KEGG   ORTHOLOGY: K01539Help
Entry
K01539                      KO                                     
Name
ATP1A
Definition
sodium/potassium-transporting ATPase subunit alpha [EC:3.6.3.9]
Pathway
Cardiac muscle contraction
Insulin secretion
Thyroid hormone synthesis
Aldosterone-regulated sodium reabsorption
Endocrine and other factor-regulated calcium reabsorption
Proximal tubule bicarbonate reclamation
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Carbohydrate digestion and absorption
Protein digestion and absorption
Bile secretion
Mineral absorption
Disease
H00775  
Familial or sporadic hemiplegic migraine
H00831  
Primary dystonia
H00998  
Alternating hemiplegia of childhood
Brite
KEGG Orthology (KO) [BR:ko00001]
 Organismal Systems
  Endocrine system
   04911 Insulin secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04918 Thyroid hormone synthesis
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Circulatory system
   04260 Cardiac muscle contraction
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04261 Adrenergic signaling in cardiomyocytes
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Digestive system
   04970 Salivary secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04971 Gastric acid secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04972 Pancreatic secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04976 Bile secretion
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04973 Carbohydrate digestion and absorption
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04974 Protein digestion and absorption
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04978 Mineral absorption
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04961 Endocrine and other factor-regulated calcium reabsorption
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
   04964 Proximal tubule bicarbonate reclamation
    K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
Enzymes [BR:ko01000]
 3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.3  Acting on acid anhydrides to catalyse transmembrane movement of substances
    3.6.3.9  Na+/K+-exchanging ATPase
     K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Exosomal proteins of other body fluids (saliva and urine)
   K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Exosomal proteins of colorectal cancer cells
   K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
  Exosomal proteins of bladder cancer cells
   K01539  ATP1A; sodium/potassium-transporting ATPase subunit alpha
BRITE hierarchy
Other DBs
GO: 
TC: 
Genes
HSA: 
476(ATP1A1) 477(ATP1A2) 478(ATP1A3) 480(ATP1A4)
PTR: 
456068(ATP1A3) 457152(ATP1A1) 457432(ATP1A2) 458010(ATP1A4)
PPS: 
100968564(ATP1A2) 100968910(ATP1A4) 100992562(ATP1A1)
GGO: 
101132606(ATP1A2) 101136136(ATP1A3) 101154367(ATP1A1)
PON: 
100172203(ATP1A2) 100174388(ATP1A1) 100440055(ATP1A3) 100451523(ATP1A4)
MCC: 
706513(ATP1A3) 710368(ATP1A1) 719623(ATP1A4) 720191(ATP1A2)
MMU: 
11928(Atp1a1) 232975(Atp1a3) 27222(Atp1a4) 98660(Atp1a2)
RNO: 
24211(Atp1a1) 24212(Atp1a2) 24213(Atp1a3) 29132(Atp1a4)
CGE: 
100763191(Atp1a4) 100763478 100771378(Atp1a1)
HGL: 
101697634(Atp1a1) 101721060(Atp1a4) 101721146(Atp1a3) 101721770(Atp1a2)
CFA: 
403992(ATP1A1) 488636(ATP1A2) 488637(ATP1A4) 612463(ATP1A3)
AML: 
100477585(ATP1A3) 100477989 100480641 100480890(ATP1A4)
FCA: 
101083636(ATP1A3) 101083695(ATP1A1) 101096375(ATP1A4)
BTA: 
282144(ATP1A1) 282598(ATP1A3) 515161(ATP1A2) 537960(ATP1A4)
SSC: 
