KEGG   ORTHOLOGY: K02677Help
Entry
K02677                      KO                                     

Name
PRKCA
Definition
classical protein kinase C alpha type [EC:2.7.11.13]
Pathway
EGFR tyrosine kinase inhibitor resistance
MAPK signaling pathway
MAPK signaling pathway - yeast
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Regulation of mitophagy - yeast
mTOR signaling pathway
PI3K-Akt signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Axon guidance
VEGF signaling pathway
Focal adhesion
Tight junction
Gap junction
Natural killer cell mediated cytotoxicity
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Long-term depression
Phototransduction - fly
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Aldosterone synthesis and secretion
AGE-RAGE signaling pathway in diabetic complications
Aldosterone-regulated sodium reabsorption
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Amphetamine addiction
Morphine addiction
Vibrio cholerae infection
Pathogenic Escherichia coli infection
African trypanosomiasis
Amoebiasis
Hepatitis B
Influenza A
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04015 Rap1 signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04010 MAPK signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04011 MAPK signaling pathway - yeast
    K02677  PRKCA; classical protein kinase C alpha type
   04012 ErbB signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04310 Wnt signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04370 VEGF signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04066 HIF-1 signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04020 Calcium signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04070 Phosphatidylinositol signaling system
    K02677  PRKCA; classical protein kinase C alpha type
   04072 Phospholipase D signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04071 Sphingolipid signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04151 PI3K-Akt signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04150 mTOR signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
 Cellular Processes
  Transport and catabolism
   04139 Regulation of mitophagy - yeast
    K02677  PRKCA; classical protein kinase C alpha type
  Cellular community
   04510 Focal adhesion
    K02677  PRKCA; classical protein kinase C alpha type
   04530 Tight junction
    K02677  PRKCA; classical protein kinase C alpha type
   04540 Gap junction
    K02677  PRKCA; classical protein kinase C alpha type
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    K02677  PRKCA; classical protein kinase C alpha type
   04664 Fc epsilon RI signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04666 Fc gamma R-mediated phagocytosis
    K02677  PRKCA; classical protein kinase C alpha type
   04670 Leukocyte transendothelial migration
    K02677  PRKCA; classical protein kinase C alpha type
  Endocrine system
   04911 Insulin secretion
    K02677  PRKCA; classical protein kinase C alpha type
   04912 GnRH signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04921 Oxytocin signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04918 Thyroid hormone synthesis
    K02677  PRKCA; classical protein kinase C alpha type
   04919 Thyroid hormone signaling pathway
    K02677  PRKCA; classical protein kinase C alpha type
   04916 Melanogenesis
    K02677  PRKCA; classical protein kinase C alpha type
   04925 Aldosterone synthesis and secretion
    K02677  PRKCA; classical protein kinase C alpha type
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K02677  PRKCA; classical protein kinase C alpha type
   04270 Vascular smooth muscle contraction
