KEGG   ORTHOLOGY: K02677Help
Entry
K02677                      KO                                     

Name
PRKCA
Definition
classical protein kinase C alpha type [EC:2.7.11.13]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04011  MAPK signaling pathway - yeast
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04066  HIF-1 signaling pathway
ko04070  Phosphatidylinositol signaling system
ko04071  Sphingolipid signaling pathway
ko04072  Phospholipase D signaling pathway
ko04139  Mitophagy - yeast
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04261  Adrenergic signaling in cardiomyocytes
ko04270  Vascular smooth muscle contraction
ko04310  Wnt signaling pathway
ko04360  Axon guidance
ko04370  VEGF signaling pathway
ko04510  Focal adhesion
ko04540  Gap junction
ko04650  Natural killer cell mediated cytotoxicity
ko04664  Fc epsilon RI signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04670  Leukocyte transendothelial migration
ko04713  Circadian entrainment
ko04720  Long-term potentiation
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko04725  Cholinergic synapse
ko04726  Serotonergic synapse
ko04727  GABAergic synapse
ko04728  Dopaminergic synapse
ko04730  Long-term depression
ko04745  Phototransduction - fly
ko04750  Inflammatory mediator regulation of TRP channels
ko04911  Insulin secretion
ko04912  GnRH signaling pathway
ko04916  Melanogenesis
ko04918  Thyroid hormone synthesis
ko04919  Thyroid hormone signaling pathway
ko04921  Oxytocin signaling pathway
ko04925  Aldosterone synthesis and secretion
ko04926  Relaxin signaling pathway
ko04928  Parathyroid hormone synthesis, secretion and action
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko04960  Aldosterone-regulated sodium reabsorption
ko04961  Endocrine and other factor-regulated calcium reabsorption
ko04970  Salivary secretion
ko04971  Gastric acid secretion
ko04972  Pancreatic secretion
ko05031  Amphetamine addiction
ko05032  Morphine addiction
ko05110  Vibrio cholerae infection
ko05130  Pathogenic Escherichia coli infection
ko05143  African trypanosomiasis
ko05146  Amoebiasis
ko05161  Hepatitis B
ko05164  Influenza A
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05214  Glioma
ko05223  Non-small cell lung cancer
ko05225  Hepatocellular carcinoma
ko05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04015 Rap1 signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04010 MAPK signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04011 MAPK signaling pathway - yeast
    K02677  PRKCA; classical protein kinase C alpha type
   04012 ErbB signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04310 Wnt signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04370 VEGF signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04066 HIF-1 signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04020 Calcium signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04070 Phosphatidylinositol signaling system
    K02677  PRKCA; classical protein kinase C alpha type
   04072 Phospholipase D signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04071 Sphingolipid signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04151 PI3K-Akt signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04150 mTOR signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
