KEGG   ORTHOLOGY: K03176
Entry
K03176                      KO                                     
Symbol
NTRK1, TRKA
Name
neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
Pathway
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04020  Calcium signaling pathway
map04151  PI3K-Akt signaling pathway
map04210  Apoptosis
map04722  Neurotrophin signaling pathway
map04750  Inflammatory mediator regulation of TRP channels
map05200  Pathways in cancer
map05202  Transcriptional misregulation in cancer
map05216  Thyroid cancer
map05230  Central carbon metabolism in cancer
Disease
H00032  Thyroid cancer
H00043  Neuroblastoma
H00265  Hereditary sensory and autonomic neuropathy
H01836  Congenital pain insensitivity with anhidrosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   04014 Ras signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   04020 Calcium signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   04151 PI3K-Akt signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
 09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   05202 Transcriptional misregulation in cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   05230 Central carbon metabolism in cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
  09162 Cancer: specific types
   05216 Thyroid cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  TRK family [OT]
   K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
Genes
HSA: 4914(NTRK1)
PTR: 457408(NTRK1)
GGO: 101125993(NTRK1)
PON: 100452269(NTRK1)
NLE: 100585466(NTRK1)
HMH: 116467918(NTRK1)
MCC: 719670(NTRK1)
MCF: 102129364(NTRK1)
MTHB: 126948042
MNI: 105498076(NTRK1)
CSAB: 103223823(NTRK1)
CATY: 105594539(NTRK1)
PANU: 101012772(NTRK1)
TGE: 112607006(NTRK1)
MLEU: 105548667(NTRK1)
RRO: 104676442(NTRK1)
RBB: 108515538(NTRK1)
TFN: 117076785(NTRK1)
PTEH: 111543817(NTRK1)
CANG: 105502088(NTRK1)
CJC: 103789024(NTRK1)
SBQ: 101035626(NTRK1)
CIMI: 108290257(NTRK1)
CSYR: 103251204(NTRK1)
MMUR: 105873105(NTRK1)
LCAT: 123634790(NTRK1) 123634791
PCOQ: 105821881(NTRK1)
OGA: 100940422(NTRK1)
MMU: 18211(Ntrk1)
MCAL: 110290875(Ntrk1)
MPAH: 110319787(Ntrk1)
RNO: 59109(Ntrk1)
MCOC: 116093096 116094433
ANU: 117707235(Ntrk1)
MUN: 110564977(Ntrk1)
CGE: 100751271(Ntrk1)
MAUA: 101843619(Ntrk1)
PROB: 127232683(Ntrk1)
PLEU: 114683361(Ntrk1)
MORG: 121450738(Ntrk1)
MFOT: 126486514
AAMP: 119800869(Ntrk1)
NGI: 103750263(Ntrk1)
HGL: 101724441(Ntrk1)
CPOC: 100725325(Ntrk1)
CCAN: 109686202(Ntrk1)
