KEGG ORTHOLOGY: K03512

ORTHOLOGY: K03512

Entry

K03512                      KO

Symbol

POLL

Name

DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]

Pathway

map03410

Base excision repair

map03450

Non-homologous end-joining

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09124 Replication and repair
   03410 Base excision repair
    K03512  POLL; DNA polymerase lambda
   03450 Non-homologous end-joining
    K03512  POLL; DNA polymerase lambda
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K03512  POLL; DNA polymerase lambda
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     K03512  POLL; DNA polymerase lambda
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Other BER factors
     K03512  POLL; DNA polymerase lambda
  DSBR (double strand breaks repair)
   NHEJ (non-homologous end-joining)
    X-family DNA polymerases
     K03512  POLL; DNA polymerase lambda
DNA polymerases [br01612.html]
DNA polymerases in prokaryotes, eukaryotes and viruses
  K03512

Other DBs

GO:

0003887

Genes

HSA:	27343(POLL)

PTR:	450687(POLL)

PPS:	100978076(POLL)

GGO:	101152688(POLL)

PON:	100458210(POLL)

NLE:	100583874(POLL)

HMH:	116484740(POLL)

MCC:	711924(POLL)

MCF:	101867295(POLL)

MTHB:

126963071

MNI:	105478368(POLL)

CSAB:

103216413(POLL)

CATY:

105581862(POLL)

PANU:

100846950(POLL)

TGE:	112631288(POLL)

MLEU:

105537766(POLL)

RRO:	104656497(POLL)

RBB:	108515127(POLL)

TFN:	117067928(POLL)

PTEH:

111538824(POLL)

CANG:

105507123(POLL)

CJC:	100390308(POLL)

SBQ:	101033540(POLL)

CIMI:

108306332(POLL)

CSYR:

103252770(POLL)

MMUR:

105873944(POLL)

LCAT:

123650105(POLL)

PCOQ:

105824330(POLL)

OGA:	100942496(POLL)

MMU:	56626(Poll)

MCAL:

110285482(Poll)

MPAH:

110326947(Poll)

RNO:	361767(Poll)

MCOC:

116103922(Poll)

ANU:	117704082(Poll)

MUN:	110556236(Poll)

CGE:	100751096(Poll)

MAUA:

101832059(Poll)

PROB:

127233257(Poll)

PLEU:

114708142(Poll)

MORG:

121453805(Poll)

MFOT:

126503244

AAMP:

119805225(Poll)

NGI:	103744002(Poll)

HGL:	101696600(Poll)

CPOC:

100729389(Poll)

CCAN:

109691320(Poll)

DORD:

105986560(Poll)

DSP:	122115896(Poll)

PLOP:

125346140(Poll)

NCAR:

124985148

MMMA:

107149818(Poll)

OCU:

100351030

OPI:	101526219(POLL)

TUP:	102485584(POLL)

GVR:	103598083(POLL)

CFA:	608341(POLL)

CLUD:

112672222(POLL)

VVP:	112915159(POLL)

VLG:	121485697(POLL)

NPO:	129523367(POLL)

AML:	100471165(POLL)

UMR:	103658987(POLL)

UAH:	113251852(POLL)

UAR:	123795889(POLL)

ELK:

111145283

LLV:

125085073

MPUF:

101690817(POLL)

MNP:	132016716(POLL)

MLK:	131828519(POLL)

NVS:	122901036(POLL)

ORO:	101372287(POLL)

EJU:	114205414(POLL)

ZCA:	113920958(POLL)

MLX:	118025220(POLL)

NSU:	110589634(POLL)

FCA:	101084138(POLL)

PYU:	121037139(POLL)

PCOO:

112854456(POLL)

PBG:	122493161(POLL)

PVIV:

125148219(POLL)

LRUF:

124507075

PTG:	102954816(POLL)

PPAD:

109272796(POLL)

PUC:

125932889

AJU:

106966879

HHV:	120243201(POLL)

BTA:	522307(POLL)

