KEGG   ORTHOLOGY: K04345Help
Entry
K04345                      KO                                     
Name
PKA
Definition
protein kinase A [EC:2.7.11.11]
Pathway
MAPK signaling pathway
Calcium signaling pathway
Chemokine signaling pathway
Meiosis - yeast
Oocyte meiosis
Apoptosis
Vascular smooth muscle contraction
Wnt signaling pathway
Hedgehog signaling pathway
Gap junction
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Olfactory transduction
Taste transduction
Insulin signaling pathway
Insulin secretion
GnRH signaling pathway
Ovarian steroidogenesis
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Endocrine and other factor-regulated calcium reabsorption
Vasopressin-regulated water reabsorption
Salivary secretion
Gastric acid secretion
Bile secretion
Prion diseases
Cocaine addiction
Amphetamine addiction
Morphine addiction
Vibrio cholerae infection
Amoebiasis
HTLV-I infection
Epstein-Barr virus infection
Viral carcinogenesis
Proteoglycans in cancer
Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04345  PKA; protein kinase A
   04310 Wnt signaling pathway
    K04345  PKA; protein kinase A
   04340 Hedgehog signaling pathway
    K04345  PKA; protein kinase A
   04020 Calcium signaling pathway
    K04345  PKA; protein kinase A
 Cellular Processes
  Cell growth and death
   04113 Meiosis - yeast
    K04345  PKA; protein kinase A
   04114 Oocyte meiosis
    K04345  PKA; protein kinase A
   04210 Apoptosis
    K04345  PKA; protein kinase A
  Cell communication
   04540 Gap junction
    K04345  PKA; protein kinase A
 Organismal Systems
  Immune system
   04062 Chemokine signaling pathway
    K04345  PKA; protein kinase A
  Endocrine system
   04911 Insulin secretion
    K04345  PKA; protein kinase A
   04910 Insulin signaling pathway
    K04345  PKA; protein kinase A
   04912 GnRH signaling pathway
    K04345  PKA; protein kinase A
   04913 Ovarian Steroidogenesis
    K04345  PKA; protein kinase A
   04915 Estrogen signaling pathway
    K04345  PKA; protein kinase A
   04914 Progesterone-mediated oocyte maturation
    K04345  PKA; protein kinase A
   04916 Melanogenesis
    K04345  PKA; protein kinase A
  Circulatory system
   04270 Vascular smooth muscle contraction
    K04345  PKA; protein kinase A
  Digestive system
   04970 Salivary secretion
    K04345  PKA; protein kinase A
   04971 Gastric acid secretion
    K04345  PKA; protein kinase A
   04976 Bile secretion
    K04345  PKA; protein kinase A
  Excretory system
   04962 Vasopressin-regulated water reabsorption
    K04345  PKA; protein kinase A
   04961 Endocrine and other factor-regulated calcium reabsorption
    K04345  PKA; protein kinase A
  Nervous system
   04724 Glutamatergic synapse
    K04345  PKA; protein kinase A
   04727 GABAergic synapse
    K04345  PKA; protein kinase A
   04725 Cholinergic synapse
