KEGG   ORTHOLOGY: K04345Help
Entry
K04345                      KO                                     

Name
PKA
Definition
protein kinase A [EC:2.7.11.11]
Pathway
MAPK signaling pathway
Ras signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
Meiosis - yeast
Oocyte meiosis
Apoptosis
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Hedgehog signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Olfactory transduction
Taste transduction
Inflammatory mediator regulation of TRP channels
Insulin signaling pathway
Insulin secretion
GnRH signaling pathway
Ovarian steroidogenesis
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Vasopressin-regulated water reabsorption
Salivary secretion
Gastric acid secretion
Bile secretion
Parkinson's disease
Prion diseases
Cocaine addiction
Amphetamine addiction
Morphine addiction
Vibrio cholerae infection
Amoebiasis
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Dilated cardiomyopathy
Module
M00695  
cAMP signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04345  PKA; protein kinase A
   04010 MAPK signaling pathway
    K04345  PKA; protein kinase A
   04310 Wnt signaling pathway
    K04345  PKA; protein kinase A
   04340 Hedgehog signaling pathway
    K04345  PKA; protein kinase A
   04020 Calcium signaling pathway
    K04345  PKA; protein kinase A
   04024 cAMP signaling pathway
    K04345  PKA; protein kinase A
 Cellular Processes
  Cell growth and death
   04113 Meiosis - yeast
    K04345  PKA; protein kinase A
   04114 Oocyte meiosis
    K04345  PKA; protein kinase A
   04210 Apoptosis
    K04345  PKA; protein kinase A
  Cellular commiunity
   04540 Gap junction
    K04345  PKA; protein kinase A
 Organismal Systems
  Immune system
   04611 Platelet activation
    K04345  PKA; protein kinase A
   04062 Chemokine signaling pathway
    K04345  PKA; protein kinase A
  Endocrine system
   04911 Insulin secretion
    K04345  PKA; protein kinase A
   04910 Insulin signaling pathway
    K04345  PKA; protein kinase A
   04912 GnRH signaling pathway
    K04345  PKA; protein kinase A
   04913 Ovarian Steroidogenesis
    K04345  PKA; protein kinase A
   04915 Estrogen signaling pathway
    K04345  PKA; protein kinase A
   04914 Progesterone-mediated oocyte maturation
    K04345  PKA; protein kinase A
   04921 Oxytocin signaling pathway
    K04345  PKA; protein kinase A
   04918 Thyroid hormone synthesis
    K04345  PKA; protein kinase A
   04919 Thyroid hormone signaling pathway
    K04345  PKA; protein kinase A
   04916 Melanogenesis
    K04345  PKA; protein kinase A
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04345  PKA; protein kinase A
   04270 Vascular smooth muscle contraction
    K04345  PKA; protein kinase A
  Digestive system
   04970 Salivary secretion
    K04345  PKA; protein kinase A
   04971 Gastric acid secretion
    K04345  PKA; protein kinase A
   04976 Bile secretion
    K04345  PKA; protein kinase A
  Excretory system
   04962 Vasopressin-regulated water reabsorption
    K04345  PKA; protein kinase A
   04961 Endocrine and other factor-regulated calcium reabsorption
    K04345  PKA; protein kinase A
  Nervous system
   04724 Glutamatergic synapse
    K04345  PKA; protein kinase A
   04727 GABAergic synapse
    K04345  PKA; protein kinase A
   04725 Cholinergic synapse
    K04345  PKA; protein kinase A
   04728 Dopaminergic synapse
    K04345  PKA; protein kinase A
   04726 Serotonergic synapse
    K04345  PKA; protein kinase A
   04720 Long-term potentiation
    K04345  PKA; protein kinase A
   04723 Retrograde endocannabinoid signaling
