KEGG ORTHOLOGY: K02223

ORTHOLOGY: K02223

Entry

K02223                      KO

Symbol

CLOCK, KAT13D

Name

circadian locomoter output cycles kaput protein [EC:2.3.1.48]

Pathway

map04710

Circadian rhythm

map04711

Circadian rhythm - fly

map04728

Dopaminergic synapse

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09156 Nervous system
   04728 Dopaminergic synapse
    K02223  CLOCK, KAT13D; circadian locomoter output cycles kaput protein
  09159 Environmental adaptation
   04710 Circadian rhythm
    K02223  CLOCK, KAT13D; circadian locomoter output cycles kaput protein
   04711 Circadian rhythm - fly
    K02223  CLOCK, KAT13D; circadian locomoter output cycles kaput protein
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K02223  CLOCK, KAT13D; circadian locomoter output cycles kaput protein
   03036 Chromosome and associated proteins
    K02223  CLOCK, KAT13D; circadian locomoter output cycles kaput protein
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.48  histone acetyltransferase
     K02223  CLOCK, KAT13D; circadian locomoter output cycles kaput protein
Transcription factors [BR:ko03000]
Eukaryotic type
  Basic helix-loop-helix (bHLH)
   Factors with PAS domain
    K02223  CLOCK, KAT13D; circadian locomoter output cycles kaput protein
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HATs (histone acetyltransferases)
    K02223  CLOCK, KAT13D; circadian locomoter output cycles kaput protein

Other DBs

GO:

0004402

Genes

HSA:	9575(CLOCK)

PTR:	461312(CLOCK)

PPS:	100986920(CLOCK)

GGO:	101140472(CLOCK)

PON:	100172630(CLOCK)

NLE:	100606130(CLOCK)

HMH:	116467567(CLOCK)

MCC:	697532(CLOCK)

MCF:	102131896(CLOCK)

MTHB:

126954737

MNI:	105463534(CLOCK)

CSAB:

103235664(CLOCK)

CATY:

105592012(CLOCK)

PANU:

101017477(CLOCK)

TGE:	112624744(CLOCK)

MLEU:

105548474(CLOCK)

RRO:	104662031(CLOCK)

RBB:	108531597(CLOCK)

TFN:	117085596(CLOCK)

PTEH:

111526472(CLOCK)

CANG:

105525912(CLOCK)

CJC:	100407407(CLOCK)

SBQ:	101035173(CLOCK)

CIMI:

108312351(CLOCK)

CSYR:

103249187(CLOCK)

MMUR:

105867862(CLOCK)

LCAT:

123624845(CLOCK)

PCOQ:

105807668(CLOCK)

OGA:	100962800(CLOCK)

MMU:	12753(Clock)

MCAL:

110294104(Clock)

MPAH:

110330520(Clock)

RNO:	60447(Clock)

MCOC:

116071288(Clock)

ANU:	117712510(Clock)

MUN:	110556888(Clock)

CGE:	100770092(Clock)

MAUA:

101830807(Clock)

PROB:

127232282(Clock)

PLEU:

114682808(Clock)

MORG:

121460743(Clock)

MFOT:

126506597

AAMP:

119827642(Clock)

NGI:	103734387(Clock)

HGL:	101725536(Clock)

CPOC:

100728432(Clock)

CCAN:

109702259(Clock)

DORD:

105980293(Clock)

DSP:	122106772(Clock)

PLOP:

125364943(Clock)

NCAR:

124994065

MMMA:

107139243(Clock)

OCU:

100349684

OPI:	101536193(CLOCK)

TUP:	102478751(CLOCK)

GVR:	103597796(CLOCK)

CFA:	475145(CLOCK)

CLUD:

112652336(CLOCK)

VVP:	112923720(CLOCK)

VLG:	121472850(CLOCK)

NPO:	129519977(CLOCK)

AML:	100463987(CLOCK)

UMR:	103672743(CLOCK)

UAH:	113262508(CLOCK)

UAR:	123804050(CLOCK)

ELK:

111149069

LLV:

125093736

MPUF:

101674500(CLOCK)

