KEGG ORTHOLOGY: K01380

ORTHOLOGY: K01380

Entry

K01380                      KO

Symbol

REN

Name

renin [EC:3.4.23.15]

Pathway

map04614

Renin-angiotensin system

map04924

Renin secretion

map05415

Diabetic cardiomyopathy

Disease

H00541

Autosomal dominant tubulointerstitial kidney disease

H00575

Renal tubular dysgenesis

H02011

Familial juvenile hyperuricemic nephropathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09152 Endocrine system
   04924 Renin secretion
    K01380  REN; renin
   04614 Renin-angiotensin system
    K01380  REN; renin
09160 Human Diseases
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K01380  REN; renin
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01380  REN; renin
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.23  Aspartic endopeptidases
    3.4.23.15  renin
     K01380  REN; renin
Peptidases and inhibitors [BR:ko01002]
Aspartic peptidases
  Family A1: pepsin family
   K01380  REN; renin

Genes

HSA:

5972(REN)

PTR:	469651(REN)

PPS:	100984353(REN)

GGO:	101130437(REN)

PON:	100435070(REN)

NLE:	100592810(REN)

HMH:	116457627(REN)

MCC:	574299(REN)

MCF:	102122446(REN)

MTHB:

126939551

MNI:	105484787(REN)

CSAB:

103230256(REN)

CATY:

105576029(REN)

PANU:

101018390(REN)

TGE:	112634039(REN)

MLEU:

105547062(REN)

RRO:	104667395(REN)

RBB:	108535194(REN)

TFN:	117075586(REN)

PTEH:

111522776(REN)

CANG:

105504381(REN)

CJC:	100399036(REN)

SBQ:	101036357(REN)

CIMI:

108302025(REN)

CSYR:

103274411(REN)

MMUR:

105869290(REN)

LCAT:

123626885(REN)

PCOQ:

105821199(REN)

OGA:	100952097(REN)

MMU:	19701(Ren1) 19702(Ren2)

MCAL:

110292479(Ren)

MPAH:

110322198(Ren)

RNO:	24715(Ren)

MCOC:

116099326(Ren)

ANU:	117716350(Ren)

MUN:	110546748(Ren)

CGE:	100763117(Ren)

MAUA:

101842518(Ren)

PROB:

127236403(Ren)

PLEU:

114698044(Ren)

MORG:

121446565(Ren)

MFOT:

126505049

AAMP:

119828011(Ren)

NGI:	103731872(Ren)

HGL:	101725618(Ren)

CPOC:

100724037(Ren)

CCAN:

109698788(Ren)

DORD:

105986474(Ren)

DSP:	122109515(Ren)

PLOP:

125359423(Ren)

NCAR:

124962370

MMMA:

107140707(Ren)

OCU:

100358545

OPI:	101517787(REN)

TUP:	102486665(REN)

GVR:	103594169(REN)

CFA:	403838(REN)

CLUD:

112643248(REN)

VVP:	112914400(REN)

VLG:	121501319(REN)

NPO:	129515340(REN)

AML:	100470089(REN)

UMR:	103657747(REN)

UAH:	113242509(REN)

UAR:	123785707(REN)

ELK:

111151146

LLV:

125085972

MPUF:

101694500(REN)

MNP:	132026166(REN)

MLK:	131815149(REN)

NVS:	122918190(REN)

ORO:	101380830(REN)

EJU:	114221868(REN)

ZCA:	113932910(REN)

MLX:	118013674(REN)

NSU:	110577315(REN)

LWW:	102742069(REN)

FCA:	101081695(REN)

PYU:	121021648(REN)

PCOO:

112857816(REN)

PBG:	122475872(REN)

PVIV:

125155528(REN)

LRUF:

124510397

PTG:	102965512(REN)

PPAD:

109256860(REN)

PUC:

125925444

AJU:

106972902

HHV:	120228933(REN)

BTA:	280909(REN)

BOM:	102267598(REN)

BIU:	109570766(REN)

BBUB:

102394688(REN)

BBIS:

104998792(REN)

CHX:	102190154(REN)

OAS:	443310(REN)

BTAX:

128061816(REN)

ODA:	120879880(REN)

CCAD:

122451911(REN)

MBEZ:

129551130(REN)

SSC:	100524822(REN)

CFR:	102506297(REN)

CBAI:

105078433(REN)

CDK:	105098650(REN)

VPC:	102527009(REN)

BACU:

103009645(REN)

BMUS:

118903027(REN)

LVE:	103068873(REN)

OOR:	101284037(REN)

DLE:	111184622(REN)

PCAD:

102980173(REN)

PSIU:

116742821(REN)

NASI:

112403454(REN)

ECB:	100054248(REN)

EPZ:	103557494(REN)

EAI:	106822997(REN)

MYB:	102262750(REN)

MYD:	102762390(REN)

MMYO:

118673786(REN)

