KEGG ORTHOLOGY: K03164

ORTHOLOGY: K03164

Entry

K03164 KO

Name

TOP2

Definition

DNA topoisomerase II [EC:5.99.1.3]

Pathway

ko01524

Platinum drug resistance

Brite

KEGG Orthology (KO) [BR:ko00001]
Human Diseases
  Drug resistance
   01524 Platinum drug resistance
    K03164  TOP2; DNA topoisomerase II
Enzymes [BR:ko01000]
5. Isomerases
  5.99  Other isomerases
   5.99.1  Sole sub-subclass for isomerases that do not belong in the other subclasses
    5.99.1.3  DNA topoisomerase (ATP-hydrolysing)
     K03164  TOP2; DNA topoisomerase II
DNA replication proteins [BR:ko03032]
Eukaryotic Type
  DNA Topoisomerases
   K03164  TOP2; DNA topoisomerase II
Chromosome [BR:ko03036]
Eukaryotic Type
  Chromosome condensation proteins
   Other regulators of chromosome condensation
    K03164  TOP2; DNA topoisomerase II
  Centrosome formation and ciliogenesis proteins
   Centriole proteins
    K03164  TOP2; DNA topoisomerase II

Other DBs

COG:

COG0187 COG0188

GO:

0003918

Genes

HSA:	7153(TOP2A) 7155(TOP2B)
PTR:	454651(TOP2A) 460232(TOP2B)
PPS:	100975829(TOP2B) 100996214(TOP2A)
GGO:	101135259(TOP2B) 101151181(TOP2A)
PON:	100433973(TOP2A) 100439073(TOP2B)
NLE:	100584797(TOP2A) 100596241(TOP2B)
MCC:	677709(TOP2B) 700707(TOP2A)
MCF:	101866992(TOP2B) 102135121(TOP2A)
CSAB:	103241775(TOP2B) 103243514(TOP2A)
RRO:	104658074(TOP2B) 104682030(TOP2A)
RBB:	108534715(TOP2A) 108543073(TOP2B)
CJC:	100396004(TOP2B) 100411777(TOP2A)
SBQ:	101035877(TOP2A) 101041566(TOP2B)
MMU:	21973(Top2a) 21974(Top2b)
RNO:	360243(Top2a) 361100(Top2b)
CGE:	100689304(Top2a) 100770041(Top2b)
NGI:	103731125(Top2a) 103734261(Top2b)
HGL:	101702367 101704972(Top2b) 101722259
CCAN:	109694415(Top2a) 109696876(Top2b)
OCU:	100351427(TOP2B) 100357676(TOP2A)
TUP:	102492167(TOP2B) 102499923(TOP2A)
CFA:	477044(TOP2B) 480525(TOP2A)
AML:	100463930(TOP2A) 100469273(TOP2B)
UMR:	103661780(TOP2A) 103682010(TOP2B)
FCA:	101083813(TOP2A) 101088949(TOP2B)
PTG:	102960613(TOP2B) 102968667 102970050(TOP2A)
AJU:	106980548(TOP2A) 106988242(TOP2B)
BTA:	282097(TOP2B) 787696(TOP2A)
BOM:	102276087(TOP2A) 102276458(TOP2B)
BIU:	109553359 109553408 109574397(TOP2A)
PHD:	102333548(TOP2B) 102341133(TOP2A)
CHX:	102180187(TOP2B) 102188973(TOP2A)
OAS:	101103037(TOP2B) 101108762(TOP2A)
SSC:	100156319(TOP2B) 396917(TOP2A)
CFR:	102503932(TOP2A) 102523203(TOP2B)
