KEGG ORTHOLOGY: K03907

ORTHOLOGY: K03907

Entry

K03907                      KO

Symbol

THBD, CD141

Name

thrombomodulin

Pathway

map04610

Complement and coagulation cascades

map04933

AGE-RAGE signaling pathway in diabetic complications

map05418

Fluid shear stress and atherosclerosis

Disease

H00223

Inherited thrombophilia

H01434

Atypical hemolytic uremic syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K03907  THBD, CD141; thrombomodulin
09160 Human Diseases
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K03907  THBD, CD141; thrombomodulin
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K03907  THBD, CD141; thrombomodulin
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K03907  THBD, CD141; thrombomodulin
   00535 Proteoglycans
    K03907  THBD, CD141; thrombomodulin
   04091 Lectins
    K03907  THBD, CD141; thrombomodulin
CD molecules [BR:ko04090]
Proteins
  K03907  CD141, THBD; thrombomodulin
Proteoglycans [BR:ko00535]
Cell surface proteoglycans
  Others
   K03907  THBD, CD141; thrombomodulin
Lectins [BR:ko04091]
C-Type lectins
  Group 14: Thrombomodulin
   K03907  THBD, CD141; thrombomodulin

Genes

HSA:	7056(THBD)

PTR:	469898(THBD)

PPS:	100971543(THBD)

GGO:	109025156(THBD)

PON:	100443362(THBD)

NLE:	100600139(THBD)

HMH:	116461060(THBD)

MCC:	702132(THBD)

MCF:	102125064(THBD)

MTHB:

126929294

MNI:	105486771(THBD)

CSAB:

103215390(THBD)

CATY:

105581992(THBD)

PANU:

101014198(THBD)

TGE:	112633354(THBD)

MLEU:

105531841(THBD)

RRO:	104666929(THBD)

RBB:	108520664(THBD)

TFN:	117068372(THBD)

PTEH:

111526269(THBD)

CANG:

105527122(THBD)

CJC:	100390722(THBD)

SBQ:	101028591(THBD)

CIMI:

108313167(THBD)

CSYR:

110595802(THBD)

MMUR:

105857103(THBD)

LCAT:

123622597(THBD)

PCOQ:

105817449(THBD)

OGA:	100951808(THBD)

MMU:	21824(Thbd)

MCAL:

110289967(Thbd)

MPAH:

110318522(Thbd)

RNO:	83580(Thbd)

MCOC:

116091098(Thbd)

ANU:	117703873(Thbd)

MUN:	110555879(Thbd)

CGE:	100765076(Thbd)

MAUA:

101835849(Thbd)

PROB:

127221327(Thbd)

PLEU:

114701694(Thbd)

MORG:

121460510(Thbd)

MFOT:

126512021

AAMP:

119814570(Thbd)

NGI:	103737551(Thbd)

HGL:	101700359(Thbd)

CPOC:

100723479(Thbd)

CCAN:

109695757(Thbd)

DORD:

105993713(Thbd)

DSP:	122096106(Thbd)

PLOP:

125353195(Thbd)

NCAR:

124977743

MMMA:

107140439(Thbd)

OCU:	100008887(THBD)

OPI:	101516184(THBD)

TUP:	102478284(THBD)

GVR:	103603310(THBD)

CFA:	474355(THBD)

CLUD:

112673476(THBD)

VVP:	112922667(THBD)

VLG:	121477882(THBD)

NPO:	129498673(THBD)

AML:	100467359(THBD)

UMR:	103677878(THBD)

UAH:	113246768(THBD)

UAR:	123779060(THBD)

ELK:

111141662

LLV:

125109432

MPUF:

101680062(THBD)

MNP:	132021684(THBD)

MLK:	131808224(THBD)

NVS:	122916318(THBD)

ORO:	101384524(THBD)

EJU:	114224507(THBD)

ZCA:	113938048(THBD)

MLX:	118011182(THBD)

NSU:	110589993(THBD)

LWW:	102748874(THBD)

FCA:	100049012(THBD)

PYU:	121012563(THBD)

PCOO:

112869324(THBD)

PBG:	122496635(THBD)

PVIV:

125162865(THBD)

LRUF:

124504260

PTG:	102952222(THBD)

PPAD:

109274650(THBD)

PUC:

125936862

AJU:

106988194

HHV:	120222957(THBD)

BTA:	281529(THBD)

BOM:	102277164(THBD)

BIU:	109568053(THBD)

BBUB:

102408111(THBD)

BBIS:

104985953(THBD)

CHX:	102182609(THBD)

OAS:	101103256(THBD)

BTAX:

128058329(THBD)

ODA:	120869507(THBD)

CCAD:

122448458(THBD)

MBEZ:

129559262(THBD)

SSC:	100157642(THBD)

CFR:	116657896(THBD)

CBAI:

