KEGG   ORTHOLOGY: K04399Help
Entry
K04399                      KO                                     

Name
CASP9
Definition
caspase 9 [EC:3.4.22.62]
Pathway
p53 signaling pathway
PI3K-Akt signaling pathway
Apoptosis
VEGF signaling pathway
Thyroid hormone signaling pathway
Alzheimer's disease
Parkinson's disease
Amyotrophic lateral sclerosis (ALS)
Huntington's disease
Legionellosis
Toxoplasmosis
Tuberculosis
Hepatitis B
Influenza A
Pathways in cancer
Colorectal cancer
Pancreatic cancer
Endometrial cancer
Prostate cancer
Small cell lung cancer
Non-small cell lung cancer
Viral myocarditis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04370 VEGF signaling pathway
    K04399  CASP9; caspase 9
   04151 PI3K-Akt signaling pathway
    K04399  CASP9; caspase 9
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K04399  CASP9; caspase 9
   04115 p53 signaling pathway
    K04399  CASP9; caspase 9
 Organismal Systems
  Endocrine system
   04919 Thyroid hormone signaling pathway
    K04399  CASP9; caspase 9
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04399  CASP9; caspase 9
   05210 Colorectal cancer
    K04399  CASP9; caspase 9
   05212 Pancreatic cancer
    K04399  CASP9; caspase 9
   05215 Prostate cancer
    K04399  CASP9; caspase 9
   05213 Endometrial cancer
    K04399  CASP9; caspase 9
   05222 Small cell lung cancer
    K04399  CASP9; caspase 9
   05223 Non-small cell lung cancer
    K04399  CASP9; caspase 9
  Neurodegenerative diseases
   05010 Alzheimer's disease
    K04399  CASP9; caspase 9
   05012 Parkinson's disease
    K04399  CASP9; caspase 9
   05014 Amyotrophic lateral sclerosis (ALS)
    K04399  CASP9; caspase 9
   05016 Huntington's disease
    K04399  CASP9; caspase 9
  Cardiovascular diseases
   05416 Viral myocarditis
    K04399  CASP9; caspase 9
  Infectious diseases
   05134 Legionellosis
    K04399  CASP9; caspase 9
   05152 Tuberculosis
    K04399  CASP9; caspase 9
   05164 Influenza A
    K04399  CASP9; caspase 9
   05161 Hepatitis B
    K04399  CASP9; caspase 9
   05145 Toxoplasmosis
    K04399  CASP9; caspase 9
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.62  caspase-9
     K04399  CASP9; caspase 9
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K04399  CASP9; caspase 9
Peptidases [BR:ko01002]
 Cysteine Peptidases
  Family C14: caspase family
   K04399  CASP9; caspase 9
BRITE hierarchy
Genes
HSA: 
842(CASP9)
PTR: 
456457(CASP9)
PPS: 
100992567(CASP9)
GGO: 
101130414(CASP9)
PON: 
100460459(CASP9)
MCC: 
694544(CASP9)
MCF: 
102126830(CASP9)
MMU: 
12371(Casp9)
RNO: 
58918(Casp9)
CGE: 
HGL: 
101702898(Casp9)
TUP: 
102470940(CASP9)
CFA: 
487432(CASP9)
AML: 
FCA: 
768260(CASP9)
PTG: 
102967404(CASP9)
BTA: 
100140945(CASP9)
BOM: 
102268660(CASP9)
PHD: 
102336217(CASP9)
CHX: 
102174681(CASP9)
OAS: 
101110953(CASP9)
SSC: 
100518913(CASP9)
CFR: 
102519816(CASP9)
BACU: 
103010071(CASP9)
LVE: 
103086745(CASP9)
ECB: 
100054331(CASP9)
MYB: 
102254877(CASP9)
MYD: 
102759481(CASP9)
PALE: 
102878565(CASP9)
MDO: 
100027338(CASP9)
SHR: 
100931481(CASP9)
OAA: 
100092345(CASP9)
GGA: 
426970(CASP9)
APLA: 
101795386(CASP9)
TGU: 
100227981(CASP9)
FAB: 
101808292(CASP9)
PHI: 
102108950(CASP9)
FPG: 
101914844(CASP9)
FCH: 
102054465(CASP9)
CLV: 
102093506(CASP9)
ASN: 
102384999(CASP9)
AMJ: 
102573968(CASP9)
PSS: 
102443524(CASP9)
CMY: 
102939753(CASP9)
ACS: 
100560103(casp9)
PBI: 
XLA: 
373560(casp9)
XTR: 
100144708(casp9)
DRE: 
492763(casp9)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102362720(CASP9)
CMK: 
103187647(casp9)
BFO: 
SPU: 
HMG: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8663294
  Authors
Duan H, Orth K, Chinnaiyan AM, Poirier GG, Froelich CJ, He WW, Dixit VM
  Title
ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.
  Journal
J Biol Chem 271:16720-4 (1996)
Reference
  Authors
Sakamaki K, Satou Y
  Title
Caspases: evolutionary aspects of their functions in vertebrates.
  Journal
J Fish Biol 74:727-53 (2009)
Reference
  Authors
Chowdhury I, Tharakan B, Bhat GK
  Title
Caspases - an update.
  Journal
Comp Biochem Physiol B Biochem Mol Biol 151:10-27 (2008)

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