DORD: 105996438(Ntrk1)
DSP: 122109658(Ntrk1)
PLOP: 125360177(Ntrk1)
NCAR: 124985938
MMMA: 107156672(Ntrk1)
OCU: 100354292
OPI: 101528482(NTRK1)
TUP: 102485200(NTRK1)
GVR: 103588563(NTRK1)
CFA: 490404(NTRK1)
CLUD: 112648872(NTRK1)
VVP: 112918800(NTRK1)
VLG: 121484071(NTRK1)
NPO: 129509029(NTRK1)
UAH: 113245211(NTRK1)
UAR: 123783398(NTRK1)
ELK: 111138872
LLV: 125085737
MPUF: 101684239(NTRK1)
MNP: 132025841(NTRK1)
MLK: 131814908(NTRK1)
NVS: 122918316(NTRK1)
ORO: 101374117(NTRK1)
EJU: 114198649(NTRK1)
ZCA: 113932722(NTRK1)
MLX: 118013921(NTRK1)
NSU: 110573455 123323631
LWW: 102727057(NTRK1)
FCA: 101081603(NTRK1)
PYU: 121015457(NTRK1)
PBG: 122475682(NTRK1)
PVIV: 125155826(NTRK1)
LRUF: 124521817
PPAD: 109256209(NTRK1)
PUC: 125925658
AJU: 106988854
HHV: 120244665(NTRK1)
BTA: 353111(NTRK1)
BOM: 102264869(NTRK1)
BIU: 109556725(NTRK1)
BBUB: 102402551(NTRK1)
BBIS: 104987347(NTRK1)
CHX: 102172584(NTRK1)
OAS: 101109763(NTRK1)
BTAX: 128044483(NTRK1)
ODA: 120855667(NTRK1)
CCAD: 122431869(NTRK1)
MBEZ: 129540753(NTRK1)
SSC: 100154471(NTRK1)
CFR: 102518397(NTRK1)
CBAI: 105068230(NTRK1)
CDK: 105105672(NTRK1)
VPC: 102543920(NTRK1)
BACU: 103003654(NTRK1)
BMUS: 118886471(NTRK1)
LVE: 103071756(NTRK1)
OOR: 101273503(NTRK1)
DLE: 111167102(NTRK1)
PCAD: 102990275(NTRK1)
PSIU: 116756746(NTRK1)
NASI: 112401754(NTRK1)
ECB: 100064594(NTRK1)
EPZ: 103548862(NTRK1)
EAI: 106828447(NTRK1)
MYD: 102765751(NTRK1)
MMYO: 118673526(NTRK1)
MLF: 102431497(NTRK1)
PKL: 118721515(NTRK1)
EFUS: 103298850(NTRK1)
MNA: 107543738(NTRK1)
DRO: 112315668(NTRK1)
AJM: 119039739(NTRK1)
PDIC: 114489015(NTRK1)
PHAS: 123804735(NTRK1)
MMF: 118637108(NTRK1)
PPAM: 129062360(NTRK1)
HAI: 109393379(NTRK1)
RFQ: 117014296(NTRK1)
PALE: 112472150(NTRK1)
PGIG: 120606120(NTRK1)
PVP: 105296416(NTRK1)
RAY: 107521477(NTRK1)
MJV: 108383338(NTRK1)
TOD: 119236305(NTRK1)
SARA: 101540859(NTRK1)
SETR: 126020472(NTRK1)
LAV: 100668650(NTRK1)
TMU: 101351378
ETF: 101647167(NTRK1)
DNM: 101425856(NTRK1)
MDO: 100618744(NTRK1)
GAS: 123246086(NTRK1)
SHR: 100916388(NTRK1)
AFZ: 127559757
PCW: 110212119(NTRK1)
OAA: 103167743
GGA: 396337(NTRK1)
PCOC: 116237273(NTRK1)
MGP: 100541244(NTRK1)
CJO: 107324385(NTRK1)
TPAI: 128090579(NTRK1)
LMUT: 125685910(NTRK1)
NMEL: 110388022(NTRK1)
CATA: 118258616(NTRK1)
AFUL: 116499797(NTRK1)
TGU: 115498457(NTRK1)
LSR: 110471556(NTRK1)
SCAN: 103824820(NTRK1)
PMOA: 120498961(NTRK1)
OTC: 121332151(NTRK1)
PRUF: 121352173(NTRK1)
GFR: 102039729(NTRK1)
FAB: 101810326(NTRK1)
OMA: 130262596(NTRK1)
