KEGG   ORTHOLOGY: K02154Help
Entry
K02154                      KO                                     

Name
ATPeV0A, ATP6N
Definition
V-type H+-transporting ATPase subunit a
Pathway
Oxidative phosphorylation
Lysosome
Phagosome
Synaptic vesicle cycle
Collecting duct acid secretion
Vibrio cholerae infection
Epithelial cell signaling in Helicobacter pylori infection
Tuberculosis
Rheumatoid arthritis
Module
M00160  
V-type ATPase, eukaryotes
Disease
H00428  
Distal renal tubular acidosis (RTA type 1)
H00436  
Osteopetrosis
H00557  
Cutis laxa
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Energy metabolism
   00190 Oxidative phosphorylation
    K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
 Cellular Processes
  Transport and catabolism
   04145 Phagosome
    K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
   04142 Lysosome
    K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
 Organismal Systems
  Excretory system
   04966 Collecting duct acid secretion
    K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
  Nervous system
   04721 Synaptic vesicle cycle
    K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
 Human Diseases
  Immune diseases
   05323 Rheumatoid arthritis
    K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
  Infectious diseases
   05110 Vibrio cholerae infection
    K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
   05152 Tuberculosis
    K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
KEGG modules [BR:ko00002]
 Structural complex
  Energy metabolism
   ATP synthesis
    M00160  V-type ATPase, eukaryotes
     K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
BRITE hierarchy
Other DBs
GO: 
TC: 
Genes
HSA: 
10312(TCIRG1) 23545(ATP6V0A2) 50617(ATP6V0A4) 535(ATP6V0A1)
PTR: 
452354(ATP6V0A2) 454685(ATP6V0A1) 463765(ATP6V0A4) 466895(TCIRG1)
PPS: 
100971999(ATP6V0A4) 100974286(ATP6V0A2) 100990028(ATP6V0A1) 100995029(TCIRG1)
GGO: 
101139544(ATP6V0A1) 101140521(ATP6V0A4) 101141834(ATP6V0A2) 101148242(TCIRG1)
PON: 
100173661(ATP6V0A1) 100451994(TCIRG1) 100939293(ATP6V0A2)
MCC: 
677865(ATP6V0A1) 710162(ATP6V0A2) 710650(TCIRG1) 715492(ATP6V0A4)
MCF: 
101867133 102118234(TCIRG1) 102118312(ATP6V0A4) 102127448(ATP6V0A1) 102129208
MMU: 
11975(Atp6v0a1) 140494(Atp6v0a4) 21871(Atp6v0a2) 27060(Tcirg1)
RNO: 
116455(Atp6v0a2) 293650(Tcirg1) 296981(Atp6v0a4) 29757(Atp6v0a1)
CGE: 
100755303(Tcirg1) 100756648(Atp6v0a1) 100766909(Atp6v0a2) 100769769(Atp6v0a4)
HGL: 
101700877(Atp6v0a2) 101718747(Atp6v0a1) 101719254(Atp6v0a4) 101720677(Tcirg1)
TUP: 
102475330(ATP6V0A4) 102493162(ATP6V0A1) 102499874(ATP6V0A2) 102500889(TCIRG1)
CFA: 
482779(ATP6V0A4) 483691(TCIRG1) 486245(ATP6V0A2) 607705(ATP6V0A1)
AML: 
FCA: 
101083709(TCIRG1) 101084995(ATP6V0A2) 101089593(ATP6V0A4) 101096367(ATP6V0A1)
PTG: 
102948629(ATP6V0A4) 102948736(ATP6V0A1) 102958914(ATP6V0A2)
BTA: 
286768(ATP6V0A1) 338038(ATP6V0A2) 513684(TCIRG1) 518974(ATP6V0A4) 785923
