KEGG ORTHOLOGY: K01437

ORTHOLOGY: K01437

Entry

K01437                      KO

Symbol

ASPA, aspA

Name

aspartoacylase [EC:3.5.1.15]

Pathway

map00250

Alanine, aspartate and glutamate metabolism

map00340

Histidine metabolism

map01100

Metabolic pathways

Reaction

R00488

N-acetyl-L-aspartate amidohydrolase

R00526

N-formyl-L-aspartate amidohydrolase

Disease

H00074

Canavan disease

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00250 Alanine, aspartate and glutamate metabolism
    K01437  ASPA, aspA; aspartoacylase
   00340 Histidine metabolism
    K01437  ASPA, aspA; aspartoacylase
Enzymes [BR:ko01000]
3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.15  aspartoacylase
     K01437  ASPA, aspA; aspartoacylase

Other DBs

GO:

0019807

Genes

HSA:

443(ASPA)

PTR:	454430(ASPA)

PPS:	100970956(ASPA)

GGO:	101146270(ASPA)

PON:	100173374(ASPA)

NLE:	100589802(ASPA)

HMH:	116458681(ASPA)

MCC:	706170(ASPA)

MCF:	102137549(ASPA)

MTHB:

126939952

MNI:	105471922(ASPA)

CSAB:

103242156(ASPA)

CATY:

105583854(ASPA)

PANU:

100999408(ASPA)

TGE:	112609805(ASPA)

MLEU:

105539970(ASPA)

RRO:	104677239(ASPA)

RBB:	108523103(ASPA)

TFN:	117067916(ASPA)

PTEH:

111521318(ASPA)

CANG:

105515652(ASPA)

CJC:	100404522 100895131(ASPA)

SBQ:	101037611(ASPA)

CIMI:

108291751(ASPA)

CSYR:

103250733(ASPA)

MMUR:

105879232(ASPA)

LCAT:

123620650(ASPA)

PCOQ:

105816992(ASPA)

OGA:	100945616(ASPA)

MMU:	11484(Aspa)

MCAL:

110305630(Aspa)

MPAH:

110332490(Aspa)

RNO:	79251(Aspa)

MCOC:

116077027(Aspa)

ANU:	117701943 117709942(Aspa)

MUN:	110559264(Aspa)

CGE:	100767695(Aspa)

MAUA:

101825641(Aspa)

PROB:

127218938(Aspa)

PLEU:

114706324(Aspa)

MORG:

121456470(Aspa)

MFOT:

126514026

AAMP:

119811979(Aspa)

NGI:	103751979(Aspa)

HGL:	101719646(Aspa)

CPOC:

100732104(Aspa)

CCAN:

109694459(Aspa)

DORD:

105983499(Aspa)

DSP:	122124836(Aspa)

PLOP:

125365192(Aspa)

NCAR:

124979983

MMMA:

107155184 107159402(Aspa)

OCU:

100355969

OPI:	101533443(ASPA)

TUP:	102472992(ASPA)

GVR:	103587410(ASPA)

CFA:	611064(ASPA)

CLUD:

112677533(ASPA)

VVP:	112911394(ASPA)

VLG:	121473296(ASPA)

NPO:	129513297(ASPA)

AML:	100483637(ASPA)

UMR:	103667137(ASPA)

UAH:	113269151(ASPA)

UAR:	123776937(ASPA)

ELK:

111158807

LLV:

125086976

MPUF:

101670848(ASPA) 106003284

MNP:

132004540

MLK:	131815711(ASPA)

NVS:	122906830(ASPA) 122907379

ORO:	101372526(ASPA)

EJU:	114202301(ASPA)

ZCA:	113939395(ASPA)

MLX:	118025177(ASPA)

NSU:	110592793(ASPA)

LWW:	102741528(ASPA)

FCA:	101094220(ASPA)

PYU:	121017355(ASPA)

PCOO:

112854102(ASPA)

PBG:	122485086(ASPA)

PVIV:

125152118(ASPA)

LRUF:

124513531

PTG:	102958701(ASPA)

PPAD:

109255112(ASPA)

PUC:

125926912

AJU:

106987366

HHV:	120224768(ASPA)

BTA:	509432(ASPA)

BOM:	102280618(ASPA)

