KEGG   ORTHOLOGY: K01593Help
Entry
K01593                      KO                                     

Name
DDC, TDC
Definition
aromatic-L-amino-acid/L-tryptophan decarboxylase [EC:4.1.1.28 4.1.1.105]
Pathway
ko00350  Tyrosine metabolism
ko00360  Phenylalanine metabolism
ko00380  Tryptophan metabolism
ko00901  Indole alkaloid biosynthesis
ko00950  Isoquinoline alkaloid biosynthesis
ko00965  Betalain biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko04726  Serotonergic synapse
ko04728  Dopaminergic synapse
ko05030  Cocaine addiction
ko05031  Amphetamine addiction
ko05034  Alcoholism
Module
M00037  Melatonin biosynthesis, tryptophan => serotonin => melatonin
M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Disease
H01161  Aromatic L-amino acid decarboxylase (AADC) deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Amino acid metabolism
   00350 Tyrosine metabolism
    K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
   00360 Phenylalanine metabolism
    K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
   00380 Tryptophan metabolism
    K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
  Biosynthesis of other secondary metabolites
   00901 Indole alkaloid biosynthesis
    K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
   00950 Isoquinoline alkaloid biosynthesis
    K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
   00965 Betalain biosynthesis
    K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
 Organismal Systems
  Nervous system
   04728 Dopaminergic synapse
    K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
   04726 Serotonergic synapse
    K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
 Human Diseases
  Substance dependence
   05030 Cocaine addiction
    K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
   05031 Amphetamine addiction
    K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
   05034 Alcoholism
    K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
KEGG modules [BR:ko00002]
 Pathway module
  Nucleotide and amino acid metabolism
   Aromatic amino acid metabolism
    M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
     K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
    M00037  Melatonin biosynthesis, tryptophan => serotonin => melatonin
     K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.28  aromatic-L-amino-acid decarboxylase
     K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
    4.1.1.105  L-tryptophan decarboxylase
     K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
BRITE hierarchy
Other DBs
RN: R00685 R00699 R00736 R02080 R02701 R04909
COG: COG0076
GO: 0004058 0036469
Genes
HSA: 1644(DDC)
PTR: 463409(DDC)
PPS: 100971531(DDC)
GGO: 101145222(DDC)
PON: 100435277(DDC)
NLE: 100597933(DDC)
MCC: 693677(DDC)
