KEGG   ORTHOLOGY: K04097
Entry
K04097                      KO                                     
Symbol
HPGDS
Name
prostaglandin-H2 D-isomerase / glutathione transferase [EC:5.3.99.2 2.5.1.18]
Pathway
map00480  Glutathione metabolism
map00590  Arachidonic acid metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map05204  Chemical carcinogenesis - DNA adducts
Reaction
R02266  (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13- dienoate D-isomerase
R03522  RX:glutathione R-transferase
R07002  (1R)-hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene glutathione-lyase (epoxide-forming)
R07003  (1R)-glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene glutathione-lyase (epoxide-forming)
R07004  (1S)-hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene glutathione-lyase (epoxide-forming)
R07023  1-nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene glutathione-lyase (epoxide-forming)
R07024  1-nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene glutathione-lyase (epoxide-forming)
R07025  1-nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene glutathione-lyase (epoxide-forming)
R07026  1-nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene glutathione-lyase (epoxide-forming)
R07069  3,4-dihydro-3-hydroxy-4-S-glutathionyl bromobenzene glutathione-lyase (epoxide-forming)
R07070  2,3-dihydro-2-S-glutathionyl-3-hydroxy bromobenzene glutathione-lyase (epoxide-forming)
R07083  4,5-dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene glutathione-lyase (epoxide-forming)
R07084  7,8-dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene hydrolase
R07091  S-(2,2-dichloro-1-hydroxy)ethyl-glutathione 2,2-dichloroacetaldehyde-lyase (glutathione-forming)
R07092  1,1-dichloroethylene-epoxide:glutathione S-(chloroepoxyethyl)transferase [2-(S-glutathionyl)acetyl-chloride-forming]
R07093  chloroacetyl-chloride:glutathione S-chloroacetyltransferase
R07094  2-(S-glutathionyl)acetyl-chloride:glutathione 2-(S-glutathionyl)acetyltransferase
R07100  trichloroethene:glutathione S-(1,2-dichlorovinyl)transferase
R07113  1,2-dibromoethane:glutathione ethylenetransferase (episulfonium-forming)
R07116  2-bromoacetaldehyde:glutathione S-(formylmethyl)transferase
R08280  4-glutathionyl cyclophosphamide hydrolase
R09409  glutathione-S-transferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K04097  HPGDS; prostaglandin-H2 D-isomerase / glutathione transferase
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    K04097  HPGDS; prostaglandin-H2 D-isomerase / glutathione transferase
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K04097  HPGDS; prostaglandin-H2 D-isomerase / glutathione transferase
   00982 Drug metabolism - cytochrome P450
