KEGG   ORTHOLOGY: K03875Help
Entry
K03875                      KO                                     
Name
SKP2, FBXL1
Definition
F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
Pathway
Cell cycle
Ubiquitin mediated proteolysis
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Small cell lung cancer
Module
M00381  
SCF-SKP2 complex
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
   05203 Viral carcinogenesis
    K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
   05222 Small cell lung cancer
    K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
  Infectious diseases
   05168 Herpes simplex infection
    K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
   05169 Epstein-Barr virus infection
    K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
KEGG pathway modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Ubiquitin system
    M00381  SCF-SKP2 complex [BR:ko04121]
     K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  multi subunit Ring-finger type E3
   SCF complex
    target recognizing subunit (F-box)
     K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
BRITE hierarchy
Genes
HSA: 
6502(SKP2)
PTR: 
471570(SKP2)
PPS: 
100978721(SKP2)
GGO: 
101134461(SKP2)
PON: 
100432371(SKP2)
MCC: 
700617(SKP2)
MMU: 
27401(Skp2)
RNO: 
294790(Skp2)
CFA: 
489228(SKP2)
AML: 
100480437(SKP2)
FCA: 
101099275(SKP2)
BTA: 
519018(SKP2) 785617
SSC: 
100329128(SKP2)
ECB: 
100053697(SKP2)
MDO: 
100020421
SHR: 
100915218(SKP2)
OAA: 
100092972
GGA: 
427437(SKP2)
MGP: 
100542923
TGU: 
100217547(SKP2)
ACS: 
100564206
XLA: 
734901(skp2)
XTR: 
100216169(skp2)
DRE: 
563708(skp2)
TRU: 
101066648
OLA: 
101156183
BFO: 
BRAFLDRAFT_281526
CIN: 
100177208
SPU: 
574970
DME: 
Dmel_CG9772(Skp2)
DPO: 
Dpse_GA22024
DAN: 
Dana_GF16815
DER: 
Dere_GG11654
DPE: 
Dper_GL12326
DSE: 
Dsec_GM10708
DSI: 
Dsim_GD19685
DWI: 
Dwil_GK11443
DYA: 
Dyak_GE25359
DGR: 
Dgri_GH18735
DMO: 
Dmoj_GI22887
DVI: 
Dvir_GJ14183
AGA: 
AgaP_AGAP005297
AAG: 
AaeL_AAEL005068
CQU: 
CpipJ_CPIJ003639
AME: 
412031(Skp2)
NVI: 
100121294(NV13547)
TCA: 
657905
API: 
100160074 100574783
PHU: 
Phum_PHUM040260
ISC: 
IscW_ISCW018128
CEL: 
CELE_F48E8.7(skpt-1)
CBR: 
CBG05188(Cbr-skpt-1)
NVE: 
NEMVE_v1g92998
ATH: 
AT1G77000(SKP2B)
ALY: 
ARALYDRAFT_472378 ARALYDRAFT_476863
GMX: 
100788845 100793275 100797840 100818928
CSV: 
101220292 101224575
RCU: 
RCOM_0559620
POP: 
POPTR_818560 POPTR_830163
VVI: 
100255759
OSA: 
4324993 4338850
DOSA: 
Os01t0881900-01(Os01g0881900) Os05t0425700-01(Os05g0425700)
BDI: 
100821602 100822312
SBI: 
SORBI_03g041770(SORBIDRAFT_03g041770) SORBI_09g020840(SORBIDRAFT_09g020840)
ZMA: 
100274332(pco067008) 100274363(FBL2)
SMO: 
SELMODRAFT_133097 SELMODRAFT_133180
PPP: 
PHYPADRAFT_136317
MBR: 
MONBRDRAFT_34230
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW.
  Title
Systematic analysis and nomenclature of mammalian F-box proteins.
  Journal
Genes Dev 18:2573-80 (2004)
Reference
  Authors
Petroski MD, Deshaies RJ.
  Title
Function and regulation of cullin-RING ubiquitin ligases.
  Journal
Nat Rev Mol Cell Biol 6:9-20 (2005)
Reference
  Authors
Frescas D, Pagano M
  Title
Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer.
  Journal
Nat Rev Cancer 8:438-49 (2008)
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