KEGG   ORTHOLOGY: K03164Help
Entry
K03164                      KO                                     
Name
TOP2
Definition
DNA topoisomerase II [EC:5.99.1.3]
Brite
Enzymes [BR:ko01000]
 5. Isomerases
  5.99  Other isomerases
   5.99.1  Sole sub-subclass for isomerases that do not belong in the other subclasses
    5.99.1.3  DNA topoisomerase (ATP-hydrolysing)
     K03164  TOP2; DNA topoisomerase II
DNA replication proteins [BR:ko03032]
 Eukaryotic Type
  DNA topo-isomerases
   K03164  TOP2; DNA topoisomerase II
Chromosome [BR:ko03036]
 Eukaryotic Type
  Chromosome condensation proteins
   Other regulators of chromosome condensation
    K03164  TOP2; DNA topoisomerase II
  Centrosomal proteins
   Centriole proteins
    K03164  TOP2; DNA topoisomerase II
BRITE hierarchy
Other DBs
Genes
HSA: 
7153(TOP2A) 7155(TOP2B)
PTR: 
454651(TOP2A) 460232(TOP2B)
PPS: 
100975829(TOP2B) 100996214(TOP2A)
GGO: 
101135259(TOP2B) 101151181(TOP2A)
PON: 
100433973(TOP2A) 100439073(TOP2B)
MCC: 
677709(TOP2B) 700707(TOP2A)
MMU: 
21973(Top2a) 21974(Top2b)
RNO: 
360243(Top2a) 361100(Top2b)
CFA: 
477044(TOP2B) 480525(TOP2A)
AML: 
FCA: 
101083813(TOP2A) 101088949(TOP2B)
BTA: 
282097(TOP2B) 787256(TOP2B) 787696(TOP2A)
SSC: 
100156319(TOP2B) 396917(TOPOII)
ECB: 
100054229 100059572
MDO: 
100016027(TOP2A) 100031654(TOP2B)
SHR: 
100930373(TOP2B) 100934974(TOP2A)
OAA: 
100075740 100090593(TOP2A)
GGA: 
395570(TOP2A) 395966(TOP2B)
MGP: 
100545483
TGU: 
100231174(TOP2B) 100231343(TOP2A)
ACS: 
100562686 100563490
XLA: 
398512(top2a)
XTR: 
100038293(topoii) 779457(top2b)
DRE: 
323733(top2a) 569877(top2b)
TRU: 
101075432 101075827
OLA: 
101157229 101158729
BFO: 
BRAFLDRAFT_67020
CIN: 
751087(ci-htf-1)
SPU: 
578275(top2b)
DME: 
Dmel_CG10223(Top2)
DPO: 
Dpse_GA10169
DAN: 
Dana_GF15632
DER: 
Dere_GG21630
DPE: 
Dper_GL21103
DSE: 
Dsec_GM17008(Dsec_Top2)
DSI: 
Dsim_GD21758(Dsim_Top2)
DWI: 
Dwil_GK24224
DYA: 
Dyak_GE12650
DGR: 
Dgri_GH10628
DMO: 
Dmoj_GI19824
DVI: 
Dvir_GJ18099
AGA: 
AgaP_AGAP008917
AAG: 
AaeL_AAEL012584
CQU: 
CpipJ_CPIJ010018
AME: 
724215(Top2)
NVI: 
100117297(NV10616)
TCA: 
656003
API: 
100167074
PHU: 
Phum_PHUM413330
ISC: 
IscW_ISCW016225
CEL: 
CELE_K12D12.1(top-2) CELE_Y46H3C.4(Y46H3C.4) CELE_ZK1127.7(cin-4)
CBR: 
CBG02746 CBG18156
BMY: 
Bm1_08705 Bm1_44575 Bm1_46835
TSP: 
Tsp_00990
SMM: 
Smp_065840
NVE: 
NEMVE_v1g162970 NEMVE_v1g94148
HMG: 
100214280(top2b)
TAD: 
TRIADDRAFT_23201
AQU: 
100632881
ATH: 
AT3G23890(TOPII)
ALY: 
ARALYDRAFT_898932
GMX: 
100796974
MTR: 
MTR_3g031040
CSV: 
101215950
RCU: 
RCOM_0966810
POP: 
POPTR_557797
VVI: 
100253371
OSA: 
4330426
DOSA: 
Os02t0699700-01(Os02g0699700)
BDI: 
100839516
SBI: 
SORBI_04g030880(SORBIDRAFT_04g030880)
SMO: 
SELMODRAFT_127267 SELMODRAFT_98330
PPP: 
PHYPADRAFT_120620 PHYPADRAFT_134247
CRE: 
CHLREDRAFT_38019(TOP2)
VCN: 
VOLCADRAFT_94598
OLU: 
OSTLU_41836
OTA: 
Ot13g00110