MNP:	132006408(CLOCK)

MLK:	131823976(CLOCK)

NVS:	122890472(CLOCK)

ORO:	101369995(CLOCK)

EJU:	114206655(CLOCK)

ZCA:	113925712(CLOCK)

MLX:	118010514(CLOCK)

NSU:	110590743(CLOCK)

LWW:	102748823(CLOCK)

FCA:	101088483(CLOCK)

PYU:	121035444(CLOCK)

PCOO:

112858052(CLOCK)

PBG:	122478860(CLOCK)

PVIV:

125163356(CLOCK)

LRUF:

124520471

PTG:	102954901(CLOCK)

PPAD:

109278868(CLOCK)

PUC:

125922736

AJU:

106971676

HHV:	120243027(CLOCK)

BTA:	100300400(CLOCK)

BOM:	102284331(CLOCK)

BIU:	109560481(CLOCK)

BBUB:

102414002(CLOCK)

BBIS:

105002842(CLOCK)

CHX:	102175105(CLOCK)

OAS:	100171391(CLOCK)

BTAX:

128049703(CLOCK)

ODA:	120862132(CLOCK)

CCAD:

122428408(CLOCK)

MBEZ:

129561775(CLOCK)

SSC:	100628097(CLOCK)

CFR:	102520407(CLOCK)

CBAI:

105077732(CLOCK)

CDK:	105091544(CLOCK)

VPC:	102529531(CLOCK)

BACU:

103000125(CLOCK)

BMUS:

118895977(CLOCK)

LVE:	103086785(CLOCK)

OOR:	101289553(CLOCK)

DLE:	111169624(CLOCK)

PCAD:

102987634(CLOCK)

PSIU:

116754341(CLOCK)

NASI:

112400752(CLOCK)

ECB:	100034166(CLOCK)

EPZ:	103561742(CLOCK)

EAI:	106836920(CLOCK)

MYB:	102257849(CLOCK)

MYD:	102759548(CLOCK)

MMYO:

118668934(CLOCK)

MLF:	102440615(CLOCK)

PKL:	118706530(CLOCK)

EFUS:

103285047(CLOCK)

MNA:	107532833(CLOCK)

DRO:	112322438(CLOCK)

SHON:

118978606(CLOCK)

AJM:	119061663(CLOCK)

PDIC:

114493338(CLOCK)

PHAS:

123815714(CLOCK)

MMF:	118638437(CLOCK)

PPAM:

129065520(CLOCK)

HAI:	109381806(CLOCK)

RFQ:	117022236(CLOCK)

PALE:

102897617(CLOCK)

PGIG:

120588086(CLOCK)

PVP:	105293806(CLOCK)

RAY:	107520892(CLOCK)

MJV:	108398515(CLOCK)

TOD:	119261361(CLOCK)

SARA:

101546890(CLOCK)

SETR:

126032278(CLOCK)

LAV:	100656519(CLOCK)

TMU:

101347694

ETF:	101643504(CLOCK)

DNM:	101423732(CLOCK)

MDO:	100017022(CLOCK)

GAS:	123252396(CLOCK)

SHR:	100928316(CLOCK)

AFZ:

127540961

PCW:	110200139(CLOCK)

OAA:	100075694(CLOCK)

GGA:	373991(CLOCK)

PCOC:

116225920(CLOCK)

MGP:	100008576(CLOCK)

CJO:	107313727(CLOCK)

TPAI:

128079867(CLOCK)

LMUT:

125691570(CLOCK)

NMEL:

110397441(CLOCK)

APLA:

101797949(CLOCK)

ACYG:

106030790(CLOCK)

CATA:

118250878(CLOCK)

AFUL:

116488426(CLOCK)

TGU:	100219382(CLOCK)

LSR:	110470537(CLOCK)

SCAN:

103825235(CLOCK)

PMOA:

120497365(CLOCK)

OTC:	121334927(CLOCK)

PRUF:

121350921(CLOCK)

GFR:	102044439(CLOCK)

FAB:	101821455(CLOCK)

OMA:	130252534(CLOCK)

PHI:	102112793(CLOCK)

PMAJ:

