KEGG   ORTHOLOGY: K01539Help
Entry
K01539                      KO                                     

Name
ATP1A
Definition
sodium/potassium-transporting ATPase subunit alpha [EC:3.6.3.9]
Pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Cardiac muscle contraction
Adrenergic signaling in cardiomyocytes
Insulin secretion
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Aldosterone-regulated sodium reabsorption
Endocrine and other factor-regulated calcium reabsorption
Proximal tubule bicarbonate reclamation
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Carbohydrate digestion and absorption
Protein digestion and absorption
Bile secretion
Mineral absorption
Disease
H00775  
Familial or sporadic hemiplegic migraine
H00831  
Primary dystonia
H00998  
Alternating hemiplegia of childhood
H01603  
Primary aldosteronism
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04024 cAMP signaling pathway
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04022 cGMP - PKG signaling pathway
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
 Organismal Systems
  Endocrine system
   04911 Insulin secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04918 Thyroid hormone synthesis
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04919 Thyroid hormone signaling pathway
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Circulatory system
   04260 Cardiac muscle contraction
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04261 Adrenergic signaling in cardiomyocytes
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Digestive system
   04970 Salivary secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04971 Gastric acid secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04972 Pancreatic secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04976 Bile secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04973 Carbohydrate digestion and absorption
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04974 Protein digestion and absorption
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04978 Mineral absorption
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04961 Endocrine and other factor-regulated calcium reabsorption
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04964 Proximal tubule bicarbonate reclamation
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
Enzymes [BR:ko01000]
 3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.3  Acting on acid anhydrides to catalyse transmembrane movement of substances
    3.6.3.9  Na+/K+-exchanging ATPase
     K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Exosomal proteins of other body fluids (saliva and urine)
   K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Exosomal proteins of colorectal cancer cells
   K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Exosomal proteins of bladder cancer cells
   K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
BRITE hierarchy
Other DBs
GO: 
TC: 
Genes
HSA: 
476(ATP1A1) 477(ATP1A2) 478(ATP1A3) 480(ATP1A4)