    K04345  PKA; protein kinase A
   04728 Dopaminergic synapse
    K04345  PKA; protein kinase A
   04726 Serotonergic synapse
    K04345  PKA; protein kinase A
   04720 Long-term potentiation
    K04345  PKA; protein kinase A
   04723 Retrograde endocannabinoid signaling
    K04345  PKA; protein kinase A
  Sensory system
   04740 Olfactory transduction
    K04345  PKA; protein kinase A
   04742 Taste transduction
    K04345  PKA; protein kinase A
  Environmental adaptation
   04713 Circadian entrainment
    K04345  PKA; protein kinase A
 Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    K04345  PKA; protein kinase A
   05203 Viral carcinogenesis
    K04345  PKA; protein kinase A
  Neurodegenerative diseases
   05020 Prion diseases
    K04345  PKA; protein kinase A
  Substance dependence
   05030 Cocaine addiction
    K04345  PKA; protein kinase A
   05031 Amphetamine addiction
    K04345  PKA; protein kinase A
   05032 Morphine addiction
    K04345  PKA; protein kinase A
  Cardiovascular diseases
   05414 Dilated cardiomyopathy (DCM)
    K04345  PKA; protein kinase A
  Infectious diseases
   05110 Vibrio cholerae infection
    K04345  PKA; protein kinase A
   05166 HTLV-I infection
    K04345  PKA; protein kinase A
   05169 Epstein-Barr virus infection
    K04345  PKA; protein kinase A
   05146 Amoebiasis
    K04345  PKA; protein kinase A
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.11  cAMP-dependent protein kinase
     K04345  PKA; protein kinase A
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: AGC group
  PKA family
   K04345  PKA; protein kinase A
Chromosome [BR:ko03036]
 Eukaryotic Type
  Centrosomal proteins
   Kinases and associated factors
    K04345  PKA; protein kinase A
BRITE hierarchy
Genes
HSA: 
5566(PRKACA) 5567(PRKACB) 5568(PRKACG) 5613(PRKX)
PTR: 
449495(PRKX) 455776(PRKACA) 469367(PRKACB) 472944(PRKACG) 751063
PPS: 
100968237(PRKACA) 100970917(PRKACB) 100982589(PRKACG) 100993844
GGO: 
101133255 101133536(PRKACA) 101134260(PRKACB) 101151469(PRKACG)
PON: 
100174748(PRKACB) 100431906(PRKACG) 100434648
MCC: 
100270699(PRKX) 709728(PRKACB) 718632(PRKACA)
MMU: 
18747(Prkaca) 18749(Prkacb) 19108(Prkx)
RNO: 
25636(Prkaca) 293508(Prkacb) 501563(Prkx)
CFA: 
403556(PRKACA) 479975(PRKACB) 610031(PRKX)
AML: 
FCA: 
101081957(PRKX) 101090494(PRKACA) 101095353(PRKACB)
BTA: 
282322(PRKACA) 282323(PRKACB) 505773(PRKX)
SSC: 
100520353 397652(PRKACA)
ECB: 
100052828 100064302(PRKACA) 100064903
MDO: 
100009830 100011211 100026861 100032298
SHR: 
100915481(PRKACA) 100928966(PRKX) 100934183(PRKACB)
OAA: 
100078846 100083943 100088079
GGA: 
418656(PRKX) 424542(PRKACB)
MGP: 
100545867 100548554
TGU: 
100226105(PRKACB) 100227397 100227619(PRKX)
ACS: 
100558272 100559138
XLA: 
100101276(prkaca) 380388(prkacb) 446502(prkacbb)
XTR: 
100038053(prkacb) 100494406 549157(prkaca)
DRE: 
