KEGG   ORTHOLOGY: K04369Help
Entry
K04369                      KO                                     

Name
MAP2K2, MEK2
Definition
mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Pathway
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
PI3K-Akt signaling pathway
Vascular smooth muscle contraction
VEGF signaling pathway
Gap junction
Signaling pathways regulating pluripotency of stem cells
Toll-like receptor signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Long-term potentiation
Neurotrophin signaling pathway
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Prion diseases
Hepatitis B
Influenza A
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Central carbon metabolism in cancer
Disease
H00523  
Noonan syndrome and related disorders
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04015 Rap1 signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04010 MAPK signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04012 ErbB signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04370 VEGF signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04066 HIF-1 signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04068 FoxO signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04024 cAMP signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04022 cGMP - PKG signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04151 PI3K-Akt signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  Cellular commiunity
   04540 Gap junction
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04550 Signaling pathways regulating pluripotency of stem cells
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04650 Natural killer cell mediated cytotoxicity
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04660 T cell receptor signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04662 B cell receptor signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04664 Fc epsilon RI signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  Endocrine system
   04910 Insulin signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04912 GnRH signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04915 Estrogen signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04917 Prolactin signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04921 Oxytocin signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04919 Thyroid hormone signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04916 Melanogenesis
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  Circulatory system
   04270 Vascular smooth muscle contraction
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  Nervous system
   04720 Long-term potentiation
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04730 Long-term depression
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04722 Neurotrophin signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05230 Central carbon metabolism in cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05206 MicroRNAs in cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05205 Proteoglycans in cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05214 Glioma
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05216 Thyroid cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05221 Acute myeloid leukemia
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05220 Chronic myeloid leukemia
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05218 Melanoma
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05211 Renal cell carcinoma
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05219 Bladder cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05215 Prostate cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05213 Endometrial cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05223 Non-small cell lung cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  Neurodegenerative diseases
   05020 Prion diseases
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  Infectious diseases
   05164 Influenza A
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05161 Hepatitis B
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: STE group
  STE7 family
   K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
5605(MAP2K2)
PTR: 
PPS: 
100977025(MAP2K2)
GGO: 
PON: 
NLE: 
100591827(MAP2K2)
MCC: 
721821(MAP2K2)
MCF: 
102140855(MAP2K2)
CJC: 
100393991(MAP2K2)
MMU: 
26396(Map2k2)
RNO: 
58960(Map2k2)
CGE: 
100774204(Map2k2)
NGI: 
103737276(Map2k2)
HGL: 
101707562(Map2k2)
TUP: 
102483700(MAP2K2)
CFA: 
611939(MAP2K2)
AML: 
UMR: 
103681834(MAP2K2)
FCA: 
PTG: 
BTA: 
510434(MAP2K2)
BOM: 
102271710(MAP2K2)
PHD: 
102325860(MAP2K2)
CHX: 
102175285(MAP2K2)
OAS: 
101113846(MAP2K2)
SSC: 
100525505(MAP2K2)
CFR: 
102511209(MAP2K2)
BACU: 
103018627(MAP2K2)
LVE: 
103090769(MAP2K2)
ECB: 
100063190(MAP2K2)
MYB: 
102245571(MAP2K2)
MYD: 
102757282(MAP2K2)
PALE: 
102879034(MAP2K2)
MDO: 
100018044(MAP2K2)
SHR: 
100917396(MAP2K2)
OAA: 
GGA: 
396349(MAP2K2)
MGP: 
APLA: 
101793398(MAP2K2)
TGU: 
100225195(MAP2K2)
FAB: 
101820507(MAP2K2)
PHI: 
102102285(MAP2K2)
FPG: 
101924296(MAP2K2)
FCH: 
102049695(MAP2K2)
CLV: 
102097053(MAP2K2)
ASN: 
102375508(MAP2K2)
AMJ: 
102563228(MAP2K2)
PSS: 
102457075(MAP2K2)
CMY: 
102931357(MAP2K2)
ACS: 
PBI: 
103067786(MAP2K2)
DRE: 
100002225(map2k2b) 563181(map2k2a)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102350370(MAP2K2)
CMK: 
103183530(map2k2)
HMG: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Shaul YD, Seger R
  Title
The MEK/ERK cascade: from signaling specificity to diverse functions.
  Journal
Biochim Biophys Acta 1773:1213-26 (2007)
Reference
  Authors
Boutros T, Chevet E, Metrakos P
  Title
Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer.
  Journal
Pharmacol Rev 60:261-310 (2008)

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