KEGG   ORTHOLOGY: K04368Help
Entry
K04368                      KO                                     

Name
MAP2K1, MEK1
Definition
mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Pathway
MAPK signaling pathway
ErbB signaling pathway
MAPK signaling pathway - fly
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Oocyte meiosis
PI3K-Akt signaling pathway
Vascular smooth muscle contraction
Dorso-ventral axis formation
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Gap junction
Toll-like receptor signaling pathway
Plant-pathogen interaction
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Long-term potentiation
Neurotrophin signaling pathway
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Prion diseases
Alcoholism
Hepatitis B
Influenza A
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Disease
H00523  
Noonan syndrome and related disorders
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04015 Rap1 signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04010 MAPK signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04013 MAPK signaling pathway - fly
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04012 ErbB signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04370 VEGF signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04668 TNF signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04066 HIF-1 signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04068 FoxO signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04024 cAMP signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04022 cGMP - PKG signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04151 PI3K-Akt signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  Cell growth and death
   04114 Oocyte meiosis
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  Cell communication
   04510 Focal adhesion
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04540 Gap junction
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04650 Natural killer cell mediated cytotoxicity
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04660 T cell receptor signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04662 B cell receptor signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04664 Fc epsilon RI signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04666 Fc gamma R-mediated phagocytosis
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04062 Chemokine signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  Endocrine system
   04910 Insulin signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04912 GnRH signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04915 Estrogen signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04914 Progesterone-mediated oocyte maturation
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04917 Prolactin signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04921 Oxytocin signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04919 Thyroid hormone signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04916 Melanogenesis
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  Circulatory system
   04270 Vascular smooth muscle contraction
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  Nervous system
   04725 Cholinergic synapse
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04726 Serotonergic synapse
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04720 Long-term potentiation
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04730 Long-term depression
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04722 Neurotrophin signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  Development
   04320 Dorso-ventral axis formation
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04380 Osteoclast differentiation
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  Environmental adaptation
   04626 Plant-pathogen interaction
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05206 MicroRNAs in cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05205 Proteoglycans in cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05210 Colorectal cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05212 Pancreatic cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05214 Glioma
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05216 Thyroid cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05221 Acute myeloid leukemia
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05220 Chronic myeloid leukemia
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05218 Melanoma
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05211 Renal cell carcinoma
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05219 Bladder cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05215 Prostate cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05213 Endometrial cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05223 Non-small cell lung cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  Neurodegenerative diseases
   05020 Prion diseases
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  Substance dependence
   05034 Alcoholism
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  Infectious diseases
   05164 Influenza A
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05161 Hepatitis B
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: STE group
  STE7 family
   K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
5604(MAP2K1)
PTR: 
450188(MAP2K1)
PPS: 
100988422(MAP2K1)
GGO: 
101132391(MAP2K1)
PON: 
100446021(MAP2K1)
MCC: 
710415(MAP2K1)
MCF: 
102141214(MAP2K1)
MMU: 
26395(Map2k1)
RNO: 
170851(Map2k1)
CGE: 
100689403(Map2k1)
HGL: 
101715628(Map2k1)
TUP: 
102476496(MAP2K1)
CFA: 
478347(MAP2K1)
AML: 
100478039(MAP2K1)
FCA: 
101081387(MAP2K1)
PTG: 
102969757(MAP2K1)
BTA: 
533199(MAP2K1)
BOM: 
102280670(MAP2K1)
PHD: 
CHX: 
102190520(MAP2K1)
SSC: 
100233191(MAP2K1)
CFR: 
102515937(MAP2K1)
BACU: 
103017381(MAP2K1)
LVE: 
103082805(MAP2K1)
ECB: 
100065996(MAP2K1)
MYB: 
102240696(MAP2K1)
MYD: 
102763997(MAP2K1)
PALE: 
102897122(MAP2K1)
MDO: 
100018410(MAP2K1)
SHR: 
OAA: 
100080362(MAP2K1)
GGA: 
415549(MAP2K1)
MGP: 
TGU: 
100226448(MAP2K1)
FAB: 
101816905(MAP2K1)
PHI: 
102110075(MAP2K1)
APLA: 
101791037(MAP2K1)
FPG: 
101924998(MAP2K1)
FCH: 
102053397(MAP2K1)
CLV: 
102096091(MAP2K1)
ASN: 
102373880(MAP2K1)
AMJ: 
102558482(MAP2K1)
PSS: 
102443595(MAP2K1)
CMY: 
102945547(MAP2K1)
PBI: 
103051071(MAP2K1)
XLA: 
379991(map2k1)
XTR: 
493420(map2k1)
DRE: 
406728(map2k1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102358560(MAP2K1)
CMK: 
103186399(map2k1)
BFO: 
CIN: 
778923(mapkk1/2)
SPU: 
DME: 
DPO: 
DAN: 
Dana_GF19085(Dana_Dsor1)
DER: 
DPE: 
DSE: 
DSI: 
Dsim_GD16945(Dsim_Dsor1)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
409925(Dsor1)
TCA: 
BMOR: 
692467(Mek)
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG04190(Cbr-mek-2)
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
AQU: 
ATH: 
AT4G26070(MEK1) AT4G29810(MKK2) AT5G56580(MKK6)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
CSV: 
RCU: 
POP: 
POPTR_0006s14850g(POPTRDRAFT_831948) POPTR_0012s04010g(POPTRDRAFT_421814) POPTR_0015s05400g POPTR_0018s05420g(POPTRDRAFT_577971) POPTR_0018s06810g
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os01t0510100-01(Os01g0510100) Os06t0147800-01(Os06g0147800) Os11t0226100-00(Os11g0226100)
OBR: 
BDI: 
SBI: 
SORBI_01g010180(SORBIDRAFT_01g010180) SORBI_01g010200(SORBIDRAFT_01g010200) SORBI_02g022450(SORBIDRAFT_02g022450) SORBI_03g033190(SORBIDRAFT_03g033190)
ZMA: 
SITA: 
ATR: 
s00056p00155580(AMTR_s00056p00155580) s00083p00130670(AMTR_s00083p00130670) s00146p00077810(AMTR_s00146p00077810)
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
MIS: 
MPP: 
BPG: 
CCP: 
CNE: 
CNB: 
CGI: 
CCI: 
SCM: 
UMA: 
MBR: 
DDI: 
DPP: 
DFA: 
DFA_10137(mekA)
ACAN: 
CHO: 
TET: 
PTM: 
PIF: 
NGD: 
EHX: 
GTT: 
TBR: 
Tb927.8.5950(Tb08.11J15.920)
TCR: 
LBZ: 
NGR: 
TVA: 
GLA: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Shaul YD, Seger R
  Title
The MEK/ERK cascade: from signaling specificity to diverse functions.
  Journal
Biochim Biophys Acta 1773:1213-26 (2007)
Reference
  Authors
Boutros T, Chevet E, Metrakos P
  Title
Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer.
  Journal
Pharmacol Rev 60:261-310 (2008)

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