    K04097  HPGDS; prostaglandin-H2 D-isomerase / glutathione transferase
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K04097  HPGDS; prostaglandin-H2 D-isomerase / glutathione transferase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     K04097  HPGDS; prostaglandin-H2 D-isomerase / glutathione transferase
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.99  Other intramolecular oxidoreductases
    5.3.99.2  prostaglandin-D synthase
     K04097  HPGDS; prostaglandin-H2 D-isomerase / glutathione transferase
Other DBs
GO: 0004667 0004364
Genes
HSA: 27306(HPGDS)
PTR: 743219(HPGDS)
PPS: 100990241(HPGDS)
GGO: 101123835(HPGDS)
PON: 100442014(HPGDS)
NLE: 100598180(HPGDS)
HMH: 116458594(HPGDS)
MCC: 705227(HPGDS)
MCF: 102131661(HPGDS)
MTHB: 126955635
MNI: 105479614(HPGDS)
CSAB: 103235987(HPGDS)
CATY: 105572356(HPGDS)
PANU: 101004192(HPGDS)
TGE: 112624964(HPGDS)
MLEU: 105530611(HPGDS)
RRO: 104679857(HPGDS)
RBB: 108531868(HPGDS)
TFN: 117085686(HPGDS)
PTEH: 111527138(HPGDS)
CANG: 105505120(HPGDS)
CJC: 100399167(HPGDS)
SBQ: 101048967(HPGDS)
CIMI: 108313832(HPGDS)
CSYR: 103257094(HPGDS)
MMUR: 105870772(HPGDS)
LCAT: 123627259(HPGDS)
PCOQ: 105812657(HPGDS)
OGA: 100962092(HPGDS)
MMU: 54486(Hpgds)
MCAL: 110295631(Hpgds)
MPAH: 110317199(Hpgds)
RNO: 58962(Hpgds)
MCOC: 116099006(Hpgds)
ANU: 117715576(Hpgds)
MUN: 110564343(Hpgds)
CGE: 100768035(Hpgds)
MAUA: 101832464(Hpgds)
PROB: 127235688(Hpgds)
PLEU: 114700915(Hpgds)
MORG: 121443234(Hpgds)
MFOT: 126513776
AAMP: 119807046(Hpgds)
NGI: 103743362(Hpgds)
HGL: 101706734(Hpgds)
CPOC: 100734640(Hpgds)
DORD: 105995855(Hpgds)
DSP: 122127126(Hpgds)
PLOP: 125341516(Hpgds)
NCAR: 124994390
MMMA: 107141326(Hpgds)
OCU: 100353701
OPI: 101519374(HPGDS)
TUP: 102485301(HPGDS)
GVR: 103594616(HPGDS)
CFA: 478481(HPGDS)
CLUD: 112645244(HPGDS)
VVP: 112932672(HPGDS)
VLG: 121492802(HPGDS)
NPO: 129501950(HPGDS)
AML: 100466392(HPGDS)
UMR: 103677906(HPGDS)
UAH: 113263135(HPGDS)
UAR: 123788557(HPGDS)
ELK: 111157708
LLV: 125093188
MPUF: 101684441(HPGDS)
MNP: 132014046(HPGDS)
MLK: 131830401(HPGDS)
NVS: 122889383(HPGDS)
ORO: 101376365(HPGDS)
EJU: 114220104(HPGDS)
ZCA: 113924932(HPGDS)
MLX: 118010320(HPGDS)
NSU: 110572125(HPGDS)
LWW: 102750153(HPGDS)
FCA: 101083337(HPGDS)
PYU: 121032347(HPGDS)
PCOO: 112858778(HPGDS)
PBG: 122478610(HPGDS)
PVIV: 125163637(HPGDS)
LRUF: 124520583
PTG: 102970849(HPGDS)
PPAD: 109275800(HPGDS)
PUC: 125922941
AJU: 106988526
HHV: 120237855(HPGDS)
BTA: 100139892(HPGDS)
BOM: 102269024(HPGDS)
BIU: 109559997(HPGDS)
BBUB: 102404824(HPGDS)
BBIS: 104994683(HPGDS)
CHX: 102191223(HPGDS)
OAS: 101116145(HPGDS)
BTAX: 128050041(HPGDS)
ODA: 120861926(HPGDS)
CCAD: 122422306(HPGDS)
MBEZ: 129561497(HPGDS)
SSC: 100623584(HPGDS)
CFR: 102513633(HPGDS)
CBAI: 105067880(HPGDS)
CDK: 105089526(HPGDS)
VPC: 102533844(HPGDS)