PHI: 102113646(NTRK1)
PMAJ: 107214529(NTRK1)
CCAE: 111939539
CBRC: 103611288(NTRK1)
ETL: 114071558(NTRK1)
ZAB: 113460658(NTRK1)
SVG: 106861108(NTRK1)
MMEA: 130584674(NTRK1)
FPG: 101920297(NTRK1)
FCH: 102060232(NTRK1)
CLV: 102086876(NTRK1)
NNI: 104015011(NTRK1)
TALA: 116965970(NTRK1)
AFOR: 103899693
ACHC: 115345406(NTRK1)
HLE: 104829748(NTRK1)
AGEN: 126040546
GCL: 127026894
CSTI: 104556722(NTRK1)
SHAB: 115602793(NTRK1)
RTD: 128900916(NTRK1)
CUCA: 104057097(NTRK1)
AAM: 106495087(NTRK1)
AROW: 112969974(NTRK1)
NPD: 112953544(NTRK1)
DNE: 112990827(NTRK1)
ASN: 102381668(NTRK1)
AMJ: 102568424(NTRK1)
CPOO: 109324023(NTRK1)
GGN: 109298723(NTRK1)
PSS: 102456174(NTRK1)
CMY: 102940175(NTRK1)
CCAY: 125625777(NTRK1)
DCC: 119847779(NTRK1)
CPIC: 101934097(NTRK1)
TST: 117869852(NTRK1)
CABI: 116831884(NTRK1)
MRV: 120390665(NTRK1)
ACS: 100556611(ntrk1)
ASAO: 132764609(NTRK1)
PVT: 110081467(NTRK1)
SUND: 121916146(NTRK1)
PBI: 103064232(NTRK1)
PMUR: 107298512(NTRK1)
TSR: 106540381
PGUT: 117670110(NTRK1)
APRI: 131186552(NTRK1)
PTEX: 113449167(NTRK1)
NSS: 113424285(NTRK1)
PMUA: 114586656(NTRK1)
PRAF: 128403853(NTRK1)
ZVI: 118094598(NTRK1)
HCG: 128337719(NTRK1)
GJA: 107114884(NTRK1)
STOW: 125436340
EMC: 129343303(NTRK1)
XLA: 108699388(ntrk1.L) 108700358(ntrk1.S)
XTR: 100489637(ntrk1)
NPR: 108802180(NTRK1)
RTEM: 120920783(NTRK1)
BBUF: 120981563(NTRK1)
BGAR: 122921449(NTRK1)
MUO: 115458339(NTRK1)
GSH: 117349556(NTRK1)
DRE: 30546(ntrk1)
SRX: 107726660(ntrk1) 107728446
SANH: 107671431 107688245
SGH: 107592146 107592455
CCAR: 109105038 109106243
CAUA: 113059262 113115732
CGIB: 127974828 128031192
PTET: 122360017(ntrk1) 122360019
LROH: 127178297(ntrk1)
OMC: 131521577(ntrk1)
PPRM: 120488019(ntrk1)
RKG: 130077673(ntrk1)
MAMB: 125242834(ntrk1)
CIDE: 127497004
MASI: 127453110 127453586
TROS: 130557490(ntrk1)
TDW: 130432440(ntrk1)
MANU: 129448654(ntrk1)
IPU: 108256584
IFU: 128599510(ntrk1)
PHYP: 113532627(ntrk1)
SMEO: 124403851(ntrk1)
TFD: 113649760(ntrk1)
TVC: 132839973(ntrk1)
AMEX: 103025260(ntrk1)
CMAO: 118798677(ntrk1)
EEE: 113571898(ntrk1)
CHAR: 105891941(ntrk1)
TRU: 101074407(ntrk1)
TFS: 130532640(ntrk1)
TNG: GSTEN00019520G001
LCO: 104933369(ntrk1)
NCC: 104949794(ntrk1)
TBEN: 117468490(ntrk1)
CGOB: 115021582(ntrk1)
PGEO: 117461351(ntrk1)
GACU: 117543250(ntrk1)
EMAC: 134861899(ntrk1)
ELY: 117265685(ntrk1)
EFO: 125892733(ntrk1)
PLEP: 121945177(ntrk1)
SLUC: 116036003(ntrk1)
ECRA: 117945668(ntrk1)
ESP: 116691144(ntrk1)
PFLV: 114557434(ntrk1)