PTR: 
456068(ATP1A3) 457152(ATP1A1) 457432(ATP1A2) 458010(ATP1A4)
PPS: 
100968564(ATP1A2) 100968910(ATP1A4) 100973141(ATP1A3) 100992562(ATP1A1)
GGO: 
101132606(ATP1A2) 101133472(ATP1A4) 101136136(ATP1A3) 101154367(ATP1A1)
PON: 
100172203(ATP1A2) 100174388(ATP1A1) 100440055(ATP1A3) 100451523(ATP1A4)
NLE: 
100585801(ATP1A2) 100586342(ATP1A4) 100596870(ATP1A1) 100604238(ATP1A3)
MCC: 
706513(ATP1A3) 710368(ATP1A1) 719623(ATP1A4) 720191(ATP1A2)
MCF: 
102122869(ATP1A3) 102124503(ATP1A1) 102144576(ATP1A4) 102145563(ATP1A2)
CSAB: 
103223730(ATP1A4) 103223733(ATP1A2) 103224143(ATP1A1) 103234751(ATP1A3)
RRO: 
104658863(ATP1A3) 104660405(ATP1A4) 104660406(ATP1A2) 104665933(ATP1A1)
CJC: 
100393318(ATP1A1) 100402438(ATP1A2) 100403160(ATP1A4) 100410682(ATP1A3)
SBQ: 
101035314 101035941(ATP1A2) 101041249(ATP1A1) 101044048(ATP1A3) 104652875
MMU: 
11928(Atp1a1) 232975(Atp1a3) 27222(Atp1a4) 98660(Atp1a2)
RNO: 
24211(Atp1a1) 24212(Atp1a2) 24213(Atp1a3) 29132(Atp1a4)
CGE: 
100758209(Atp1a3) 100763191(Atp1a4) 100763478(Atp1a2) 100771378(Atp1a1)
NGI: 
103734951(Atp1a1) 103740231(Atp1a2) 103740266(Atp1a4) 103744609(Atp1a3)
HGL: 
101697634(Atp1a1) 101721060(Atp1a4) 101721146(Atp1a3) 101721770(Atp1a2)
CCAN: 
109681948 109688512(Atp1a3) 109690073(Atp1a4) 109690076
OCU: 
100008756(ATP1A2) 100302415(ATP1A1) 100349382(ATP1A3) 100358269(ATP1A4) 103346768
TUP: 
102475448(ATP1A3) 102483255(ATP1A2) 102483989 102483994(ATP1A1)
CFA: 
403992(ATP1A1) 488636(ATP1A2) 488637(ATP1A4) 612463(ATP1A3)
AML: 
100477585(ATP1A3) 100477989(ATP1A1) 100480641(ATP1A2) 100480890(ATP1A4)
UMR: 
103669413(ATP1A1) 103672049(ATP1A4) 103672113(ATP1A2) 103680185(ATP1A3)
FCA: 
101083636(ATP1A3) 101083695(ATP1A1) 101096375(ATP1A4) 101096785(ATP1A2)
PTG: 
102954810 102955336(ATP1A3) 102955398 102957431(ATP1A4) 102971148(ATP1A1)
AJU: 
106969643(ATP1A1) 106978517(ATP1A4) 106985576(ATP1A2) 106987698(ATP1A3)
BTA: 
282144(ATP1A1) 282598(ATP1A3) 515161(ATP1A2) 537960(ATP1A4)
BOM: 
102270922(ATP1A3) 102271837(ATP1A2) 102272122(ATP1A4) 102287260(ATP1A1)
BIU: 
109555876(ATP1A1) 109571737(ATP1A3) 109578704(ATP1A4) 109578722
PHD: 
102341310(ATP1A1) 102343479(ATP1A2) 102343841(ATP1A4) 102344375(ATP1A3)
CHX: 
102179588(ATP1A3) 102183561(ATP1A1) 102186069(ATP1A4) 102186539(ATP1A2)
OAS: 
101103751(ATP1A3) 101118148(ATP1A2) 101118398(ATP1A4) 443381(ATP1A1)
SSC: 
100157711(ATP1A4) 100329126(ATP1A3) 396828(ATP1A2) 397481(ATP1A1)
CFR: 
102509736(ATP1A1) 102516053(ATP1A2) 102516646(ATP1A4) 102517975(ATP1A3)
BACU: 
102998568(ATP1A1) 103005321(ATP1A4) 103005600(ATP1A2) 103011003(ATP1A3)
LVE: 
103068908(ATP1A3) 103074614(ATP1A4) 103074894(ATP1A2) 103085693(ATP1A1)
ECB: 
100034139(ATP1A1) 100058251(ATP1A2) 100058301(ATP1A4) 100069796(ATP1A3)
MYB: 
102242637(ATP1A3) 102243691(ATP1A1) 102243972(ATP1A4) 102244267(ATP1A2) 102260737
MYD: 
102757270(ATP1A2) 102757556(ATP1A4) 102762810(ATP1A3) 102770472(ATP1A1)
HAI: 
109374442 109374464(ATP1A3) 109386454 109386501(ATP1A2) 109392813(ATP1A1)
PALE: 
102884868(ATP1A4) 102885125(ATP1A2) 102888359(ATP1A1) 102893697(ATP1A3)