100538234(prkacb) 393998(prkacba) 445076(prkacab) 561941 563147(prkacbb) 564064(prkacaa)
TRU: 
101062935 101066292 101067856 101069822 101075373
OLA: 
101163742 101168847 101170876
BFO: 
BRAFLDRAFT_132295
CIN: 
100175976 100176009
SPU: 
583938 589947
DME: 
Dmel_CG12066(Pka-C2) Dmel_CG4379(Pka-C1) Dmel_CG6117(Pka-C3)
DPO: 
Dpse_GA11370 Dpse_GA11372 Dpse_GA18145 Dpse_GA23555
DAN: 
Dana_GF10368 Dana_GF21892 Dana_GF23314 Dana_GF23315
DER: 
Dere_GG11916 Dere_GG11917 Dere_GG13511 Dere_GG24016
DPE: 
Dper_GL13992 Dper_GL13993 Dper_GL19216 Dper_GL24922
DSE: 
Dsec_GM12137 Dsec_GM12138 Dsec_GM12352
DSI: 
Dsim_GD12529 Dsim_GD16880 Dsim_GD16891 Dsim_GD22345
DWI: 
Dwil_GK13113 Dwil_GK13114 Dwil_GK15458 Dwil_GK20594
DYA: 
Dyak_GE10413(Dyak_Pka-C1) Dyak_GE19804 Dyak_GE23130 Dyak_GE23365 Dyak_GE23367
DGR: 
Dgri_GH11053 Dgri_GH14103 Dgri_GH14104 Dgri_GH17207
DMO: 
Dmoj_GI10635 Dmoj_GI10636 Dmoj_GI11297 Dmoj_GI17571
DVI: 
Dvir_GJ17913 Dvir_GJ22991 Dvir_GJ22992
AGA: 
AgaP_AGAP001384 AgaP_AGAP008039 AgaP_AGAP011840
AAG: 
AaeL_AAEL001976 AaeL_AAEL007293 AaeL_AAEL011837
CQU: 
CpipJ_CPIJ002636 CpipJ_CPIJ018257
AME: 
409791(Pka-C1) 410228(Pka-C3)
NVI: 
100119822(NV15281) 100328539(Pka-C1)
TCA: 
656552(Pka-C1) 661839
API: 
100159120 100161173 100163418
PHU: 
Phum_PHUM090820 Phum_PHUM318270
ISC: 
IscW_ISCW013988
CEL: 
CELE_F47F2.1(F47F2.1) CELE_ZK909.2(kin-1)
CBR: 
CBG14305 CBG19814(Cbr-kin-1)
BMY: 
Bm1_11790
TSP: 
Tsp_03463
SMM: 
Smp_152330 Smp_194610
NVE: 
NEMVE_v1g230515
HMG: 
100198292(prkaca)
AQU: 
100640804 100641589
ATH: 
AT2G20050
ALY: 
ARALYDRAFT_480465
ZMA: 
100279221
SMO: 
SELMODRAFT_110120
PPP: 
PHYPADRAFT_126373
CRE: 
CHLREDRAFT_121355
VCN: 
VOLCADRAFT_81085
SCE: 
YJL164C(TPK1) YKL166C(TPK3) YPL203W(TPK2)
AGO: 
AGOS_AEL115C AGOS_AFL090W
ERC: 
Ecym_2203 Ecym_8095
KLA: 
KLLA0B07205g KLLA0D03190g
LTH: 
KLTH0F04840g KLTH0H04180g
PPA: 
PAS_chr1-4_0357 PAS_chr3_0964
VPO: 
Kpol_1033p50 Kpol_2002p75
ZRO: 
ZYRO0G08844g ZYRO0G18502g
CGR: 
CAGL0G09020g CAGL0M08404g
NCS: 
NCAS_0A01100(NCAS0A01100) NCAS_0I02840(NCAS0I02840)
NDI: 
NDAI_0A00960(NDAI0A00960) NDAI_0B00210(NDAI0B00210) NDAI_0F01650(NDAI0F01650)
TPF: 
TPHA_0E02840(TPHA0E02840) TPHA_0E03300(TPHA0E03300)
TBL: 
TBLA_0A02030(TBLA0A02030) TBLA_0C05830(TBLA0C05830)
TDL: 
TDEL_0C03710(TDEL0C03710) TDEL_0E05220(TDEL0E05220)
KAF: 
KAFR_0F01800(KAFR0F01800) KAFR_0G00480(KAFR0G00480) KAFR_0K00330(KAFR0K00330)
DHA: 
DEHA2B12386g DEHA2F23782g
PIC: 
PICST_68202(TPK2) PICST_70266
PGU: 
PGUG_00446 PGUG_01778
LEL: 
LELG_00555 LELG_02456
CAL: 
CaO19.12357(TPK3) CaO19.2277(TPK2) CaO19.4892(TPK3) CaO19.9817(TPK2)
CTP: 
CTRG_01736 CTRG_03315
CDU: 
CD36_09610 CD36_21480(CaTPK2)
COT: 
CORT_0A04970 CORT_0C05890
YLI: 
YALI0C08305g
CLU: 
CLUG_00572 CLUG_05816
NCR: 
NCU06240
SMP: 
SMAC_01361 SMAC_07080
PAN: 
PODANSg4388
TTT: 
THITE_2112048 THITE_2119633
MTM: 
MYCTH_2297709 MYCTH_2304075
MGR: 
MGG_06368
