KEGG   ORTHOLOGY: K04431
Entry
K04431                      KO                                     
Symbol
MAP2K7, MKK7
Name
mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
Pathway
map04010  MAPK signaling pathway
map04012  ErbB signaling pathway
map04013  MAPK signaling pathway - fly
map04141  Protein processing in endoplasmic reticulum
map04214  Apoptosis - fly
map04361  Axon regeneration
map04380  Osteoclast differentiation
map04530  Tight junction
map04620  Toll-like receptor signaling pathway
map04624  Toll and Imd signaling pathway
map04660  T cell receptor signaling pathway
map04664  Fc epsilon RI signaling pathway
map04668  TNF signaling pathway
map04722  Neurotrophin signaling pathway
map04912  GnRH signaling pathway
map04926  Relaxin signaling pathway
map04936  Alcoholic liver disease
map05010  Alzheimer disease
map05016  Huntington disease
map05022  Pathways of neurodegeneration - multiple diseases
map05132  Salmonella infection
map05135  Yersinia infection
map05161  Hepatitis B
map05167  Kaposi sarcoma-associated herpesvirus infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05208  Chemical carcinogenesis - reactive oxygen species
map05417  Lipid and atherosclerosis
map05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   04013 MAPK signaling pathway - fly
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   04012 ErbB signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   04668 TNF signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
 09140 Cellular Processes
  09143 Cell growth and death
   04214 Apoptosis - fly
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   04624 Toll and Imd signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   04660 T cell receptor signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   04664 Fc epsilon RI signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   04926 Relaxin signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
  09158 Development and regeneration
   04361 Axon regeneration
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   04380 Osteoclast differentiation
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   05161 Hepatitis B
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   05169 Epstein-Barr virus infection
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   05135 Yersinia infection
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   05016 Huntington disease
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   05022 Pathways of neurodegeneration - multiple diseases
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   05418 Fluid shear stress and atherosclerosis