CDK:	105095626(TOP2B) 105099019(TOP2A)
BACU:	103001897(TOP2B) 103010475(TOP2A)
LVE:	103074383 103080885(TOP2B) 103083356(TOP2A)
ECB:	100054229(TOP2A) 100059572(TOP2B)
EPZ:	103549779(TOP2B) 103550180(TOP2A)
EAI:	106823875(TOP2B) 106826503(TOP2A)
MYB:	102247329(TOP2A) 102253721(TOP2B)
MYD:	102757012(TOP2A) 102759143(TOP2B)
HAI:	109374239(TOP2B) 109380662(TOP2A)
RSS:	109454534(TOP2B) 109455882(TOP2A)
PALE:	102879554(TOP2B) 102879885(TOP2A)
LAV:	100667411(TOP2A) 100668841(TOP2B)
MDO:	100016027(TOP2A) 100031654(TOP2B)
SHR:	100930373(TOP2B) 100934974(TOP2A)
OAA:	100075740(TOP2B) 100090593(TOP2A)
GGA:	395570(TOP2A) 395966(MIR4442)
MGP:	100541484(TOP2A) 100545483(TOP2B)
CJO:	107309267 107309329 107325246(TOP2A)
APLA:	101792282(TOP2A) 101793977(TOP2B)
ACYG:	106030293(TOP2B) 106049567(TOP2A)
TGU:	100231174(TOP2B) 100231343(TOP2A)
GFR:	102037381(TOP2B) 102040919(TOP2A)
FAB:	101814631(TOP2A) 101815052(TOP2B)
PHI:	102110562(TOP2B) 102111409(TOP2A)
CCW:	104689051(TOP2B) 104697736(TOP2A)
FPG:	101911797(TOP2A) 101913022(TOP2B)
FCH:	102054858(TOP2A) 102059770(TOP2B)
CLV:	102091898(TOP2A) 102096719(TOP2B)
AAM:	106483492(TOP2B) 106486418(TOP2A)
ASN:	102379109(TOP2A) 102384021(TOP2B)
AMJ:	102563910(TOP2A) 102570158(TOP2B)
PSS:	102448610(TOP2B) 102450222(TOP2A)
CMY:	102930295(TOP2B) 102930501(TOP2A)
CPIC:	101948778(TOP2A) 101952681(TOP2B)
ACS:	100562686(top2a) 100563490(top2b)
PBI:	103063882(TOP2B) 103065748(TOP2A)
GJA:	107107876(TOP2B) 107108908 107119950(TOP2A)
XLA:	100381038(top2b.L) 108719958 398512(top2a.L)
XTR:	100038293(top2a) 779457(top2b)
NPR:	108798407(TOP2B) 108804294(TOP2A)
DRE:	323733(top2a) 569877(top2b)
SRX:	107716453 107716454 107717721 107719851 107736279
SANH:	107655887 107660475 107700653
SGH:	107563214 107565242 107598028
IPU:	108272783(top2b) 108274033(top2a)
TRU:	101075432(top2a) 101075827(top2b)
TNG:	GSTEN00024101G001 GSTEN00033707G001
LCO:	104923244(top2a) 104931637(top2b)
NCC:	104946376(top2a) 104960822(top2b)
MZE:	101467018(top2b) 101474611(top2a)
OLA:	101157229(top2b) 101158729(top2a)
XMA:	102218577(top2a) 102228295(top2b)
CSEM:	103381751 103394321(top2b)
LCF:	108875718(top2a) 108900254(top2b)
SASA:	100380718(top2a) 106570304 106588671
ELS:	105012550(top2b) 105024531(top2a)
SFM:	108928126(top2a) 108933428(top2b)
LCM:	102346568(TOP2B) 102360928(TOP2A)