FGR: 
FG07251.1 FG08729.1
NHE: 
NECHADRAFT_59012 NECHADRAFT_68629
VAL: 
VDBG_02174 VDBG_08817
SSL: 
SS1G_03171 SS1G_13577
BFU: 
BC1G_07542 BC1G_10410
ANI: 
AN6305.2
NFI: 
NFIA_078710 NFIA_087380
AFM: 
AFUA_2G12200
AOR: 
AOR_1_360094(AO090120000207) AOR_1_786014(AO090026000426)
AFV: 
AFLA_091910 AFLA_135040
ACT: 
ACLA_011960 ACLA_071080
PCS: 
Pc20g14470 Pc22g16500
CIM: 
CIMG_05383 CIMG_06775
CPW: 
CPC735_032030 CPC735_065510
PBL: 
PAAG_00108 PAAG_04050
URE: 
UREG_03689 UREG_06328
ABE: 
ARB_00580 ARB_06644
TVE: 
TRV_02144 TRV_02424
AJE: 
HCAG_00714 HCAG_03889
PNO: 
SNOG_09577 SNOG_13001
PTE: 
PTT_11769 PTT_12790
ZTR: 
MYCGRDRAFT_38697(MgTpk1) MYCGRDRAFT_99725(Tpk2)
TML: 
GSTUM_00000085001 GSTUM_00000447001
SPO: 
SPBC106.10(pka1)
CNE: 
CNA03840 CNI02980
CNB: 
CNBA3650 CNBH2850
CGI: 
CGB_A3580C CGB_H5240W
PPL: 
POSPLDRAFT_112798 POSPLDRAFT_44442
LBC: 
LACBIDRAFT_189547 LACBIDRAFT_255253
CCI: 
CC1G_04466 CC1G_05183
SCM: 
SCHCODRAFT_16601(pkac2) SCHCODRAFT_65574(pkac1)
UMA: 
UM01124.1 UM04456.1
MGL: 
MGL_3248
PGR: 
PGTG_17146
ECU: 
ECU07_0520
EIN: 
Eint_070460
EHE: 
EHEL_070490
NCE: 
NCER_101539
MBR: 
MONBRDRAFT_12960 MONBRDRAFT_31027
NGR: 
NAEGRDRAFT_31357
DDI: 
DDB_G0283907(pkaC)
DPP: 
DICPUDRAFT_42383(PKAC)
EHI: 
EHI_053040(4.t00093)
PFA: 
PFI1685w(PfPKAc)
PFD: 
PFDG_02360
PFH: 
PFHG_02233
PYO: 
PY05235
PCB: 
PC000802.04.0
PBE: 
PB000532.02.0
PKN: 
PKH_073290
PVX: 
PVX_086975
PCY: 
PCYB_074210
TAN: 
TA12860 TA14790
TPV: 
TP02_0378 TP02_0727
BBO: 
BBOV_I004190(19.m02221) BBOV_III005740(17.m07511)
CPV: 
cgd3_3040
CHO: 
Chro.30344
TGO: 
TGME49_026030 TGME49_028420 TGME49_086470
TET: 
TTHERM_00433420 TTHERM_00658860 TTHERM_00992710 TTHERM_01020820
PTM: 
GSPATT00000190001 GSPATT00007679001 GSPATT00008150001 GSPATT00010342001 GSPATT00011825001 GSPATT00012047001 GSPATT00019371001 GSPATT00021511001 GSPATT00021701001 GSPATT00029731001 GSPATT00030705001 PTMB.308
TBR: 
Tb09.211.2360 Tb09.211.2410 Tb10.389.0490
TCR: 
508461.310 511269.50
LMA: 
LMJF_18_1080(PKAC1)
LIF: 
LINJ_18_1090(PKAC1) LINJ_35_4010 LINJ_35_4060
LDO: 
LDBPK_181090
LMI: 
LMXM_18_1080 LMXM_34_3960 LMXM_34_4010
LBZ: 
LBRM_18_1180 LBRM_34_3990
GLA: 
GL50803_11214
PTI: 
PHATRDRAFT_9413
TPS: 
THAPSDRAFT_261973 THAPSDRAFT_30963(PKA) THAPS_16501
PIF: 
PITG_02429 PITG_20156
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Tasken K, Aandahl EM
  Title
Localized effects of cAMP mediated by distinct routes of protein kinase A.
  Journal
Physiol Rev 84:137-67 (2004)
Reference
  Authors
Taylor SS, Yang J, Wu J, Haste NM, Radzio-Andzelm E, Anand G
  Title
PKA: a portrait of protein kinase dynamics.
  Journal
Biochim Biophys Acta 1697:259-69 (2004)
Reference
  Authors
Edwards AS, Scott JD
  Title
A-kinase anchoring proteins: protein kinase A and beyond.
  Journal
Curr Opin Cell Biol 12:217-21 (2000)
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