KEGG   ORTHOLOGY: K01539Help
Entry
K01539                      KO                                     

Name
ATP1A
Definition
sodium/potassium-transporting ATPase subunit alpha [EC:3.6.3.9]
Pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Cardiac muscle contraction
Adrenergic signaling in cardiomyocytes
Insulin secretion
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Aldosterone-regulated sodium reabsorption
Endocrine and other factor-regulated calcium reabsorption
Proximal tubule bicarbonate reclamation
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Carbohydrate digestion and absorption
Protein digestion and absorption
Bile secretion
Mineral absorption
Disease
H00775  
Familial or sporadic hemiplegic migraine
H00831  
Primary dystonia
H00998  
Alternating hemiplegia of childhood
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04024 cAMP signaling pathway
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04022 cGMP - PKG signaling pathway
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
 Organismal Systems
  Endocrine system
   04911 Insulin secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04918 Thyroid hormone synthesis
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04919 Thyroid hormone signaling pathway
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Circulatory system
   04260 Cardiac muscle contraction
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04261 Adrenergic signaling in cardiomyocytes
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Digestive system
   04970 Salivary secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04971 Gastric acid secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04972 Pancreatic secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04976 Bile secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04973 Carbohydrate digestion and absorption
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04974 Protein digestion and absorption
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04978 Mineral absorption
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04961 Endocrine and other factor-regulated calcium reabsorption
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04964 Proximal tubule bicarbonate reclamation
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
Enzymes [BR:ko01000]
 3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.3  Acting on acid anhydrides to catalyse transmembrane movement of substances
    3.6.3.9  Na+/K+-exchanging ATPase
     K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Exosomal proteins of other body fluids (saliva and urine)
   K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Exosomal proteins of colorectal cancer cells
   K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Exosomal proteins of bladder cancer cells
   K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
BRITE hierarchy
Other DBs
GO: 
TC: 
Genes
HSA: 
476(ATP1A1) 477(ATP1A2) 478(ATP1A3) 480(ATP1A4)
PTR: 
456068(ATP1A3) 457152(ATP1A1) 457432(ATP1A2) 458010(ATP1A4)
PPS: 
100968564(ATP1A2) 100968910(ATP1A4) 100973141(ATP1A3) 100992562(ATP1A1)
GGO: 
101132606(ATP1A2) 101133472(ATP1A4) 101136136(ATP1A3) 101154367(ATP1A1)
PON: 
100172203(ATP1A2) 100174388(ATP1A1) 100440055(ATP1A3) 100451523(ATP1A4)
MCC: 
706513(ATP1A3) 710368(ATP1A1) 719623(ATP1A4) 720191(ATP1A2)
MCF: 
102122869(ATP1A3) 102124503(ATP1A1) 102144576(ATP1A4) 102145563(ATP1A2)
MMU: 
11928(Atp1a1) 232975(Atp1a3) 27222(Atp1a4) 98660(Atp1a2)
RNO: 
24211(Atp1a1) 24212(Atp1a2) 24213(Atp1a3) 29132(Atp1a4)
CGE: 