107202959(CLOCK)

CCAE:

111928016(CLOCK)

CCW:	104690627(CLOCK)

CBRC:

103622464(CLOCK)

ETL:	114058328(CLOCK)

ZAB:	102066123(CPEB2) 102071580(CLOCK)

ACHL:

103803546(CLOCK)

SVG:	106851469(CLOCK)

MMEA:

130573951(CLOCK)

HRT:	120752627(CLOCK)

FPG:	101913246(CLOCK)

FCH:	102054484(CLOCK)

CLV:	102087081(CLOCK)

EGZ:	104129500(CLOCK)

NNI:	104020777(CLOCK)

PCRI:

104031820

PLET:

104628520(CLOCK)

EHS:	104508981(CLOCK)

PCAO:

104044514(CLOCK)

ACUN:

113479085(CLOCK)

TALA:

104358378(CLOCK)

PADL:

103926286(CLOCK)

AFOR:

103897400(CLOCK)

ACHC:

115340608(CLOCK)

HALD:

104322714(CLOCK)

HLE:	104836129(CLOCK)

AGEN:

126051789

GCL:

127015682

CCRI:

104158991(CLOCK)

CMAC:

104482777(CLOCK)

MUI:	104536434(CLOCK)

BREG:

104631100(CLOCK)

FGA:

104070553

GSTE:

104252543(CLOCK)

LDI:	104345175(CLOCK)

MNB:

103778008

OHA:	104334895(CLOCK)

NNT:

104409500

SHAB:

115610951(CLOCK)

DPUB:

104299133(CLOCK)

PGUU:

104461901(CLOCK)

ACAR:

104523448(CLOCK)

CPEA:

104393036(CLOCK)

AVIT:

104274434(CLOCK)

CVF:	104286394(CLOCK)

RTD:	128909793(CLOCK)

CUCA:

104067137(CLOCK)

TEO:	104375180(CLOCK)

BRHI:

104496995(CLOCK)

AAM:	106490149(CLOCK)

AROW:

112975831(CLOCK)

NPD:	112942560(CLOCK)

TGT:	104565612(CLOCK)

DNE:	112979428(CLOCK)

SCAM:

104138540(CLOCK)

ASN:	102379511(CLOCK)

AMJ:	102567584(CLOCK)

CPOO:

109322228(CLOCK)

GGN:	109304031(CLOCK)

PSS:	102444504(CLOCK)

CMY:	102941363(CLOCK)

CCAY:

125635905(CLOCK)

DCC:	119854340(CLOCK)

CPIC:

101937929(CLOCK)

TST:	117878593(CLOCK)

CABI:

116826033(CLOCK)

MRV:	120406110(CLOCK)

ACS:	100552330(clock)

ASAO:

132776656(CLOCK)

PVT:	110078394(CLOCK)

SUND:

121931061(CLOCK)

PBI:	103063171(CLOCK)

PMUR:

107292122(CLOCK) 107300605

CTIG:

120316817(CLOCK)

TSR:	106548317(CLOCK)

PGUT:

117662095(CLOCK)

APRI:

131202886(CLOCK)

PTEX:

113435830(CLOCK)

NSS:	113417942(CLOCK)

VKO:	123016932(CLOCK)

PMUA:

114604715(CLOCK)

PRAF:

128421431(CLOCK)

ZVI:	118083328(CLOCK)

HCG:	128326641(CLOCK)

GJA:	107106037(CLOCK)

STOW:

125440403(CLOCK)

EMC:	129337097(CLOCK)

XLA:	108706595(clock.S) 399157(clock.L)

XTR:	100038163(clock)

NPR:	108803914(CLOCK)

RTEM:

120922786(CLOCK)

BBUF:

120990203(CLOCK)

BGAR:

122941807(CLOCK)

MUO:	115462190(CLOCK)

GSH:	117360772(CLOCK)

DRE:	30140(clocka) 352927(clockb)

SRX:	107718423 107746006 107754154 107755212

SANH:

107656111 107683961 107701480 107702364

SGH:	107551585 107568120 107573987 107591535 107601911(clock)

CCAR:

109044823(clock) 109066967

CAUA:

113044203 113063324 113106618 113106984 113120992

CGIB:

127938573 127963180 127983949 127987525

PTET:

122341736(clockb) 122342750(clocka)

LROH:

127166259(clockb) 127183139(clocka)

OMC:	131526823(clocka) 131532529(clockb)

PPRM:

120493483(clocka) 120493503(clockb)

RKG:	130089510(clockb) 130097538(clocka)

MAMB:

125272587(clockb) 125277991(clocka)

CIDE:

127501867 127510739

MASI:

127409862 127415739 127443356 127444702

TROS:

130552695(clockb) 130565648(clocka)

TDW:	130434071(clocka) 130440088(clockb)

MANU:

129429221(clocka) 129444734(clockb)

IPU:	108257920(clocka) 108260793(clockb)

IFU:	128600860(clocka) 128604214(clockb)

PHYP:

113544362 113545188(clock)

SMEO:

124377028(clocka) 124381437(clockb)

TFD:	113642579(clocka) 113660732(clockb)

TVC:	132841886(clockb) 132843452(clocka)

AMEX:

103025395 103040704(clock)

CMAO:

118815394(clocka) 118816584(clockb)

EEE:	113567705 113586381(clock) 113591593

CHAR:

105895219(clocka) 105908495(clockb)

TRU:	101072867 101078879

TFS:	130527084(clockb) 130528420(clocka)

TNG:	GSTEN00006765G001 GSTEN00032758G001

LCO:	104919094(clock) 104939547

NCC:	104947079(clock) 104968026

TBEN:

117481678 117496173(clocka)

CGOB:

115006717(clock) 115009851

PGEO:

117445733(clockb) 117445826(clocka)

GACU:

117537954(clockb) 117555237(clocka)

EMAC:

134864825 134869282(clocka)

ELY:	117253325(clocka) 117255396(clockb)

EFO:	125886623 125895638(clocka)

PLEP:

121940342(clocka) 121941889

SLUC:

116040458(clockb) 116058742(clocka)

ECRA:

117936516(clockb) 117950152(clocka)

ESP:	116695599 116706880

PFLV:

114561591(clock) 114572646

GAT:	120824892(clockb)

PPUG:

119217783(clockb)

AFB:	129094564(clocka) 129095343(clockb)

CLUM:

117729242(clocka) 117730508(clockb)

PSWI:

130190007(clockb)

MSAM:

119894693(clocka) 119899138

SCHU:

122873230(clockb) 122877333(clocka)

CUD:	121508281 121512592(clocka)

ALAT:

119020669(clockb) 119028119(clocka)

MZE:	101473932 101478070

ONL:	100690629 100703460

OAU:	116325997(clockb) 116331167(clocka)

OLA:	101163159(clock) 101165450

OML:	112136976 112157001(clockb)

CSAI:

133456933(clockb) 133458272(clocka)

XMA:	102219340 102234992(clock)

XCO:	114144178 114150659(clock)

XHE:	116719796 116726021(clock)

PRET:

103463833(clock) 103468951

PFOR:

103137111(clock) 103137774

PLAI:

106954374 106963416(clock)

PMEI:

106918699 106924117

GAF:	122829536(clockb) 122838025(clocka)

PPRL:

129376630(clocka)

CVG:	107091551(clock) 107093492

CTUL:

119780636(clocka) 119788452(clockb)

GMU:	124868635(clockb) 124874039(clocka)

NFU:	107382188 107393399(clock)

KMR:	108241552(clockb) 108243364(clocka)

ALIM:

106515206(clock)

NWH:

119430791

AOCE:

111569579(clock) 111569807

MCEP:

125003667(clockb) 125009080(clocka)

CSEM:

103376701(clock) 103383760

POV:	109625881(clock) 109637843

SSEN:

122760329(clockb) 122769730(clocka)

HHIP:

117759683(clocka) 117760301(clockb)

HSP:	118120305 118121615(clocka)

SMAU:

118312519(clockb) 118318589(clocka)

LCF:	108879109(clocka) 108896436

SDU:	111226339(clock) 111231527

SLAL:

111644362(clock) 111664538

XGL:	120790866(clocka) 120800034(clockb)

HCQ:	109511238 109532108

SSCV:

125967141 125968581

SBIA:

133503369(clocka) 133505792

PEE:	133403773 133406054(clocka)

PTAO:

133477075(clockb) 133481405(clocka)

BPEC:

110154690(clock) 110172558

MALB:

109958403 109961996

BSPL:

114852972(clockb) 114853927(clocka)

SJO:	128362113(clocka) 128368896(clockb)

SASA:

106560272 106584123(clock) 106594386

STRU:

115158534 115190785 115190786 115192380(clock)

OTW:	112249169(clocka) 112251141

OMY:	100135915 110513597 110521676(clocka) 118936633

OGO:	123996813 124018469 124037863(clocka)

ONE:	115108538 115145135(clock)

OKI:	109887115 109898030(clock) 109902721

OKE:	118359030(clocka) 118383006 118392568

SALP:

111972321(clock) 111975703

SNH:	120036034(clockb) 120051867 120054929

CCLU:

121533952 121540149(clocka) 121551709

ELS:	105011842(clock) 105020861

SFM:	108922741(clock)

PKI:	111850120(clock)

AANG:

118225583(clocka)

LOC:

102696965

PSPA:

121298178 121320081(clocka)

ARUT:

117409483 117421158

PSEX:

120528719(clocka)

LCM:	102363676(CLOCK)

CMK:	103178171(clocka)

RTP:	109934781(clocka)

CPLA:

122550104(clocka)

HOC:	132819300(clocka)

PMRN:

116942863

LRJ:

133342891

BFO:	118418936 118419537

SPU:	100889647 576191

APLC:

110979766

AJC:

117114455

SKO:

102809671

DME:	Dmel_CG7391(Clk)

DER:

6543946

DSE:

6604777

DSI:	Dsimw501_GD13034(Dsim_GD13034)

DYA:	Dyak_GE20389

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI12195

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:	101889860 131805379

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AAG:

AALB:

CQU:	CpipJ_CPIJ002146 CpipJ_CPIJ002147

CPII:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:	105182101 105190712

DQU:

106742585

CFO:	105251019 105257275

FEX:

115237720

LHU:	105676055 105678065

PGC:	109852004 109861318

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:	100114103 100123168

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:	655469(Clk)

DPA:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_206046

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CCRN:

API:	100163752(clk)

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM426300

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_346996(CLOCK)

DMK:

DPZ:

PVM:

PJA:

PCHN:

PTRU:

EAF:

LSM:

VJA:

TUT:

PTEP:

ABRU:

UDV:

PCAN:

BGT:

GAE:

HRF:	124139813 124143674

HRJ:	124284360 124292056

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

NVE:	5506840 5519866

EPA:	110232062 110251036 110252532

ATEN:

116307440

ADF:	107345125 107348463 107349953

AMIL:

114964640 114969846

PDAM:

113667617 113681287

SPIS:

111321901 111322834 111326918

» show all

Reference

PMID:9630223

Authors

Allada R, White NE, So WV, Hall JC, Rosbash M

Title

A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless.

Journal

Cell 93:791-804 (1998)
DOI:10.1016/s0092-8674(00)81440-3

Sequence

[dme:Dmel_CG7391]

Reference

PMID:16448219

Authors

Kaeffer B, Pardini L

Title

Clock genes of Mammalian cells: practical implications in tissue culture.

Journal

In Vitro Cell Dev Biol Anim 41:311-20 (2005)
DOI:10.1007/s11626-005-0001-7

Reference

PMID:14769864

Authors

Isojima Y, Okumura N, Nagai K

Title

Molecular mechanism of mammalian circadian clock.

Journal

J Biochem 134:777-84 (2003)
DOI:10.1093/jb/mvg219

All links

Ontology (5)   
   KEGG BRITE (4)   
   GO (1)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1419)   
   KEGG GENES (745)   
   KEGG MGENES (204)   
   RefGene (465)   
   OC (5)   
Literature (3)   
   PubMed (3)   
All databases (1434)   

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