 Cellular Processes
  Transport and catabolism
   04139 Mitophagy - yeast
    K02677  PRKCA; classical protein kinase C alpha type
  Cellular community - eukaryotes
   04510 Focal adhesion
    K02677  PRKCA; classical protein kinase C alpha type
   04540 Gap junction
    K02677  PRKCA; classical protein kinase C alpha type
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    K02677  PRKCA; classical protein kinase C alpha type
   04664 Fc epsilon RI signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04666 Fc gamma R-mediated phagocytosis
    K02677  PRKCA; classical protein kinase C alpha type
   04670 Leukocyte transendothelial migration
    K02677  PRKCA; classical protein kinase C alpha type
  Endocrine system
   04911 Insulin secretion
    K02677  PRKCA; classical protein kinase C alpha type
   04912 GnRH signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04921 Oxytocin signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04926 Relaxin signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04918 Thyroid hormone synthesis
    K02677  PRKCA; classical protein kinase C alpha type
   04919 Thyroid hormone signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04928 Parathyroid hormone synthesis, secretion and action
    K02677  PRKCA; classical protein kinase C alpha type
   04916 Melanogenesis
    K02677  PRKCA; classical protein kinase C alpha type
   04925 Aldosterone synthesis and secretion
    K02677  PRKCA; classical protein kinase C alpha type
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K02677  PRKCA; classical protein kinase C alpha type
   04270 Vascular smooth muscle contraction
    K02677  PRKCA; classical protein kinase C alpha type
  Digestive system
   04970 Salivary secretion
    K02677  PRKCA; classical protein kinase C alpha type
   04971 Gastric acid secretion
    K02677  PRKCA; classical protein kinase C alpha type
   04972 Pancreatic secretion
    K02677  PRKCA; classical protein kinase C alpha type
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K02677  PRKCA; classical protein kinase C alpha type
   04961 Endocrine and other factor-regulated calcium reabsorption
    K02677  PRKCA; classical protein kinase C alpha type
  Nervous system
   04724 Glutamatergic synapse
    K02677  PRKCA; classical protein kinase C alpha type
   04727 GABAergic synapse
    K02677  PRKCA; classical protein kinase C alpha type
   04725 Cholinergic synapse
    K02677  PRKCA; classical protein kinase C alpha type
   04728 Dopaminergic synapse
    K02677  PRKCA; classical protein kinase C alpha type
   04726 Serotonergic synapse
    K02677  PRKCA; classical protein kinase C alpha type
   04720 Long-term potentiation
    K02677  PRKCA; classical protein kinase C alpha type
   04730 Long-term depression
    K02677  PRKCA; classical protein kinase C alpha type
   04723 Retrograde endocannabinoid signaling
    K02677  PRKCA; classical protein kinase C alpha type
  Sensory system
   04745 Phototransduction - fly
    K02677  PRKCA; classical protein kinase C alpha type
   04750 Inflammatory mediator regulation of TRP channels
    K02677  PRKCA; classical protein kinase C alpha type
  Development
   04360 Axon guidance
    K02677  PRKCA; classical protein kinase C alpha type
  Environmental adaptation