    K04345  PKA; protein kinase A
  Sensory system
   04740 Olfactory transduction
    K04345  PKA; protein kinase A
   04742 Taste transduction
    K04345  PKA; protein kinase A
   04750 Inflammatory mediator regulation of TRP channels
    K04345  PKA; protein kinase A
  Environmental adaptation
   04713 Circadian entrainment
    K04345  PKA; protein kinase A
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04345  PKA; protein kinase A
   05205 Proteoglycans in cancer
    K04345  PKA; protein kinase A
   05203 Viral carcinogenesis
    K04345  PKA; protein kinase A
  Neurodegenerative diseases
   05012 Parkinson's disease
    K04345  PKA; protein kinase A
   05020 Prion diseases
    K04345  PKA; protein kinase A
  Substance dependence
   05030 Cocaine addiction
    K04345  PKA; protein kinase A
   05031 Amphetamine addiction
    K04345  PKA; protein kinase A
   05032 Morphine addiction
    K04345  PKA; protein kinase A
  Cardiovascular diseases
   05414 Dilated cardiomyopathy (DCM)
    K04345  PKA; protein kinase A
  Infectious diseases
   05110 Vibrio cholerae infection
    K04345  PKA; protein kinase A
   05166 HTLV-I infection
    K04345  PKA; protein kinase A
   05169 Epstein-Barr virus infection
    K04345  PKA; protein kinase A
   05146 Amoebiasis
    K04345  PKA; protein kinase A
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00695  cAMP signaling
     K04345  PKA; protein kinase A
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.11  cAMP-dependent protein kinase
     K04345  PKA; protein kinase A
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: AGC group
  PKA family
   K04345  PKA; protein kinase A
Messenger RNA biogenesis [BR:ko03019]
 Eukaryotic Type
  mRNA surveillance and transport factors
   mRNA cycle factors
    Common to processing body (P body) and stress granule
     K04345  PKA; protein kinase A
Chromosome [BR:ko03036]
 Eukaryotic Type
  Centrosomal proteins
   Kinases and associated factors
    K04345  PKA; protein kinase A
BRITE hierarchy
Genes
HSA: 
5566(PRKACA) 5567(PRKACB) 5568(PRKACG) 5613(PRKX)
PTR: 
449495(PRKX) 455776(PRKACA) 469367(PRKACB) 472944(PRKACG) 751063
PPS: 
100968237(PRKACA) 100970917(PRKACB) 100982589(PRKACG) 100993844(PRKX)
GGO: 
PON: 
100174748(PRKACB) 100431906(PRKACG) 100434648
NLE: 
100579779(PRKACA) 100581903 100583577(PRKACB) 100607741(PRKACG)
MCC: 
100270699(PRKX) 709728(PRKACB) 718632(PRKACA)
MCF: 
101926461 102117414(PRKACG) 102141574(PRKX) 102142443(PRKACA)
CJC: 
100392123(PRKACG) 100400737(PRKACA) 100407692(PRKACB) 100407753(PRKACG) 100408115 100413182(PRKX)
MMU: 
18747(Prkaca) 18749(Prkacb) 19108(Prkx)
RNO: 
25636(Prkaca) 293508(Prkacb) 501563(Prkx)
CGE: 
100756471(Prkx) 100767097(Prkacb) 100768997(Prkaca)
NGI: 
103728095(Prkacb) 103747214(Prkx) 103751850(Prkaca)
HGL: 
101700033(Prkx) 101707235(Prkaca) 101721558(Prkacb)
OCU: 
100008815(PRKACA) 100342212(PRKACB)
TUP: 
CFA: 
403556(PRKACA) 479975(PRKACB) 610031(PRKX)
AML: 
UMR: 
103662972(PRKACB) 103666338(PRKX) 103682183(PRKACA)
FCA: 
101081957(PRKX) 101090494(PRKACA) 101095353(PRKACB)
PTG: 
102948983(PRKACA) 102963584(PRKX) 102972158(PRKACB)
BTA: 
282322(PRKACA) 282323(PRKACB) 505773(PRKX)
BOM: 
102269124(PRKACB) 102281757(PRKACA)
PHD: 
102315955(PRKACA) 102332024(PRKACB) 102334687(PRKX) 102343013
CHX: 
102168790(PRKACB) 102173379(PRKACA) 102176517 102181859(PRKX)
OAS: 
101108785(PRKACB) 101116807(PRKX) 443094(PRKACA)
SSC: 
100520353(PRKX) 397652(PRKACA)
CFR: 
102506255(PRKACB) 102508985(PRKACA) 102515891(PRKX)
BACU: 
103000011(PRKACA) 103007447(PRKX) 103008319(PRKACB)
LVE: 
103074112(PRKACA) 103077464(PRKACB) 103081147(PRKX)