PKL:	118721667(REN)

EFUS:

103297507(REN)

MNA:	107538629(REN)

DRO:	112314863(REN)

SHON:

119001671(REN)

AJM:	119055067(REN)

PDIC:

114512024(REN)

PHAS:

123820662(REN)

MMF:	118637934(REN)

PPAM:

129062036(REN)

HAI:	109386469(REN)

RFQ:	117015129(REN)

PALE:

102898369(REN)

PVP:	105300684(REN)

RAY:	107508230(REN)

MJV:	108391626(REN)

TOD:	119234263(REN)

SARA:

101549468(REN)

SETR:

126004202(REN)

LAV:	100653930(REN)

TMU:

101361683

ETF:	101642532(REN)

DNM:	101432688(REN)

MDO:	100016857 100017009 100017048 100017089 100017171 100618729

GAS:	123243981 123244828 123245961 123245962 123247900 123247901

SHR:	100935150(REN)

AFZ:

127562675

PCW:	110219584(REN)

OAA:	100092330(REN)

GGA:	431167(REN)

PCOC:

116237093(REN)

MGP:	100544109(REN)

CJO:	107324665(REN)

LMUT:

125684263(REN)

NMEL:

110388076(REN)

APLA:

101800278(REN)

ACYG:

106041262(REN)

CATA:

118255276(REN)

AFUL:

116498679(REN)

TGU:	115498536(REN)

LSR:	110475004(REN)

PMOA:

120499104(REN)

OTC:	121345504(REN)

PRUF:

121355250(REN)

GFR:	102032412(REN)

FAB:	101811288(REN)

OMA:	130263547(REN)

PHI:	102103389(REN)

PMAJ:

107214777(REN)

CCAE:

111939690(REN)

CCW:	120411274(REN)

CBRC:

103625384(REN)

ETL:	114069117(REN)

ZAB:

102075270

ACHL:

103810706(REN)

SVG:	106850915(REN)

MMEA:

130586498(REN)

HRT:	120762984(REN)

FPG:	101916979(REN)

FCH:	102049731(REN)

CLV:	102093221(REN)

EGZ:	104125792(REN)

NNI:	104013208(REN)

EHS:	104514014(REN)

PCAO:

104048854(REN)

ACUN:

113488782(REN)

TALA:

104359087(REN)

PADL:

103919859(REN)

AFOR:

103893698(REN)

ACHC:

115335477(REN)

HALD:

104320571

HLE:	104839368(REN)

AGEN:

126051936

GCL:

127026264

CCRI:

104167002(REN)

CSTI:

104562143(REN)

CMAC:

104483348(REN)

MUI:	104541589(REN)

FGA:	104074689(REN)

GSTE:

104256729(REN)

LDI:	104355007(REN)

MNB:	103778582(REN)

OHA:	104328204(REN)

NNT:	104408996(REN)

SHAB:

115602370(REN)

DPUB:

104305358(REN)

PGUU:

104470590

ACAR:

104530585(REN)

CPEA:

104398251(REN)

AVIT:

104270977

CVF:	104289359(REN)

RTD:	128900313(REN)

CUCA:

104060298(REN)

TEO:	104373494(REN)

AAM:	106484864(REN)

AROW:

112971650(REN)

NPD:	112959127(REN)

TGT:	104577266(REN)

DNE:	112990286(REN)

SCAM:

104142403(REN)

ASN:	102387440(REN)

AMJ:	102563732(REN)

CPOO:

109317753(REN)

GGN:	109295222(REN)

PSS:	102463928(REN)

CMY:	102937199(REN)

CCAY:

125624938(REN)

DCC:	119846425(REN)

CPIC:

101934640(REN)

TST:	117875812(REN)

CABI:

116827881(REN)

MRV:	120404525(REN)

ACS:	100557560(ren)

ASAO:

132772648(REN)

PVT:	110081398(REN)

SUND:

121928633(REN)

PBI:	103048990(REN)

PMUR:

107302993(REN)

CTIG:

120306802(REN)

TSR:	106557103(REN)

PGUT:

117664390(REN)

PTEX:

113446137(REN)

NSS:	113418161(REN)

VKO:	123031044(REN)

PMUA:

114599283(REN)

PRAF:

128416087(REN)

ZVI:	118088539(REN)

HCG:	128322978(REN)

GJA:	107107084(REN)

STOW:

125432913(REN)

EMC:	129330892(REN)

XLA:	108709447(ren.S)

XTR:	100487524(ren)

NPR:	108804894(REN)

RTEM:

120927129(REN)

BBUF:

120993324(REN)

BGAR:

122932868(REN)

MUO:	115481842(REN)

GSH:	117347652(REN)

DRE:	405786(ren)

SRX:	107727110 107747224

SANH:

107683898 107702841(ren)

SGH:	107550929 107570508

CCAR:

109054870 109067585 109070272

CAUA:

113070732 113107375

CGIB:

127963650 128018370

PTET:

122350112(ren)

LROH:

127169249(ren)

OMC:	131545604(ren)

PPRM:

120485994(ren)

RKG:	130081934(ren)

MAMB:

125279764(ren)

CIDE:

127517497 127517498

MASI:

127414647 127424545

TROS:

130568327(ren)

TDW:	130440222(ren)

MANU:

129414401(ren)

IPU:

108265134

IFU:	128607517(ren)

PHYP:

113533495

SMEO:

124399494(ren)

TFD:	113656325(ren)

TVC:	132853581(ren)

AMEX:

103036504

CMAO:

118812939(ren)

EEE:	113578769(ren)

CHAR:

105906799(ren)

TRU:	777957(ren)

TFS:	130530050(ren)

TNG:	GSTEN00033243G001

LCO:

104927909

NCC:	104956331(ren)

TBEN:

117479551(ren)

CGOB:

115011106(ren)

PGEO:

117449037(ren)

GACU:

117543063(ren)

EMAC:

134868398(ren)

ELY:	117258621(ren)

EFO:	125892099(ren)

PLEP:

121947084(ren)

SLUC:

116062097(ren)

ECRA:

117947826(ren)

ESP:

116693170

PFLV:

114559029(ren)

GAT:	120828707(ren)

PPUG:

119222679(ren)

AFB:	129099747(ren)

CLUM:

117733978(ren)

PSWI:

130199613(ren)

MSAM:

119905982(ren)

SCHU:

122883350(ren)

CUD:	121517750(ren)

ALAT:

119022665(ren)

MZE:

101472021

ONL:

100691504

OAU:	116324774(ren)

OLA:

101168210

OML:	112159510(ren)

CSAI:

133456346(ren)

XMA:	102237116(ren)

XCO:	114144744(ren)

XHE:	116719432(ren)

PRET:

103467540(ren)

PFOR:

103145051(ctse)

PLAI:

106940528(ren)

PMEI:

106907869(ren)

GAF:	122830051(ren)

PPRL:

129370237(ren)

CVG:

107090387

CTUL:

119774136(ren)

GMU:	124860834(ren)

NFU:	107391136(ren)

KMR:	108231996(ren)

ALIM:

106522579(ctse)

NWH:	119416579(ren)

AOCE:

111576838

MCEP:

125018351(ren)

CSEM:

103385502(ctse)

POV:

109635083

SSEN:

122777902(ren)

HHIP:

117764761(ren)

HSP:	118111106(ren)

SMAU:

118317454(ren)

LCF:	108889478(ren)

SDU:

111217305

SLAL:

111667152

XGL:	120803999(ren)

HCQ:

109528441

SSCV:

125989399

SBIA:

133494397(ren)

PEE:	133405574(ren)

PTAO:

133488981(ren)

BPEC:

110158062

MALB:

109951129

BSPL:

114858312(ren)

SJO:	128357214(ren)

SASA:

106566646 106571888

STRU:

115166437 115168453

OTW:	112216579 112222265

OMY:	110492465 110531962

OGO:	124021234 124045030

ONE:	115101624 115132775

OKI:	109869840 109907734

OKE:	118359429 118360455

SALP:

111966170 111972574

SNH:	120058995 120061369

CCLU:

121537548 121546534

ELS:

105007023

SFM:	108940277(ren)

AANG:

118207472 118210736(ren)

LOC:	102690320(ren)

PSPA:

121299963 121304643

ARUT:

117397667 117433153 117964495 117968795

PSEX:

120526172(ren)

LCM:	102363906(REN)

CMK:

103182446

RTP:	109929130(ren)

CPLA:

122563065(ren)

HOC:	132828145(ren)

LERI:

129708871(ren)

HVI:

124359524

MQU:	128993112 128993207 128996675 128997192

DSV:

119441438

» show all

Reference

PMID:3516796

Authors

Soubrier F, Panthier JJ, Houot AM, Rougeon F, Corvol P

Title

Segmental homology between the promoter region of the human renin gene and the mouse ren1 and ren2 promoter regions.

Journal

Gene 41:85-92 (1986)
DOI:10.1016/0378-1119(86)90270-2

Sequence

[hsa:5972]

Reference

PMID:1608447

Authors

Dhanaraj V, Dealwis CG, Frazao C, Badasso M, Sibanda BL, Tickle IJ, Cooper JB, Driessen HP, Newman M, Aguilar C, et al.

Title

X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins.

Journal

Nature 357:466-72 (1992)
DOI:10.1038/357466a0

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (3)   
   KEGG DISEASE (3)   
Drug (7)   
   KEGG DRUG (7)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (2160)   
   KEGG GENES (420)   
   KEGG MGENES (60)   
   RefGene (1679)   
   OC (1)   
Literature (2)   
   PubMed (2)   
All databases (2182)   

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