CME: 
CMB013C CML330C
SCE: 
YNL088W(TOP2)
AGO: 
AGOS_AER410W
KLA: 
KLLA0C13838g
LTH: 
KLTH0G08338g
PPA: 
PAS_chr3_0322
VPO: 
Kpol_1002p113
ZRO: 
ZYRO0C15422g
CGR: 
CAGL0J05610g
NCS: 
NCAS_0G02740(NCAS0G02740)
NDI: 
NDAI_0F02550(NDAI0F02550)
TPF: 
TPHA_0C02900(TPHA0C02900)
TBL: 
TBLA_0E03570(TBLA0E03570)
TDL: 
TDEL_0C04170(TDEL0C04170)
KAF: 
KAFR_0J01230(KAFR0J01230)
DHA: 
DEHA2E01738g
PIC: 
PICST_74317(TOP2)
PGU: 
PGUG_04026
LEL: 
LELG_05716
CAL: 
CaO19.10391(TOP2) CaO19.2873(TOP2)
CTP: 
CTRG_03824
CDU: 
CD36_46080(TOP2)
COT: 
CORT_0B01230
YLI: 
YALI0D23969g
CLU: 
CLUG_05525
NCR: 
NCU06338
SMP: 
SMAC_01010(top2)
PAN: 
PODANSg3615
TTT: 
THITE_72528
MTM: 
MYCTH_74764
MGR: 
MGG_06162
FGR: 
FG09801.1
NHE: 
NECHADRAFT_33819
VAL: 
VDBG_00992
SSL: 
SS1G_01930
BFU: 
BC1G_12611
ANI: 
AN5406.2
NFI: 
NFIA_059660
AFM: 
AFUA_6G13690
AOR: 
AOR_1_570034(AO090103000347)
ANG: 
ANI_1_1186074(An08g08550)
AFV: 
AFLA_008840
ACT: 
ACLA_087000
PCS: 
Pc22g00700(top2)
CIM: 
CIMG_02836
CPW: 
CPC735_036030
PBL: 
PAAG_03486
URE: 
UREG_02997
ABE: 
ARB_01513
TVE: 
TRV_04248
AJE: 
HCAG_08644
PNO: 
SNOG_06355
PTE: 
PTT_11728
ZTR: 
MYCGRDRAFT_98287
TML: 
GSTUM_00006716001
SPO: 
SPBC1A4.03c(top2)
CNE: 
CNA03600
CNB: 
CNBA3470
CGI: 
CGB_B4210C
MPR: 
MPER_04586 MPER_07581
CCI: 
CC1G_03723
SCM: 
SCHCODRAFT_17796
UMA: 
UM03501.1
MGL: 
MGL_0413
PGR: 
PGTG_00741
ECU: 
ECU04_0350
EIN: 
Eint_040290
EHE: 
EHEL_040280
NCE: 
NCER_100008
NGR: 
NAEGRDRAFT_29557
DDI: 
DDB_G0270418(top2) DDB_G0279737(top2mt)
DPP: 
DICPUDRAFT_28071 DICPUDRAFT_4475
EHI: 
EHI_120640(138.t00004)
EDI: 
EDI_308810
PFA: 
PF14_0316
PFD: 
PFDG_03941 PFDG_04646
PFH: 
PFHG_00531
PYO: 
PY03394
PCB: 
PC000063.00.0 PC302631.00.0
PBE: 
PB000671.01.0
PKN: 
PKH_131580
PVX: 
PVX_084855
PCY: 
PCYB_132540
TAN: 
TA13325
TPV: 
TP02_0467
BBO: 
BBOV_III004820(17.m07431)
CPV: 
cgd4_780
CHO: 
Chro.40097
TGO: 
TGME49_112230
TET: 
TTHERM_00052080 TTHERM_00456750 TTHERM_00825440 TTHERM_01335310
PTM: 
GSPATT00006180001 GSPATT00014565001 GSPATT00029541001 GSPATT00036041001
TBR: 
Tb09.160.4090 Tb11.01.3390
TCR: 
506445.60 508277.370 508699.10 509203.70
LMA: 
LMJF_15_1290(TOP2) LMJF_28_2280
LIF: 
LINJ_15_1310(TOP2) LINJ_28_2450
LDO: 
LDBPK_151310 LDBPK_282450
LMI: 
LMXM_15_1290 LMXM_28_2280
LBZ: 
LBRM_15_1230 LBRM_28_2480
GLA: 
GL50803_16975
TVA: 
TVAG_038880
PTI: 
PHATRDRAFT_13581 PHATRDRAFT_52174
TPS: 
THAPSDRAFT_263644(TopoII_2) THAPSDRAFT_36420 THAPSDRAFT_36522(TOP2)
PIF: 
PITG_01300 PITG_07874
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S
  Title
The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome.
  Journal
Cell 113:905-17 (2003)
Reference
  Authors
Chen W, Qiu J, Shen YM
  Title
Topoisomerase IIalpha, rather than IIbeta, is a promising target in development of anti-cancer drugs.
  Journal
Drug Discov Ther 6:230-7 (2012)
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