KEGG ORTHOLOGY: K04369

ORTHOLOGY: K04369

Entry

K04369 KO

Name

MAP2K2, MEK2

Definition

mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]

Pathway

ko04010	MAPK signaling pathway
ko04012	ErbB signaling pathway
ko04066	HIF-1 signaling pathway
ko04151	PI3K-Akt signaling pathway
ko04270	Vascular smooth muscle contraction
ko04370	VEGF signaling pathway
ko04540	Gap junction
ko04620	Toll-like receptor signaling pathway
ko04650	Natural killer cell mediated cytotoxicity
ko04660	T cell receptor signaling pathway
ko04662	B cell receptor signaling pathway
ko04664	Fc epsilon RI signaling pathway
ko04720	Long-term potentiation
ko04722	Neurotrophin signaling pathway
ko04730	Long-term depression
ko04810	Regulation of actin cytoskeleton
ko04910	Insulin signaling pathway
ko04912	GnRH signaling pathway
ko04915	Estrogen signaling pathway
ko04916	Melanogenesis
ko05020	Prion diseases
ko05161	Hepatitis B
ko05164	Influenza A
ko05200	Pathways in cancer
ko05205	Proteoglycans in cancer
ko05211	Renal cell carcinoma
ko05213	Endometrial cancer
ko05214	Glioma
ko05215	Prostate cancer
ko05216	Thyroid cancer
ko05218	Melanoma
ko05219	Bladder cancer
ko05220	Chronic myeloid leukemia
ko05221	Acute myeloid leukemia
ko05223	Non-small cell lung cancer

Disease

H00523

Noonan syndrome and related disorders

Brite

KEGG Orthology (KO) [BR:ko00001]
Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04012 ErbB signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04370 VEGF signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04066 HIF-1 signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04151 PI3K-Akt signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  Cell communication
   04540 Gap junction
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04650 Natural killer cell mediated cytotoxicity
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04660 T cell receptor signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04662 B cell receptor signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04664 Fc epsilon RI signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  Endocrine system
   04910 Insulin signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04912 GnRH signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04915 Estrogen signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04916 Melanogenesis
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  Circulatory system
   04270 Vascular smooth muscle contraction
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  Nervous system
   04720 Long-term potentiation
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04730 Long-term depression
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04722 Neurotrophin signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
Human Diseases
  Cancers
   05200 Pathways in cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05205 Proteoglycans in cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05214 Glioma
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05216 Thyroid cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05221 Acute myeloid leukemia
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05220 Chronic myeloid leukemia
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05218 Melanoma
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05211 Renal cell carcinoma
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05219 Bladder cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05215 Prostate cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05213 Endometrial cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05223 Non-small cell lung cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  Neurodegenerative diseases
   05020 Prion diseases
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  Infectious diseases
   05164 Influenza A
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05161 Hepatitis B
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
Protein kinases [BR:ko01001]
Serine/threonine protein kinases: STE group
  STE7 family
   K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2

Other DBs

GO:

0004708

Genes

HSA:	5605(MAP2K2)
PTR:	100611792 456390(MAP2K2)
PPS:	100977025(MAP2K2) 100988437
GGO:	101126885(MAP2K2) 101148200
PON:	100450988
MCC:	721821(MAP2K2)
MMU:	26396(Map2k2)
RNO:	58960(Map2k2)
CFA:	611939(MAP2K2)
AML:	100465700
FCA:	101100281
BTA:	510434(MAP2K2)
SSC:	100525505(MAP2K2)
MDO:	100018044
SHR:	100917396(MAP2K2)
OAA:	100087942
GGA:	396349(MAP2K2)
MGP:	100551337
ACS:	100567176
DRE:	100002225(map2k2b) 563181(map2k2a)
TRU:	101070236
OLA:	101173453
HMG:	100213114

» show all

Reference

PMID:17112607

Authors

Shaul YD, Seger R

Title

The MEK/ERK cascade: from signaling specificity to diverse functions.

Journal

Biochim Biophys Acta 1773:1213-26 (2007)

Reference

PMID:18922965

Authors

Boutros T, Chevet E, Metrakos P

Title

Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer.

Journal

Pharmacol Rev 60:261-310 (2008)

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Ontology (6)   
   KEGG BRITE (5)   
   GO (1)   
Pathway (70)   
   KEGG PATHWAY (70)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (4)   
   KEGG DRUG (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (36)   
   KEGG GENES (27)   
   KEGG DGENES (1)   
   KEGG EGENES (6)   
   KEGG MGENES (2)   
Protein sequence (15)   
   UniProt (15)   
Literature (2)   
   PubMed (2)   
All databases (135)   

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