CMK:	103179948(top2b) 103190991 103191468
BFO:	BRAFLDRAFT_67020
CIN:	751087(ci-htf-1)
SPU:	578275(top2b)
SKO:	100372229(TOP2B)
DME:	Dmel_CG10223(Top2)
DPO:	Dpse_GA10169
DAN:	Dana_GF15632
DER:	Dere_GG21630
DPE:	Dper_GL21103
DSE:	Dsec_GM17008(Dsec_Top2)
DSI:	Dsimw501_GD21758(Dsim_Top2)
DWI:	Dwil_GK24224
DYA:	Dyak_GE12650
DGR:	Dgri_GH10628
DMO:	Dmoj_GI19824
DVI:	Dvir_GJ18099
MDE:	101893954
AGA:	AgaP_AGAP008917
AAG:	AaeL_AAEL012584
CQU:	CpipJ_CPIJ010018
AME:	724215(Top2)
BIM:	100741177
BTER:	100650868
SOC:	105201702
AEC:	105144262
ACEP:	105619228
PBAR:	105433086
HST:	105180567
CFO:	105251341
LHU:	105677045
NVI:	100117297
TCA:	656003(Top2)
DPA:	109538111
NVL:	108563602
BMOR:	692558(TOP2)
DPL:	KGM_212970
PXY:	105383739
API:	100167074 100574960
DNX:	107168938
PHU:	Phum_PHUM413330
DPX:	DAPPUDRAFT_104556 DAPPUDRAFT_14901 DAPPUDRAFT_274376 DAPPUDRAFT_30330 DAPPUDRAFT_315718 DAPPUDRAFT_315938 DAPPUDRAFT_317722 DAPPUDRAFT_323396 DAPPUDRAFT_329527 DAPPUDRAFT_332921 DAPPUDRAFT_333898 DAPPUDRAFT_333905 DAPPUDRAFT_340411 DAPPUDRAFT_3936 DAPPUDRAFT_47063 DAPPUDRAFT_670 DAPPUDRAFT_67762
ISC:	IscW_ISCW016225
TUT:	107361708 107370122
CEL:	CELE_K12D12.1(top-2) CELE_R05D3.12(R05D3.12) CELE_ZK1127.7(cin-4)
CBR:	CBG02746 CBG18156
NAI:	NECAME_10365 NECAME_10714
BMY:	Bm1_08705 Bm1_44575 Bm1_46835
LOA:	LOAG_05201 LOAG_17267 LOAG_17616 LOAG_18426
TSP:	Tsp_00990
HRO:	HELRODRAFT_68444
LGI:	LOTGIDRAFT_145577 LOTGIDRAFT_146901 LOTGIDRAFT_176819 LOTGIDRAFT_223462
CRG:	105343567
OBI:	106883641
LAK:	106174550
SMM:	Smp_065840
NVE:	NEMVE_v1g162970 NEMVE_v1g94148
ADF:	107347001 107352240
HMG:	100214280(top2b)
TAD:	TRIADDRAFT_23201
AQU:	100632881
ATH:	AT3G23890(TOPII)
ALY:	ARALYDRAFT_313269 ARALYDRAFT_329101 ARALYDRAFT_683570 ARALYDRAFT_684862 ARALYDRAFT_896968 ARALYDRAFT_898932 ARALYDRAFT_901604 ARALYDRAFT_916718
CRB:	CARUB_v10012826mg
EUS:	EUTSA_v10024219mg
BRP:	103853975 103870592
BNA:	106375558 106383351 106386317
THJ:	104820131
CIT:	102610705
CIC:	CICLE_v10030505mg
TCC:	18586085
GRA:	105776898
GHI:	107934399
EGR:	104414246 104414311
GMX:	100787008 100796974
PVU:	PHAVU_005G024200g
VRA:	106762134
VAR:	108334280
CCAJ:	109796924
MTR:	MTR_0756s0010 MTR_1g051315 MTR_1g075370 MTR_3g031040 MTR_3g085840
CAM:	101495004 101495557
ADU:	107462777 107477451
AIP:	107613041 107629690
LJA:	Lj3g3v0826110.1(Lj3g3v0826110.1) Lj4g3v0877830.1(Lj4g3v0877830.1)