BOM: 
102267750(TCIRG1) 102270383 102271215(ATP6V0A4) 102281348(ATP6V0A1) 102285852(ATP6V0A2)
PHD: 
102326293(ATP6V0A4) 102331486(ATP6V0A2) 102331795(TCIRG1) 102341031(ATP6V0A1) 102342726
CHX: 
102171404(ATP6V0A4) 102179797(ATP6V0A2) 102186280(TCIRG1) 102186995(ATP6V0A1)
SSC: 
100519402(ATP6V0A4) 100519868 100521769(TCIRG1) 100523018(ATP6V0A1)
CFR: 
102519197(ATP6V0A1) 102520369(ATP6V0A4) 102520543(TCIRG1) 102523048(ATP6V0A2)
BACU: 
103002161(ATP6V0A2) 103010634(TCIRG1) 103016593 103019480 103019646(ATP6V0A4)
LVE: 
103068412(TCIRG1) 103068959(ATP6V0A1) 103073171(ATP6V0A4) 103076601(ATP6V0A2)
ECB: 
100052802(ATP6V0A1) 100061140(ATP6V0A2) 100064797(ATP6V0A4) 100146660(TCIRG1)
MYB: 
102242178(ATP6V0A4) 102247063(ATP6V0A2) 102257182(TCIRG1) 102263953(ATP6V0A1)
MYD: 
102752608(ATP6V0A1) 102757306(ATP6V0A4) 102761519(TCIRG1) 102762561(ATP6V0A2)
PALE: 
102881960(ATP6V0A4) 102883439(ATP6V0A1) 102887580(TCIRG1) 102896777(ATP6V0A2)
MDO: 
100011213(ATP6V0A1) 100013156(TCIRG1) 100017370(ATP6V0A4) 103101820(ATP6V0A2)
SHR: 
100917978(TCIRG1) 100919520(ATP6V0A1) 100934805(ATP6V0A4)
OAA: 
100076253(ATP6V0A2) 100092966(ATP6V0A1)
GGA: 
395472(TCIRG1) 395473(ATP6V0A2) 395474(ATP6V0A1) 418104(ATP6V0A4)
MGP: 
TGU: 
100218036(ATP6V0A2) 100221499(ATP6V0A4) 100229310(ATP6V0A1) 100231607(TCIRG1)
FAB: 
101806637(ATP6V0A2) 101808415(TCIRG1) 101808613 101810144(ATP6V0A1) 101819803(ATP6V0A4)
PHI: 
102100193(ATP6V0A4) 102102158(ATP6V0A1) 102103818(TCIRG1) 102107361(ATP6V0A2)
APLA: 
101797534(ATP6V0A4) 101798773(TCIRG1) 101799483(ATP6V0A2) 101805176(ATP6V0A1)
FPG: 
101913873(ATP6V0A2) 101917386(ATP6V0A1) 101919327(TCIRG1) 101921111(ATP6V0A4)
FCH: 
102046363(TCIRG1) 102052471(ATP6V0A2) 102053061(ATP6V0A1) 102058535(ATP6V0A4)
CLV: 
102089335(ATP6V0A1) 102089604(ATP6V0A2) 102090200(ATP6V0A4) 102096711(TCIRG1)
ASN: 
102368239(ATP6V0A2) 102382487(ATP6V0A1) 102383193(ATP6V0A4) 102386370(TCIRG1)
AMJ: 
102559672(TCIRG1) 102569694(ATP6V0A4) 102570007(ATP6V0A2) 102572518(ATP6V0A1)
PSS: 
102449675(ATP6V0A2) 102458115(TCIRG1) 102460878(ATP6V0A1) 102462728(ATP6V0A4)
CMY: 
102933238(ATP6V0A1) 102935940(ATP6V0A4) 102936752(TCIRG1) 102946850(ATP6V0A2)
ACS: 
PBI: 
103050744(ATP6V0A4) 103055362(TCIRG1) 103057407(ATP6V0A2) 103058859(ATP6V0A1) 103063299
XLA: 
379986(atp6v0a1) 398897(atp6v0a4)
XTR: 
100036694(atp6v0a1) 100135019(atp6v0a4) 548977(atp6v0a2) 549603(tcirg1)
DRE: 
100003139(tcirg1) 100147923 324307(atp6v0a1a) 406342(tcirg1) 553691(atp6v0a1b) 561117(atp6v0a2b) 561469(atp6v0a2a)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102351124(ATP6V0A2) 102352206 102354813 102356894(ATP6V0A4) 102365079(ATP6V0A1)
CMK: 
103181272 103187833 103188002(atp6v0a2) 103189172(atp6v0a1) 103189838(atp6v0a4)
BFO: 
CIN: 
SPU: 
DME: 
Dmel_CG12602(Vha100-5) Dmel_CG1709(Vha100-1) Dmel_CG18617(Vha100-2) Dmel_CG30329(Vha100-3) Dmel_CG7678(Vha100-4)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