BACU: 103019771(HPGDS)
BMUS: 118896028(HPGDS)
LVE: 103079273(HPGDS)
OOR: 101285619(HPGDS)
DLE: 111179078(HPGDS)
PCAD: 102992900(HPGDS)
PSIU: 116754407(HPGDS)
NASI: 112393840(HPGDS)
ECB: 100053460(HPGDS)
EPZ: 103552392(HPGDS)
EAI: 106829529(HPGDS)
MYB: 102240667(HPGDS)
MYD: 102767586(HPGDS)
MMYO: 118655408(HPGDS)
MLF: 102425719(HPGDS)
PKL: 118703961(HPGDS)
EFUS: 103287844(HPGDS)
MNA: 107532072(HPGDS)
DRO: 112317839(HPGDS)
SHON: 118987041(HPGDS)
AJM: 119045375(HPGDS)
PDIC: 114492842(HPGDS)
PHAS: 123806942(HPGDS)
MMF: 118643101(HPGDS)
PPAM: 129085347(HPGDS)
HAI: 109385325(HPGDS)
RFQ: 117021896(HPGDS)
PALE: 102895654(HPGDS)
PGIG: 120588327(HPGDS)
PVP: 105289548(HPGDS)
RAY: 107510631(HPGDS)
MJV: 108393953(HPGDS)
TOD: 119260659(HPGDS)
SARA: 101540852(HPGDS)
SETR: 126032328(HPGDS)
LAV: 100666840(HPGDS)
TMU: 101346527
ETF: 101660770(HPGDS)
DNM: 101418256(HPGDS)
MDO: 100016454(HPGDS)
GAS: 123251287(HPGDS)
SHR: 100926080(HPGDS)
AFZ: 127541184
PCW: 110223073(HPGDS)
OAA: 100078645(HPGDS)
GGA: 395863(HPGDS)
PCOC: 116238035(HPGDS)
MGP: 100541600 104910670(HPGDS)
CJO: 107313254(HPGDS)
TPAI: 128079997(HPGDS)
LMUT: 125691684(HPGDS)
NMEL: 110397718(HPGDS)
APLA: 101796320(HPGDS)
ACYG: 106041241(HPGDS)
CATA: 118244204(HPGDS)
AFUL: 116489226(HPGDS)
TGU: 100224496(HPGDS)
LSR: 110481595(HPGDS)
SCAN: 103826041(HPGDS)
PMOA: 120502745(HPGDS)
OTC: 121346553(HPGDS)
PRUF: 121362601(HPGDS)
GFR: 102044676(HPGDS)
FAB: 101817277(HPGDS)
OMA: 130252655(HPGDS)
PHI: 102102732(HPGDS)
PMAJ: 107203035(HPGDS)
CCAE: 111928487(HPGDS)
CCW: 104697200(HPGDS)
CBRC: 103622381(HPGDS)
ETL: 114067155(HPGDS)
ZAB: 102070416(HPGDS)
ACHL: 103798277(HPGDS)
SVG: 106852568(HPGDS)
MMEA: 130573821(HPGDS)
HRT: 120752995(HPGDS)
FPG: 101913476(HPGDS)
FCH: 102054810(HPGDS)
CLV: 102094022(HPGDS)
EGZ: 104122621(HPGDS)
NNI: 104021198(HPGDS)
PCRI: 104027480
PLET: 104627759(HPGDS)
EHS: 104513643(HPGDS)
PCAO: 104048627(HPGDS)
ACUN: 113479530(HPGDS)
TALA: 104369440(HPGDS)
PADL: 103921746(HPGDS)
AFOR: 103894200(HPGDS)
ACHC: 115339733(HPGDS)
HALD: 104318133(HPGDS)
HLE: 104843304(HPGDS)
AGEN: 126044809
GCL: 127015810
CCRI: 104162782(HPGDS)
CSTI: 104553511(HPGDS)
MUI: 104534401(HPGDS)
BREG: 104635870(HPGDS)
FGA: 104080885(HPGDS)
GSTE: 104259109(HPGDS)
LDI: 104344725(HPGDS)
MNB: 103774128(HPGDS)
OHA: 104331637(HPGDS)
NNT: 104403588(HPGDS)
SHAB: 115610580(HPGDS)
DPUB: 104299135(HPGDS)
ACAR: 104528555(HPGDS)
CPEA: 104392010(HPGDS)
AVIT: 104275729(HPGDS)
CVF: 104284634(HPGDS)
RTD: 128910076(HPGDS)
CUCA: 104060905(HPGDS)
TEO: 104374123(HPGDS)
BRHI: 104501785(HPGDS)
AAM: 106491909(HPGDS)
AROW: 112974835(HPGDS)
NPD: 112949061(HPGDS)
TGT: 104573713(HPGDS)
DNE: 112984520(HPGDS)
SCAM: 104143793(HPGDS)
ASN: 102384182(HPGDS)
AMJ: 102574977(HPGDS)
CPOO: 109322344(HPGDS)
GGN: 109304080(HPGDS)
