KEGG   ORTHOLOGY: K02599Help
Entry
K02599                      KO                                     

Name
NOTCH1
Definition
Notch 1
Pathway
Endocrine resistance
Dorso-ventral axis formation
Notch signaling pathway
Th1 and Th2 cell differentiation
Thyroid hormone signaling pathway
Prion diseases
MicroRNAs in cancer
Breast cancer
Module
M00682  
Notch signaling
Disease
H00002  
Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia/lymphoma)
H00554  
Bicuspid aortic valve
H01413  
Adams-Oliver syndrome (AOS)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04330 Notch signaling pathway
    K02599  NOTCH1; Notch 1
 Organismal Systems
  Immune system
   04658 Th1 and Th2 cell differentiation
    K02599  NOTCH1; Notch 1
  Endocrine system
   04919 Thyroid hormone signaling pathway
    K02599  NOTCH1; Notch 1
  Development
   04320 Dorso-ventral axis formation
    K02599  NOTCH1; Notch 1
 Human Diseases
  Cancers
   05206 MicroRNAs in cancer
    K02599  NOTCH1; Notch 1
   05224 Breast cancer
    K02599  NOTCH1; Notch 1
  Neurodegenerative diseases
   05020 Prion diseases
    K02599  NOTCH1; Notch 1
  Drug resistance
   01522 Endocrine resistance
    K02599  NOTCH1; Notch 1
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00682  Notch signaling
     K02599  NOTCH; Notch
BRITE hierarchy
Genes
HSA: 
4851(NOTCH1)
PTR: 
464865(NOTCH1)
PON: 
MCC: 
709947(NOTCH1)
MMU: 
18128(Notch1)
RNO: 
25496(Notch1)
CFA: 
480676(NOTCH1)
AML: 
100468934(NOTCH1)
BTA: 
767866(NOTCH1)
ECB: 
100068764(NOTCH1)
MDO: 
100616999(NOTCH1)
OAA: 
GGA: 
395655(NOTCH1)
MGP: 
100546162(NOTCH1)
TGU: 
100224074(NOTCH1)
XLA: 
394367(notch1.S)
XTR: 
100037842(notch1)
DRE: 
30718(notch1a) 794892(notch1b)
CIN: 
SPU: 
DME: 
DPO: 
AGA: 
AAG: 
AME: 
NVI: 
BMY: 
NVE: 
TAD: 
AQU: 
GLA: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1831692
  Authors
Ellisen LW, Bird J, West DC, Soreng AL, Reynolds TC, Smith SD, Sklar J
  Title
TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.
  Journal
Cell 66:649-61 (1991)

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