LAV: 
100661428(ATP1A1) 100667801(ATP1A4) 100668326(ATP1A3) 100674070(ATP1A2)
MDO: 
100029759(ATP1A2)
SHR: 
100914130(ATP1A2) 100918637 100922123(ATP1A3) 100928210(ATP1A1)
GGA: 
396467(ATP1A3) 396468(ATP1A2) 396530(ATP1A1)
MGP: 
100303690(ATP1A1)
CJO: 
107307592 107319786(ATP1A1) 107324341
APLA: 
101797095 101801864(ATP1A1)
TGU: 
100190719(ATP1A1)
GFR: 
102036467(ATP1A1) 102044935
FAB: 
101813002(ATP1A1) 101813385 101820590 101820976
PHI: 
102099305 102104980 102106372(ATP1A1) 102107817(ATP1A2)
CCW: 
104687046(ATP1A1)
FPG: 
101914787(ATP1A1) 101915017(ATP1A2)
FCH: 
102050259(ATP1A1) 102059303(ATP1A2)
CLV: 
102092496(ATP1A1) 102093141(ATP1A2)
AAM: 
106490649(ATP1A1) 106500059(ATP1A2)
ASN: 
102371189(ATP1A2) 102372830(ATP1A1) 102376674(ATP1A3)
AMJ: 
102567591(ATP1A1) 102575084(ATP1A2) 106737151
PSS: 
102460622(ATP1A1) 102462326(ATP1A2)
CMY: 
102936217(ATP1A1) 102938341(ATP1A2) 102943620
CPIC: 
101931556(ATP1A3) 101933418(ATP1A1) 101934511 101950302(ATP1A2)
ACS: 
100552628 100554142 100554397 100557516(atp1a2) 100564542
PBI: 
103051176(ATP1A2) 103054113(ATP1A1) 103058247(ATP1A3)
GJA: 
107107597 107109259(ATP1A1) 107122231 107126069
XLA: 
108697760 108699431 380132(atp1a3.L) 398583(atp1a1.S) 398752(atp1a2.S) 399285(atp1a1.L)
XTR: 
100125050(atp1a2) 100145440(atp1a3) 395044(atp1a1)
DRE: 
64609(atp1a2a) 64610(atp1a3a) 64611(atp1a3b) 64612(atp1a1a.1) 64616(atp1a1b)
IPU: 
108258574 108258575 108258576 108258577 108258578 108261056 108262725 108266346 108266666(atp1a1) 108272709(atp1a3)
TRU: 
101065136 101065620 101066343 101066712 101075427 101078763(atp1a3)
TNG: 
GSTEN00002034G001 GSTEN00006344G001 GSTEN00007366G001 GSTEN00008580G001 GSTEN00008842G001 GSTEN00011875G001 GSTEN00012164G001 GSTEN00015288G001 GSTEN00031760G001 GSTEN00031761G001 GSTEN00038061G001 GSTEN00038932G001
LCO: 
104922250(atp1a3) 104926550 104928331 104929040 109139027
MZE: 
101473612(atp1a3) 101476311 101476791 101477070 101477348 101477629 101481172 101487824
OLA: 
100049445 101156309 101159291 101161996 101166845 101168472
XMA: 
102217063 102218145 102222505 102223525 102231053(atp1a3) 102236496
SASA: 
100136390(ATP1A1) 100380633(ATP1A1C/ii) 106569580 106569974 106574724(ATP1A1C/i) 106575572(AT1A1) 106583316 106588414 106596139 106596208 106597561 106600489(ATP1A2) 106602157(ATP1A1A) 106602248 106605102 106610479
LCM: 
102346835 102352604(ATP1A2) 102353554(ATP1A1) 102356851(ATP1A3)
CMK: 
103177451 103191236
BFO: 
BRAFLDRAFT_57104
CIN: 
100175029 101243505
SPU: 
404637
SKO: 
100370816(ATP1A1)
DME: 
Dmel_CG45062(CG45062) Dmel_CG45760 Dmel_CG5670(Atpalpha)
DPO: 
Dpse_GA17624 Dpse_GA19046 Dpse_GA23078
DAN: 
Dana_GF13018 Dana_GF17998
DER: 
Dere_GG16375 Dere_GG21788 Dere_GG24266
DPE: 
Dper_GL16518 Dper_GL16920 Dper_GL18190 Dper_GL24291
DSE: 
Dsec_GM10716 Dsec_GM15055 Dsec_GM15637
DSI: 
Dsimw501_GD19388(Dsim_GD19388) Dsimw501_GD19691(Dsim_GD19691) Dsimw501_GD29095(Dsim_GD29095)
DWI: 
Dwil_GK11950 Dwil_GK17901 Dwil_GK18474 Dwil_GK23675
DYA: 
Dyak_GE11863 Dyak_GE14534 Dyak_GE25699
DGR: 
