KEGG   ORTHOLOGY: K04366Help
Entry
K04366                      KO                                     
Name
RAF1
Definition
RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Pathway
MAPK signaling pathway
ErbB signaling pathway
Chemokine signaling pathway
PI3K-Akt signaling pathway
Vascular smooth muscle contraction
VEGF signaling pathway
Focal adhesion
Gap junction
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Long-term potentiation
Neurotrophin signaling pathway
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Alcoholism
Tuberculosis
Hepatitis C
Hepatitis B
Influenza A
Pathways in cancer
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04012 ErbB signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04370 VEGF signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04151 PI3K-Akt signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  Cell communication
   04510 Focal adhesion
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04540 Gap junction
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04660 T cell receptor signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04662 B cell receptor signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04664 Fc epsilon RI signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04666 Fc gamma R-mediated phagocytosis
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04062 Chemokine signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  Endocrine system
   04910 Insulin signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04912 GnRH signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04915 Estrogen signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04914 Progesterone-mediated oocyte maturation
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04916 Melanogenesis
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  Circulatory system
   04270 Vascular smooth muscle contraction
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  Nervous system
   04726 Serotonergic synapse
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04720 Long-term potentiation
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04730 Long-term depression
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04722 Neurotrophin signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05205 Proteoglycans in cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05210 Colorectal cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05212 Pancreatic cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05214 Glioma
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05221 Acute myeloid leukemia
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05220 Chronic myeloid leukemia
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05218 Melanoma
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05211 Renal cell carcinoma
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05219 Bladder cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05215 Prostate cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05213 Endometrial cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05223 Non-small cell lung cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  Substance dependence
   05034 Alcoholism
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  Infectious diseases
   05152 Tuberculosis
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05164 Influenza A
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05161 Hepatitis B
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05160 Hepatitis C
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: TKL group
  RAF family
   K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
BRITE hierarchy
Genes
HSA: 
5894(RAF1)
PTR: 
460182(RAF1)
PPS: 
100972902(RAF1)
GGO: 
101136454(RAF1)
PON: 
100173732(RAF1)
MCC: 
694725(RAF1)
MMU: 
110157(Raf1)
RNO: 
24703(Raf1)
CFA: 
484648(RAF1)
AML: 
100482255(RAF1)
FCA: 
101096047(RAF1)
BTA: 
521196(RAF1)
ECB: 
100050968 100051110(RAF1)
MDO: 
100015410
SHR: 
100935202(RAF1)
OAA: 
100089456
GGA: 
396245(RAF1)
MGP: 
100541264
TGU: 
100218264(RAF1)
ACS: 
100557613
XLA: 
397857(c-raf)
XTR: 
549871(raf1)
DRE: 
30716(raf1a) 557109(raf1b)
TRU: 
654310(raf1)
OLA: 
101173784
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Roskoski R Jr
  Title
RAF protein-serine/threonine kinases: structure and regulation.
  Journal
Biochem Biophys Res Commun 399:313-7 (2010)
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