KEGG   ORTHOLOGY: K04368Help
Entry
K04368                      KO                                     
Name
MAP2K1, MEK1
Definition
mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Pathway
MAPK signaling pathway
ErbB signaling pathway
MAPK signaling pathway - fly
Chemokine signaling pathway
HIF-1 signaling pathway
Oocyte meiosis
PI3K-Akt signaling pathway
Vascular smooth muscle contraction
Dorso-ventral axis formation
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Gap junction
Toll-like receptor signaling pathway
Plant-pathogen interaction
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Long-term potentiation
Neurotrophin signaling pathway
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Prion diseases
Alcoholism
Hepatitis B
Influenza A
Pathways in cancer
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Disease
H00523  
Noonan syndrome and related disorders
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04013 MAPK signaling pathway - fly
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04012 ErbB signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04370 VEGF signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04066 HIF-1 signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04151 PI3K-Akt signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  Cell growth and death
   04114 Oocyte meiosis
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  Cell communication
   04510 Focal adhesion
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04540 Gap junction
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04650 Natural killer cell mediated cytotoxicity
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04660 T cell receptor signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04662 B cell receptor signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04664 Fc epsilon RI signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04666 Fc gamma R-mediated phagocytosis
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04062 Chemokine signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  Endocrine system
   04910 Insulin signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04912 GnRH signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04915 Estrogen signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04914 Progesterone-mediated oocyte maturation
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04916 Melanogenesis
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  Circulatory system
   04270 Vascular smooth muscle contraction
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  Nervous system
   04725 Cholinergic synapse
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04726 Serotonergic synapse
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04720 Long-term potentiation
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04730 Long-term depression
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04722 Neurotrophin signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  Development
   04320 Dorso-ventral axis formation
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04380 Osteoclast differentiation
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  Environmental adaptation
   04626 Plant-pathogen interaction
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05205 Proteoglycans in cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05210 Colorectal cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05212 Pancreatic cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05214 Glioma
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05216 Thyroid cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05221 Acute myeloid leukemia
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05220 Chronic myeloid leukemia
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05218 Melanoma
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05211 Renal cell carcinoma
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05219 Bladder cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05215 Prostate cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05213 Endometrial cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05223 Non-small cell lung cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  Neurodegenerative diseases
   05020 Prion diseases
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  Substance dependence
   05034 Alcoholism
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  Infectious diseases
   05164 Influenza A
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05161 Hepatitis B
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: STE group
  STE7 family
   K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
5604(MAP2K1)
PTR: 
450188(MAP2K1)
PPS: 
100988422(MAP2K1)
GGO: 
101132391(MAP2K1)
PON: 
100446021(MAP2K1)
MCC: 
710415(MAP2K1)
MMU: 
26395(Map2k1)
RNO: 
170851(Map2k1)
CFA: 
478347(MAP2K1)
AML: 
100478039(MAP2K1)
FCA: 
101081387(MAP2K1)
BTA: 
533199(MAP2K1)
SSC: 
100233191(MAP2K1)
ECB: 
100065996(MAP2K1)
MDO: 
100018410(MAP2K1)
OAA: 
100080362
GGA: 
415549(MAP2K1)
MGP: 
100543421
TGU: 
100226448(MAP2K1)
XLA: 
379991(map2k1)
XTR: 
493420(map2k1)
DRE: 
406728(map2k1)
TRU: 
101063584
OLA: 
101162677
BFO: 
BRAFLDRAFT_124326
CIN: 
778923(mapkk1/2)
SPU: 
576066
DME: 
Dmel_CG15793(Dsor1)
DPO: 
Dpse_GA13960
DAN: 
Dana_GF19085(Dana_Dsor1)
DER: 
Dere_GG18305
DPE: 
Dper_GL16493
DSE: 
Dsec_GM22414
DSI: 
Dsim_GD16945(Dsim_Dsor1)
DWI: 
Dwil_GK25111
DYA: 
Dyak_GE17784
DGR: 
Dgri_GH12793
DMO: 
Dmoj_GI15238
DVI: 
Dvir_GJ18839
AGA: 
AgaP_AGAP001103
AAG: 
AaeL_AAEL012723
CQU: 
CpipJ_CPIJ015801
AME: 
409925(Dsor1)
TCA: 
661995
API: 
100159396
PHU: 
Phum_PHUM413460
ISC: 
IscW_ISCW005428
CEL: 
CELE_Y54E10BL.6(mek-2)
CBR: 
CBG04190(Cbr-mek-2)
BMY: 
Bm1_48560
TSP: 
Tsp_10801
SMM: 
Smp_026510
NVE: 
NEMVE_v1g91949
AQU: 
100638124
ATH: 
AT4G26070(MEK1) AT4G29810(MKK2) AT5G56580(MKK6)
ALY: 
ARALYDRAFT_329070 ARALYDRAFT_491777 ARALYDRAFT_495747
GMX: 
100786284 100789734 100792457 547701(MAPKK2)
MTR: 
MTR_6g090470
CSV: 
101204545 101218848
RCU: 
RCOM_1046440 RCOM_1049070
POP: 
POPTR_577971 POPTR_745168
VVI: 
100247508 100252603
OSA: 
4324023 4340126
DOSA: 
Os01t0510100-01(Os01g0510100) Os06t0147800-01(Os06g0147800)
BDI: 
100823700 100826178(MKK6.1)
SBI: 
SORBI_03g033190(SORBIDRAFT_03g033190)
ZMA: 
542356(mek1)
SMO: 
SELMODRAFT_272204(NQK-2) SELMODRAFT_450110(NQK-1)
PPP: 
PHYPADRAFT_181532 PHYPADRAFT_206232
CRE: 
CHLREDRAFT_187846
VCN: 
VOLCADRAFT_73333
OLU: 
OSTLU_4731
OTA: 
Ot04g04050
CNE: 
CNC02350
CNB: 
CNBC4890
CGI: 
CGB_C3420C
CCI: 
CC1G_02205
UMA: 
UM01514.1
MBR: 
MONBRDRAFT_18821
NGR: 
NAEGRDRAFT_55909
DDI: 
DDB_G0269152(mekA)
DPP: 
DICPUDRAFT_98833
PTM: 
GSPATT00011700001 GSPATT00026784001 GSPATT00039140001
GLA: 
GL50803_22165
TVA: 
TVAG_495060
PIF: 
PITG_00124
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Shaul YD, Seger R
  Title
The MEK/ERK cascade: from signaling specificity to diverse functions.
  Journal
Biochim Biophys Acta 1773:1213-26 (2007)
Reference
  Authors
Boutros T, Chevet E, Metrakos P
  Title
Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer.
  Journal
Pharmacol Rev 60:261-310 (2008)
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