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE7 family
   K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
Other DBs
GO: 0004708
Genes
HSA: 5609(MAP2K7)
PTR: 743199(MAP2K7)
PPS: 100989537(MAP2K7)
GGO: 101124339(MAP2K7)
PON: 100431600(MAP2K7)
NLE: 100587140(MAP2K7)
HMH: 116478375(MAP2K7)
MCC: 710077(MAP2K7)
MCF: 102126975(MAP2K7)
MTHB: 126942652
MNI: 105481345(MAP2K7)
CSAB: 103233823(MAP2K7)
CATY: 105589128(MAP2K7)
PANU: 101011807(MAP2K7)
TGE: 112613256(MAP2K7)
MLEU: 105541149(MAP2K7)
RRO: 104679497(MAP2K7)
RBB: 108534524(MAP2K7)
TFN: 117074239(MAP2K7)
PTEH: 111522663(MAP2K7)
CANG: 105512966(MAP2K7)
CJC: 100412930(MAP2K7)
SBQ: 101047840(MAP2K7)
CIMI: 108283651(MAP2K7)
CSYR: 103251143(MAP2K7)
MMUR: 105885655(MAP2K7)
LCAT: 123635482(MAP2K7)
PCOQ: 105807933(MAP2K7)
OGA: 100966900(MAP2K7)
MMU: 26400(Map2k7)
MCAL: 110299603(Map2k7)
MPAH: 110336400(Map2k7)
RNO: 363855(Map2k7)
MCOC: 116068848(Map2k7)
ANU: 117697775(Map2k7)
MUN: 132650544(Map2k7)
CGE: 100754421(Map2k7)
MAUA: 101838095(Map2k7)
PROB: 127237193(Map2k7)
PLEU: 114686066(Map2k7)
MORG: 121464926(Map2k7)
MFOT: 126491615
AAMP: 119824883(Map2k7)
NGI: 103726522(Map2k7)
HGL: 101710666(Map2k7)
CPOC: 100731057(Map2k7)
CCAN: 109698434(Map2k7)
DORD: 105998779(Map2k7)
DSP: 122119668(Map2k7)
PLOP: 125348683(Map2k7)
NCAR: 124968601
MMMA: 107157355(Map2k7)
OCU: 103345313
OPI: 101518825(MAP2K7)
TUP: 102500732(MAP2K7)
GVR: 103596394(MAP2K7)
CFA: 485004(MAP2K7)
CLUD: 112666418(MAP2K7)
VVP: 112909663(MAP2K7)
VLG: 121495379(MAP2K7)
NPO: 129521885(MAP2K7)
AML: 100475975(MAP2K7)
UMR: 103681888(MAP2K7)
UAH: 113242915(MAP2K7)
UAR: 123777544(MAP2K7)
ELK: 111161723
LLV: 125085818
MPUF: 101690814(MAP2K7)
MNP: 132010893(MAP2K7)
MLK: 131823426(MAP2K7)
NVS: 122909795(MAP2K7)
ORO: 101382078(MAP2K7)
EJU: 114200845(MAP2K7)
ZCA: 113917379(MAP2K7)
MLX: 118005180(MAP2K7)
NSU: 110593849(MAP2K7)
LWW: 102744013(MAP2K7)
FCA: 101095157(MAP2K7)
PYU: 121013900(MAP2K7)
PBG: 122488616(MAP2K7)
LRUF: 124523965
PTG: 102949140(MAP2K7)
PPAD: 109254200(MAP2K7)
PUC: 125928966
AJU: 106970785
HHV: 120244848(MAP2K7)
BTA: 787278(MAP2K7)
BOM: 102272638(MAP2K7)
BIU: 109560948(MAP2K7)
BBUB: 102404881(MAP2K7)
BBIS: 104979935(MAP2K7)
CHX: 102173178(MAP2K7)
OAS: 100302082(MAP2K7)
BTAX: 128050697(MAP2K7)
ODA: 120863895(MAP2K7)
CCAD: 122440347(MAP2K7)
MBEZ: 129558655(MAP2K7)
SSC: 100520418(MAP2K7)
CFR: 102506459(MAP2K7)
CBAI: 105078286(MAP2K7)
CDK: 105087572(MAP2K7)
VPC: 102525041(MAP2K7)
BACU: 103011683(MAP2K7)
LVE: 103091499(MAP2K7)
OOR: 101288079(MAP2K7)
DLE: 111166011(MAP2K7)
PCAD: 102991774(MAP2K7)
PSIU: 116750630(MAP2K7)
NASI: 112400298(MAP2K7)
