KEGG   ORTHOLOGY: K03176Help
Entry
K03176                      KO                                     

Name
NTRK1, TRKA
Definition
neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
Pathway
MAPK signaling pathway
Endocytosis
Apoptosis
Neurotrophin signaling pathway
Inflammatory mediator regulation of TRP channels
Pathways in cancer
Transcriptional misregulation in cancer
Thyroid cancer
Disease
H00032  
Thyroid cancer
H00043  
Neuroblastoma
H00265  
Hereditary sensory and autonomic neuropathy (HSAN)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
  Cell growth and death
   04210 Apoptosis
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
 Organismal Systems
  Nervous system
   04722 Neurotrophin signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   05202 Transcriptional misregulation in cancers
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   05216 Thyroid cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
Protein kinases [BR:ko01001]
 Tyrosine protein kinases
  Trk family [Table]
   K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
Enzyme-linked receptors [BR:ko01020]
 Receptor tyrosine kinases
  RTK class VII (TRK receptor family)
   K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class VII (TRK receptor family)
   K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
BRITE hierarchy
Genes
HSA: 
4914(NTRK1)
PTR: 
457408(NTRK1)
PPS: 
100995426(NTRK1)
GGO: 
101125993(NTRK1)
PON: 
100452269(NTRK1)
MCC: 
719670(NTRK1)
MCF: 
102129364(NTRK1)
MMU: 
18211(Ntrk1)
RNO: 
59109(Ntrk1)
CGE: 
HGL: 
101724441(Ntrk1)
TUP: 
102485200(NTRK1)
CFA: 
490404(NTRK1)
AML: 
100474165(NTRK1)
FCA: 
101081603(NTRK1)
BTA: 
353111(NTRK1)
BOM: 
102264869(NTRK1)
PHD: 
102316134(NTRK1)
CHX: 
102172584(NTRK1)
SSC: 
100154471(NTRK1)
CFR: 
102518397(NTRK1)
ECB: 
100064594(NTRK1)
MYB: 
102258231(NTRK1)
MYD: 
102765751(NTRK1)
PALE: 
102893370(NTRK1)
MDO: 
100618744(NTRK1)
SHR: 
100916388(NTRK1)
GGA: 
396337(NTRK1)
MGP: 
FAB: 
101810326(NTRK1)
PHI: 
102113646(NTRK1)
FPG: 
FCH: 
CLV: 
ASN: 
102381668(NTRK1)
PSS: 
102456174(NTRK1)
CMY: 
102940175(NTRK1)
ACS: 
XTR: 
100489637(ntrk1)
DRE: 
30546(ntrk1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102354132(NTRK1)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Tacconelli A, Farina AR, Cappabianca L, Desantis G, Tessitore A, Vetuschi A, Sferra R, Rucci N, Argenti B, Screpanti I, Gulino A, Mackay AR
  Title
TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma.
  Journal
Cancer Cell 6:347-60 (2004)
Reference
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)

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