   04713 Circadian entrainment
    K02677  PRKCA; classical protein kinase C alpha type
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K02677  PRKCA; classical protein kinase C alpha type
   05231 Choline metabolism in cancer
    K02677  PRKCA; classical protein kinase C alpha type
   05206 MicroRNAs in cancer
    K02677  PRKCA; classical protein kinase C alpha type
   05205 Proteoglycans in cancer
    K02677  PRKCA; classical protein kinase C alpha type
   05225 Hepatocellular carcinoma
    K02677  PRKCA; classical protein kinase C alpha type
   05214 Glioma
    K02677  PRKCA; classical protein kinase C alpha type
   05223 Non-small cell lung cancer
    K02677  PRKCA; classical protein kinase C alpha type
  Substance dependence
   05031 Amphetamine addiction
    K02677  PRKCA; classical protein kinase C alpha type
   05032 Morphine addiction
    K02677  PRKCA; classical protein kinase C alpha type
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K02677  PRKCA; classical protein kinase C alpha type
  Infectious diseases
   05110 Vibrio cholerae infection
    K02677  PRKCA; classical protein kinase C alpha type
   05130 Pathogenic Escherichia coli infection
    K02677  PRKCA; classical protein kinase C alpha type
   05164 Influenza A
    K02677  PRKCA; classical protein kinase C alpha type
   05161 Hepatitis B
    K02677  PRKCA; classical protein kinase C alpha type
   05146 Amoebiasis
    K02677  PRKCA; classical protein kinase C alpha type
   05143 African trypanosomiasis
    K02677  PRKCA; classical protein kinase C alpha type
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K02677  PRKCA; classical protein kinase C alpha type
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.13  protein kinase C
     K02677  PRKCA; classical protein kinase C alpha type
Protein kinases [BR:ko01001]
 Serine/threonine kinases: AGC group
  PKC family [OT]
   K02677  PRKCA; classical protein kinase C alpha type
Membrane trafficking [BR:ko04131]
 Endocytosis
  Lipid raft mediated endocytosis
   Caveolin-mediated endocytosis
    K02677  PRKCA; classical protein kinase C alpha type
BRITE hierarchy
Other DBs
COG: COG0515
GO: 0004697
Genes
HSA: 5578(PRKCA)
PTR: 454832(PRKCA)
PPS: 100967981(PRKCA)
GGO: 101124828(PRKCA)
NLE: 100591651(PRKCA)
MCC: 718412(PRKCA)
MCF: 102135875(PRKCA)
CSAB: 103243171(PRKCA)
RRO: 104675428(PRKCA)
RBB: 108517746(PRKCA)
CJC: 100391814(PRKCA)
SBQ: 101046010(PRKCA)
MMU: 18750(Prkca)
RNO: 24680(Prkca)
CGE: 100766006(Prkca)
NGI: 103742202(Prkca)
HGL: 101716044(Prkca)
CCAN: 109687351(Prkca)
OCU: 100037720(PRKCA)
TUP: 102495954(PRKCA)
CFA: 490904(PRKCA)
AML: 100477326(PRKCA)
UMR: 103665907(PRKCA)
ORO: 101386060(PRKCA)
FCA: 101086433(PRKCA)
PTG: 102968590(PRKCA)
AJU: 106975306(PRKCA)
BTA: 282001(PRKCA)
BOM: 102278724(PRKCA)
BIU: 109573366(PRKCA)
PHD: 102325983(PRKCA)
CHX: 102180890(PRKCA) 108638200
OAS: 101110074(PRKCA)
SSC: 397184(PRKCA)
CFR: 102507832(PRKCA)
CDK: 105092299(PRKCA)
BACU: 103004532(PRKCA)
LVE: 103073028(PRKCA)
OOR: 101276350(PRKCA)
ECB: 100063318(PRKCA)
EAI: 106835567(PRKCA)
MYB: 102260557(PRKCA)
MYD: 102765661(PRKCA)
HAI: 109380289(PRKCA)
RSS: 109448023(PRKCA)
PALE: 102887078(PRKCA)
LAV: 100665537(PRKCA)
TMU: 101348250
MDO: 100024674(PRKCA)
SHR: 100913337(PRKCA)
OAA: 100079107(PRKCA)
GGA: 417430(PRKCA)
MGP: 100541727(PRKCA)
