(CTSS)

STOW:

125438579

EMC:	129342335(CTSS)

XLA:	100036949(ctsh.L) 108699062 108699063 108699333 108699334 108699410 108700331 108700332 108700335 108700336 380516(ctss.L) 398927 443661(XB5914295.S) 443722 446505(ctss.S)

XTR:	100124852 100494325 100498084 100498238 105945585 105948322 116406662 116406764 448203(ctss) 496647(ctss.2) 496748(ctsh) 594890

NPR:	108789799(CTSS) 108800693

RTEM:

120920090 120920158 120920159 120920357

BBUF:

120982070 120982478

BGAR:

122923217 122923219

MUO:	115458070(CTSS) 115482541 115482548

GSH:	117350278(CTSS)

DRE:	337572(ctss2.2) 393398(ctss1) 554157(ctss2.1)

SRX:	107714774 107741752 107741753 107741774

SANH:

107663319 107663331 107689850 107689852 107689853 107691368

SGH:	107571626 107587832 107587833 107597985 107597987

CCAR:

109051923 109056426 109058805 109089990 109096260 109099830

CAUA:

113059153 113059154 113062485 113116109 113116110 113116111 113116112 113116113 113119713 113119760

CGIB:

127935130 127975150 127975152 127975153 127975154 127975155 127978622 128030611 128030613

PTET:

122335176(ctss1) 122359890 122359892(ctss2.1) 122359893

LROH:

127160604 127161848 127178603 127178604 127178607 127181820(ctss1)

OMC:	131521518 131522036 131522320 131525527(ctss1)

PPRM:

120475234(ctss1) 120484669(ctss2.1) 120484670

RKG:	130069295(ctss2.1) 130069296 130092410(ctss1)

MAMB:

125243015(ctss2.1) 125243016 125275994(ctss1)

CIDE:

127496727 127496728 127501492

MASI:

127421230 127452791 127454233

TROS:

130558096 130566896(ctss1)

TDW:	130415513(ctss1) 130432807

MANU:

129448283(ctss2.1) 129455226(ctss1)

IPU:	100305010(ctss2.1) 108274831

IFU:	128610342(ctss2.1)

PHYP:

113525243 113533916

SMEO:

124383789

TFD:	113634015 113642169 113644583 113647392(ctss1) 125145725

TVC:	132845887(ctss2.1) 132856753(ctss1) 132857241 132857244 132857254 132857353

AMEX:

103044830 103045424

CMAO:

118817502(ctss2.1)

EEE:	113575272 113590155

CHAR:

105891892 105901987(ctss1) 105902024

TRU:	101066490 101073909

TFS:

130532153

TNG:	GSTEN00011685G001

LCO:	104923937 104931628 104931629

NCC:

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:	117263943 117265981(ctss2.1)

EFO:	125892608 125904820

PLEP:

121945417

SLUC:

116047397 116049093

ECRA:

117946034(ctss2.1)

ESP:	116677005 116690788

PFLV:

114556853 114556913 114567831

GAT:	120810481(ctss2.1)

PPUG:

119197582(ctss2.1) 119219161

AFB:	129097576 129109044(ctss2.1)

CLUM:

117745280

PSWI:

130187947

MSAM:

119882210 119897015(ctss2.1) 119906692(ctss1)

SCHU:

122864987 122882284(ctss2.1)

CUD:	121513325 121523314

ALAT:

119005463 119005464 119016604

MZE:	101485929 105940410

ONL:	100690368 100690911 100695758 100705431

OAU:	116333435 116333436

OLA:	100049247(ctss) 101165175

OML:	112136685(ctss2.1) 112137547

CSAI:

133440236 133461476

XMA:	102230330 102235885

XCO:	114142240 114156396

XHE:	116717363 116731587

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122831313(ctss2.1)

PPRL:

129371019

CVG:	107086772 107088360

CTUL:

119781874(ctss2.1) 119784819

GMU:	124865441(ctss2.1)

NFU:	107379223 107394690

KMR:	108243190(ctss2.1)

ALIM:

106518088 106524065

NWH:	119409270(ctss2.1)

AOCE:

111571630

MCEP:

125016156(ctss2.1) 125020405

CSEM:

103388697 103394262 103394264

POV:	109633509 109638767 109638800

SSEN:

122774431(ctss2.1) 122786334

HHIP:

117770319 117776444(ctss2.1)

HSP:	118113996(ctss2.1) 118125133

SMAU:

118284857(ctss2.1) 118292024

LCF:	108883175(ctss2.1) 108898158

SDU:	111222413 111222981

SLAL:

111659220 111669221

XGL:	120784605(ctss2.1) 120786191(ctss1) 120786192

HCQ:	109512113 109514600

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

110162666 110162667 110162671 110168875 110168941

MALB:

109968960

BSPL:

114843549(ctss2.1)

SJO:	128365727 128365728 128365729 128365732 128365733 128365737 128365739 128365740 128366611 128366619 128366620 128366621 128366893 128373691

SASA:

100196462(cats) 106605328(CATS)

STRU:

115176789 115178898

OTW:	112222947(ctss2.1) 112229276

OMY:	100136261 110487241

OGO:	123997753 124006231

ONE:	115103957 115141062

OKI:	109902020 109908571

OKE:	118364448(ctss2.1) 118367491

SALP:

111958812 112081015

SNH:	120031296 120048417

CCLU:

121543126 121566614

ELS:	105031242 105031251 114829684

SFM:	108930364 108930365 108930367 108930412 108930417 108941877 108941910 114909387

PKI:	111838382 111838421

AANG:

118220535 118233653 118233655 118233657

LOC:	102686501 102694713 107075469

PSPA:

121307010 121309884

ARUT:

117395491 117395567 117965122 117965129 117965168 117971317

PSEX:

120527405 120527412 120528705 120528720

LCM:	102351684(CTSS) 102365039

LERI:

RZE:

LCQ:

LSQ:

CLON:

CNS:

BCOO:

TCA:

AGRG:

126739299 126740656 126740657

CSET:

123316307

AGB:	108903191 108903193 108909798 108914557 108915519

LDC:

111506937

TPAL:

117651242

DPX:	DAPPUDRAFT_216612 DAPPUDRAFT_315499 DAPPUDRAFT_315500

DMK:

VDE:

DFR:

UDV:

HRF:	124126641 124126648

MCAF:

127725378

RPHI:

132714057 132742004 132753731 132753732

DPOL:

127839802 127867697 127867705

SMM:	Smp_187140

NTO:

104097067

NCOL:

116244932

PTM:	GSPATT00038477001

» show all

Reference

PMID:2604727

Authors

Bromme D, Steinert A, Friebe S, Fittkau S, Wiederanders B, Kirschke H

Title

The specificity of bovine spleen cathepsin S. A comparison with rat liver cathepsins L and B.

Journal

Biochem J 264:475-81 (1989)
DOI:10.1042/bj2640475

Sequence

[bta:327711]

Reference

PMID:8157683

Authors

Shi GP, Webb AC, Foster KE, Knoll JH, Lemere CA, Munger JS, Chapman HA

Title

Human cathepsin S: chromosomal localization, gene structure, and tissue distribution.

Journal

J Biol Chem 269:11530-6 (1994)

Reference

PMID:15661874

Authors

Beers C, Burich A, Kleijmeer MJ, Griffith JM, Wong P, Rudensky AY

Title

Cathepsin S controls MHC class II-mediated antigen presentation by epithelial cells in vivo.

Journal

J Immunol 174:1205-12 (2005)
DOI:10.4049/jimmunol.174.3.1205

Reference

PMID:24780878

Authors

Rauner M, Foger-Samwald U, Kurz MF, Brunner-Kubath C, Schamall D, Kapfenberger A, Varga P, Kudlacek S, Wutzl A, Hoger H, Zysset PK, Shi GP, Hofbauer LC, Sipos W, Pietschmann P

Title

Cathepsin S controls adipocytic and osteoblastic differentiation, bone turnover, and bone microarchitecture.

Journal

Bone 64:281-7 (2014)
DOI:10.1016/j.bone.2014.04.022

Sequence

[mmu:13040]

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (10)   
   KEGG PATHWAY (10)   
Drug (1)   
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Chemical reaction (1)   
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Gene (1791)   
   KEGG GENES (675)   
   KEGG MGENES (68)   
   RefGene (1037)   
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