ECB: 100147230(MAP2K7)
EPZ: 103543808(MAP2K7)
EAI: 106844503(MAP2K7)
MYB: 102247950(MAP2K7)
MYD: 102760954(MAP2K7)
MMYO: 118659182(MAP2K7)
MLF: 102429748(MAP2K7)
MNA: 107529906(MAP2K7)
PKL: 118725973(MAP2K7)
EFUS: 103295027(MAP2K7)
HAI: 109396087(MAP2K7)
DRO: 112305131(MAP2K7)
SHON: 118994072(MAP2K7)
AJM: 119059334(MAP2K7)
PDIC: 114515070(MAP2K7)
PHAS: 123826609(MAP2K7)
MMF: 118615560(MAP2K7)
RFQ: 117037761(MAP2K7)
PPAM: 129078555(MAP2K7)
PALE: 102892533(MAP2K7)
PGIG: 120598851(MAP2K7)
PVP: 105307700(MAP2K7)
RAY: 107519926(MAP2K7)
MJV: 108409616(MAP2K7)
TOD: 119240438(MAP2K7)
SARA: 101554595(MAP2K7)
LAV: 100673238(MAP2K7)
TMU: 101346746
ETF: 101663385(MAP2K7)
DNM: 101420451(MAP2K7)
MDO: 100026752(MAP2K7)
GAS: 123232293(MAP2K7)
SHR: 100926110(MAP2K7)
AFZ: 127545314
PCW: 110202112(MAP2K7)
OAA: 100089737(MAP2K7)
GGA: 107050551
PCOC: 116240373(MAP2K7)
CJO: 107307804
NMEL: 110390478(MAP2K7)
LSR: 110480664(MAP2K7)
PMOA: 120507221(MAP2K7)
OTC: 121339061(MAP2K7)
PRUF: 121359336(MAP2K7)
GFR: 102038813(MAP2K7)
FAB: 101812216
OMA: 130263048(MAP2K7)
PHI: 102100701(MAP2K7)
PMAJ: 107198843(MAP2K7)
CCAE: 111922673(MAP2K7)
SVG: 106864315(MAP2K7)
MMEA: 130587083
FPG: 101924219(MAP2K7)
FCH: 102048069
ACHC: 115348378(MAP2K7)
HLE: 104832630(MAP2K7)
AGEN: 126043166
SHAB: 115603011(MAP2K7)
RTD: 128901461(MAP2K7)
AROW: 112964469
ASN: 102372350(MAP2K7)
AMJ: 102562496(MAP2K7)
PSS: 102463924(MAP2K7)
CMY: 102932325(MAP2K7)
CCAY: 125627826(MAP2K7)
DCC: 119845784(MAP2K7)
CPIC: 101931768(MAP2K7)
TST: 117888469(MAP2K7)
CABI: 116825425(MAP2K7)
ACS: 100566152(map2k7)
ASAO: 132768725(MAP2K7)
PVT: 110082669(MAP2K7)
SUND: 121920395(MAP2K7)
PBI: 103066234(MAP2K7)
PMUR: 107291150(MAP2K7)
CTIG: 120304578(MAP2K7)
TSR: 106547907(MAP2K7)
PGUT: 117658997(MAP2K7)
APRI: 131189657(MAP2K7)
PTEX: 113433617(MAP2K7)
NSS: 113418170(MAP2K7)
VKO: 123035442(MAP2K7)
PMUA: 114590811(MAP2K7)
PRAF: 128407685(MAP2K7)
ZVI: 118079984(MAP2K7)
HCG: 128345198(MAP2K7)
GJA: 107117671(MAP2K7)
STOW: 125428306(MAP2K7)
EMC: 129327488(MAP2K7)
XLA: 108712658(map2k7.S) 394391(map2k7.L)
XTR: 613115(map2k7)
NPR: 108790540(MAP2K7)
RTEM: 120933221(MAP2K7)
BBUF: 120986233(MAP2K7)
BGAR: 122927344(MAP2K7)
MUO: 115466111(MAP2K7)
GSH: 117350117(MAP2K7)
DRE: 560913(map2k7)
SGH: 107567797(map2k7) 107602992
CCAR: 109066210
PTET: 122345306(map2k7)
LROH: 127164041(map2k7)
OMC: 131541690(map2k7)
PPRM: 120490141(map2k7)
RKG: 130084929(map2k7)
MAMB: 125272001(map2k7)
CIDE: 127514659
TROS: 130552981(map2k7)
TDW: 130439432(map2k7)
MANU: 129444208(map2k7)
IPU: 108258614
IFU: 128601752(map2k7)
PHYP: 113537632(map2k7)
SMEO: 124378210(map2k7)
TFD: 113649058(map2k7)