BOM:	102280445(POLL)

BIU:	109552987(POLL)

BBUB:

102400301(POLL)

BBIS:

105002693(POLL)

CHX:	100861350(POLL)

OAS:	101102947(POLL)

BTAX:

128067671(POLL)

ODA:	120873544(POLL)

CCAD:

122446006(POLL)

MBEZ:

129555423(POLL)

SSC:	100153781(POLL)

CFR:	102509908(POLL)

CBAI:

105081723(POLL)

CDK:	105084339(POLL)

VPC:	102528120(POLL)

BACU:

103002412(POLL)

BMUS:

118882531(POLL)

LVE:	103068329(POLL)

OOR:	101287047(POLL)

DLE:	111172374(POLL)

PCAD:

102975367(POLL)

PSIU:

116741723(POLL)

NASI:

112393061(POLL)

ECB:	100070125(POLL)

EPZ:	103551397(POLL)

EAI:	106828853(POLL)

MYB:	102249173(POLL)

MYD:	102751765(POLL)

MMYO:

118669826(POLL)

MLF:	102428615(POLL)

PKL:	118718904(POLL)

EFUS:

103288494(POLL)

MNA:	107542640(POLL)

DRO:	112300375(POLL)

SHON:

118999494(POLL)

AJM:	119059693(POLL)

PDIC:

114497927(POLL)

PHAS:

123829094(POLL)

MMF:	118632149(POLL)

PPAM:

129077130(POLL)

HAI:	109379628(POLL)

RFQ:	117035912(POLL)

PALE:

102894809(POLL)

PGIG:

120609172(POLL)

PVP:	105304645(POLL)

RAY:	107497799(POLL)

MJV:	108405918(POLL)

TOD:	119233545(POLL)

SARA:

101540935(POLL)

SETR:

126033838(POLL)

LAV:	100661337(POLL)

TMU:

101346358

ETF:	101660853(POLL)

DNM:	101438287(POLL)

MDO:	100023482(POLL)

GAS:	123236240(POLL)

SHR:	100929690(POLL)

AFZ:

127551498

PCW:	110194590(POLL)

OAA:	100080532(POLL)

GGA:	423853(POLL)

PCOC:

116231694(POLL)

MGP:	100545174(POLL)

CJO:	107316010(POLL)

TPAI:

128077476(POLL)

LMUT:

125693206(POLL)

NMEL:

110399277(POLL)

APLA:

101796177(POLL)

ACYG:

106035621(POLL)

CATA:

118248590(POLL)

AFUL:

116491138(POLL)

TGU:	100226666(POLL)

LSR:	110473588(POLL)

SCAN:

103813870(POLL)

PMOA:

120502027(POLL)

OTC:	121341836(POLL)

PRUF:

121350150(POLL)

GFR:	102040081(POLL)

FAB:	101812248(POLL)

OMA:	130254765(POLL)

PHI:	102101584(POLL)

PMAJ:

107206778(POLL)

CCAE:

111931253(POLL)

CCW:	104695735(POLL)

CBRC:

103624549(POLL)

ETL:	114070479(POLL)

ZAB:	102074270(POLL)

ACHL:

103807530(POLL)

SVG:	106857618(POLL)

MMEA:

130581830(POLL)

HRT:	120756011(POLL)

FPG:	101923241(POLL)

FCH:	102050496(POLL)

CLV:	102083800(POLL)

EGZ:	104125636(POLL)

NNI:	104012624(POLL)

PCRI:

104025787(POLL)

PLET:

104617929(POLL)

EHS:	104511459(POLL)

PCAO:

104040347(POLL)

ACUN:

113481523(POLL)

TALA:

104363027(POLL)

PADL:

103916273(POLL)

AFOR:

103897695(POLL)

ACHC:

115348203(POLL)

HALD:

104319721(POLL)

HLE:	104830117(POLL)

AGEN:

126042595

GCL:

127017648

CCRI:

104160650(POLL)

CSTI:

104551922(POLL)

CMAC:

104487546(POLL)

MUI:	104547401(POLL)

BREG:

104634601(POLL)

FGA:	104081546(POLL)

GSTE:

104252738(POLL)

LDI:	104342850(POLL)

MNB:	103770406(POLL)

OHA:	104337991(POLL)

NNT:	104400652(POLL)

SHAB:

115608034(POLL)

DPUB:

104307088(POLL)

PGUU:

104472236(POLL)

ACAR:

104529383(POLL)

CPEA:

104390873(POLL)

AVIT:

104279890(POLL)

CVF:	104294619(POLL)

RTD:	128911367(POLL)

CUCA:

104059755(POLL)

TEO:	104373954(POLL)

BRHI:

104488460(POLL)

AAM:

106484671

AROW:

112967885(POLL)

NPD:	112957079(POLL)

TGT:	104578760(POLL)

DNE:	112984808(POLL)

SCAM:

104138119(POLL)

ASN:	102381613(POLL)

AMJ:	102568731(POLL)

CPOO:

109324263(POLL)

GGN:	109287548(POLL)

PSS:	102451534(POLL)

CMY:	102947270(POLL)

CCAY:

125639686(POLL)

DCC:	119858178(POLL)

CPIC:

101935622(POLL)

TST:	117879886(POLL)

CABI:

116833944(POLL)

MRV:	120409339(POLL)

ACS:	100558291(poll)

ASAO:

132770881(POLL)

PVT:	110077591(POLL)

SUND:

121926508(POLL)

PBI:	103062692(POLL)

PMUR:

107285274(POLL)

CTIG:

120302576(POLL)

TSR:	106549200(POLL)

PGUT:

117678624(POLL)

APRI:

131201453(POLL)

PTEX:

113436663(POLL)

NSS:	113413733(POLL)

VKO:	123026924(POLL)

PMUA:

114597558(POLL)

PRAF:

128414317(POLL)

ZVI:	118094085(POLL)

HCG:	128351544(POLL)

GJA:	107114449(POLL)

STOW:

125438291(POLL)

EMC:	129332798(POLL)

XLA:	108696155(poll.L)

XTR:	100101731(poll)

NPR:	108794058(POLL)

RTEM:

120947015(POLL)

BBUF:

121003847(POLL)

BGAR:

122919916(POLL)

MUO:

115459069

GSH:	117358719(POLL)

DRE:	406697(poll)

SRX:

107708667

SANH:

107704325

SGH:

107602756

CAUA:

113044411(poll)

CGIB:

127949609

PTET:

122352519(poll)

LROH:

127171838(poll)

OMC:	131539801(poll)

PPRM:

120468872(poll)

RKG:	130087861(poll)

MAMB:

125272364(poll)

CIDE:

127516197

MASI:

127443817

TROS:

130552610(poll)

TDW:	130438717(poll)

MANU:

129444350(poll)

IPU:

108259057

IFU:	128602006(poll)

PHYP:

113537583(poll)

SMEO:

124378501(poll)

TFD:	113663836(poll)

TVC:	132839696(poll)

AMEX:

103047297(poll)

CMAO:

118801961(poll)

EEE:	113577002(poll)

CHAR:

105891046(poll)

TRU:	101065601(poll)

TFS:	130526947(poll)

TNG:	GSTEN00022704G001

LCO:	104921617(poll)

NCC:	104946031(poll)

TBEN:

117474468 117474778

CGOB:

115010487(poll)

PGEO:

117453465(poll)

GACU:

117561600(poll)

EMAC:

134865318(poll)

ELY:	117254558(poll)

EFO:	125885412(poll)

PLEP:

121942152(poll)

SLUC:

116043056(poll)

ECRA:

117937508(poll)

ESP:	116696826(poll)

PFLV:

114569009(poll)

GAT:	120825169(poll)

PPUG:

119217539(poll)

AFB:	129096006(poll)

CLUM:

117736563(poll)

PSWI:

130190070(poll)

MSAM:

119892815 119899575(poll)

