KEGG   ORTHOLOGY: K03875Help
Entry
K03875                      KO                                     

Name
SKP2, FBXL1
Definition
F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
Pathway
FoxO signaling pathway
Cell cycle
Ubiquitin mediated proteolysis
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Small cell lung cancer
Module
M00381  
SCF-SKP2 complex
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
 Environmental Information Processing
  Signal transduction
   04068 FoxO signaling pathway
    K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
   05203 Viral carcinogenesis
    K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
   05222 Small cell lung cancer
    K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
  Infectious diseases
   05168 Herpes simplex infection
    K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
   05169 Epstein-Barr virus infection
    K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
KEGG modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Ubiquitin system
    M00381  SCF-SKP2 complex
     K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  multi subunit Ring-finger type E3
   SCF complex
    target recognizing subunit (F-box)
     K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
BRITE hierarchy
Genes
HSA: 
6502(SKP2)
PTR: 
471570(SKP2)
PPS: 
100978721(SKP2)
GGO: 
101134461(SKP2)
PON: 
100432371(SKP2)
NLE: 
100586655(SKP2)
MCC: 
700617(SKP2)
MCF: 
102114882(SKP2)
CJC: 
100393248(SKP2)
MMU: 
27401(Skp2)
RNO: 
294790(Skp2)
CGE: 
100771396(Skp2)
NGI: 
103741317(Skp2)
HGL: 
101706248(Skp2)
OCU: 
100342452(SKP2)
TUP: 
102497164(SKP2)
CFA: 
489228(SKP2)
AML: 
100480437(SKP2)
UMR: 
103664708(SKP2)
FCA: 
101099275(SKP2)
PTG: 
102964396(SKP2)
BTA: 
BOM: 
102269700(SKP2)
PHD: 
102339171(SKP2)
CHX: 
102172762(SKP2)
OAS: 
101109483(SKP2)
SSC: 
100329128(SKP2)
CFR: 
102523584(SKP2)
BACU: 
103007736(SKP2)
LVE: 
103090160(SKP2)
ECB: 
100053697(SKP2)
MYB: 
102262715(SKP2)
MYD: 
102770564(SKP2)
PALE: 
102880695(SKP2)
MDO: 
100020421(SKP2)
SHR: 
100915218(SKP2)
OAA: 
GGA: 
427437(SKP2)
MGP: 
APLA: 
101802477(SKP2)
TGU: 
100217547(SKP2)
FAB: 
101810388(SKP2)
PHI: 
102109076(SKP2)
FPG: 
101911609(SKP2)
FCH: 
102053148(SKP2)
CLV: 
102084967(SKP2)
ASN: 
102367894(SKP2)
AMJ: 
102558881(SKP2)
PSS: 
102445640(SKP2)
CMY: 
ACS: 
100564206(skp2)
PBI: 
XLA: 
734901(skp2)
XTR: 
100216169(skp2)
DRE: 
563708(skp2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102356499(SKP2)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
412031(Skp2)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_F48E8.7(skpt-1)
CBR: 
CBG05188(Cbr-skpt-1)
LGI: 
NVE: 
HMG: 
ATH: 
AT1G21410(SKP2A) AT1G77000(SKP2B)
ALY: 
CRB: 
EUS: 
BRP: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
POP: 
POPTR_0002s07540g(POPTRDRAFT_830163) POPTR_0005s20800g(POPTRDRAFT_818560)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os01t0881900-01(Os01g0881900) Os05t0425700-01(Os05g0425700)
OBR: 
BDI: 
SBI: 
SORBI_03g041770(SORBIDRAFT_03g041770) SORBI_09g020840(SORBIDRAFT_09g020840)
ZMA: 
100274332(pco067008) 100274363(FBL2)
SITA: 
PDA: 
MUS: 
ATR: 
s00017p00256710(AMTR_s00017p00256710)
SMO: 
PPP: 
CSL: 
MBR: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Nie L, Wu H, Sun XH
  Title
Ubiquitination and degradation of Tal1/SCL are induced by notch signaling and depend on Skp2 and CHIP.
  Journal
J Biol Chem 283:684-92 (2008)
  Sequence
[hsa:6502]
Reference
  Authors
Wang W, Nacusi L, Sheaff RJ, Liu X
  Title
Ubiquitination of p21Cip1/WAF1 by SCFSkp2: substrate requirement and ubiquitination site selection.
  Journal
Biochemistry 44:14553-64 (2005)
  Sequence
[hsa:6502]
Reference
  Authors
Li X, Zhao Q, Liao R, Sun P, Wu X
  Title
The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation.
  Journal
J Biol Chem 278:30854-8 (2003)
  Sequence
[hsa:6502]

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