TVC: 132839161(map2k7)
AMEX: 103024363(map2k7)
CMAO: 118802941(map2k7)
EEE: 113580330(map2k7)
CHAR: 105904987(map2k7)
TRU: 101064650(map2k7)
TFS: 130527894(map2k7)
LCO: 104934939(map2k7)
NCC: 104951572(map2k7)
TBEN: 117481609(map2k7)
CGOB: 115007203(map2k7)
PGEO: 117446901(map2k7)
GACU: 117537936(map2k7)
ELY: 117255429(map2k7)
EFO: 125885455(map2k7)
PLEP: 121942123(map2k7)
SLUC: 116042635(map2k7)
ECRA: 117957114(map2k7)
ESP: 116705548(map2k7)
PFLV: 114570500(map2k7)
GAT: 120825459(map2k7)
PPUG: 119218454(map2k7)
AFB: 129095918(map2k7)
CLUM: 117735363(map2k7)
MSAM: 119899297(map2k7)
SCHU: 122870668(map2k7)
CUD: 121507965(map2k7)
ALAT: 119026740(map2k7)
MZE: 101475777(map2k7)
ONL: 100705501(map2k7)
OAU: 116310902(map2k7)
OLA: 101164950(map2k7)
OML: 112157187(map2k7)
XMA: 102238025(map2k7)
XCO: 114144382(map2k7)
XHE: 116719884(map2k7)
PRET: 103467648(map2k7)
PFOR: 103153184(map2k7)
PLAI: 106950657(map2k7)
PMEI: 106917328(map2k7)
GAF: 122830227(map2k7)
CVG: 107101318(map2k7)
CTUL: 119775517(map2k7)
GMU: 124868478(map2k7)
NFU: 107382265(map2k7)
KMR: 108242723(map2k7)
ALIM: 106515295(map2k7)
NWH: 119422598(map2k7)
AOCE: 111564211(map2k7)
MCEP: 125003975(map2k7)
CSEM: 103383563(map2k7)
POV: 109627519(map2k7)
SSEN: 122771483(map2k7)
HHIP: 117762324(map2k7)
HSP: 118117141(map2k7)
LCF: 108875834
SDU: 111236339(map2k7)
SLAL: 111659787(map2k7)
XGL: 120800202(map2k7)
HCQ: 109511101(map2k7)
SSCV: 125969589
SBIA: 133505540(map2k7)
PEE: 133403602(map2k7)
PTAO: 133477200(map2k7)
BPEC: 110166191(map2k7)
MALB: 109966260(map2k7)
BSPL: 114863852(map2k7)
SJO: 128364664(map2k7)
ELS: 105021508(map2k7)
SFM: 108939797(map2k7)
PKI: 111833549(map2k7)
AANG: 118218059(map2k7)
LOC: 102697033(map2k7)
PSPA: 121309118(map2k7)
PSEX: 120540006(map2k7)
LCM: 102365163(MAP2K7)
CMK: 121851675
RTP: 109911816(map2k7)
CPLA: 122552163(map2k7)
HOC: 132835794(map2k7)
LERI: 129714404(map2k7)
PMRN: 116938943(MAP2K7)
LRJ: 133348675(MAP2K7)
BFO: 118420702
BBEL: 109484714
CIN: 778674(mapkk7)
SCLV: 120344497
SPU: 591137
LPIC: 129277916
APLC: 110986882
AJC: 117100424
SKO: 100376238
DME: Dmel_CG4353(hep)
DER: 6551002
DSE: 6618620
DSI: Dsimw501_GD15909(Dsim_GD15909)
DAN: 6503566
DSR: 110183528
DPO: 6902255
DPE: 6597692
DMN: 108164891
DAZ: 108620344
DNV: 108656874
DHE: 111593442
DVI: 6633831
RZE: 108354289
LCQ: 111679763
ECOE: 129941830
ACOZ: 120950206
AARA: 120898722
AAG: 5578019
BCOO: 119074769
AME: 413389
ACER: 107997109
ALAB: 122716338
ADR: 102675503
AFLR: 100872794
BIM: 100740833
BBIF: 117205895
BVK: 117231547
BVAN: 117153851
BTER: 100631092
BAFF: 126916776
BPYO: 122577934
BPAS: 132905483
FVI: 122527477
CCAL: 108623498