100157711(ATP1A4) 100329126(ATP1A3) 396828(ATP1A2) 397481(ATP1A1)
ECB: 
100034139(ATP1A1) 100058251(ATP1A2) 100058301(ATP1A4) 100069796(ATP1A3)
MDO: 
100010919 100029759(ATP1A2)
SHR: 
100914130 100922123(ATP1A3) 100928210
GGA: 
396467(ATP1A3) 396468(ATP1A2) 396530(ATP1A1)
MGP: 
100303690(ATP1A1)
FAB: 
101813002(ATP1A1)
APLA: 
101801864(ATP1A1)
FPG: 
101914787(ATP1A1)
ACS: 
100564542
XLA: 
380132(atp1a3) 398583(atp1a1-b) 398752(atp1a2) 399285(atp1a1-a)
XTR: 
100125050(atp1a2) 100145440(atp1a3) 395044(atp1a1)
DRE: 
64609(atp1a2a) 64610(atp1a3a) 64611(atp1a3b) 64612(atp1a1a.1) 64616(atp1a1b)
TRU: 
101065136 101066343
MZE: 
101476311 101476791 101481172 101487824
OLA: 
101156309 101161996 101168472
BFO: 
BRAFLDRAFT_57104
CIN: 
100175029
SPU: 
404637
DME: 
Dmel_CG3701 Dmel_CG5670(Atpalpha)
DPO: 
Dpse_GA17624 Dpse_GA19046
DAN: 
Dana_GF13018 Dana_GF17998
DER: 
Dere_GG21788 Dere_GG24266
DPE: 
Dper_GL16920 Dper_GL24291
DSE: 
Dsec_GM15055
DSI: 
Dsim_GD19388
DWI: 
Dwil_GK11950 Dwil_GK17901
DYA: 
Dyak_GE11863 Dyak_GE25699
DGR: 
Dgri_GH20530 Dgri_GH21713
DMO: 
Dmoj_GI10755 Dmoj_GI18976
DVI: 
Dvir_GJ10697 Dvir_GJ22439
AGA: 
AgaP_AGAP002858
AAG: 
AaeL_AAEL012062
CQU: 
CpipJ_CPIJ005966
NVI: 
100122763
TCA: 
663833
BMOR: 
101743662
API: 
100167886
PHU: 
Phum_PHUM336910 Phum_PHUM361900
ISC: 
IscW_ISCW002538
CEL: 
CELE_B0365.3(eat-6) CELE_C01G12.8(catp-4) CELE_C02E7.1(catp-2)
CBR: 
CBG01656 CBG09434(Cbr-eat-6)
BMY: 
Bm1_51740
LOA: 
LOAG_07482 LOAG_07650
TSP: 
Tsp_04833
SMM: 
Smp_015020(SNaK1)
NVE: 
NEMVE_v1g186331 NEMVE_v1g245490
HMG: 
100197585 100209869(atp1a3)
TAD: 
TRIADDRAFT_63163
AQU: 
100634317
ZMA: 
100382948
CRE: 
CHLREDRAFT_187139
VCN: 
VOLCADRAFT_78789
OLU: 
OSTLU_48492
OTA: 
Ot01g00900
PIC: 
PICST_60178(PMR2)
PAN: 
PODANSg1282 PODANSg8259
TTT: 
THITE_125028 THITE_2118086
MGR: 
MGG_10027 MGG_16361
FGR: 
FG04512.1
NHE: 
NECHADRAFT_103674 NECHADRAFT_71444
VAL: 
VDBG_02452
SSL: 
SS1G_00628
BFU: 
BC1G_04401 BC1G_06532
NFI: 
NFIA_025530 NFIA_041430
AFM: 
AFUA_7G04570
AOR: 
AOR_1_264174(AO090005000141)
ANG: 
ANI_1_1014084(An09g00930)
AFV: 
AFLA_073840 AFLA_125660
ACT: 
ACLA_004560 ACLA_006260
PCS: 
Pc21g08760
PBL: 
PAAG_04243
ABE: 
ARB_01038 ARB_06970
TVE: 
TRV_00354 TRV_02788
PNO: 
SNOG_00706
PTE: 
PTT_00480
ZTR: 
MYCGRDRAFT_70478
LBC: 
LACBIDRAFT_186573 LACBIDRAFT_232929
PGR: 
PGTG_03133
MBR: 
MONBRDRAFT_35405
DPP: 
DICPUDRAFT_47441 DICPUDRAFT_90846
DFA: 
DFA_09533 DFA_09785
TET: 
TTHERM_00049030 TTHERM_00061570 TTHERM_00245100 TTHERM_00268190 TTHERM_00355800 TTHERM_00365390 TTHERM_00365450 TTHERM_00420900 TTHERM_00643550 TTHERM_00700900 TTHERM_00989440 TTHERM_01149330 TTHERM_01150350
PTM: 
GSPATT00000481001 GSPATT00015953001 GSPATT00030416001 GSPATT00032952001 PTMB.66
PIF: 
PITG_14384
NGR: 
NAEGRDRAFT_258 NAEGRDRAFT_30663
GLA: 
GL50803_96670
TCX: 
Tcr_1065
DAR: 
Daro_1851
GUR: 
Gura_3300
GEO: 
Geob_1849
PCA: 
Pcar_2279
SAT: 
SYN_02485
MAC: 
MA4378
MBA: 
Mbar_A1053
MMA: 
MM_1069
MMAZ: 
MmTuc01_1100
MBU: 
Mbur_0431
MZH: 
Mzhil_1847
MPY: 
Mpsy_0778
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1328175
  Authors
Lingrel JB
  Title
Na,K-ATPase: isoform structure, function, and expression.
  Journal
J Bioenerg Biomembr 24:263-70 (1992)
Reference
  Authors
Morth JP, Poulsen H, Toustrup-Jensen MS, Schack VR, Egebjerg J, Andersen JP, Vilsen B, Nissen P
  Title
The structure of the Na+,K+-ATPase and mapping of isoform differences and disease-related mutations.
  Journal
Philos Trans R Soc Lond B Biol Sci 364:217-27 (2009)
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