LANG:	109355599
FVE:	101299838 101308524
PPER:	18786685
PMUM:	103330635
MDM:	103407514 103409964 103438420 108175007
PXB:	103945911 103945915
ZJU:	107417559
CSV:	101215950
CMO:	103500322
RCU:	8259305
JCU:	105628725
POP:	POPTR_0001s27120g(POPTRDRAFT_706393) POPTR_0009s06380g(POPTRDRAFT_557797)
VVI:	100253371
SLY:	101250733
SPEN:	107006903
SOT:	102583378
CANN:	107839447
NTA:	107792933 107825899
INI:	109147754
SIND:	105169247
BVG:	104898161 104898163 104907798
NNU:	104585888 104597381 104612782
OSA:	4330426
DOSA:	Os02t0699700-01(Os02g0699700)
OBR:	102703591 102704031 102706664
BDI:	100839516
ATS:	F775_00124 F775_01346 F775_01347 F775_01510 F775_01861 F775_02070 F775_04294 F775_22809 F775_24649 F775_33183 F775_52511
SBI:	8073171
ZMA:	100381789
SITA:	101760596 105913819
PDA:	103698181 103699084 103708090 103724132 108510813
EGU:	105044001
MUS:	103983855 103986633
ATR:	18428924
SMO:	SELMODRAFT_127267 SELMODRAFT_138946 SELMODRAFT_98330
PPP:	PHYPADRAFT_120620 PHYPADRAFT_134247
CRE:	CHLREDRAFT_38019(TOP2)
VCN:	VOLCADRAFT_94598
OLU:	OSTLU_41836
OTA:	Ot13g00110
BPG:	Bathy02g05900
MIS:	MICPUN_58377
MPP:	MICPUCDRAFT_46870
CSL:	COCSUDRAFT_36592
CVR:	CHLNCDRAFT_137783
APRO:	F751_1302
CME:	CYME_CMB013C CYME_CML330C
GSL:	Gasu_00250 Gasu_65780
CCP:	CHC_T00006305001
SCE:	YNL088W(TOP2)
AGO:	AGOS_AER410W
KLA:	KLLA0C13838g
LTH:	KLTH0G08338g
VPO:	Kpol_1002p113
ZRO:	ZYRO0C15422g
CGR:	CAGL0J05610g
NCS:	NCAS_0G02740(NCAS0G02740)
NDI:	NDAI_0F02550(NDAI0F02550)
TPF:	TPHA_0C02900(TPHA0C02900)
TBL:	TBLA_0E03570(TBLA0E03570)
TDL:	TDEL_0C04170(TDEL0C04170)
KAF:	KAFR_0J01230(KAFR0J01230)
PPA:	PAS_chr3_0322
DHA:	DEHA2E01738g
PIC:	PICST_74317(TOP2)
PGU:	PGUG_04026
SPAA:	SPAPADRAFT_131140
LEL:	LELG_05716
CAL:	CAALFM_C406600WA(TOP2)
CTP:	CTRG_03824
COT:	CORT_0B01230
CDU:	CD36_46080(TOP2)
CTEN:	CANTEDRAFT_104632
YLI:	YALI0D23969g
CLU:	CLUG_05525 CLUG_05526 CLUG_05527
CAUR:	QG37_06171
NCR:	NCU06338
NTE:	NEUTE1DRAFT79101(NEUTE1DRAFT_79101)
SMP:	SMAC_01010(top2)
PAN:	PODANSg3615
TTT:	THITE_72528
MTM:	MYCTH_74764
CTHR:	CTHT_0038710
MGR:	MGG_06162
TMN:	UCRPA7_8097
FGR:	FGSG_09801
FPU:	FPSE_00841
FVR:	FVEG_06414
FOX:	FOXG_08257
NHE:	NECHADRAFT_33819
TRE:	TRIREDRAFT_55125
MAW:	MAC_06425
MAJ:	MAA_05049
CMT:	CCM_04288
VAL:	VDBG_00992
VDA:	VDAG_00604
CFJ:	CFIO01_07750
ELA:	UCREL1_6058
PFY:	PFICI_05176
