KEGG ORTHOLOGY: K04377

ORTHOLOGY: K04377

Entry

K04377                      KO

Symbol

MYC

Name

Myc proto-oncogene protein

Pathway

map04010

MAPK signaling pathway

map04012

ErbB signaling pathway

map04110

Cell cycle

map04151

PI3K-Akt signaling pathway

map04218

Cellular senescence

map04310

Wnt signaling pathway

map04350

TGF-beta signaling pathway

map04390

Hippo signaling pathway

map04391

Hippo signaling pathway - fly

map04550

Signaling pathways regulating pluripotency of stem cells

map04630

JAK-STAT signaling pathway

map04919

Thyroid hormone signaling pathway

map05132

Salmonella infection

map05160

Hepatitis C

map05161

Hepatitis B

map05163

Human cytomegalovirus infection

map05166

Human T-cell leukemia virus 1 infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05169

Epstein-Barr virus infection

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05205

Proteoglycans in cancer

map05206

MicroRNAs in cancer

map05207

Chemical carcinogenesis - receptor activation

map05210

Colorectal cancer

map05213

Endometrial cancer

map05216

Thyroid cancer

map05219

Bladder cancer

map05220

Chronic myeloid leukemia

map05221

Acute myeloid leukemia

map05222

Small cell lung cancer

map05224

Breast cancer

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

map05230

Central carbon metabolism in cancer

Disease

H00001

B-cell acute lymphoblastic leukemia

H00002

T-cell acute lymphoblastic leukemia

H00008

Burkitt lymphoma

H00010

Multiple myeloma

H00013

Small cell lung cancer

H00016

Oral cancer

H00025

Penile cancer

H00027

Ovarian cancer

H00028

Choriocarcinoma

H00036

Osteosarcoma

H00041

Kaposi sarcoma

H00048

Hepatocellular carcinoma

H00055

Laryngeal cancer

H01463

Mycosis fungoides

H01509

Tonsillar cancer

H01554

Fallopian tube cancer

H01667

Medulloblastoma

H02434

Diffuse large B-cell lymphoma, not otherwise specified

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04377  MYC; Myc proto-oncogene protein
   04012 ErbB signaling pathway
    K04377  MYC; Myc proto-oncogene protein
   04310 Wnt signaling pathway
    K04377  MYC; Myc proto-oncogene protein
   04350 TGF-beta signaling pathway
    K04377  MYC; Myc proto-oncogene protein
   04390 Hippo signaling pathway
    K04377  MYC; Myc proto-oncogene protein
   04391 Hippo signaling pathway - fly
    K04377  MYC; Myc proto-oncogene protein
   04630 JAK-STAT signaling pathway
    K04377  MYC; Myc proto-oncogene protein
   04151 PI3K-Akt signaling pathway
    K04377  MYC; Myc proto-oncogene protein
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K04377  MYC; Myc proto-oncogene protein
   04218 Cellular senescence
    K04377  MYC; Myc proto-oncogene protein
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K04377  MYC; Myc proto-oncogene protein
09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    K04377  MYC; Myc proto-oncogene protein
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04377  MYC; Myc proto-oncogene protein
   05202 Transcriptional misregulation in cancer
    K04377  MYC; Myc proto-oncogene protein
   05206 MicroRNAs in cancer
    K04377  MYC; Myc proto-oncogene protein
   05205 Proteoglycans in cancer
    K04377  MYC; Myc proto-oncogene protein
   05207 Chemical carcinogenesis - receptor activation
    K04377  MYC; Myc proto-oncogene protein
   05230 Central carbon metabolism in cancer
    K04377  MYC; Myc proto-oncogene protein
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04377  MYC; Myc proto-oncogene protein
   05225 Hepatocellular carcinoma
    K04377  MYC; Myc proto-oncogene protein
   05226 Gastric cancer
    K04377  MYC; Myc proto-oncogene protein
   05216 Thyroid cancer
    K04377  MYC; Myc proto-oncogene protein
   05221 Acute myeloid leukemia
    K04377  MYC; Myc proto-oncogene protein
   05220 Chronic myeloid leukemia
    K04377  MYC; Myc proto-oncogene protein
   05219 Bladder cancer
    K04377  MYC; Myc proto-oncogene protein
   05213 Endometrial cancer
    K04377  MYC; Myc proto-oncogene protein
   05224 Breast cancer
    K04377  MYC; Myc proto-oncogene protein
   05222 Small cell lung cancer
    K04377  MYC; Myc proto-oncogene protein
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04377  MYC; Myc proto-oncogene protein
   05161 Hepatitis B
    K04377  MYC; Myc proto-oncogene protein
   05160 Hepatitis C
    K04377  MYC; Myc proto-oncogene protein
   05163 Human cytomegalovirus infection
    K04377  MYC; Myc proto-oncogene protein
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04377  MYC; Myc proto-oncogene protein
   05169 Epstein-Barr virus infection
    K04377  MYC; Myc proto-oncogene protein
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04377  MYC; Myc proto-oncogene protein
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04377  MYC; Myc proto-oncogene protein
   03019 Messenger RNA biogenesis
    K04377  MYC; Myc proto-oncogene protein
Transcription factors [BR:ko03000]
Eukaryotic type
  Basic helix-loop-helix/leucine zipper (bHLH-ZIP)
   Cell cycle controlling factors, Myc
    K04377  MYC; Myc proto-oncogene protein
Messenger RNA biogenesis [BR:ko03019]
Eukaryotic type
  mRNA surveillance and transport factors
   Factors involved in mRNA localization
    Factors that have mRNA localization signals
     K04377  MYC; Myc proto-oncogene protein