GAT: 120810204(ntrk1)
PPUG: 119197939(ntrk1)
AFB: 129109152(ntrk1)
CLUM: 117728257(ntrk1)
PSWI: 130213198(ntrk1)
MSAM: 119897108(ntrk1)
SCHU: 122881515(ntrk1)
CUD: 121513058(ntrk1)
ALAT: 119005315(ntrk1)
MZE: 101473195(ntrk1)
ONL: 100699013(ntrk1)
OAU: 116315384(ntrk1)
OLA: 101164184(ntrk1)
OML: 112136520(ntrk1)
CSAI: 133438997(ntrk1)
XMA: 102217423
XCO: 114141649(ntrk1)
XHE: 116716954
PRET: 103477579(ntrk1)
PFOR: 103150831
PLAI: 106954407
PMEI: 106919456
GAF: 122830607(ntrk1)
PPRL: 129370914(ntrk1)
CVG: 107101837(ntrk1)
CTUL: 119796673(ntrk1)
GMU: 124865367(ntrk1)
NFU: 107379148(ntrk1)
KMR: 108246005(ntrk1)
ALIM: 106528305(ntrk1)
NWH: 119409238(ntrk1)
AOCE: 111579099(ntrk1)
MCEP: 125015712(ntrk1)
CSEM: 103388944(ntrk1)
POV: 109642014(ntrk1)
SSEN: 122775185(ntrk1)
HHIP: 117776253(ntrk1)
HSP: 118113983(ntrk1)
SMAU: 118285185(ntrk1)
LCF: 108899467
SDU: 111222591(ntrk1)
SLAL: 111655673(ntrk1)
XGL: 120784416(ntrk1)
HCQ: 109512189(ntrk1)
SSCV: 125975659
SBIA: 133500412(ntrk1)
PEE: 133401853(ntrk1)
PTAO: 133480037(ntrk1)
BPEC: 110172749
MALB: 109965566(ntrk1)
BSPL: 114842814(ntrk1)
SJO: 128366649(ntrk1)
SASA: 106581868 106605284
STRU: 115176899 115178403
OTW: 112222988(ntrk1) 112223654
OMY: 110487707(ntrk1) 110503966
OGO: 123997297 124005334
ONE: 115114168 115141105
OKI: 109901732 109908819
OKE: 118364403 118367456
SALP: 111959090 111965133
SNH: 120031620 120048389
CCLU: 121543083(ntrk1)
ELS: 105019278(ntrk1)
SFM: 108926773(ntrk1) 108930374
PKI: 111838441 111853509
AANG: 118234166(ntrk1)
LOC: 102683487(ntrk1)
PSPA: 121309852(ntrk1)
ARUT: 117395629 117970830
PSEX: 120517965(ntrk1)
LCM: 102354132(NTRK1)
LERI: 129694513
BBEL: 109465943
SOC: 105208070
MPHA: 105837008
AEC: 105142993
ACEP: 105627688
HST: 105184311
CFO: 105252670
FEX: 115243626
LHU: 105678901
CSOL: 105359701
FAS: 105267403
AGS: 114133003
PMOO: 119585320
CQD: 128685951
HAZT: 108672725
DSV: 119444986
RSAN: 119379220
RMP: 119176617
VDE: 111246321
VJA: 111268435 111273063
SDM: 118204971
BGT: 106065012
GAE: 121387037
 » show all
Reference
PMID:15488758
  Authors
Tacconelli A, Farina AR, Cappabianca L, Desantis G, Tessitore A, Vetuschi A, Sferra R, Rucci N, Argenti B, Screpanti I, Gulino A, Mackay AR
  Title
TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma.
  Journal
Cancer Cell 6:347-60 (2004)
DOI:10.1016/j.ccr.2004.09.011
  Sequence
[hsa:4914]

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Pathway (22)   
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