SSL:	SS1G_01930
BFU:	BC1G_12611
MBE:	MBM_04172
PSCO:	LY89DRAFT_782231
GLZ:	GLAREA_06678
ANI:	AN5406.2
AFM:	AFUA_6G13690
AOR:	AOR_1_570034(AO090103000347)
ANG:	ANI_1_1186074(An08g08550)
AFV:	AFLA_008840
ACT:	ACLA_087000
NFI:	NFIA_059660
PCS:	Pc22g00700(top2)
PDP:	PDIP_46230
CIM:	CIMG_02836
CPW:	CPC735_036030
PBL:	PAAG_03486
PBN:	PADG_06339
URE:	UREG_02997
ABE:	ARB_01513
TVE:	TRV_04248
AJE:	HCAG_08644
PNO:	SNOG_06355
PTE:	PTT_11728
BZE:	COCCADRAFT_33223
BSC:	COCSADRAFT_80849
BOR:	COCMIDRAFT_94384
ZTR:	MYCGRDRAFT_98287
PFJ:	MYCFIDRAFT_164213
BCOM:	BAUCODRAFT_144266
NPA:	UCRNP2_10086
TML:	GSTUM_00006716001
SPO:	SPBC1A4.03c(top2)
CNE:	CNA03600
CNB:	CNBA3470
CGI:	CGB_B4210C
TMS:	TREMEDRAFT_43154
TVS:	TRAVEDRAFT_68760
DSQ:	DICSQDRAFT_128647 DICSQDRAFT_156586
PCO:	PHACADRAFT_83842
SHS:	STEHIDRAFT_70358
HIR:	HETIRDRAFT_165527
PSQ:	PUNSTDRAFT_94342
ADL:	AURDEDRAFT_140942
FME:	FOMMEDRAFT_122296
GTR:	GLOTRDRAFT_102844
MPR:	MPER_04586 MPER_07581
MRR:	Moror_378
CCI:	CC1G_03723 CC1G_12208
SCM:	SCHCODRAFT_17796
ABP:	AGABI1DRAFT117173(AGABI1DRAFT_117173)
ABV:	AGABI2DRAFT197775(AGABI2DRAFT_197775)
CPUT:	CONPUDRAFT_114400
SLA:	SERLADRAFT_453445
WSE:	WALSEDRAFT_14295
WIC:	J056_004105
UMA:	UMAG_03501
PFP:	PFL1_02287
MGL:	MGL_0413
PGR:	PGTG_00741 PGTG_22746 PGTG_22747
MLR:	MELLADRAFT_46846
ECU:	ECU04_0350
EIN:	Eint_040290
EHE:	EHEL_040280
ERO:	EROM_040310
NCE:	NCER_100008
SRE:	PTSG_04681
DDI:	DDB_G0270418(top2) DDB_G0279737(top2mt)
DPP:	DICPUDRAFT_28071 DICPUDRAFT_4475
DFA:	DFA_00132(top2) DFA_03520(top2mt)
EHI:	EHI_120640(138.t00004)
EDI:	EDI_308810
EIV:	EIN_145900
ACAN:	ACA1_327230 ACA1_366710
PFA:	PF14_0316
PFD:	PFDG_03941 PFDG_04646
PFH:	PFHG_00531
PYO:	PY03394
PCB:	PCHAS_101220(PC000063.00.0)
PBE:	PB000671.01.0 PB300551.00.0 PB300632.00.0
PKN:	PKH_131580
PVX:	PVX_084855
PCY:	PCYB_132540
TAN:	TA13325
TPV:	TP02_0467
TOT:	TOT_020000455
BEQ:	BEWA_022040
BBO:	BBOV_III004820(17.m07431)
CPV:	cgd4_780
CHO:	Chro.40097
TGO:	TGME49_312230
TET:	TTHERM_00052080 TTHERM_00192100 TTHERM_00456750 TTHERM_00825440 TTHERM_01335310
PTM:	GSPATT00006180001 GSPATT00014565001 GSPATT00029541001 GSPATT00029542001 GSPATT00036041001