MCF: 102119567(DDC)
CSAB: 103226076(DDC)
RRO: 104657651(DDC)
RBB: 108527366(DDC)
CJC: 100402255(DDC)
SBQ: 101040684(DDC)
MMU: 13195(Ddc)
RNO: 24311(Ddc)
CGE: 100761742(Ddc)
NGI: 103746991(Ddc)
HGL: 101697555(Ddc)
CCAN: 109689534(Ddc)
OCU: 100355492(DDC)
TUP: 102499553(DDC)
CFA: 606852(DDC)
AML: 100475392(DDC)
UMR: 103674553(DDC)
ORO: 101364177(DDC)
FCA: 101082989(DDC)
PTG: 102955370(DDC)
AJU: 106968187(DDC)
BTA: 107131141 280762(DDC)
BOM: 102287020(DDC)
BIU: 109558177(DDC)
PHD: 102325577(DDC) 102325580
CHX: 102169726(DDC)
OAS: 101106765(DDC)
SSC: 396857(DDC)
CFR: 102513068(DDC)
CDK: 105105292(DDC)
BACU: 102999539(DDC)
LVE: 103080634(DDC)
OOR: 101290071(DDC)
ECB: 100052557(DDC)
EPZ: 103558736 103563419(DDC)
EAI: 106822940(DDC)
MYB: 102254659(DDC)
MYD: 102774614(DDC)
HAI: 109388356(DDC)
RSS: 109447363(DDC)
PALE: 102893985(DDC)
LAV: 100677538(DDC)
TMU: 101348227
MDO: 100030001(DDC)
SHR: 100917570(DDC)
OAA: 100074589(DDC)
GGA: 420947(DDC)
MGP: 100542576(DDC)
CJO: 107309491(DDC)
APLA: 101796508(DDC)
ACYG: 106036562(DDC)
TGU: 100226623(DDC)
GFR: 102032520(DDC)
FAB: 101811896(DDC)
PHI: 102104958(DDC)
PMAJ: 107216322(DDC)
CCW: 104685862(DDC)
FPG: 101922826(DDC)
FCH: 102059671(DDC)
EGZ: 104126196(DDC)
AAM: 106492855(DDC)
ASN: 102375703(DDC)
AMJ: 106736839(DDC)
PSS: 102452351(DDC)
CMY: 102937578(DDC)
CPIC: 101939746(DDC)
ACS: 100564794(ddc)
PVT: 110085760(DDC)
PBI: 103055744(DDC)
GJA: 107121867(DDC)
XLA: 100126640(ddc.L)
XTR: 496742(ddc)
NPR: 108788303(DDC)
DRE: 406651(ddc)
SANH: 107657571(ddc) 107704081
CCAR: 109066248 109071918(ddc)
IPU: 108275746(ddc)
AMEX: 103039119(ddc)
TRU: 101070663(ddc)
LCO: 104939491(ddc)
NCC: 104957402
MZE: 101472888(ddc)
OLA: 100301599(ddc)
XMA: 102226428(ddc)
PRET: 103478360(ddc)
NFU: 107378764(ddc)
CSEM: 103388766(ddc)
LCF: 108888820(ddc)
HCQ: 109531054(ddc)
BPEC: 110171777(ddc)
ELS: 105025918(ddc)
SFM: 108940501(ddc)
CMK: 103181195(ddc)
CIN: 100101815(hdcl)
APLC: 110989624
SKO: 100374376
DME: Dmel_CG10697(Ddc)
DPO: Dpse_GA10503(Dpse_Ddc)
DSI: Dsimw501_GD21778(Dsim_Ddc)
DWI: Dwil_GK24237(Dwil_Ddc)
DVI: Dvir_GJ17995(Dvir_Ddc)
AAG: 5563940
AME: 410638(Ddc) 410639(GB14019)
CEL: CELE_C05D2.3(basl-1) CELE_ZK829.2(hdl-1)
TSP: Tsp_00610
ATH: AT2G20340(AAS)
LJA: Lj0g3v0211149.1(Lj0g3v0211149.1) Lj1g3v4528440.1(Lj1g3v4528440.1) Lj6g3v1679480.1(Lj6g3v1679480.1)
CSV: 101205061
CMO: 103489832
MCHA: 111022679
RCU: 8266698
CANN: 107842494(TDC2) 107878308
DOSA: Os07t0437500-01(Os07g0437500) Os08t0140300-01(Os08g0140300) Os08t0140500-00(Os08g0140500) Os10t0400500-00(Os10g0400500)
ATS: 109748394(LOC109748394) 109749204(LOC109749204) 109751651(LOC109751651) 109754049(LOC109754049) 109782055(LOC109782055)
SMO: SELMODRAFT_169665(TYDC5-2) SELMODRAFT_84876(TYDC5-1)
CRE: CHLREDRAFT_116869(DDC1)
APRO: F751_5176
NCR: NCU08275
NTE: NEUTE1DRAFT128600(NEUTE1DRAFT_128600)