Dgri_GH20530 Dgri_GH21713
DMO: 
Dmoj_GI10755 Dmoj_GI18976 Dmoj_GI21352
DVI: 
Dvir_GJ10697 Dvir_GJ18410 Dvir_GJ18574(Dvir_JYalpha) Dvir_GJ22439
MDE: 
101893028
AGA: 
AgaP_AGAP002858
AAG: 
AaeL_AAEL012062
CQU: 
CpipJ_CPIJ005966
AME: 
410913(GB10508) 411083(Rpb8) 413471(GB17873)
BIM: 
100740458 100745576
BTER: 
100643682 100647333 110119661
SOC: 
105200410 105204687
AEC: 
105143877 105144349 105151970
HST: 
105182517 105189690 105191858
CFO: 
105252935 105255730
NVI: 
100116320 100122763
TCA: 
660125 661036 661092 663833
BMOR: 
101741364 101743662
DPL: 
KGM_02030 KGM_02739 KGM_09831
PXY: 
105380390 105384743 105384761 105393938 105395060 105395131
API: 
100167886 103310367
PHU: 
Phum_PHUM336910 Phum_PHUM361900 Phum_PHUM432700
DPX: 
DAPPUDRAFT_106456 DAPPUDRAFT_202800 DAPPUDRAFT_256165 DAPPUDRAFT_305634 DAPPUDRAFT_305693 DAPPUDRAFT_309219 DAPPUDRAFT_60674
ISC: 
IscW_ISCW002538
CEL: 
CELE_B0365.3(eat-6) CELE_C01G12.8(catp-4) CELE_C02E7.1(catp-2) CELE_Y105E8A.12(catp-1)
CBR: 
CBG01656 CBG09434(Cbr-eat-6)
BMY: 
Bm1_51740
LOA: 
LOAG_07482 LOAG_07650 LOAG_17214 LOAG_17981
TSP: 
Tsp_02677 Tsp_04833 Tsp_14317 Tsp_14686 Tsp_15146
HRO: 
HELRODRAFT_102867 HELRODRAFT_135885 HELRODRAFT_156333 HELRODRAFT_157527 HELRODRAFT_157737 HELRODRAFT_185638 HELRODRAFT_187047 HELRODRAFT_188923 HELRODRAFT_92935 HELRODRAFT_94922 HELRODRAFT_94925
LGI: 
LOTGIDRAFT_169374
CRG: 
105338008
OBI: 
106880261
SMM: 
Smp_015020(SNaK1)
NVE: 
NEMVE_v1g186331 NEMVE_v1g245490
ADF: 
107343492 107343529
HMG: 
100197585 100199062 100199690 100205960 100206577 100209230 100209869(atp1a3) 100210266 100212925 100213157 101234349 105846521
TAD: 
TRIADDRAFT_63163
AQU: 
100634317 100641151
CRE: 
CHLREDRAFT_187139
VCN: 
VOLCADRAFT_78789
OLU: 
OSTLU_48492
OTA: 
Ot01g00900
BPG: 
Bathy01g00820
CVR: 
CHLNCDRAFT_56139
CCP: 
CHC_T00002703001 CHC_T00009537001
PIC: 
PICST_60178(PMR2)
CAL: 
CAALFM_CR01630CA(CaO19.2552) CAALFM_CR01640CA(CaO19.2553)
CTEN: 
CANTEDRAFT_102766
CAUR: 
QG37_03453
PAN: 
PODANSg1282 PODANSg8259
TTT: 
THITE_125028 THITE_2118086
MGR: 
MGG_10027 MGG_16361
TMN: 
UCRPA7_4282
FGR: 
FGSG_04512
FPU: 
FPSE_03734
NHE: 
NECHADRAFT_103674 NECHADRAFT_71444 NECHADRAFT_85426
TRE: 
TRIREDRAFT_106928
MAW: 
MAC_01563 MAC_06634
MAJ: 
MAA_02399 MAA_07893
CMT: 
CCM_01962 CCM_03289
VAL: 
VDBG_02452
VDA: 
VDAG_02927
CFJ: 
CFIO01_05596 CFIO01_05597 CFIO01_09611
ELA: 
UCREL1_3885
SSL: 
SS1G_00628
BFU: 
BC1G_04401 BC1G_06532
MBE: 
MBM_04409
ANI: 
AN8941.2
AFM: 
AFUA_7G04570
AOR: 
AOR_1_144074(AO090038000088) AOR_1_264174(AO090005000141)
ANG: 
ANI_1_1014084(An09g00930) ANI_1_352124(An14g02290)
AFV: 
AFLA_073840 AFLA_125660
ACT: 
ACLA_004560 ACLA_006260
NFI: 
NFIA_025530 NFIA_041430
PCS: 
Pc21g08760
PDP: 
PDIP_58430
PBL: 
PAAG_04243
PBN: 
PADG_07481
ABE: 
ARB_01038 ARB_06970
TVE: 
TRV_00354 TRV_02788
PNO: 
SNOG_00706
PTE: 
PTT_00480
BZE: 
COCCADRAFT_81950 COCCADRAFT_84757
BSC: 
COCSADRAFT_349006 COCSADRAFT_354769
BOR: 
COCMIDRAFT_5291 COCMIDRAFT_88396
ZTR: 
MYCGRDRAFT_70478
PFJ: 
MYCFIDRAFT_163458
BCOM: 
BAUCODRAFT_144399 BAUCODRAFT_38353