Genes

HSA:

4609(MYC)

PTR:	464393(MYC)

PPS:	103786410(MYC)

GGO:	101137026(MYC)

PON:	100456735(MYC)

NLE:	100589322(MYC)

HMH:	116813588(MYC)

MCC:	694626(MYC)

MCF:	102127966(MYC)

MTHB:

126960612

MNI:	105492792(MYC)

CSAB:

103237430(MYC)

CATY:

105588384(MYC)

PANU:

101000645(MYC)

TGE:	112630275(MYC)

MLEU:

105537628(MYC)

RRO:	104674798(MYC)

RBB:	108528761(MYC)

TFN:	117078846(MYC)

PTEH:

111550563(MYC)

CANG:

105509076(MYC)

CJC:	100407754(MYC)

SBQ:	101047066(MYC)

CIMI:

108283896(MYC)

CSYR:

103264057(MYC)

MMUR:

105882748(MYC)

LCAT:

123644625(MYC)

PCOQ:

105811323(MYC)

OGA:	100952981(MYC)

MMU:	17869(Myc)

MCAL:

110310583(Myc)

MPAH:

110334656(Myc)

RNO:	24577(Myc)

MCOC:

116082253(Myc)

ANU:	117695826 117695848 117696009 117719150(Myc)

MUN:	110560064(Myc)

CGE:	100773301(Myc)

MAUA:

101826382(Myc)

PROB:

127235215(Myc)

PLEU:

114701991(Myc)

MORG:

121461531(Myc)

MFOT:

126503554

AAMP:

119822940(Myc)

NGI:	103743920(Myc)

HGL:	101704740(Myc)

CPOC:

100724557(Myc)

CCAN:

109699943(Myc)

DORD:

105992358(Myc)

DSP:	122102408(Myc)

PLOP:

125360808(Myc)

NCAR:

124965808

MMMA:

107142789(Myc)

OCU:	100327265(MYC)

OPI:	101522285(MYC)

TUP:	102501999(MYC)

GVR:	103587820(MYC)

CFA:	403924(MYC)

CLUD:

112662261(MYC)

VVP:	112915979(MYC)

VLG:	121499098(MYC)

NPO:	129502657(MYC)

AML:	100464396(MYC)

UMR:	103661697(MYC)

UAH:	113252726(MYC)

UAR:	123801908(MYC)

ELK:

111146783

LLV:

125098611

MPUF:

101689754(MYC)

MNP:	132014301(MYC)

MLK:	131826401(MYC)

NVS:	122904298(MYC)

ORO:	101369253(MYC)

EJU:	114211166(MYC)

ZCA:	113911568(MYC)

MLX:	118015212(MYC)

NSU:	110578930(MYC)

LWW:	102739954(MYC)

FCA:	100379628(MYC)

PYU:	121042977(MYC)

PCOO:

112859511(MYC)

PBG:	122495809(MYC)

PVIV:

125156689(MYC)

LRUF:

124507805

PTG:	102954147(MYC)

PPAD:

109273136(MYC)

PUC:

125924410

AJU:

106976895

HHV:	120240874(MYC)

BTA:	511077(MYC)

BOM:	102274304(MYC)

BIU:	109568594(MYC)

BBUB:

102402664(MYC)

BBIS:

104991741(MYC)

CHX:	102171262(MYC)

OAS:	443447(MYC)

BTAX:

128059120(MYC)

ODA:	120878883(MYC)

CCAD:

122451212(MYC)

MBEZ:

129560340(MYC)

SSC:	448810(MYC)

CFR:	102511086(MYC)

CBAI:

