KEGG   ORTHOLOGY: K03083Help
Entry
K03083                      KO                                     

Name
GSK3B
Definition
glycogen synthase kinase 3 beta [EC:2.7.11.26]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04012  ErbB signaling pathway
ko04062  Chemokine signaling pathway
ko04110  Cell cycle
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04310  Wnt signaling pathway
ko04340  Hedgehog signaling pathway
ko04341  Hedgehog signaling pathway - fly
ko04360  Axon guidance
ko04390  Hippo signaling pathway
ko04510  Focal adhesion
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04657  IL-17 signaling pathway
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko04711  Circadian rhythm - fly
ko04722  Neurotrophin signaling pathway
ko04728  Dopaminergic synapse
ko04910  Insulin signaling pathway
ko04916  Melanogenesis
ko04917  Prolactin signaling pathway
ko04919  Thyroid hormone signaling pathway
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko04934  Cushing's syndrome
ko05010  Alzheimer's disease
ko05160  Hepatitis C
ko05162  Measles
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05166  HTLV-I infection
ko05167  Kaposi's sarcoma-associated herpesvirus infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05213  Endometrial cancer
ko05215  Prostate cancer
ko05217  Basal cell carcinoma
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Module
M00677  Wnt signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04310 Wnt signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04340 Hedgehog signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04341 Hedgehog signaling pathway - fly
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04390 Hippo signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04151 PI3K-Akt signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04150 mTOR signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K03083  GSK3B; glycogen synthase kinase 3 beta
  Cellular community - eukaryotes
   04510 Focal adhesion
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04550 Signaling pathways regulating pluripotency of stem cells
    K03083  GSK3B; glycogen synthase kinase 3 beta
 Organismal Systems
  Immune system
   04660 T cell receptor signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04657 IL-17 signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04662 B cell receptor signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04062 Chemokine signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
  Endocrine system
   04910 Insulin signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04917 Prolactin signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04919 Thyroid hormone signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04916 Melanogenesis
    K03083  GSK3B; glycogen synthase kinase 3 beta
  Nervous system
   04728 Dopaminergic synapse
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04722 Neurotrophin signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
  Development
   04360 Axon guidance
    K03083  GSK3B; glycogen synthase kinase 3 beta
  Environmental adaptation
   04711 Circadian rhythm - fly
    K03083  GSK3B; glycogen synthase kinase 3 beta
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05210 Colorectal cancer
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05225 Hepatocellular carcinoma
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05226 Gastric cancer
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05217 Basal cell carcinoma
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05215 Prostate cancer
