KEGG   ORTHOLOGY: K02216Help
Entry
K02216                      KO                                     

Name
CHK1
Definition
serine/threonine-protein kinase Chk1 [EC:2.7.11.1]
Pathway
Cell cycle
Cell cycle - yeast
Meiosis - yeast
p53 signaling pathway
HTLV-I infection
Viral carcinogenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K02216  CHK1; serine/threonine-protein kinase Chk1
   04111 Cell cycle - yeast
    K02216  CHK1; serine/threonine-protein kinase Chk1
   04113 Meiosis - yeast
    K02216  CHK1; serine/threonine-protein kinase Chk1
   04115 p53 signaling pathway
    K02216  CHK1; serine/threonine-protein kinase Chk1
 Human Diseases
  Cancers
   05203 Viral carcinogenesis
    K02216  CHK1; serine/threonine-protein kinase Chk1
  Infectious diseases
   05166 HTLV-I infection
    K02216  CHK1; serine/threonine-protein kinase Chk1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K02216  CHK1; serine/threonine-protein kinase Chk1
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: CAMK group
  CAMKL family
   K02216  CHK1; serine/threonine-protein kinase Chk1
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic Type
  Check point factors
   Other check point factors
    K02216  CHK1; serine/threonine-protein kinase Chk1
BRITE hierarchy
Genes
HSA: 
1111(CHEK1)
PTR: 
739836(CHEK1)
PPS: 
100982317(CHEK1)
GGO: 
101131993(CHEK1)
PON: 
100436550(CHEK1)
MCC: 
MCF: 
MMU: 
12649(Chek1)
RNO: 
140583(Chek1)
CGE: 
HGL: 
101701035(Chek1)
TUP: 
102480757(CHEK1)
CFA: 
609767(CHEK1)
AML: 
100467858(CHEK1)
FCA: 
101083365(CHEK1)
BTA: 
513678(CHEK1)
BOM: 
PHD: 
102340885(CHEK1)
CHX: 
102184881(CHEK1)
SSC: 
100511709(CHEK1)
CFR: 
102505566(CHEK1)
ECB: 
100064353(CHEK1)
MYB: 
102255905(CHEK1)
MDO: 
100016170(CHEK1)
SHR: 
100933648(CHEK1)
OAA: 
100090345(CHEK1)
GGA: 
374260(STT3A)
MGP: 
TGU: 
100219597(CHEK1)
FAB: 
101815748(CHEK1)
PHI: 
102103508(CHEK1)
APLA: 
101790669(CHEK1)
FPG: 
101911598(CHEK1)
FCH: 
102048652(CHEK1)
CLV: 
102094428(CHEK1)
ASN: 
102385348(CHEK1)
PSS: 
ACS: 
100564808(chek1)
XLA: 
398191(chek1)
XTR: 
100038224(chek1)
DRE: 
393162(chek1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102357495(CHEK1)
BFO: 
CIN: 
SPU: 
592974(Chk1)
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
413964(grp)
NVI: 
TCA: 
658323(grp)
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG06670(Cbr-chk-1)
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
SCE: 
YBR274W(CHK1)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0B07380(NCAS0B07380)
NDI: 
NDAI_0B04700(NDAI0B04700)
TPF: 
TPHA_0O01400(TPHA0O01400)
TDL: 
TDEL_0D02040(TDEL0D02040)
KAF: 
KAFR_0C04280(KAFR0C04280)
DHA: 
PIC: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
MGR: 
FGR: 
NHE: 
VAL: 
SSL: 
BFU: 
ANI: 
NFI: 
AFM: 
AOR: 
AOR_1_768154(AO090003000441)
ANG: 
ANI_1_2436074(An08g10320)
AFV: 
ACT: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
ZTR: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
CCI: 
SCM: 
MGL: 
PGR: 
ECU: 
EHE: 
NCE: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Yang XH, Shiotani B, Classon M, Zou L
  Title
Chk1 and Claspin potentiate PCNA ubiquitination.
  Journal
Genes Dev 22:1147-52 (2008)
Reference
  Authors
Huang M, Miao ZH, Zhu H, Cai YJ, Lu W, Ding J
  Title
Chk1 and Chk2 are differentially involved in homologous recombination repair and  cell cycle arrest in response to DNA double-strand breaks induced by camptothecins.
  Journal
Mol Cancer Ther 7:1440-9 (2008)

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