PSS: 102450743(HPGDS)
CMY: 102944217(HPGDS)
CCAY: 125635430(HPGDS)
DCC: 119854880(HPGDS)
CPIC: 101943956(HPGDS)
TST: 117877704(HPGDS)
CABI: 116814755(HPGDS)
MRV: 120406752(HPGDS)
XLA: 379417(hpgds.S) 398969(hpgds.L)
XTR: 448666(hpgds)
BBUF: 120989820(HPGDS) 120989866
BGAR: 122925492(HPGDS)
MUO: 115461113(HPGDS)
SASA: 100196042(hpgds)
STRU: 115164976(hpgds)
OTW: 112248322
OMY: 110525250
OGO: 124034646
ONE: 115111261(hpgds)
OKI: 109875212(hpgds)
OKE: 118371126
SALP: 111973822(hpgds)
SNH: 120044662
CCLU: 121584393
ELS: 105014622(hpgds)
LOC: 102686400(hpgds)
PSPA: 121328178
ARUT: 117408430
PSEX: 120527556
LCM: 102352378(HPGDS)
CMK: 103184489
RTP: 109912194(gstp1.1)
CPLA: 122539497
HOC: 132833365
LERI: 129700792
PMRN: 116950915(HPGDS)
LRJ: 133354392(HPGDS)
DME: Dmel_CG8938(GstS1)
DER: 6548275
DSI: Dsimw501_GD25495(Dsim_GD25495)
DSR: 110182597
DPO: 4805388
DPE: 6592395
DWI: 6646015
DGR: 6561326
DAZ: 108616338
DNV: 108654342
DHE: 111595404
CCAT: 101458129
BOD: 106615995
BDR: 105228691
RZE: 108369393
AOQ: 129245965
TDA: 119685720
MDE: 101890455(GST) 131805341
SCAC: 106084338
LCQ: 111687996
GFS: 119636186
ECOE: 129949879
CLON: 129606541
HIS: 119656068
ACOZ: 120956136
AARA: 120901071
ASTE: 118507916
AFUN: 125769461
AMOU: 128297021
AALI: 118462638
AAG: 5575278
AALB: 109401280
CPII: 120424451
AME: 411045(GstS4) 552283 552304(GstS1)
CSET: 123312992
BMOR: 692543(GSTs2) 692631(GSTs1)
RMP: 119171407
VDE: 111253932
VJA: 111259404
CSCU: 111638117
PTEP: 107450189
UDV: 129217827
CEL: CELE_C02A12.1(gst-33) CELE_R11G1.3(gst-11) CELE_ZK546.11(gst-30)
CBR: CBG_02278(Cbr-gst-30) CBG_14247(Cbr-gst-11) CBG_22411(Cbr-gst-33)
EGL: EGR_04787
MPP: MICPUCDRAFT_15637(JGI:MicpuC2_15637) MICPUCDRAFT_26627(JGI:MicpuC2_26627) MICPUCDRAFT_58725(JGI:MicpuC2_58725)
SLA: SERLADRAFT_417671(glt1.1)
SMIN: v1.2.000995.t1(symbB.v1.2.000995.t1) v1.2.003070.t1(symbB.v1.2.003070.t1) v1.2.014814.t1(symbB.v1.2.014814.t1) v1.2.014815.t1(symbB.v1.2.014815.t1) v1.2.017551.t1(symbB.v1.2.017551.t1) v1.2.017577.t1(symbB.v1.2.017577.t1)
SAZ: Sama_0385
SAGA: M5M_17045
RFR: Rfer_3267
MCG: GL4_2957
 » show all
Reference
  Authors
Kanaoka Y, Fujimori K, Kikuno R, Sakaguchi Y, Urade Y, Hayaishi O
  Title
Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Conservation of the ancestral genomic structure of sigma-class glutathione S-transferase.
  Journal
Eur J Biochem 267:3315-22 (2000)
DOI:10.1046/j.1432-1327.2000.01362.x
  Sequence
[hsa:27306] [mmu:54486]
Reference
  Authors
Pinzar E, Miyano M, Kanaoka Y, Urade Y, Hayaishi O
  Title
Structural basis of hematopoietic prostaglandin D synthase activity elucidated by site-directed mutagenesis.
  Journal
J Biol Chem 275:31239-44 (2000)
DOI:10.1074/jbc.M000750200

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