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05213 Endometrial cancer
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05224 Breast cancer
    K03083  GSK3B; glycogen synthase kinase 3 beta
  Neurodegenerative diseases
   05010 Alzheimer's disease
    K03083  GSK3B; glycogen synthase kinase 3 beta
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04931 Insulin resistance
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04934 Cushing's syndrome
    K03083  GSK3B; glycogen synthase kinase 3 beta
  Infectious diseases
   05166 HTLV-I infection
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05162 Measles
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05164 Influenza A
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05160 Hepatitis C
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05169 Epstein-Barr virus infection
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05165 Human papillomavirus infection
    K03083  GSK3B; glycogen synthase kinase 3 beta
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K03083  GSK3B; glycogen synthase kinase 3 beta
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00677  Wnt signaling
     K03083  GSK3B; glycogen synthase kinase 3 beta
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.26  tau-protein kinase
     K03083  GSK3B; glycogen synthase kinase 3 beta
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CMGC group
  GSK family [OT]
   K03083  GSK3B; glycogen synthase kinase 3 beta
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic Type
  Centrosome formation and ciliogenesis proteins
   Kinases and associated factors
    K03083  GSK3B; glycogen synthase kinase 3 beta
BRITE hierarchy
Other DBs
GO: 0050321
Genes
HSA: 2932(GSK3B)
PTR: 100616510(GSK3B)
PPS: 100972306(GSK3B)
GGO: 101125534(GSK3B)
PON: 100447772(GSK3B)
NLE: 100606885(GSK3B)
MCC: 713114(GSK3B)
MCF: 102133756(GSK3B)
CSAB: 103228213(GSK3B)
RRO: 104680990(GSK3B)
RBB: 108541757(GSK3B)
CJC: 100387683(GSK3B)
SBQ: 101051107(GSK3B)
MMU: 56637(Gsk3b)
RNO: 84027(Gsk3b)
CGE: 100760865(Gsk3b)
NGI: 103741948(Gsk3b)
HGL: 101701301(Gsk3b)
CCAN: 109685333(Gsk3b)
OCU: 100348842(GSK3B)
TUP: 102476038(GSK3B)
CFA: 478575(GSK3B)
AML: 100479224(GSK3B)
UMR: 103678785(GSK3B)
ORO: 101365718(GSK3B)
FCA: 101081660(GSK3B)
PTG: 102961382(GSK3B)
AJU: 106968274(GSK3B)
BTA: 107131288 790875(GSK3B)
BOM: 102275260(GSK3B)
BIU: 109578123(GSK3B) 109578227
PHD: 102335629(GSK3B)
CHX: 102176363(GSK3B)
OAS: 100169938(GSK3B)
SSC: 100126852(GSK3B)
CFR: 102504696(GSK3B)
CDK: 105090321(GSK3B)
BACU: 102998893(GSK3B)
LVE: 103074757(GSK3B)
OOR: 101283259(GSK3B)
ECB: 100061033(GSK3B)
EPZ: 103547424(GSK3B)
EAI: 106829188(GSK3B)
MYB: 102248758(GSK3B)
MYD: 102751662(GSK3B)
HAI: 109388396(GSK3B)
PALE: 102882441(GSK3B)
LAV: 100675105(GSK3B)
TMU: 101349186
MDO: 100012447(GSK3B)
SHR: 100920192(GSK3B)
OAA: 100092089
GGA: 418335(GSK3B)
MGP: 100545864(GSK3B)
CJO: 107319718(GSK3B)
APLA: 101802112(GSK3B)
TGU: 100224604(GSK3B)
GFR: 102034944(GSK3B)
FAB: 101807423(GSK3B)
PHI: 102105491(GSK3B)
PMAJ: 107205227(GSK3B)
CCW: 104687192(GSK3B)
FCH: 102059271(GSK3B)
CLV: 102090893(GSK3B)
EGZ: 104126562(GSK3B)
AAM: 106497256(GSK3B)
ASN: 102387985(GSK3B)
AMJ: 106737044(GSK3B)
PSS: 102461748(GSK3B)
CMY: 102935600(GSK3B)
CPIC: 101935079(GSK3B)
ACS: 100564023(gsk3b)
PVT: 110076947(GSK3B) 110086774(GSK3A)
PBI: 103066659(GSK3B)
GJA: 107109342(GSK3B)
XLA: 399097(gsk3b.L) 779056
XTR: 100489648(gsk3b)
NPR: 108801162(GSK3B)
DRE: 30654(gsk3b) 560194(gsk3aa)
IPU: 108258646 108266408(gsk3b)
AMEX: 103021870(gsk3b) 103043574