412810(GB11840) 727630(GB15121)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG01592(Cbr-vha-5) CBG02894(Cbr-vha-6) CBG03483(Cbr-vha-7) CBG06881(Cbr-unc-32)
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
ATH: 
AT2G21410(VHA-A2) AT2G28520(VHA-A1) AT4G39080(VHA-A3)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
CSV: 
RCU: 
POP: 
POPTR_0002s03010g(POPTRDRAFT_754083) POPTR_0004s16750g(POPTRDRAFT_831271) POPTR_0005s25550g(POPTRDRAFT_801528) POPTR_0009s12430g(POPTRDRAFT_821153)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os01t0834200-01(Os01g0834200) Os03t0251500-01(Os03g0251500) Os10t0184300-01(Os10g0184300)
OBR: 
BDI: 
SBI: 
SORBI_01g040970(SORBIDRAFT_01g040970) SORBI_03g038990(SORBIDRAFT_03g038990)
SITA: 
ATR: 
s00001p00110790(AMTR_s00001p00110790) s00080p00100430(AMTR_s00080p00100430)
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
MIS: 
MPP: 
BPG: 
CSL: 
CVR: 
CME: 
GSL: 
CCP: 
SCE: 
YMR054W(STV1) YOR270C(VPH1)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A08230(NCAS0A08230) NCAS_0B00440(NCAS0B00440)
NDI: 
NDAI_0E00940(NDAI0E00940) NDAI_0G04680(NDAI0G04680)
TPF: 
TPHA_0G00710(TPHA0G00710) TPHA_0N01550(TPHA0N01550)
TBL: 
TBLA_0B03580(TBLA0B03580) TBLA_0C01430(TBLA0C01430)
TDL: 
TDEL_0A06620(TDEL0A06620) TDEL_0B07100(TDEL0B07100)
KAF: 
KAFR_0A04090(KAFR0A04090) KAFR_0B05200(KAFR0B05200)
DHA: 
PIC: 
PGU: 
LEL: 
SPAA: 
CAL: 
CTP: 
CDU: 
COT: 
CTEN: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_1942154(AO090003001090)
ANG: 
ANI_1_886184(An04g05310)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
ZTR: 
PFJ: 
BCOM: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
LBC: 
MPR: 
CCI: 
SCM: 
UMA: 
MGL: 
PGR: 
ECU: 
EIN: 
EHE: 
NCE: 
MBR: 
DDI: 
DPP: 
DFA: 
DFA_09893(vatM)
EHI: 
EHI_074020(79.t00005) EHI_107280(105.t00023)
EDI: 
ACAN: 
PFA: 
PFD: 
PFH: 
PYO: 
PCB: 
PBE: 
PKN: 
PVX: 
PCY: 
TAN: 
TPV: 
BBO: 
BBOV_III008300(17.m07725)
BEQ: 
CPV: 
CHO: 
TGO: 
TET: 
PTM: 
PTI: 
TPS: 
PIF: 
EHX: 
GTT: 
TBR: 
Tb927.5.1300(Tb05.30H13.310)
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
TVA: 
GLA: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Cipriano DJ, Wang Y, Bond S, Hinton A, Jefferies KC, Qi J, Forgac M
  Title
Structure and regulation of the vacuolar ATPases.
  Journal
Biochim Biophys Acta 1777:599-604 (2008)
Reference
  Authors
Jefferies KC, Cipriano DJ, Forgac M
  Title
Function, structure and regulation of the vacuolar (H+)-ATPases.
  Journal
Arch Biochem Biophys 476:33-42 (2008)
Reference
  Authors
Kornak U, Reynders E, Dimopoulou A, van Reeuwijk J, Fischer B, Rajab A, Budde B, Nurnberg P, Foulquier F, Lefeber D, Urban Z, Gruenewald S, Annaert W, Brunner HG, van Bokhoven H, Wevers R, Morava E, Matthijs G, Van Maldergem L, Mundlos S
  Title
Impaired glycosylation and cutis laxa caused by mutations in the vesicular H+-ATPase subunit ATP6V0A2.
  Journal
Nat Genet 40:32-4 (2008)

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