BIU:	109574453(ASPA)

BBUB:

102404518(ASPA)

BBIS:

104994023(ASPA)

CHX:	102186241(ASPA)

OAS:	101121435(ASPA)

BTAX:

128065489(ASPA)

ODA:	120866181(ASPA)

CCAD:

122447334(ASPA)

MBEZ:

129541683(ASPA)

SSC:	100142661(ASPA)

CFR:	102519504 116669147(ASPA)

CBAI:

105065177(ASPA) 105076766

CDK:	105106230 105106295 116157879

VPC:	102537505(ASPA)

BACU:

103015753(ASPA)

BMUS:

118886211(ASPA)

LVE:	103077806(ASPA)

OOR:	101275918(ASPA)

DLE:	111185765(ASPA)

PCAD:

102982760(ASPA)

PSIU:

116746262(ASPA)

NASI:

112394484(ASPA)

ECB:	100060454(ASPA)

EPZ:	103562931(ASPA)

EAI:	106825733(ASPA)

MYB:	102241447(ASPA)

MYD:	102760639(ASPA)

MMYO:

118672401(ASPA)

MLF:	102417566(ASPA)

PKL:	118702550(ASPA)

EFUS:

103299902(ASPA)

MNA:	107528000(ASPA)

DRO:	112308578(ASPA)

SHON:

118975577(ASPA)

AJM:	119040164(ASPA)

PDIC:

114515154(ASPA)

PHAS:

123809444(ASPA)

MMF:	118634594(ASPA)

PPAM:

129072388(ASPA)

HAI:	109378201(ASPA)

RFQ:	117013871(ASPA)

PALE:

102898221(ASPA)

PGIG:

120621072(ASPA)

PVP:	105291821(ASPA)

RAY:	107507681(ASPA)

MJV:	108392718(ASPA)

TOD:	119232227(ASPA)

SARA:

101538517(ASPA)

SETR:

126021124(ASPA)

LAV:	100669034(ASPA)

TMU:

101356304

ETF:	101648226(ASPA)

DNM:	101441010(ASPA)

MDO:	100032140(ASPA)

GAS:	123240218(ASPA)

AFZ:

127558279

PCW:	110193138(ASPA)

OAA:	100077458(ASPA)

GGA:	417609(ASPA)

PCOC:

116228005(ASPA)

MGP:	100538648(ASPA)

CJO:	107322402(ASPA)

TPAI:

128083674(ASPA)

LMUT:

125703149(ASPA)

NMEL:

110407641(ASPA)

APLA:

101795665(ASPA)

ACYG:

106045794(ASPA)

CATA:

118255045(ASPA)

AFUL:

116497174(ASPA)

TGU:	100224319(ASPA)

LSR:	110467678(ASPA)

SCAN:

103820155(ASPA)

PMOA:

120507824(ASPA)

OTC:	121345762(ASPA)

PRUF:

121361805(ASPA)

GFR:	102039255(ASPA)

FAB:	101818614(ASPA)

OMA:	130261014(ASPA)

PHI:	102104584(ASPA)

PMAJ:

107212712(ASPA)

CCAE:

111937810(ASPA)

CCW:	104691024(ASPA)

CBRC:

103613341(ASPA)

ETL:	114061227(ASPA)

ZAB:	102072028(ASPA)

ACHL:

103806986(ASPA)

SVG:	106853435(ASPA)

MMEA:

130576939(ASPA)

HRT:	120761346(ASPA)

FPG:	101911410(ASPA)

FCH:	102045863(ASPA)

CLV:	102084088(ASPA)

EGZ:	104121899(ASPA)

NNI:	104012174(ASPA)

PCRI:

104028576(ASPA)

PLET:

104619995(ASPA)

EHS:	104512071(ASPA)

PCAO:

104043832(ASPA)

ACUN:

113487197(ASPA)

TALA:

104365846(ASPA)

PADL:

103920790(ASPA)

AFOR:

103898002(ASPA)

ACHC:

115346875(ASPA)

HALD:

104313401(ASPA)

HLE:	104835629(ASPA)

AGEN:

126039670

GCL:

127024468

CCRI:

104162706(ASPA)

CSTI:

104557949(ASPA)

CMAC:

104481761(ASPA)

MUI:	104541456(ASPA)

BREG:

104641111(ASPA)

FGA:	104078150(ASPA)

GSTE:

104262319(ASPA)

LDI:	104340755(ASPA)

MNB:	103770592(ASPA)

OHA:	104339617(ASPA)

NNT:	104402456(ASPA)

SHAB:

115602073(ASPA)

DPUB:

104302726(ASPA)

PGUU:

104469251(ASPA)

ACAR:

104518617(ASPA)

CPEA:

104398919(ASPA)

AVIT:

104280283(ASPA)

CVF:	104284377(ASPA)

RTD:	128912297(ASPA)

CUCA:

104057188(ASPA)

TEO:	104371978(ASPA)

BRHI:

104495207(ASPA)

AAM:	106493751(ASPA)

AROW:

112960711(ASPA)

NPD:	112954573(ASPA)

TGT:	104577498(ASPA)

DNE:	112983977(ASPA)

SCAM:

104142793(ASPA)

ASN:	102386537(ASPA)

AMJ:	102566685(ASPA)

CPOO:

109317202(ASPA)

GGN:	109293328(ASPA)

PSS:	102445294(ASPA)

CMY:	102933639(ASPA)

CCAY:

125623730(ASPA)

DCC:	119844682(ASPA)

CPIC:

101942834(ASPA)

TST:	117867340(ASPA)

CABI:

116827914(ASPA)

MRV:	120387341(ASPA)

ACS:	103282484(aspa)

ASAO:

132770932(ASPA)

PVT:	110087377(ASPA)

SUND:

121916858(ASPA)

PBI:	103064073(ASPA)

PMUR:

107296942(ASPA)

CTIG:

120318776(ASPA)

APRI:

131188643(ASPA)

PTEX:

113442525(ASPA)

NSS:	113426160(ASPA)

VKO:	123023544(ASPA)

PMUA:

114585322(ASPA)

PRAF:

128402486(ASPA)

ZVI:	118096823(ASPA)

HCG:	128335899(ASPA)

GJA:	107106700(ASPA)

STOW:

125445846(ASPA)

EMC:	129344398(ASPA)

XLA:	108707927(aspa.L)

XTR:	733935(aspa)

NPR:	108787947(ASPA)

RTEM:

120927752(ASPA)

BBUF:

120994633(ASPA)

BGAR:

122930380(ASPA)

MUO:	115456736(ASPA)

GSH:	117349435(ASPA)

DRE:	557232(aspa)

SRX:	107712162 107731059

SANH:

107665049 107688617

SGH:	107587675 107595485

CCAR:

109092774 109107517(aspa)

CAUA:

113049733 113081298

CGIB:

127958260 127996214

PTET:

122345210(aspa)

LROH:

127165549(aspa)

OMC:	131540465(aspa)

PPRM:

120495092(aspa)

RKG:	130071359(aspa)

MAMB:

125280015

CIDE:

127512681

MASI:

127421429 127440141

TDW:	130420049(aspa)

MANU:

129440947(aspa)

IPU:

108260349

IFU:	128603356(aspa)

PHYP:

113531039(aspa)

SMEO:

124379210(aspa)

TFD:	113663349(aspa)

TVC:	132840990(aspa)

AMEX:

103046324(aspa)

CMAO:

118814350(aspa)

EEE:	113573793(aspa)

CHAR:

105895395

TRU:	101065938(aspa)

TFS:	130537759(aspa)

TNG:	GSTEN00018837G001

LCO:	104923428(aspa)

NCC:	104942045(aspa)

CGOB:

115018766(aspa)

PGEO:

117458866(aspa)

GACU:

117557259(aspa)

EMAC:

134871679(aspa)

ELY:	117272148(aspa)

EFO:	125898282(aspa)

SLUC:

116058171(aspa)

ECRA:

117955716(aspa)

ESP:	116700770(aspa)

PFLV:

114566856(aspa)

GAT:	120821462(aspa)

PPUG:

119214948(aspa)

CLUM:

117742486(aspa)

PSWI:

130190469(aspa)

SCHU:

122888139(aspa)

CUD:	121519315(aspa)

ALAT:

119031131(aspa)

MZE:

101486428

ONL:	100706566(aspa)