SCHU:

122873654(poll)

CUD:	121507994(poll)

ALAT:

119028691(poll)

MZE:	101473944(poll)

ONL:	100699150(poll)

OAU:	116331075(poll)

OLA:	101161125(poll)

OML:	112137283(poll)

CSAI:

133452913(poll)

XMA:	102228851(poll)

XCO:	114144861(poll)

XHE:	116720179(poll)

PRET:

103465121(poll)

PFOR:

103131407(poll)

PLAI:

106939721(poll)

PMEI:

106933733(poll)

GAF:	122829548(poll)

PPRL:

129366865(poll)

CVG:	107090744(poll)

CTUL:

119783317(poll)

GMU:	124863075 124863792

NFU:	107395362(poll)

KMR:	108236311(poll)

ALIM:

106518789(poll)

NWH:	119422845(poll)

AOCE:

111566306(poll)

MCEP:

125003634(polL)

POV:	109627542(poll)

SSEN:

122771543(poll)

HHIP:

117770635(poll)

HSP:	118122812(poll)

SMAU:

118312412(poll)

LCF:

108875602

SDU:	111229383(poll)

SLAL:

111663385 111666620(poll)

XGL:	120800637(poll)

HCQ:	109527313(poll)

SSCV:

125968896

SBIA:

133506128(poll)

PEE:	133404037(poll)

PTAO:

133476429(poll)

BPEC:

110175710(poll)

MALB:

109957981(poll)

BSPL:

114852351(poll)

SJO:	128371209(poll)

SASA:

STRU:

OTW:

OMY:

OGO:

ONE:

OKI:	109887484(poll)

OKE:

118389332

SALP:

112073878

SNH:

120027787

CCLU:

121532623(poll)

ELS:	105012237(poll)

SFM:	108933662(poll)

PKI:	111836988(poll)

AANG:

118220581(poll)

LOC:	102682906(poll)

PSPA:

121321627

ARUT:

117416065

PSEX:

120514436(poll)

LCM:	102345867(POLL)

CMK:	103190566(poll)

RTP:	109923288(poll)

CPLA:

122561277(poll)

HOC:	132826340(poll)

LERI:

129704174(poll)

PMRN:

116941394(POLL)

LRJ:	133345461(POLL)

BFO:

BBEL:

SPU:

LPIC:

APLC:

AJC:

SKO:

HVI:

MQU:

PHU:	Phum_PHUM359150

FOC:

TPAL:

CSEC:

BROR:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

TCF:

DSV:

RSAN:

RMP:	119176604 119182102

CSCU:

SDM:

LPOL:

PMEO:

TSP:

HRO:	HELRODRAFT_161346

LGI:	LOTGIDRAFT_72491

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

NVE:

EPA:

ATEN:

ADF:	107331921 107331924

AMIL:

PDAM:

SPIS:

DGT:

XEN:

TAD:	TRIADDRAFT_28268

AQU:

100640740

ATH:	AT1G10520(Pol{lambda})

ALY:	9325878 9328770

CRB:

17898374

CSAT:

104739664 104755267 104768943

EUS:	EUTSA_v10009477mg

BRP:

BNA:

BOE:

RSZ:

THJ:

CPAP:

CIT:

CIC:	CICLE_v10031184mg

PVY:

MINC:

TCC:

GRA:

GHI:	107901984 107948535

GAB:

HSYR:

DZI:

EGR:

GMX:

GSJ:

PVU:	PHAVU_004G0710000

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:	11418046 25498091

TPRA:

123906784

CAM:

101499677

PSAT:

127119404

VVO:	131646259 131651241 131651256

LJA:	Lj1g3v0627680.1(Lj1g3v0627680.1)

ADU:

107488909

AIP:

107643500

AHF:	112750080 112801052

LANG:

109330533

PCIN:

129323210

QSA:	O6P43_025346

FVE:	101307784 101308082

RCN:	112199835 112200406

PPER:

PMUM:

PAVI:

PDUL:

MDM:

MSYL:

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:	8270388 8280791

JCU:

HBR:

MESC:

POP:

PEU:

PALZ:

JRE:

CILL:

CAVE:

QSU:

QLO:

TWL:	119999850 120001034

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107793193 107817483

NSY:

NTO:

NAU:

INI:

ITR:	116004188 116027911

SIND:

OEU:

EGT:

SSPL:

SMIL:

SHIS:

APAN:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:

BVG:

SOE:

CQI:	110713045 110713687

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

DOSA:

Os06t0237200-00(Os06g0237200)

OBR:

OGL:

BDI:

ATS:

TDC:	119327557 119342063

TAES:

123148969 123156776 123164745

TUA:

125518710

LPER:

127317506

LRD:	124674529 124708371

SBI:

ZMA:

SITA:

SVS:

PVIR:

PHAI:

EGU:

MUS:

ZOF:	121969904 121975009

DCT:

PEQ:

AOF:

MSIN:

NCOL:

ATR:

SMO:	SELMODRAFT_106459 SELMODRAFT_155063 SELMODRAFT_83116 SELMODRAFT_86291

PPP:

112292860

MNG:

MNEG_0586

CSL:	COCSUDRAFT_60646

CVR:	CHLNCDRAFT_138090 CHLNCDRAFT_138091

APRO:

F751_2729

OTA:	OT_ostta09g04280

BPG:	Bathy10g00110

MIS:	MICPUN_59282

MPP:	MICPUCDRAFT_45770(JGI:MicpuC2_45770)

CME:	CYME_CMQ426C

CCP:	CHC_T00005704001

BNN:	FOA43_000660

BBRX:

BRETT_003279

OPA:	HPODL_00479

CNE:

CNI01570

CNB:

CNBH1480

CNG:	CNAG_07766

CGI:	CGB_H2300W

CDEU:

CNBG_2658

TMS:	TREMEDRAFT_26921

TASA:

A1Q1_07852

CCAC:

CcaHIS019_0511040(CcaverHIS019_0511040)

TVS:	TRAVEDRAFT_59518

SHS:	STEHIDRAFT_68704

ADL:	AURDEDRAFT_83573

FME:	FOMMEDRAFT_105006

LBC:	LACBIDRAFT_319108

CCI:	CC1G_01597

ABP:	AGABI1DRAFT122771(AGABI1DRAFT_122771)

ABV:	AGABI2DRAFT227537(AGABI2DRAFT_227537)

MRR:	Moror_16092

E1B28_013753

CPUT:

CONPUDRAFT_63239

SLA:	SERLADRAFT_452929

UMA:	UMAG_00599

MBR:	MONBRDRAFT_39216 MONBRDRAFT_7518

SRE:	PTSG_10190

DFA:

DFA_08207

TET:	TTHERM_00732550

PTM:	GSPATT00008489001 GSPATT00012937001 GSPATT00015723001 GSPATT00027758001

SMIN:

v1.2.007119.t1(symbB.v1.2.007119.t1) v1.2.039928.t1(symbB.v1.2.039928.t1)

NGD:	NGA_0387800(POLL)

PIF:	PITG_03516

PSOJ:

PHYSODRAFT_309246

SPAR:

SPRG_07053

EHX:	EMIHUDRAFT_214242 EMIHUDRAFT_237588

GTT:	GUITHDRAFT_52423

NGR:	NAEGRDRAFT_62711

» show all

Reference

PMID:11457865

Authors

Garcia-Diaz M, Bebenek K, Kunkel TA, Blanco L

Title

Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repair.

Journal

J Biol Chem 276:34659-63 (2001)
DOI:10.1074/jbc.M106336200

Sequence

[hsa:27343]

Reference

PMID:15537631

Authors

Maga G, Ramadan K, Locatelli GA, Shevelev I, Spadari S, Hubscher U

Title

DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A.

Journal

J Biol Chem 280:1971-81 (2005)
DOI:10.1074/jbc.M411650200

Sequence

[hsa:27343]

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