KEGG   ORTHOLOGY: K04361Help
Entry
K04361                      KO                                     

Name
EGFR, ERBB1
Definition
epidermal growth factor receptor [EC:2.7.10.1]
Pathway
EGFR tyrosine kinase inhibitor resistance
MAPK signaling pathway
ErbB signaling pathway
MAPK signaling pathway - fly
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Apoptosis - fly
Dorso-ventral axis formation
Focal adhesion
Adherens junction
Gap junction
Regulation of actin cytoskeleton
GnRH signaling pathway
Estrogen signaling pathway
Oxytocin signaling pathway
Epithelial cell signaling in Helicobacter pylori infection
Hepatitis C
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Bladder cancer
Non-small cell lung cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
Disease
H00014  
Non-small cell lung cancer
H00016  
Oral cancer
H00017  
Esophageal cancer
H00018  
Gastric cancer
H00022  
Bladder cancer
H00028  
Choriocarcinoma
H00030  
Cervical cancer
H00042  
Glioma
H00055  
Laryngeal cancer
H01508  
Salivary gland cancer
H01559  
Oropharyngeal cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04015 Rap1 signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04010 MAPK signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04013 MAPK signaling pathway - fly
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04012 ErbB signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04066 HIF-1 signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04068 FoxO signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04020 Calcium signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04072 Phospholipase D signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04151 PI3K-Akt signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  Cell growth and death
   04214 Apoptosis - fly
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  Cellular commiunity
   04510 Focal adhesion
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04520 Adherens junction
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04540 Gap junction
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 Organismal Systems
  Endocrine system
   04912 GnRH signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04915 Estrogen signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04921 Oxytocin signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  Development
   04320 Dorso-ventral axis formation
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05230 Central carbon metabolism in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05231 Choline metabolism in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05206 MicroRNAs in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05205 Proteoglycans in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05212 Pancreatic cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05214 Glioma
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05218 Melanoma
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05219 Bladder cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05215 Prostate cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05213 Endometrial cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05223 Non-small cell lung cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05160 Hepatitis C
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  Antineoplastic resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K04361  EGFR, ERBB1; epidermal growth factor receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04361  EGFR, ERBB1; epidermal growth factor receptor
Protein kinases [BR:ko01001]
 Tyrosine protein kinases
  EGFR family [OT]
   K04361  EGFR, ERBB1; epidermal growth factor receptor
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor
  Exosomal proteins of pancreatic cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor
  Exosomal proteins of bladder cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor
Enzyme-linked receptors [BR:ko01020]
 Receptor tyrosine kinases
  RTK class I (EGF receptor family)
   K04361  EGFR, ERBB1; epidermal growth factor receptor
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class I (EGF receptor family)
   K04361  EGFR, ERBB1; epidermal growth factor receptor
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Neural system
   6/5 subfamily
    L1CAM; L1 cell adhesion molecule
     K04361 EGFR, ERBB1; epidermal growth factor receptor
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
1956(EGFR)
PTR: 
463415(EGFR)
PPS: 
100974885(EGFR)
GGO: 
101126190(EGFR)
PON: 
100459280(EGFR)
NLE: 
100597255(EGFR)
MCC: 
613027(EGFR)
MCF: 
102138724(EGFR)
RRO: 
104675886(EGFR)
CJC: 
MMU: 
13649(Egfr)
RNO: 
24329(Egfr)
CGE: 
100774580(Egfr)
NGI: 
HGL: 
101723771(Egfr)
OCU: 
100008806(EGFR)
TUP: 
102485304(EGFR)
CFA: 
404306(EGFR)
UMR: 
103674660(EGFR)
FCA: 
100510799(EGFR)
PTG: 
102967370(EGFR)
BTA: 
407217(EGFR)
BOM: 
PHD: 
102337306(EGFR)
CHX: 
102172767(EGFR)
OAS: 
780479(EGFR)
SSC: 
397070(EGFR)
CFR: 
BACU: 
103017029(EGFR)
LVE: 
103071962(EGFR)
ECB: 
100067755(EGFR)
MYB: 
102257758(EGFR)
MYD: 
102775204(EGFR)
PALE: 
102893495(EGFR)
MDO: 
100029625(EGFR)
SHR: 
100914017(EGFR)
OAA: 
100075894(EGFR)
GGA: 
396494(EGFR)
MGP: 
100543252(EGFR)
CJO: 
107309802(EGFR)
APLA: 
101797830(EGFR)
TGU: 
100221035(EGFR)
GFR: 
102045482(EGFR)
FAB: 
101818290(EGFR)
PHI: 
102101445(EGFR)
CCW: 
104689262(EGFR)
FPG: 
101910521(EGFR)
FCH: 
102058683(EGFR)
CLV: 
102097879(EGFR)
AAM: 
106495273(EGFR)
ASN: 
102378285(EGFR)
AMJ: 
102565209(EGFR)
PSS: 
102443405(EGFR)
CMY: 
102933326(EGFR)
ACS: 
100562231(egfr)
PBI: 
103050691(EGFR)
GJA: 
107119225(EGFR)
XTR: 
100492965(egfr)
DRE: 
378478(egfra) 571431
TRU: 
MZE: 
OLA: 
XMA: 
102236062(egfr)
LCM: 
CMK: 
103181270(egfr)
BFO: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD11601(Dsim_GD11601)
DWI: 
DYA: 
Dyak_GE12201(dyak_GLEANR_12474)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
100577393(Egfr)
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
100118970(Egfr)
TCA: 
660037(DER)
BMOR: 
PXY: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG00911(Cbr-let-23)
BMY: 
LOA: 
HRO: 
LGI: 
CRG: 
105330118(Egfr)
OBI: 
SMM: 
AQU: 
MBR: 
SRE: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Shao H, Cheng HY, Cook RG, Tweardy DJ
  Title
Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor.
  Journal
Cancer Res 63:3923-30 (2003)
  Sequence
[hsa:1956]
Reference
  Authors
Habib AA, Chatterjee S, Park SK, Ratan RR, Lefebvre S, Vartanian T
  Title
The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome.
  Journal
J Biol Chem 276:8865-74 (2001)
  Sequence
[hsa:1956]
Reference
PMID:6328312
  Authors
Ullrich A, Coussens L, Hayflick JS, Dull TJ, Gray A, Tam AW, Lee J, Yarden Y, Libermann TA, Schlessinger J, et al.
  Title
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells.
  Journal
Nature 309:418-25 (1984)
  Sequence
[hsa:1956]

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