OAU:	116316928(aspa)

OLA:	101164583(aspa)

OML:	112142702(aspa)

CSAI:

133459785 133459792(aspa)

XMA:	102228360(aspa)

XCO:	114153486(aspa)

XHE:	116728715(aspa)

PRET:

103476025(aspa)

PFOR:

103133874(aspa)

PLAI:

106949399(aspa)

PMEI:

106919397(aspa)

GAF:	122844369(aspa)

PPRL:

129368616(aspa)

CVG:	107091751(aspa)

GMU:	124876120(aspa)

NFU:	107386659(aspa)

KMR:	108233827(aspa)

ALIM:

106523136(aspa)

NWH:	119420075(aspa)

AOCE:

111572621(aspa)

MCEP:

125021046(aspA)

CSEM:

103394877(aspa)

POV:	109644965(aspa)

SSEN:

122779336(aspa)

HHIP:

117774055(aspa)

HSP:	118122102(aspa)

SMAU:

118300205(aspa)

LCF:

108893836

SDU:	111222278(aspa)

SLAL:

111663882(aspa)

XGL:	120803133(aspa)

HCQ:	109531113(aspa)

SSCV:

125982713

SBIA:

133491571(aspa)

PEE:	133415599(aspa)

PTAO:

133467569(aspa)

BPEC:

110165139(aspa)

MALB:

109960477(aspa)

BSPL:

114869080(aspa)

SJO:	128371463(aspa)

STRU:

115154322(aspa)

OTW:	112228580(aspa)

OMY:	110533639(aspa)

OGO:	124010654(aspa)

ONE:	115135916(aspa)

OKI:	109872975(aspa)

OKE:	118390076(aspa)

SALP:

111950880(aspa)

SNH:	120057060(aspa)

CCLU:

121579448(aspa)

ELS:	105010987(aspa)

SFM:	108936033(aspa)

PKI:	111854810(aspa)

PSPA:

121308452(aspa)

ARUT:

117430829 117963352

PSEX:

120531540(aspa)

LCM:	102356980(ASPA)

CMK:	103183308(aspa)

RTP:	109914018(aspa)

CPLA:

122563960(aspa)

HOC:	132830285(aspa)

LERI:

129710530(aspa)

PMRN:

LRJ:

BFO:

BBEL:

CIN:

SCLV:

AJC:	117121890 117121891

SKO:

NVE:

EPA:

ATEN:

PTI:	PHATR_44003

FCY:	FRACYDRAFT_269769

TPS:	THAPSDRAFT_264717

VHA:	VIBHAR_06634

VCA:	M892_19250

VOW:	A9237_24780

VEJ:	VEJY3_05255

VCY:	IX92_23465

VCT:	JV59_16085

VTU:	IX91_23135

VEU:	IXK98_04630

VCC:	FAZ90_08550

VJP:	NP165_19025

PPR:	PBPRB0781(HCBP1)

PGB:	H744_1c1250

PDS:	CAY62_15555

PGH:	FH974_17370

GHO:	AL542_01120

GKD:	K6Q96_23025

SALY:

E8E00_16185

SKS:	FCN78_15040

SCOT:

HBA18_16050

SPRO:

N7E60_14670

AMC:	MADE_1015045

AMAA:

AMAL:

AMAE:

AMAO:

AMAD:

AMAI:

AMAG:

AMAC:

AMB:	AMBAS45_14605

AMG:	AMEC673_14410

AMK:	AMBLS11_13990

ALT:	ambt_02255

AAL:	EP13_14405

AAUS:

EP12_14970

ASP:

AOR13_436

ASQ:	AVL57_16315

AAW:	AVL56_15235

ALE:	AV939_15255

ALZ:	AV940_15005

APEL:

SALM:

SALK:

SMAA:

GNI:

CATE:

PAEW:

AGZ:	M0C34_19450

AGQ:	LQZ07_02530

CATT:

OLW01_10035

PMAW:

MACH26_02680

FBL:

Fbal_2465

FES:	HER31_08370

GIL:	NHM04_08510

MAGA:

Mag101_04925

FCN:	FN3523_1806

FHI:	FSC454_09025

FRX:	F7310_01405

FSR:	KQR59_09170

FRL:	FIP56_01345

RHH:	E0Z06_06270

MMW:	Mmwyl1_1144

RFO:	REIFOR_00168

ENW:	MJO57_06715

PLEI:

Q9312_17855

OPE:	PU634_04635

KKO:

Kkor_2505

KGE:

TQ33_2151

KSD:	KS2013_2190

KPD:	CW740_11775

KAM:	SR900_02460

CDIZ:

CEDIAZO_00516

NST:	Nstercoris_01873

DMS:	E8L03_20120

PSTI:

SOO65_11495

SYN:	slr1705(aspA)

SYZ:	MYO_16690(aspA)

SYY:	SYNGTS_0663(aspA)

SYT:	SYNGTI_0663(aspA)

SYS:	SYNPCCN_0662(aspA)

SYQ:	SYNPCCP_0662(aspA)

SYJ:	D082_18980(aspA)

SYO:	C7I86_03430

SYD:	Syncc9605_0517

SYE:	Syncc9902_1819

SYG:

sync_2389

SYR:	SynRCC307_0357

SYX:	SynWH7803_2088

SYNK:

KR100_04135

SYNR:

KR49_11650

SYND:

KR52_14330

SYH:	Syncc8109_0569

SYNW:

SynWH8103_02196

SYNC:

CB0101_07245 CB0101_11750

SYNY:

BM449_09665

SYW:

SYNW1922

CGC:	Cyagr_1453

CYI:	CBM981_2944

PMA:	Pro_0251(aspA)

PMM:

PMM0222

PMT:

PMT_1537

PMN:	PMN2A_1591

PMI:	PMT9312_0224

PMB:	A9601_02421(aspA)

PMC:	P9515_02521(aspA)

PMF:	P9303_04021(aspA)

PMG:	P9301_02431(aspA)

PMH:	P9215_02421(aspA)

PMJ:	P9211_02441(aspA)

PME:	NATL1_03011(aspA)

PRC:

EW14_0265

PRM:

EW15_0314

WNA:	KA717_29990

CMP:	Cha6605_0349

AMR:

AM1_5959

ACAM:

HRE53_09165 HRE53_25050

LSK:	J5X98_19340

TOG:	HNI00_21645

TSIN:

OXH18_14835

CYT:	cce_1772(aspA)

CWA:	CwatDRAFT_5318

CYP:	PCC8801_0363

CYH:	Cyan8802_0370

CYC:	PCC7424_3769

TER:

Tery_4698

MVAG:

D0A34_24170 D0A34_25100

ONI:	Osc7112_5715

MPRO:

BJP34_20735

MIC:	Mic7113_4843

ANA:

alr3912

NPU:	Npun_F2951 Npun_R2728

NOS:	Nos7107_0120

NOP:	Nos7524_3932

NON:	NOS3756_30720

NFL:	COO91_04831

NOE:	CLI64_18095

NSH:	GXM_04496 GXM_05049

NED:	HUN01_14155 HUN01_24290

AVA:

Ava_1785

NAZ:

Aazo_3116

ANB:	ANA_C10046 ANA_C13654

ACY:	Anacy_0275

AWA:	AA650_23735

ANN:	EH233_24070

CSG:	Cylst_2230 Cylst_4708

RSIN:

B6N60_02278

HBQ:	QI031_04980 QI031_15655

CALO:

Cal7507_0678

CALN:

NIES2098_01750

RIV:	Riv7116_4170 Riv7116_4483

FIS:	FIS3754_38720

DOU:	BMF77_00055

DFS:	HGD76_19840

DHT:	NG743_11965

CCUR:

IAR63_00310

CRK:	L3I90_11810

AFLO:

HEQ12_13995

STOQ:

K2F26_10830

RCS:	NIES932_14120

TOQ:	HCG51_04425

ALAX:

NIES50_60510 NIES50_66880

UAM:	UABAM_01938

SAAL:

L336_0989

» show all

Reference

PMID:8252036

Authors

Kaul R, Gao GP, Balamurugan K, Matalon R

Title

Cloning of the human aspartoacylase cDNA and a common missense mutation in Canavan disease.

Journal

Nat Genet 5:118-23 (1993)
DOI:10.1038/ng1093-118

Sequence

[hsa:443]

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