105083203(THBD)

CDK:	105106290(THBD)

BACU:

103012848(THBD)

BMUS:

118881460(THBD)

LVE:	103086739(THBD)

OOR:	101284582(THBD)

DLE:	111185044(THBD)

PCAD:

102973124(THBD)

PSIU:

116740802(THBD)

NASI:

112403367(THBD)

ECB:	100146206(THBD)

EPZ:	103565362(THBD)

EAI:	106841803(THBD)

MYB:	102242682(THBD)

MYD:	102761233(THBD)

MMYO:

118663077(THBD)

MLF:	102427878(THBD)

PKL:	118707756(THBD)

EFUS:

103285716(THBD)

MNA:	107536268(THBD)

DRO:	112304194(THBD)

SHON:

118994364(THBD)

AJM:	119057518(THBD)

PDIC:

114506716(THBD)

PHAS:

123815232(THBD)

MMF:	118618914(THBD)

PPAM:

129070102(THBD)

HAI:	109390443(THBD)

RFQ:	117016159(THBD)

PALE:

102892208(THBD)

PGIG:

120611835(THBD)

PVP:	105307976(THBD)

RAY:	107516388(THBD)

MJV:	108396921(THBD)

TOD:	119231989(THBD)

SARA:

101537488(THBD)

SETR:

126011486(THBD)

LAV:	100666649(THBD)

TMU:

101353397

ETF:	101658762(THBD)

DNM:	101429348(THBD)

MDO:	100033239(THBD)

GAS:	123234778(THBD)

SHR:	100916254(THBD)

AFZ:

127548428

PCW:	110208810(THBD)

OAA:	100078930(THBD)

GGA:	101752029(THBD)

PCOC:

116231835(THBD)

MGP:

104909486

CJO:	107310744(THBD)

NMEL:

110396122(THBD)

ACYG:

106042246(THBD)

CATA:

118257468(THBD)

AFUL:

116487083(THBD)

TGU:	115494442(THBD)

LSR:	110474315(THBD)

SCAN:

115484935(THBD)

PMOA:

120505982(THBD)

OTC:	121342643(THBD)

PRUF:

121357121(THBD)

FAB:	101820274(THBD)

OMA:	130251468(THBD)

PHI:	102101341(THBD)

PMAJ:

107201363(THBD)

CCW:	120411742(THBD)

ETL:	114071383(THBD)

SVG:	106865146(THBD)

MMEA:

130582828(THBD)

HRT:	120751158(THBD)

FPG:	106112352(THBD)

FCH:	102053084(THBD)

CLV:	102092796(THBD)

NNI:	104022458(THBD)

TALA:

116960773(THBD)

ACHC:

115345030(THBD)

HLE:	104836460(THBD)

AGEN:

126038832

GCL:

127014411

LDI:	104347440(THBD)

SHAB:

115609849(THBD)

DPUB:

104298603(THBD)

RTD:	128907872(THBD)

AAM:

106487077

AROW:

112963288(THBD)

NPD:	112947219(THBD)

DNE:

112986660

SCAM:

104142953(THBD)

ASN:	102380951(THBD) 102381191

AMJ:	102573031(THBD) 106738222

CPOO:

109316197(THBD)

GGN:	109296460(THBD) 109296633

PSS:	102461635 106731484

CMY:	114021528(THBD)

CCAY:

125633351(THBD)

DCC:	119853998(THBD)

CPIC:

101951481(THBD)

TST:	117874200(THBD)

CABI:

116834064(THBD)

MRV:	120400119(THBD)

PVT:

110089605

SUND:

121929963(THBD)

PBI:	103055128(THBD)

PMUR:

107297751(THBD)

CTIG:

120301726(THBD)

PGUT:

117662372(THBD)

APRI:

131195736(THBD)

PMUA:

114601211(THBD)

PRAF:

128418080(THBD)

ZVI:	118077647(THBD)

HCG:	128321955(THBD)

GJA:	107116082(THBD)

STOW:

125443275(THBD)

EMC:	129333822(THBD)

XLA:	108716407(thbd.S) 108717752

XTR:	100485229(thbd) 100497748

NPR:	108795275(THBD) 108795284

RTEM:

120938021 120938022

BBUF:

120998882 120998883

BGAR:

122936376(THBD)

MUO:	115465653(THBD)

GSH:	117358058(THBD)

DRE:	108180329(thbd)

SRX:	107712573 107732497 107739226

SANH:

107664495 107669416 107704048

SGH:	107559112 107577146

CCAR:

109099378 109113504

CAUA:

113068533 113117057 113120576

CGIB:

127938260 127984061

PTET:

122325458(thbd)

LROH:

127151854(thbd) 127151855

OMC:	131527556(thbd)

PPRM:

120492096(thbd)

RKG:	130096149(thbd)

MAMB:

125278547(thbd)

CIDE:

127501830

MASI:

127409661 127416318

TROS:

130565393(thbd)

TDW:	130434407(thbd)

MANU:

129429567 129429568

IPU:	108274163(thbd)

IFU:	128617120(thbd)

PHYP:

113529146

SMEO:

124401273(thbd)

TFD:	113643401(thbd)

TVC:	132854588(thbd)

AMEX:

103037465(thbd)

CMAO:

118815850(thbd)

EEE:

113572121

TRU:	101067120 101067342 115253072

TFS:	130515869 130516083 130516084

TNG:	GSTEN00011332G001 GSTEN00011333G001

LCO:	104927237 104927238

NCC:	104954603 104954605

TBEN:

117498589 117498619

CGOB:

115028859 115028860

PGEO:

117439741 117439742 117439981

GACU:

117554165(thbd) 117554174

EMAC:

134876652 134877014

ELY:	117270315 117270453(thbd)

EFO:	125897377(thbd) 125897382

PLEP:

121955596(thbd) 121955631

SLUC:

116047008 116047009

ECRA:

117961262 117961265

ESP:	116706530 116706531

PFLV:

114573286(thbd) 114573289

GAT:	120808236 120808237(thbd)

PPUG:

119194867 119194868(thbd)

AFB:	129106949(thbd) 129107235

CLUM:

117727475 117727624

PSWI:

130202545 130202627(thbd)

MSAM:

119908791(thbd) 119908792

SCHU:

122863661 122863662

CUD:	121521028(thbd) 121521281

ALAT:

119012764(thbd) 119012765

MZE:

101486834

ONL:

102081914

OAU:	116325910(thbd)

OLA:

110017766

OML:	112158147 118598120

CSAI:

133418418 133464506

XMA:	102232492 106700080

XCO:	114158562 114158563

XHE:	116733831 116733832

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122825392 122825865

PPRL:

129368915(thbd) 129369270

CVG:	107080874 107080875 107100250

CTUL:

119772549(thbd)

GMU:	124881836 124882230

NFU:

107378228

KMR:	108245477(thbd) 108245478

ALIM:

106526865 106526883

NWH:	119418748(thbd) 119418749

AOCE:

111567867 111575405 111587032

CSEM:

103398571 103398572

POV:	109632510 109632511

SSEN:

122784244 122784245(thbd)

HHIP:

117758467 117758546(thbd)

HSP:	118099740 118099776

SMAU:

118290122 118290123(thbd)

LCF:	108895806 108895807 108897538

SDU:	111238070 111238082

SLAL:

111661441 111661442

XGL:	120789104 120789105

HCQ:	109531752 109531753

SSCV:

125990666

SBIA:

133496166(thbd) 133496167

PEE:	133416963(thbd) 133416992

PTAO:

133468412(thbd) 133468413

BPEC:

110154729 110159215

MALB:

109969811

BSPL:

114849591(thbd) 114849592

SJO:	128376800 128377531 128377532

SASA:

106571465 106607879 106611383

STRU:

115174716 115174717 115191864

OTW:	112217654(thbd) 112256943

OMY:

110505908

OGO:	123990817 123995148

ONE:	115107820 115140475

OKE:	118386971 118398598

SALP:

111972525 112068753 112068754 112069499

SNH:	120024577 120024578

CCLU:

121549271 123482698

ELS:	105017602 105017603 106024670

SFM:	108929237 108934164

PKI:	111837528 111858003

AANG:

118223227 118228796(thbd)

LOC:	102692457 107077740

PSPA:

121315945 121317068 121317069 121317070

ARUT:

117402496 117410788 117410789 117410790

LCM:	102348480 102349806 106701781

CMK:

103179315

LERI:

129699305(thbd)

» show all

Reference

PMID:2820710

Authors

Suzuki K, Kusumoto H, Deyashiki Y, Nishioka J, Maruyama I, Zushi M, Kawahara S, Honda G, Yamamoto S, Horiguchi S

Title

Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation.

Journal

EMBO J 6:1891-7 (1987)
DOI:10.1002/j.1460-2075.1987.tb02448.x

Sequence

[hsa:7056]

Reference

PMID:21041299

Authors

Mosnier LO

Title

Platelet factor 4 inhibits thrombomodulin-dependent activation of thrombin-activatable fibrinolysis inhibitor (TAFI) by thrombin.

Journal

J Biol Chem 286:502-10 (2011)
DOI:10.1074/jbc.M110.147959

Sequence

[hsa:7056]

All links

Ontology (4)   
   KEGG BRITE (4)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (2)   
   KEGG DISEASE (2)   
Gene (474)   
   KEGG GENES (453)   
   KEGG MGENES (10)   
   RefGene (7)   
   OC (4)   
Literature (2)   
   PubMed (2)   
All databases (488)   

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