    K02677  PRKCA; classical protein kinase C alpha type
  Digestive system
   04970 Salivary secretion
    K02677  PRKCA; classical protein kinase C alpha type
   04971 Gastric acid secretion
    K02677  PRKCA; classical protein kinase C alpha type
   04972 Pancreatic secretion
    K02677  PRKCA; classical protein kinase C alpha type
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K02677  PRKCA; classical protein kinase C alpha type
   04961 Endocrine and other factor-regulated calcium reabsorption
    K02677  PRKCA; classical protein kinase C alpha type
  Nervous system
   04724 Glutamatergic synapse
    K02677  PRKCA; classical protein kinase C alpha type
   04727 GABAergic synapse
    K02677  PRKCA; classical protein kinase C alpha type
   04725 Cholinergic synapse
    K02677  PRKCA; classical protein kinase C alpha type
   04728 Dopaminergic synapse
    K02677  PRKCA; classical protein kinase C alpha type
   04726 Serotonergic synapse
    K02677  PRKCA; classical protein kinase C alpha type
   04720 Long-term potentiation
    K02677  PRKCA; classical protein kinase C alpha type
   04730 Long-term depression
    K02677  PRKCA; classical protein kinase C alpha type
   04723 Retrograde endocannabinoid signaling
    K02677  PRKCA; classical protein kinase C alpha type
  Sensory system
   04745 Phototransduction - fly
    K02677  PRKCA; classical protein kinase C alpha type
   04750 Inflammatory mediator regulation of TRP channels
    K02677  PRKCA; classical protein kinase C alpha type
  Development
   04360 Axon guidance
    K02677  PRKCA; classical protein kinase C alpha type
  Environmental adaptation
   04713 Circadian entrainment
    K02677  PRKCA; classical protein kinase C alpha type
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K02677  PRKCA; classical protein kinase C alpha type
   05231 Choline metabolism in cancer
    K02677  PRKCA; classical protein kinase C alpha type
   05206 MicroRNAs in cancer
    K02677  PRKCA; classical protein kinase C alpha type
   05205 Proteoglycans in cancer
    K02677  PRKCA; classical protein kinase C alpha type
   05214 Glioma
    K02677  PRKCA; classical protein kinase C alpha type
   05223 Non-small cell lung cancer
    K02677  PRKCA; classical protein kinase C alpha type
  Substance dependence
   05031 Amphetamine addiction
    K02677  PRKCA; classical protein kinase C alpha type
   05032 Morphine addiction
    K02677  PRKCA; classical protein kinase C alpha type
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K02677  PRKCA; classical protein kinase C alpha type
  Infectious diseases
   05110 Vibrio cholerae infection
    K02677  PRKCA; classical protein kinase C alpha type
   05130 Pathogenic Escherichia coli infection
    K02677  PRKCA; classical protein kinase C alpha type
   05164 Influenza A
    K02677  PRKCA; classical protein kinase C alpha type
   05161 Hepatitis B
    K02677  PRKCA; classical protein kinase C alpha type
   05146 Amoebiasis
    K02677  PRKCA; classical protein kinase C alpha type
   05143 African trypanosomiasis
    K02677  PRKCA; classical protein kinase C alpha type
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K02677  PRKCA; classical protein kinase C alpha type
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.13  protein kinase C
     K02677  PRKCA; classical protein kinase C alpha type
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: AGC group
  PKC family [OT]
   K02677  PRKCA; classical protein kinase C alpha type
Membrane trafficking [BR:ko04131]
 Endocytosis
  Lipid raft mediated endocytosis
   Caveolin-mediated endocytosis
    K02677  PRKCA; classical protein kinase C alpha type