OBB: 114873219
OLG: 117605298
MGEN: 117220436
NMEA: 116434861
CGIG: 122398265
SOC: 105195984
MPHA: 105833681
AEC: 105151228
ACEP: 105619941
PBAR: 105424720
VEM: 105568514
HST: 105185444
DQU: 106745527
CFO: 105252678
FEX: 115240135
LHU: 105675778
PGC: 109857214
OBO: 105285129
PCF: 106787706
PFUC: 122522997
VPS: 122629111
VCRB: 124423335
NVI: 100121060
CSOL: 105368763
TPRE: 106650145
LHT: 122499816
LBD: 127285115
MDL: 103573420
CGLO: 123272484
FAS: 105264806
DAM: 107035668
AGIF: 122847724
CINS: 118072496
VCAN: 122410864
CCIN: 107274219
DSM: 124407167
NPT: 124214876
NFB: 124178454
NLO: 107223169
NVG: 124300474
AROA: 105682958
TCA: 103315236(hep)
DPA: 109543217
AGRG: 126743363
ATD: 109609105
CSET: 123318809
AGB: 108911176
LDC: 111502266
NVL: 108566466
APLN: 108738775
PPYR: 116163149
OTU: 111418457
BMOR: 100862753
BMAN: 114242559
MSEX: 115455022
BANY: 112055177
MJU: 123864929
NIQ: 126777207
VCD: 124535653
MCIX: 123661149
PMAC: 106711754
PPOT: 106107766
PXU: 106117320
PRAP: 111002093
PBX: 123720496
PNAP: 125063467
ZCE: 119830012
CCRC: 123698631
LSIN: 126964644
HZE: 124640100
TNL: 113494585
SLIU: 111353767
OFU: 114355322
PGW: 126380112
CFEL: 113371997
CCRN: 123293227
API: 100165019
DNX: 107167783
AGS: 114127951
RMD: 113551935
ACOO: 126838612
DVT: 126900648
BTAB: 109034576
DCI: 103512031
CLEC: 106668141
NLU: 111046650
HVI: 124360201
FOC: 113210603
TPAL: 117641320
ZNE: 110838369
CSEC: 111867889
SGRE: 126297663
FCD: 110847803
DMK: 116927923
DPZ: 124315156
PCHN: 125046830
HAME: 121862490
PCLA: 123767696
PTRU: 123509393
EAF: 111704368
LSM: 121117095
TCF: 131893126
PPOI: 119103901
DSV: 119436590
RSAN: 119399813
RMP: 119161503
VDE: 111248800
VJA: 111261190
TUT: 107371332
DPTE: 113793114
DFR: 124491813
CSCU: 111640167
PTEP: 107450140
UDV: 129234607
SDM: 118204925
PMEO: 129598520
CEL: CELE_K08A8.1(mek-1)
CBR: CBG_16698(Cbr-mek-1)
PVUL: 126830858
PCAN: 112575282
BGT: 106066037
GAE: 121383132
HRF: 124114981
HRJ: 124257625
CRG: 105339236
CANU: 128155517
OED: 125679744
MYI: 110464981
PMAX: 117345321
MCAF: 127730232
MMER: 123547019
RPHI: 132727676
DPOL: 127837046
OBI: 106868012
OSN: 115212821
SHX: MS3_00001436(MAP2K7_1)
EGL: EGR_04146
NVE: 5515320
EPA: 110244754
ATEN: 116308668
ADF: 107332902
AMIL: 114947543
PDAM: 113681688
SPIS: 111326634
DGT: 114518977
XEN: 124438136
HMG: 100201328
HSY: 130662655
AQU: 100640493
 » show all
Reference
PMID:9372971
  Authors
Wu Z, Wu J, Jacinto E, Karin M
  Title
Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase.
  Journal
Mol Cell Biol 17:7407-16 (1997)
DOI:10.1128/MCB.17.12.7407
  Sequence
[hsa:5609]

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