100758209(Atp1a3) 100763191(Atp1a4) 100763478(Atp1a2) 100771378(Atp1a1)
HGL: 
101697634(Atp1a1) 101721060(Atp1a4) 101721146(Atp1a3) 101721770(Atp1a2)
TUP: 
102475448(ATP1A3) 102483255(ATP1A4) 102483989 102483994(ATP1A1)
CFA: 
403992(ATP1A1) 488636(ATP1A2) 488637(ATP1A4) 612463(ATP1A3)
AML: 
FCA: 
101083636(ATP1A3) 101083695(ATP1A1) 101096375(ATP1A4) 101096785(ATP1A2)
PTG: 
BTA: 
282144(ATP1A1) 282598(ATP1A3) 515161(ATP1A2) 537960(ATP1A4)
BOM: 
102270922(ATP1A3) 102271837(ATP1A2) 102272122(ATP1A4) 102287260(ATP1A1)
PHD: 
102341310(ATP1A1) 102343479(ATP1A2) 102343841(ATP1A4) 102344375(ATP1A3)
CHX: 
102179588(ATP1A3) 102183561(ATP1A1) 102186069(ATP1A4) 102186539(ATP1A2)
OAS: 
101103751(ATP1A3) 101118148(ATP1A2) 101118398(ATP1A4) 443381(ATP1A1)
SSC: 
100157711(ATP1A4) 100329126(ATP1A3) 396828(ATP1A2) 397481(ATP1A1)
CFR: 
102509736(ATP1A1) 102516053(ATP1A2) 102516646(ATP1A4) 102517975(ATP1A3)
BACU: 
102998568(ATP1A1) 103005321(ATP1A4) 103005600(ATP1A2) 103011003(ATP1A3)
LVE: 
103068908(ATP1A3) 103074614(ATP1A4) 103074894(ATP1A2) 103085693(ATP1A1)
ECB: 
100034139(ATP1A1) 100058251(ATP1A2) 100058301(ATP1A4) 100069796(ATP1A3)
MYB: 
102242637(ATP1A3) 102243691(ATP1A1) 102243972(ATP1A4) 102244267(ATP1A2) 102260737
MYD: 
102757270(ATP1A2) 102757556(ATP1A4) 102762810(ATP1A3) 102770178 102770472(ATP1A1)
PALE: 
102884868(ATP1A4) 102885125(ATP1A2) 102888359(ATP1A1) 102893697(ATP1A3)
MDO: 
100010919(ATP1A1) 100029759(ATP1A2)
SHR: 
GGA: 
396467(ATP1A3) 396468(ATP1A2) 396530(ATP1A1)
MGP: 
100303690(ATP1A1)
TGU: 
100190719(ATP1A1)
FAB: 
PHI: 
APLA: 
FPG: 
101914787(ATP1A1) 101915017(ATP1A2)
FCH: 
102050259(ATP1A1) 102059303(ATP1A2)
CLV: 
102092496(ATP1A1) 102093141(ATP1A2)
ASN: 
102371189(ATP1A2) 102372830(ATP1A1) 102376674(ATP1A3)
AMJ: 
102566197(ATP1A2) 102567591(ATP1A1) 102575084(ATP1A3)
PSS: 
102460622(ATP1A1) 102462326(ATP1A2)
CMY: 
102936217(ATP1A1) 102938341(ATP1A2) 102943620
ACS: 
PBI: 
103051176(ATP1A2) 103054113(ATP1A1) 103058247(ATP1A3) 103063371
XLA: 
380132(atp1a3) 398583(atp1a1-b) 398752(atp1a2) 399285(atp1a1-a)
XTR: 
100125050(atp1a2) 100145440(atp1a3) 395044(atp1a1)
DRE: 
64609(atp1a2a) 64610(atp1a3a) 64611(atp1a3b) 64612(atp1a1a.1) 64616(atp1a1b)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102346835 102352604(ATP1A2) 102353554(ATP1A1) 102356851(ATP1A3)
CMK: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_B0365.3(eat-6) CELE_C01G12.8(catp-4) CELE_C02E7.1(catp-2)
CBR: 
CBG01656 CBG09434(Cbr-eat-6)
BMY: 
LOA: 
TSP: 
SMM: 
Smp_015020(SNaK1)
NVE: 
HMG: 
TAD: 
AQU: 
ZMA: 
CRE: 
VCN: 
OLU: 
OTA: 
BPG: 
CVR: 
CCP: 
PIC: 
CTEN: 
PAN: 
TTT: 
MGR: 
TMN: 
FGR: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
ELA: 
SSL: 
BFU: 
MBE: 
AFM: 
AOR: 
AOR_1_264174(AO090005000141)
ANG: 
ANI_1_1014084(An09g00930)
AFV: 
ACT: 
NFI: 
PCS: 
PBL: 
ABE: 
TVE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
DSQ: 
SHS: 
PCO: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MRR: 
CPUT: 
SLA: 
PFP: 
PGR: 
MLR: 
MBR: 
DDI: 
DPP: 
DFA: 
ACAN: 
TET: 
PTM: 
PIF: 
NGR: 
GLA: 
TCX: 
DAR: 
GUR: 
GEO: 
PCA: 
SAT: 
MAC: 
MBA: 
MMA: 
MMAZ: 
MBU: 
MZH: 
MPY: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1328175
  Authors
Lingrel JB
  Title
Na,K-ATPase: isoform structure, function, and expression.
  Journal
J Bioenerg Biomembr 24:263-70 (1992)
Reference
  Authors
Morth JP, Poulsen H, Toustrup-Jensen MS, Schack VR, Egebjerg J, Andersen JP, Vilsen B, Nissen P
  Title
The structure of the Na+,K+-ATPase and mapping of isoform differences and disease-related mutations.
  Journal
Philos Trans R Soc Lond B Biol Sci 364:217-27 (2009)

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