BRITE hierarchy
Other DBs
COG: 
GO: 
Genes
HSA: 
5578(PRKCA)
PTR: 
454832(PRKCA)
PPS: 
100967981(PRKCA)
GGO: 
101124828(PRKCA)
NLE: 
100591651(PRKCA)
MCC: 
718412(PRKCA)
MCF: 
102135875(PRKCA)
CSAB: 
103243171(PRKCA)
RRO: 
104675428(PRKCA)
CJC: 
100391814(PRKCA)
SBQ: 
101046010(PRKCA)
MMU: 
18750(Prkca)
RNO: 
24680(Prkca)
CGE: 
100766006(Prkca)
NGI: 
103742202(Prkca)
HGL: 
101716044(Prkca)
OCU: 
100037720(PRKCA)
TUP: 
102495954(PRKCA)
CFA: 
490904(PRKCA)
AML: 
100477326(PRKCA)
UMR: 
103665907(PRKCA)
FCA: 
101086433(PRKCA)
PTG: 
102968590(PRKCA)
BTA: 
282001(PRKCA)
BOM: 
102278724(PRKCA)
PHD: 
102325983(PRKCA)
CHX: 
102180890(PRKCA)
OAS: 
101110074(PRKCA)
SSC: 
397184(PRKCA)
CFR: 
102507832(PRKCA)
BACU: 
103004532(PRKCA)
LVE: 
103073028(PRKCA)
ECB: 
100063318(PRKCA)
MYB: 
102260557(PRKCA)
MYD: 
102765661(PRKCA)
PALE: 
102887078(PRKCA)
LAV: 
100665537(PRKCA)
MDO: 
100024674(PRKCA)
SHR: 
100913337(PRKCA)
OAA: 
100079107(PRKCA)
GGA: 
417430(PRKCA)
MGP: 
100541727(PRKCA)
CJO: 
107322193(PRKCA)
APLA: 
101802546(PRKCA)
TGU: 
100219195(PRKCA)
GFR: 
102043485(PRKCA)
FAB: 
101810891(PRKCA)
PHI: 
102100311(PRKCA)
CCW: 
104696032(PRKCA)
FPG: 
101914699(PRKCA)
FCH: 
102053069(PRKCA)
CLV: 
102084059(PRKCA)
AAM: 
106493092(PRKCA)
ASN: 
102377784(PRKCA)
AMJ: 
102572836(PRKCA)
PSS: 
102459336(PRKCA)
CMY: 
102941618(PRKCA)
ACS: 
100554897(prkca)
PBI: 
103057756(PRKCA)
GJA: 
XLA: 
447031(prkca)
XTR: 
780209(prkca)
DRE: 
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
102361415(PRKCA)
CMK: 
103175619(prkca)
BFO: 
CIN: 
100186768(prkca)
SPU: 
DME: 
Dmel_CG6518(inaC) Dmel_CG6622(Pkc53E)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD11232(Dsim_GD11232) Dsimw501_GD11233(Dsim_GD11233)
DWI: 
DYA: 
Dyak_GE11630(dyak_GLEANR_11946) Dyak_GE11833(dyak_GLEANR_12131)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
406106(Pkc)
BIM: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
692526(Cpkc)
DPL: 
API: 
ISC: 
CEL: 
CBR: 
CBG16150(Cbr-pkc-2)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
NVE: 
ADF: 
HMG: 
100199454(PKC1a)
TAD: 
AQU: 
CCP: 
SCE: 
YBL105C(PKC1)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0E03010(NCAS0E03010)
NDI: 
NDAI_0E04610(NDAI0E04610)
TPF: 
TPHA_0B01520(TPHA0B01520)
TBL: 
TBLA_0I00910(TBLA0I00910)
TDL: 
TDEL_0C03050(TDEL0C03050)
KAF: 
KAFR_0G01080(KAFR0G01080)
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NCR: 
NTE: 
NEUTE1DRAFT19420(NEUTE1DRAFT_19420)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
VDA: 
ELA: 
SSL: 
BFU: 
MBE: 
AFM: 
AOR: 
AOR_1_552094(AO090120000316)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
PBN: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
ZTR: 
PFJ: 
BCOM: 
SPO: 
CNE: 
CNB: 
TMS: 
DSQ: 
PCO: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT100325(AGABI1DRAFT_100325)
ABV: 
AGABI2DRAFT152055(AGABI2DRAFT_152055)
CPUT: 
SLA: 
UMA: 
PFP: 
MGL: 
PGR: 
MLR: 
MBR: 
SRE: 
NGR: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2336401
  Authors
Finkenzeller G, Marme D, Hug H
  Title
Sequence of human protein kinase C alpha.
  Journal
Nucleic Acids Res 18:2183 (1990)
  Sequence
[hsa:5578]
Reference
PMID:8321321
  Authors
Kolch W, Heidecker G, Kochs G, Hummel R, Vahidi H, Mischak H, Finkenzeller G, Marme D, Rapp UR
  Title
Protein kinase C alpha activates RAF-1 by direct phosphorylation.
  Journal
Nature 364:249-52 (1993)
  Sequence
[hsa:5578]
Reference
  Authors
Darieva Z, Han N, Warwood S, Doris KS, Morgan BA, Sharrocks AD
  Title
Protein kinase C regulates late cell cycle-dependent gene expression.
  Journal
Mol Cell Biol 32:4651-61 (2012)
  Sequence
[sce:YBL105C]

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