CJO: 107322193(PRKCA)
APLA: 101802546(PRKCA)
ACYG: 106034675(PRKCA)
TGU: 100219195(PRKCA)
GFR: 102043485(PRKCA)
FAB: 101810891(PRKCA)
PHI: 102100311(PRKCA)
PMAJ: 107212334(PRKCA)
CCW: 104696032(PRKCA)
FPG: 101914699(PRKCA)
FCH: 102053069(PRKCA)
CLV: 102084059(PRKCA)
EGZ: 104129413(PRKCA)
AAM: 106493092(PRKCA)
ASN: 102377784(PRKCA)
AMJ: 102572836(PRKCA)
PSS: 102459336(PRKCA)
CMY: 102941618(PRKCA)
CPIC: 101949360(PRKCA)
ACS: 100554897(prkca)
PVT: 110088714(PRKCA)
PBI: 103057756(PRKCA)
XLA: 108702159 447031(prkca.L)
XTR: 780209(prkca)
NPR: 108800970
DRE: 100333967(si:ch73-374l24.1) 497384(prkca)
IPU: 108259727 108273127(prkca)
NCC: 104947710 104952470(prkca)
MZE: 101464257(prkca) 101487097
OLA: 101159746 101160465(prkca)
XMA: 102227289 102228309(prkca)
PRET: 103469320 103471309(prkca)
CSEM: 103383975(prkca) 103393016
HCQ: 109515231 109519811(prkca)
BPEC: 110166265(prkca) 110167023
ELS: 105021568(prkca) 105026133
SFM: 108937063 108940048(prkca)
LCM: 102361415(PRKCA)
CMK: 103175619(prkca)
CIN: 100186768(prkca)
SPU: 754681
APLC: 110985585
DME: Dmel_CG6518(inaC) Dmel_CG6622(Pkc53E)
DSI: Dsimw501_GD11232(Dsim_GD11232) Dsimw501_GD11233(Dsim_GD11233)
AAG: 5568580
AME: 406106(Pkc)
BIM: 100746615
BTER: 100643492
SOC: 105198587
AEC: 105150950
ACEP: 105627224
PBAR: 105426214
HST: 105188500
CFO: 105256106
LHU: 105673816
PGC: 109859297
NVI: 100116629
TCA: 656250
DPA: 109538750
NVL: 108566221
BMOR: 692526(Cpkc)
PMAC: 106709219
PRAP: 110992968
PXY: 105390120
API: 100161464
DNX: 107173460
ZNE: 110835611
FCD: 110848043
TUT: 107366475
CEL: CELE_E01H11.1(pkc-2)
CBR: CBG16150(Cbr-pkc-2)
BMY: Bm1_31105
TSP: Tsp_12157
CRG: 105335066
MYI: 110451208
OBI: 106874285
LAK: 106160836
EPA: 110241619
HMG: 100199454(PKC1a)
AQU: 100633579
SCE: YBL105C(PKC1)
ERC: Ecym_4652
KMX: KLMA_70130(PKC1)
NCS: NCAS_0E03010(NCAS0E03010)
NDI: NDAI_0E04610(NDAI0E04610)
TPF: TPHA_0B01520(TPHA0B01520)
TBL: TBLA_0I00910(TBLA0I00910)
TDL: TDEL_0C03050(TDEL0C03050)
KAF: KAFR_0G01080(KAFR0G01080)
CAL: CAALFM_C304470WA(PKC1)
CDU: CD36_84410(PKC1)
CAUR: QG37_02496
SLB: AWJ20_859(PKC1)
NCR: NCU06544(pkc)
NTE: NEUTE1DRAFT19420(NEUTE1DRAFT_19420)
MGR: MGG_08689
TRE: TRIREDRAFT_2526(pkc1)
MAW: MAC_03999
MAJ: MAA_07035
CMT: CCM_00005
MBE: MBM_00835
ABE: ARB_04376
TVE: TRV_03166
PTE: PTT_19155
ZTR: MYCGRDRAFT_87605(Pkc1b)
SPO: SPAC17G8.14c(pck1)
CNE: CNC03300
CNB: CNBC3910
LBC: LACBIDRAFT_309070(LbPKC1)
ABP: AGABI1DRAFT100325(AGABI1DRAFT_100325)
ABV: AGABI2DRAFT152055(AGABI2DRAFT_152055)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2336401
  Authors
Finkenzeller G, Marme D, Hug H
  Title
Sequence of human protein kinase C alpha.
  Journal
Nucleic Acids Res 18:2183 (1990)
DOI:10.1093/nar/18.8.2183
  Sequence
[hsa:5578]
Reference
PMID:8321321
  Authors
Kolch W, Heidecker G, Kochs G, Hummel R, Vahidi H, Mischak H, Finkenzeller G, Marme D, Rapp UR
  Title
Protein kinase C alpha activates RAF-1 by direct phosphorylation.
  Journal
Nature 364:249-52 (1993)
DOI:10.1038/364249a0
  Sequence
[hsa:5578]
Reference
  Authors
Darieva Z, Han N, Warwood S, Doris KS, Morgan BA, Sharrocks AD
  Title
Protein kinase C regulates late cell cycle-dependent gene expression.
  Journal
Mol Cell Biol 32:4651-61 (2012)
DOI:10.1128/MCB.06000-11
  Sequence
[sce:YBL105C]

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