NPA: 
UCRNP2_6234
TVS: 
TRAVEDRAFT_30295 TRAVEDRAFT_36490
DSQ: 
DICSQDRAFT_110606 DICSQDRAFT_156959 DICSQDRAFT_161018 DICSQDRAFT_47382
PCO: 
PHACADRAFT_257070
SHS: 
STEHIDRAFT_102924
HIR: 
HETIRDRAFT_122733 HETIRDRAFT_157468
PSQ: 
PUNSTDRAFT_114331
ADL: 
AURDEDRAFT_137746 AURDEDRAFT_144754 AURDEDRAFT_167218
FME: 
FOMMEDRAFT_112538 FOMMEDRAFT_92115
GTR: 
GLOTRDRAFT_35605
LBC: 
LACBIDRAFT_186573 LACBIDRAFT_232929
MRR: 
Moror_1938 Moror_4747
CPUT: 
CONPUDRAFT_112134 CONPUDRAFT_123858 CONPUDRAFT_155151
SLA: 
SERLADRAFT_354456 SERLADRAFT_446026
UMA: 
UMAG_05038 UMAG_06433
PFP: 
PFL1_01803
PGR: 
PGTG_03133
MLR: 
MELLADRAFT_22597 MELLADRAFT_37617 MELLADRAFT_43430 MELLADRAFT_48408
MBR: 
MONBRDRAFT_35405
SRE: 
PTSG_01035 PTSG_05228 PTSG_07829 PTSG_08530 PTSG_08937 PTSG_12751
DDI: 
DDB_G0267924 DDB_G0277269(ionA)
DPP: 
DICPUDRAFT_42780 DICPUDRAFT_47441 DICPUDRAFT_90846
DFA: 
DFA_05945(ionA) DFA_09533 DFA_09785
ACAN: 
ACA1_203720
TET: 
TTHERM_00049030 TTHERM_00061570 TTHERM_00245100 TTHERM_00266610 TTHERM_00268190 TTHERM_00355800 TTHERM_00365390 TTHERM_00365450 TTHERM_00420880 TTHERM_00420900 TTHERM_00508970 TTHERM_00508990 TTHERM_00643550 TTHERM_00700900 TTHERM_00840060 TTHERM_00854430 TTHERM_00855430 TTHERM_00856430 TTHERM_00856440 TTHERM_00989440 TTHERM_01149330 TTHERM_01150350
PTM: 
GSPATT00000481001 GSPATT00006140001 GSPATT00013152001 GSPATT00014598001 GSPATT00014599001 GSPATT00015926001 GSPATT00015953001 GSPATT00021041001 GSPATT00022945001 GSPATT00026301001 GSPATT00030416001 GSPATT00032952001 GSPATT00033380001 PTMB.66
SMIN: 
v1.2.000245.t1(symbB.v1.2.000245.t1) v1.2.028598.t1(symbB.v1.2.028598.t1)
AAF: 
AURANDRAFT_70232
PIF: 
PITG_14384 PITG_16061
PSOJ: 
PHYSODRAFT_245875 PHYSODRAFT_495494
SPAR: 
SPRG_00285 SPRG_13744 SPRG_17035
NGR: 
NAEGRDRAFT_258 NAEGRDRAFT_30663 NAEGRDRAFT_62984
GLA: 
GL50803_96670
TCX: 
Tcr_1065
CYQ: 
Q91_1618
CZA: 
CYCME_0842
DAR: 
Daro_1851
GUR: 
Gura_3300
GEO: 
Geob_1849
PCA: 
Pcar_2279
SAT: 
SYN_02485
MAC: 
MA_4378
MBA: 
Mbar_A1053
MBY: 
MSBRM_3311 MSBRM_3312
MBW: 
MSBRW_3669
MBAR: 
MSBR2_3266
MBAK: 
MSBR3_3261
MMA: 
MM_1069
MMAZ: 
MmTuc01_1100
MMJ: 
MSMAS_0232
MMAC: 
MSMAC_0238
MVC: 
MSVAZ_0218 MSVAZ_0627
MEK: 
MSKOL_0212 MSKOL_0609
MLS: 
MSLAZ_2966
METM: 
MSMTP_0268
MEF: 
MSWH1_0533
MEQ: 
MSWHS_0548
MSJ: 
MSSAC_4063
MSZ: 
MSSIH_3599
MSW: 
MSSIT_3652
MHOR: 
MSHOH_0294
MBU: 
Mbur_0431
MHAZ: 
BHR79_09450
MZH: 
Mzhil_1847
MPY: 
Mpsy_0778
MHZ: 
Metho_1783
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1328175
  Authors
Lingrel JB
  Title
Na,K-ATPase: isoform structure, function, and expression.
  Journal
J Bioenerg Biomembr 24:263-70 (1992)
DOI:10.1007/BF00768847
Reference
  Authors
Morth JP, Poulsen H, Toustrup-Jensen MS, Schack VR, Egebjerg J, Andersen JP, Vilsen B, Nissen P
  Title
The structure of the Na+,K+-ATPase and mapping of isoform differences and disease-related mutations.
  Journal
Philos Trans R Soc Lond B Biol Sci 364:217-27 (2009)
DOI:10.1098/rstb.2008.0201
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