MAW: MAC_06737
MAJ: MAA_01165
CMT: CCM_04742
MBE: MBM_06276
ANI: AN2357.2
ANG: ANI_1_2316014(An01g02000)
ABE: ARB_03722
TVE: TRV_07554
PTE: PTT_10253
CNE: CND00950
CNB: CNBD5350
ABP: AGABI1DRAFT119334(AGABI1DRAFT_119334)
ABV: AGABI2DRAFT185212(AGABI2DRAFT_185212)
MGL: MGL_3372
SMIN: v1.2.008729.t1(symbB.v1.2.008729.t1)
SPAR: SPRG_03246
YPE: YPO1193
YPK: y2996(dcd)
YPA: YPA_0905
YPN: YPN_2783
YPM: YP_0943(dcd1)
YPZ: YPZ3_1100
YPD: YPD4_1061
YPX: YPD8_1086
YPH: YPC_3018
YPW: CH59_650
YPJ: CH55_1355
YPV: BZ15_2363
YPL: CH46_3938
YPS: YPTB1234
YPO: BZ17_1292
YPY: YPK_2867
YPB: YPTS_1322
YPQ: DJ40_1004
YPU: BZ21_503
YPR: BZ20_754
YPC: BZ23_833
YPF: BZ19_633
YRU: BD65_352
SRL: SOD_c40120(ddc)
PPU: PP_2552
PPF: Pput_3163
PPT: PPS_2093
PPI: YSA_00462
PPX: T1E_3359
PPUH: B479_10915
PPUT: L483_10035
PPUN: PP4_33460
PPUD: DW66_2355
PMON: X969_08790
PMOT: X970_08450
PFC: PflA506_1055(ddc)
PFB: VO64_4209
PEN: PSEEN2370
PSEC: CCOS191_3137(ELI5)
NOC: Noc_2983
DVU: DVU0867
DVL: Dvul_2115
DVM: DvMF_2916
DDE: Dde_1124
MLO: mll0712
ARA: Arad_0017
SHZ: shn_28130
NWI: Nwi_1102
XAU: Xaut_0071
MET: M446_1957
MNO: Mnod_1238
MAQU: Maq22A_c11740(gadB)
RVA: Rvan_3231
RBM: TEF_10700
SIL: SPO3687
JAN: Jann_3501
PGD: Gal_00109
RHC: RGUI_0736
SPSE: SULPSESMR1_00270(ddc)
RFA: A3L23_05009(ddc)
SALU: DC74_159
SALL: SAZ_01240
STRE: GZL_08019
GOB: Gobs_3209
BSD: BLASA_2287(tdcA)
MMAR: MODMU_3399(ELI)
SEN: SACE_2888
PDX: Psed_3994
PSEA: WY02_04890
AMI: Amir_5685
SESP: BN6_68200
KAL: KALB_5849
ACTI: UA75_21780
ACAD: UA74_21300
AHG: AHOG_18795(ddc2)
RXY: Rxyl_1038
CAU: Caur_2842
CAG: Cagg_1126
MRB: Mrub_1738
GES: VT84_23180(ddc)
SUS: Acid_1182
ABAC: LuPra_06070(ddc_2)
GAU: GAU_3087
DORI: FH5T_14760
IAL: IALB_2412
MRO: MROS_1175
CABY: Cabys_2336
AG: AAB39708(TDC1) AAB39709(TDC2) CAA47898(TDC)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2192610
  Authors
Siow YL, Dakshinamurti K
  Title
Neuronal dopa decarboxylase.
  Journal
Ann N Y Acad Sci 585:173-88 (1990)
DOI:10.1111/j.1749-6632.1990.tb28052.x
Reference
  Authors
Koyanagi T, Nakagawa A, Sakurama H, Yamamoto K, Sakurai N, Takagi Y, Minami H, Katayama T, Kumagai H
  Title
Eukaryotic-type aromatic amino acid decarboxylase from the root colonizer Pseudomonas putida is highly specific for 3,4-dihydroxyphenyl-L-alanine, an allelochemical in the rhizosphere.
  Journal
Microbiology 158:2965-74 (2012)
DOI:10.1099/mic.0.062463-0
  Sequence
[ppu:PP_2552]
Reference
PMID:8159173
  Authors
Goddijn OJ, Lohman FP, de Kam RJ, Schilperoort RA, Hoge JH
  Title
Nucleotide sequence of the tryptophan decarboxylase gene of Catharanthus roseus and expression of tdc-gusA gene fusions in Nicotiana tabacum.
  Journal
Mol Gen Genet 242:217-25 (1994)
DOI:10.1007/BF00391016
  Sequence

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