TRU: 101067898(gsk3b)
LCO: 104936875(gsk3b)
NCC: 104952807(gsk3b) 104962754
MZE: 101487930(gsk3b)
OLA: 101174787(gsk3b)
XMA: 102224919(gsk3b)
PRET: 103459583(gsk3b)
NFU: 107389867(gsk3b)
CSEM: 103392124(gsk3b)
LCF: 108884414(gsk3b)
HCQ: 109531284(gsk3b)
BPEC: 110166530(gsk3b)
ELS: 105027876(gsk3b) 105031009
LCM: 102350787(GSK3B)
CMK: 103180204(gsk3b)
CIN: 445595(gsk)
SPU: 764638(gsk3b)
APLC: 110988900
SKO: 100303595(gsk3b)
DME: Dmel_CG2621(sgg) Dmel_CG31003(gskt)
DSI: Dsimw501_GD21574(Dsim_GD21574)
MDE: 101897532
AAG: 5566167
AME: 408976(sgg)
BIM: 100747625
BTER: 100645880
SOC: 105193199
AEC: 105152459
ACEP: 105620830
PBAR: 105429295
HST: 105188825
CFO: 105258655
LHU: 105675406
PGC: 109852652
NVI: 100117808
TCA: 664299(sgg)
NVL: 108568051
BMOR: 100862751
PMAC: 106711245
PRAP: 110992991
PXY: 105391020
ZNE: 110828127
FCD: 110845357
DPX: DAPPUDRAFT_299658(GSK-3B)
TUT: 107371053
CEL: CELE_C44H4.6(C44H4.6) CELE_R03D7.5(R03D7.5) CELE_Y18D10A.5(gsk-3)
CBR: CBG07560 CBG07972(Cbr-gsk-3) CBG20633
CRG: 105346012
MYI: 110450343
OBI: 106867885
LAK: 106175040
SHX: MS3_07368
EPA: 110246760
ADF: 107338367
HMG: 100203080(GSK3)
AQU: 100616537(Gsk3)
ATH: AT1G09840(SK41) AT1G57870(SK42) AT5G14640(SK13)
EGR: 104420009
CAM: 101499607
ADU: 107482736
AIP: 107638504
LJA: Lj0g3v0357589.1(Lj0g3v0357589.1) Lj6g3v2286310.1(Lj6g3v2286310.1) Lj6g3v2286310.2(Lj6g3v2286310.2)
LANG: 109345710
ZJU: 107412572
RCU: 8263267
DCR: 108208830
BVG: 104896931
SOE: 110797331
DOSA: Os01t0296100-01(Os01g0296100) Os03t0841800-01(Os03g0841800)
ATS: 109745525(LOC109745525) 109766472(LOC109766472)
ZMA: 100273692 103655927 541696(pco107502b) 542518(gpm645)
EGU: 105036107
DCT: 110109893
AOF: 109827173
CRE: CHLREDRAFT_114692(GSK3)
VCN: VOLCADRAFT_80100(gsk3)
MIS: MICPUN_104950(GSK3)
MPP: MICPUCDRAFT_30445(GSK3)
PIC: PICST_77550(RIM11)
CAL: CAALFM_C204280WA(CaO19.792) CAALFM_C204290WA(RIM11)
CAUR: QG37_00924
SLB: AWJ20_1413(RIM11)
NCR: NCU04185(prk-1)
NTE: NEUTE1DRAFT115704(NEUTE1DRAFT_115704)
SMP: SMAC_04408(putative rim11)
MGR: MGG_12122
TRE: TRIREDRAFT_74400(gsk3)
MAW: MAC_05229
MAJ: MAA_07562
CMT: CCM_03795
MBE: MBM_03205
ANI: AN6508.2
ANG: ANI_1_32134(An15g00170)
ABE: ARB_04291
TVE: TRV_06272
PTE: PTT_18800
ZTR: MYCGRDRAFT_100881(GSK3)
PFJ: MYCFIDRAFT_50287(GSK3)
SPO: SPAC1687.15(gsk3) SPBC8D2.01(gsk31)
CNE: CNB00720
CNB: CNBB4980
ABP: AGABI1DRAFT111475(AGABI1DRAFT_111475)
ABV: AGABI2DRAFT190701(AGABI2DRAFT_190701)
MGL: MGL_1055
DDI: DDB_G0270218(glkA) DDB_G0272110(gskA)
DFA: DFA_06870(gskA) DFA_08988(glkA)
EHI: EHI_003900(370.t00002) EHI_121880(147.t00016)
PYO: PY17X_0412900(PY01719) PY17X_1416200(PY06554)
PCB: PCHAS_041130(PC001308.02.0) PCHAS_141630(PC000418.03.0)
TAN: TA02550
CPV: cgd4_240
SMIN: v1.2.003582.t1(symbB.v1.2.003582.t1) v1.2.003582.t2(symbB.v1.2.003582.t2) v1.2.011523.t1(symbB.v1.2.011523.t1) v1.2.015655.t1(symbB.v1.2.015655.t1) v1.2.026205.t1(symbB.v1.2.026205.t1) v1.2.026205.t2(symbB.v1.2.026205.t2) v1.2.026205.t3(symbB.v1.2.026205.t3) v1.2.039074.t1(symbB.v1.2.039074.t1)
TPS: THAPSDRAFT_38559(GSK-3)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7980435
  Authors
Stambolic V, Woodgett JR
  Title
Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation.
  Journal
Biochem J 303 ( Pt 3):701-4 (1994)
DOI:10.1042/bj3030701
  Sequence
[hsa:2932]
Reference
  Authors
Bobinnec Y, Morin X, Debec A
  Title
Shaggy/GSK-3beta kinase localizes to the centrosome and to specialized cytoskeletal structures in Drosophila.
  Journal
Cell Motil Cytoskeleton 63:313-20 (2006)
DOI:10.1002/cm.20128

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