KEGG   ORTHOLOGY: K01398Help
Entry
K01398                      KO                                     
Name
MMP2
Definition
matrix metalloproteinase-2 (gelatinase A) [EC:3.4.24.24]
Pathway
Leukocyte transendothelial migration
GnRH signaling pathway
Estrogen signaling pathway
Pathways in cancer
Proteoglycans in cancer
Bladder cancer
Disease
H00025  
Penile cancer
H00028  
Choriocarcinoma
H00472  
Torg-Winchester syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Organismal Systems
  Immune system
   04670 Leukocyte transendothelial migration
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
  Endocrine system
   04912 GnRH signaling pathway
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
   04915 Estrogen signaling pathway
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
   05205 Proteoglycans in cancer
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
   05219 Bladder cancer
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.24  gelatinase A
     K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
Peptidases [BR:ko01002]
 Metallo Peptidases
  Family M10
   K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
Cell adhesion molecules and their ligands [BR:ko04516]
 2. Integrin Family
  Beta3 integrins
   VNR
    ITGB3; integrin beta 3
     K01398 MMP2; matrix metalloproteinase-2 (gelatinase A)
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
4313(MMP2)
PTR: 
454094(MMP2)
PPS: 
100970966(MMP2)
GGO: 
101147102(MMP2)
PON: 
100451667(MMP2)
MCC: 
698478(MMP2)
MMU: 
17390(Mmp2)
RNO: 
81686(Mmp2)
CFA: 
403733(MMP2)
AML: 
100476183(MMP2)
FCA: 
101098838(MMP2)
BTA: 
282872(MMP2)
SSC: 
397391(MMP2)
ECB: 
100033948(MMP2)
MDO: 
100020585
SHR: 
100935012(MMP2)
OAA: 
100077120(MMP2)
GGA: 
386583(MMP2)
MGP: 
100125331(MMP2)
TGU: 
100228546(MMP2)
ACS: 
100557569(mmp2)
XLA: 
380389(mmp2)
XTR: 
548506(mmp2)
DRE: 
337179(mmp2)
TRU: 
653022(mmp-2)
OLA: 
100125419(gel-a)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Fanjul-Fernandez M, Folgueras AR, Cabrera S, Lopez-Otin C
  Title
Matrix metalloproteinases: evolution, gene regulation and functional analysis in  mouse models.
  Journal
Biochim Biophys Acta 1803:3-19 (2010)
Reference
  Authors
Amalinei C, Caruntu ID, Balan RA
  Title
Biology of metalloproteinases.
  Journal
Rom J Morphol Embryol 48:323-34 (2007)
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