SMIN:	v1.2.006137.t1(symbB.v1.2.006137.t1) v1.2.006137.t2(symbB.v1.2.006137.t2) v1.2.006137.t3(symbB.v1.2.006137.t3) v1.2.006138.t1(symbB.v1.2.006138.t1) v1.2.006541.t1(symbB.v1.2.006541.t1) v1.2.011504.t1(symbB.v1.2.011504.t1) v1.2.011504.t2(symbB.v1.2.011504.t2) v1.2.012523.t1(symbB.v1.2.012523.t1) v1.2.012523.t2(symbB.v1.2.012523.t2) v1.2.014754.t1(symbB.v1.2.014754.t1) v1.2.015202.t1(symbB.v1.2.015202.t1) v1.2.015289.t1(symbB.v1.2.015289.t1) v1.2.015327.t1(symbB.v1.2.015327.t1) v1.2.016997.t1(symbB.v1.2.016997.t1) v1.2.033145.t1(symbB.v1.2.033145.t1) v1.2.033147.t1(symbB.v1.2.033147.t1) v1.2.035889.t1(symbB.v1.2.035889.t1) v1.2.035890.t1(symbB.v1.2.035890.t1)
PTI:	PHATRDRAFT_13581 PHATRDRAFT_52174
FCY:	FRACYDRAFT_145893(Top2a_1) FRACYDRAFT_185561(Top2b_1)
TPS:	THAPSDRAFT_263644(TopoII_2) THAPSDRAFT_36420 THAPSDRAFT_36522(TOP2)
AAF:	AURANDRAFT_22331
PIF:	PITG_01300 PITG_07823 PITG_07874
PSOJ:	PHYSODRAFT_559851 PHYSODRAFT_565596
SPAR:	SPRG_03191 SPRG_03642
EHX:	EMIHUDRAFT_451325 EMIHUDRAFT_458166 EMIHUDRAFT_466869
GTT:	GUITHDRAFT_113071 GUITHDRAFT_139486 GUITHDRAFT_158481
TBR:	Tb09.160.4090 Tb11.01.3390
TCR:	506445.60 508277.370 508699.10 509203.70
LMA:	LMJF_15_1290(TOP2) LMJF_28_2280
LIF:	LINJ_15_1310(TOP2) LINJ_28_2450
LDO:	LDBPK_151310 LDBPK_282450
LMI:	LMXM_15_1290 LMXM_28_2280
LBZ:	LBRM_15_1230 LBRM_28_2480
NGR:	NAEGRDRAFT_29557 NAEGRDRAFT_31388
TVA:	TVAG_038880
GLA:	GL50803_16975

» show all

Reference

PMID:2845399

Authors

Tsai-Pflugfelder M, Liu LF, Liu AA, Tewey KM, Whang-Peng J, Knutsen T, Huebner K, Croce CM, Wang JC

Title

Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22.

Journal

Proc Natl Acad Sci U S A 85:7177-81 (1988)
DOI:10.1073/pnas.85.19.7177

Sequence

[hsa:7153 7155]

Reference

PMID:12837248

Authors

Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S

Title

The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome.

Journal

Cell 113:905-17 (2003)
DOI:10.1016/S0092-8674(03)00436-7

Sequence

[hsa:7155]

All links

Ontology (7)   
   KEGG BRITE (4)   
   GO (1)   
   COG (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Drug (49)   
   KEGG DRUG (34)   
   KEGG DGROUP (15)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (22263)   
   KEGG GENES (644)   
   KEGG MGENES (14821)   
   RefGene (6616)   
   EGENES (167)   
   OC (15)   
Protein sequence (650)   
   UniProt (624)   
   SWISS-PROT (26)   
Literature (2)   
   PubMed (2)   
All databases (22974)   

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