ECB: 
100052828(PRKACB) 100064302(PRKACA) 100064903(PRKX)
MYB: 
102244919(PRKACB) 102252927(PRKACA)
MYD: 
PALE: 
102877853(PRKACB) 102886679(PRKACA) 102896618(PRKX)
MDO: 
100009830(PRKX) 100011211(PRKACB) 100026861(PRKACA)
SHR: 
100913731 100915481(PRKACA) 100928966(PRKX) 100934183(PRKACB)
OAA: 
GGA: 
418656(PRKX) 424542(PRKACB)
MGP: 
APLA: 
101791856(PRKACB) 101792690(PRKX)
TGU: 
FAB: 
PHI: 
102112042(PRKX) 102112800(PRKACB)
FPG: 
101915967(PRKX) 101921803(PRKACB)
FCH: 
102052736(PRKACB) 102056586(PRKX)
CLV: 
102093121(PRKX) 102094181(PRKACB)
ASN: 
102369602(PRKACA) 102372671(PRKX) 102373080(PRKACB)
AMJ: 
102558584(PRKX) 102560332(PRKACA) 102572143(PRKACB)
PSS: 
102454969(PRKACB) 102458631(PRKACA) 102461440(PRKX)
CMY: 
ACS: 
100554863(prkaca) 100558272(prkx) 100559138(prkacb) 103279522
PBI: 
XLA: 
100101276(prkaca) 380388(prkacb) 446502(prkacbb)
XTR: 
100038053(prkacb) 100494406(prkx) 549157(prkaca)
DRE: 
100538234(prkacb) 393998(prkacba) 445076(prkacab) 561941(prkx) 563147(prkacbb) 564064(prkacaa)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103174709(prkacb) 103189096(prkaca) 103189206(prkx)
BFO: 
CIN: 
SPU: 
DME: 
Dmel_CG12066(Pka-C2) Dmel_CG4379(Pka-C1) Dmel_CG6117(Pka-C3)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
409791(Pka-C1) 410228(Pka-C3)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_F47F2.1(F47F2.1) CELE_ZK909.2(kin-1)
CBR: 
CBG14305 CBG19814(Cbr-kin-1)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
NVE: 
HMG: 
100198292(prkaca)
AQU: 
BRP: 
ZMA: 
SMO: 
PPP: 
CRE: 
VCN: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
SCE: 
YJL164C(TPK1) YKL166C(TPK3) YPL203W(TPK2)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A01100(NCAS0A01100) NCAS_0B08280(NCAS0B08280) NCAS_0I02840(NCAS0I02840)
NDI: 
NDAI_0A00960(NDAI0A00960) NDAI_0B00210(NDAI0B00210) NDAI_0F01650(NDAI0F01650)
TPF: 
TPHA_0E02840(TPHA0E02840) TPHA_0E03300(TPHA0E03300)
TBL: 
TBLA_0A02030(TBLA0A02030) TBLA_0C05830(TBLA0C05830)
TDL: 
TDEL_0C03710(TDEL0C03710) TDEL_0E05220(TDEL0E05220)
KAF: 
KAFR_0F01800(KAFR0F01800) KAFR_0G00480(KAFR0G00480) KAFR_0K00330(KAFR0K00330)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_360094(AO090120000207) AOR_1_786014(AO090026000426)
ANG: 
ANI_1_1786064(An07g05060) ANI_1_594024(An02g04270)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
PPL: 
DSQ: 
PCO: 
SHS: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT34901(AGABI1DRAFT_34901) AGABI1DRAFT84160(AGABI1DRAFT_84160)
ABV: 
AGABI2DRAFT136405(AGABI2DRAFT_136405) AGABI2DRAFT64256(AGABI2DRAFT_64256)
CPUT: 
SLA: 
UMA: 
PFP: 
MGL: 
PGR: 
MLR: 
WSE: 
ECU: 
EIN: 
EHE: 
NCE: 
MBR: 
DDI: 
DPP: 
DFA: 
DFA_06591(pkaC)
EHI: 
EHI_053040(4.t00093)
ACAN: 
PFA: 
PFI1685w(PfPKAc)
PFD: 
PFH: 
PYO: 
PCB: 
PBE: 
PKN: 
PVX: 
PCY: 
TAN: 
TPV: 
BBO: 
BBOV_I004190(19.m02221) BBOV_III005740(17.m07511)
BEQ: 
CPV: 
CHO: 
TGO: 
TET: 
PTM: 
PTI: 
TPS: 
PIF: 
EHX: 
GTT: 
TBR: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
GLA: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Tasken K, Aandahl EM
  Title
Localized effects of cAMP mediated by distinct routes of protein kinase A.
  Journal
Physiol Rev 84:137-67 (2004)
  Sequence
[rno:25636]
Reference
  Authors
Taylor SS, Yang J, Wu J, Haste NM, Radzio-Andzelm E, Anand G
  Title
PKA: a portrait of protein kinase dynamics.
  Journal
Biochim Biophys Acta 1697:259-69 (2004)
  Sequence
[mmu:18747]
Reference
  Authors
Edwards AS, Scott JD
  Title
A-kinase anchoring proteins: protein kinase A and beyond.
  Journal
Curr Opin Cell Biol 12:217-21 (2000)

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