105082940(MYC)

CDK:	105096445(MYC)

VPC:	102541072(MYC)

BACU:

103016933(MYC)

BMUS:

118883580(MYC)

LVE:	103089962(MYC)

OOR:	101274490(MYC)

DLE:	111164391(MYC)

PCAD:

102988128(MYC)

PSIU:

116742545(MYC)

NASI:

112397143(MYC)

ECB:	100068097(MYC)

EPZ:	103567860(MYC)

EAI:	106824829(MYC)

MYB:	102257498(MYC)

MYD:	102758544(MYC)

MMYO:

118670599(MYC)

MLF:	102426511(MYC)

PKL:	118718671(MYC)

EFUS:

103292358(MYC)

MNA:	107539494(MYC)

DRO:	112315592(MYC)

SHON:

118988677(MYC)

AJM:	119064823(MYC)

PDIC:

114514698(MYC)

PHAS:

123833339(MYC)

MMF:	118631560(MYC)

PPAM:

129084081(MYC)

HAI:	109383211(MYC)

RFQ:	117034063(MYC)

PALE:

102895524(MYC)

PGIG:

120595433(MYC)

PVP:	105292561(MYC)

RAY:	107506202(MYC)

MJV:	108399996(MYC)

TOD:	119238040(MYC)

SARA:

101541387(MYC)

SETR:

125997181(MYC)

LAV:	100665874(MYC)

TMU:

101349786

ETF:	101649029(MYC)

DNM:	101411312(MYC)

MDO:	100032344(MYC)

GAS:	123241543(MYC)

SHR:	100921308(MYC)

AFZ:

127544452

PCW:	110216083(MYC)

OAA:	100079391(MYC)

GGA:	420332(MYC)

MGP:	100547931(MYC)

CJO:	107310561(MYC)

TPAI:

128091562(MYC)

LMUT:

125691213(MYC)

NMEL:

110394505(MYC)

APLA:

101803370(MYC)

ACYG:

106038450(MYC)

CATA:

118252717(MYC)

AFUL:

116486166(MYC)

TGU:	100219849(MYC)

LSR:	110476978(MYC)

SCAN:

103816707(MYC)

PMOA:

120505192(MYC)

OTC:	121337475(MYC)

PRUF:

121364668(MYC)

FAB:	101819732(MYC)

OMA:	130250060(MYC)

PHI:	102108851(MYC)

PMAJ:

107200993(MYC)

CCAE:

111925128(MYC)

CCW:	104692644(MYC)

ETL:	114055794(MYC)

SVG:	106860585(MYC)

MMEA:

130574989(MYC)

HRT:	120752847(MYC)

FPG:	101923426(MYC)

FCH:	102056832(MYC)

CLV:	102085948(MYC)

EGZ:	104134424(MYC)

NNI:	104016870(MYC)

ACUN:

113476188(MYC)

TALA:

104361388(MYC)

ACHC:

115340741(MYC)

HLE:	104837769(MYC)

AGEN:

126050260

GCL:

127013024

SHAB:

115616653(MYC)

DPUB:

104302934(MYC)

CPEA:

104392843(MYC)

RTD:	128906254(MYC)

CUCA:

104058510(MYC)

AAM:	106496220(MYC)

AROW:

112971811(MYC)

NPD:	112959422(MYC)

TGT:	104570855(MYC)

DNE:	112989193(MYC)

ASN:	102370393(MYC)

AMJ:	102561083(MYC)

GGN:	109299072(MYC)

PSS:	102449445(MYC)

CMY:	102943256(MYC)

CCAY:

125632839(MYC)

DCC:	119852135(MYC)

CPIC:

101945997(MYC)

TST:	117873814(MYC)

CABI:

116826543(MYC)

MRV:	120398075(MYC)

ACS:	100558533(myc)

ASAO:

132775112(MYC)

PVT:	110085305(MYC)

SUND:

121929441(MYC)

PBI:	103057606(MYC)

PMUR:

107299311(MYC)

CTIG:

120304829(MYC)

TSR:	106542510(MYC)

PGUT:

117668415(MYC)

APRI:

131195762(MYC)

PTEX:

113438317(MYC)

NSS:	113419634(MYC)

VKO:	123033703(MYC)

PMUA:

114600250(MYC)

PRAF:

128417079(MYC)

ZVI:	118090392(MYC)

HCG:	128324239(MYC)

GJA:	107122472(MYC)

STOW:

125439325(MYC)

EMC:	129333559(MYC)

XLA:	379052(myc.S) 399315(myc.L)

XTR:	395024(myc)

NPR:	108788968(MYC)

RTEM:

120941525(MYC)

BBUF:

121001196(MYC)

MUO:	115480440(MYC)

GSH:	117355351(MYC)

DRE:	30686(myca) 393141(mycb)

SRX:	107713991 107724569 107748305

SANH:

107657430 107681468 107691431

SGH:	107558335 107584016 107589955

CCAR:

109074830 109074831 109091773 109104004

CAUA:

113042350 113045698 113045699 113066038 113078257 113118297

CGIB:

127945911 127951108 128013593 128030400

PTET:

122325413(mycb) 122329955(myca)

LROH:

127154385(mycb) 127156107(myca)

OMC:	131521827(mycb) 131532794(myca)

PPRM:

120476017(myca) 120481646(mycb)

RKG:	130087718(myca) 130101734(mycb)

MAMB:

125251860(mycb) 125258151(myca)

CIDE:

127506190 127506739

MASI:

127431776 127434738 127441502 127442144

TROS:

130546959(myca) 130554414(mycb)

TDW:	130413701(myca) 130418541(mycb)

MANU:

129425893(myca) 129442068(mycb)

IPU:	100304504(myca) 108268289(mycb)

IFU:	128599743(myca) 128609564(mycb)

PHYP:

113540692 113541047

SMEO:

124387216(mycb) 124403655(myca)

TFD:	113657589(mycb) 113660062(myca)

TVC:	132840463(myca) 132848371(mycb)

AMEX:

103033997 103038167

CMAO:

118799079(myca) 118826448(mycb)

EEE:	113573843 113589820

CHAR:

105889299(myca) 105907531(mycb)

TRU:	101072742 101079255 653028(myc)

TFS:	130513619(myca)

TNG:	GSTEN00031807G001

LCO:	104934318 104935616(myc) 104938695

NCC:	104954577(myc) 104958803

TBEN:

117472040 117494349(myca)

CGOB:

115005048 115025812(myc)

PGEO:

117443435 117465696(myca)

GACU:

117534628 117544662(myca)

EMAC:

134865853 134883736(myca)

ELY:	117257284(mych) 117264404(myca) 117271564

EFO:	125882091(myca) 125902294

PLEP:

121960607 121960696(mych) 121965585

SLUC:

116045331(myca) 116047779(mych) 116064649

ECRA:

117938040(myca) 117953951

ESP:	116672376(myc)

PFLV:

114549120(myc) 114565462

GAT:	120811943(myca) 120834660(mych)

PPUG:

119198565(myca)

AFB:	129088896 129110739(myca)

CLUM:

117749293(myca)

PSWI:

130206496(myca)

MSAM:

119882023(mych) 119902666 119911475(myca)

SCHU:

122866331(myca) 122886971

CUD:	121506822(mych) 121520189 121527273(myca)

ALAT:

119008730(myca) 119010664 119021652(mych)

MZE:	101464606 101474120(myc) 101479046

ONL:	100689989(myc) 100693620 100703314

OAU:	116314968 116317109(mych) 116335970(myca)

OLA:	101164933(myc) 101171524(c-myc17)

OML:	112144350 112151214(myca)

CSAI:

133422973(myca) 133452370

XMA:	102220374 102224917(myc) 102229551

XCO:	114136008 114137130(myc) 114146318

XHE:	116710401 116711129 116712209(myc) 116721002

PRET:

103456842(myc) 103460619 103464233

PFOR:

103149787 103149788 103156129 103156957

PLAI:

106940530 106945081 106952749 106962582

PMEI:

106905808 106916071 106921410 106930758

GAF:	122824063(myca) 122834505(mych) 122841724

PPRL:

129352704 129356143 129364770(myca)

CVG:	107085371(myc) 107093432 107102162

CTUL:

119774253 119790937(mych) 119791708(myca)

GMU:	124856963(mych) 124858439(myca) 124869726

NFU:	107382539(myc) 107383716 107385060

KMR:	108230277(myca) 108249494(mych) 108251479

ALIM:

106525658(myc) 106529105 106531183

NWH:	119412726(mych) 119414333 119426681(myca)

AOCE:

111563189 111568600 111570036(myc)

MCEP:

124995915(mycA) 125006852(mycH) 125011002

CSEM:

103377415 103386756

POV:	109629885(myc) 109642921

SSEN:

122765450(mycb) 122768632(myca)

HHIP:

117754053(myca) 117761588(mych)

HSP:	118098820(myca) 118104858(mych)

SMAU:

118287792(myca) 118308779(mych) 118311397

LCF:	108874403(mych) 108882464 108895017

SDU:	111237873(myc) 111238287 111239852

SLAL:

111649068 111656568(myc) 111662034

XGL:	120783284(mych) 120789537(myca) 120800118

HCQ:	109521513 109521620 109521839(myc)

SSCV:

125986048

SBIA:

133492564(myca)

PEE:	133396416(myca)

PTAO:

133469959(myca)

BPEC:

110168965 110170064(myc)

MALB:

109971489(myc) 109973991 109974776

BSPL:

114854531(myca) 114855486(mych)

SJO:	128368661 128382709(myca)

SASA:

100380346(myc2) 100380531(myc) 106568625(myc) 106578682 106590162(c-myc)

STRU:

115151122 115154720 115156503(myc) 115195764 115208402

OTW:	112215682 112227947 112250064(mycb) 112254112 112266912(mych)

OMY:	100136645(myc) 110493870(mych) 110527649 110529924(mycb) 110535641(c-myc)

OGO:	123991710 124003998 124008172 124010168(mycb) 124039768

ONE:	115105179 115114043(myc) 115130353 115135000 115142871

OKI:	109874940 109890756 109891040 109899466 109908800

OKE:	118361486 118370058 118373368 118388909(mych) 118402411

SALP:

111953622(myc) 111956764 111961527 111969668 111973342

SNH:	120026673(mych) 120028045 120050402 120055724(mycb) 120064987

CCLU:

121534858(mycb) 121550033 121569899 121575608(mych) 121578302

ELS:	105019386 105023685(myc) 105029935

SFM:	108937539(myc) 108942150

PKI:	111841624 111846207

AANG:

118224511 118234756

LOC:	102684410(myc)

PSPA:

121298159 121307859 121314608

ARUT:

117394278(mycb) 117409784 117428910

PSEX:

120529802

LCM:	102357079(MYC) 102359985

CMK:

103185113

RTP:	109916636 109923817(mych)

CPLA:

HOC:

LERI:

BFO:

BBEL:

SPU:	115923034 373385

APLC:

110980035

SKO:	100303478(myc)

DME:	Dmel_CG10798(Myc)

DER:

6550855

DSE:

6616230

DSI:	Dsimw501_GD16640(Dsim_GD16640)

DYA:	Dyak_GE16299

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI14431

DAZ:	108620333 108620486

DNV:	108657983 108658135

DHE:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

ACOZ:

AARA:

ASTE:

AAG:

AALB:

CQU:	CpipJ_CPIJ009795

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

MPHA:

CFO:

FEX:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

MDL:

CGLO:

123267250 123267254 123267255 123268334

FAS:

DAM:

CCIN:

SOY:

ATD:

CSET:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

100862782(myc)

BMAN:

114243276

MSEX:

115447895

DPL:	KGM_212323

BANY:

MJU:

NIQ:

VCD:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

CCRC:

LSIN:

AAGE:

HAW:	110373683(myc)

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

BTAB:

DCI:

CLEC:

NLU:

ZNE:

CSEC:

PVM:

PJA:

PCHN:

HAME:

PTRU:

MNZ:

EAF:	111698550 111698610 111712953

CSCU:

111624731

SDM:

118182885

LPOL:

106461001 106470940 106474333

PCAN:

112574050

BGT:

106051578

GAE:	121374318 121391225

HRJ:

MYI:

MMER:

OBI:

OSN:

LAK:

NVE:	5506937 5520948

EPA:	110235021 110252441 110252442

ATEN:

116288923

ADF:	107347212 107347213 107347303

AMIL:

114953257 114966470

PDAM:

113676714 113681741 113681742 113681758

SPIS:

111322965 111322966 111331277

DGT:	114525473 114532128 114542420

XEN:	124450523 124450582 124455223 124458000 124459186

HMG:	100197524(myc1) 100199110(myc2) 105844435

HSY:

130653927

TAD:	TRIADDRAFT_57914

AQU:	100636430 105315217 109590575

MBR:	MONBRDRAFT_33423(MbMyc)

VG:	1491953(ACVgp1)

» show all

Reference

PMID:6462227

Authors

Stanton LW, Fahrlander PD, Tesser PM, Marcu KB

Title

Nucleotide sequence comparison of normal and translocated murine c-myc genes.

Journal

Nature 310:423-5 (1984)
DOI:10.1038/310423a0

Sequence

[mmu:17869]

Reference

PMID:16087886

Authors

Bellosta P, Hulf T, Balla Diop S, Usseglio F, Pradel J, Aragnol D, Gallant P

Title

Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development.

Journal

Proc Natl Acad Sci U S A 102:11799-804 (2005)
DOI:10.1073/pnas.0408945102

Sequence

[dme:Dmel_CG10798]

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