KEGG   ORTHOLOGY: K04440Help
Entry
K04440                      KO                                     

Name
JNK
Definition
c-Jun N-terminal kinase [EC:2.7.11.24]
Pathway
MAPK signaling pathway
ErbB signaling pathway
MAPK signaling pathway - fly
Ras signaling pathway
cAMP signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Protein processing in endoplasmic reticulum
Apoptosis
Longevity regulating pathway - worm
Apoptosis - fly
Apoptosis - multiple species
Wnt signaling pathway
Osteoclast differentiation
Hippo signaling pathway - fly
Focal adhesion
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Dopaminergic synapse
Inflammatory mediator regulation of TRP channels
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Prolactin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
AGE-RAGE signaling pathway in diabetic complications
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Salmonella infection
Pertussis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Influenza A
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Colorectal cancer
Pancreatic cancer
Choline metabolism in cancer
Module
M00688  
MAPK (JNK) signaling
Disease
H00606  
Early infantile epileptic encephalopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K04440  JNK; c-Jun N-terminal kinase
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04440  JNK; c-Jun N-terminal kinase
   04010 MAPK signaling pathway
    K04440  JNK; c-Jun N-terminal kinase
   04013 MAPK signaling pathway - fly
    K04440  JNK; c-Jun N-terminal kinase
   04012 ErbB signaling pathway
    K04440  JNK; c-Jun N-terminal kinase
   04310 Wnt signaling pathway
    K04440  JNK; c-Jun N-terminal kinase
   04391 Hippo signaling pathway -fly
    K04440  JNK; c-Jun N-terminal kinase
   04668 TNF signaling pathway
    K04440  JNK; c-Jun N-terminal kinase
   04068 FoxO signaling pathway
    K04440  JNK; c-Jun N-terminal kinase
   04071 Sphingolipid signaling pathway
    K04440  JNK; c-Jun N-terminal kinase
   04024 cAMP signaling pathway
    K04440  JNK; c-Jun N-terminal kinase
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K04440  JNK; c-Jun N-terminal kinase
   04214 Apoptosis - fly
    K04440  JNK; c-Jun N-terminal kinase
   04215 Apoptosis - multiple species
    K04440  JNK; c-Jun N-terminal kinase
  Cellular commiunity
   04510 Focal adhesion
    K04440  JNK; c-Jun N-terminal kinase
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K04440  JNK; c-Jun N-terminal kinase
   04621 NOD-like receptor signaling pathway
    K04440  JNK; c-Jun N-terminal kinase
   04622 RIG-I-like receptor signaling pathway
    K04440  JNK; c-Jun N-terminal kinase
   04664 Fc epsilon RI signaling pathway
    K04440  JNK; c-Jun N-terminal kinase
  Endocrine system
   04910 Insulin signaling pathway
    K04440  JNK; c-Jun N-terminal kinase
   04920 Adipocytokine signaling pathway
    K04440  JNK; c-Jun N-terminal kinase
   04912 GnRH signaling pathway
    K04440  JNK; c-Jun N-terminal kinase
   04914 Progesterone-mediated oocyte maturation
    K04440  JNK; c-Jun N-terminal kinase
   04917 Prolactin signaling pathway
    K04440  JNK; c-Jun N-terminal kinase
  Nervous system
   04728 Dopaminergic synapse
    K04440  JNK; c-Jun N-terminal kinase
   04723 Retrograde endocannabinoid signaling
    K04440  JNK; c-Jun N-terminal kinase
   04722 Neurotrophin signaling pathway
    K04440  JNK; c-Jun N-terminal kinase
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04440  JNK; c-Jun N-terminal kinase
  Development
   04380 Osteoclast differentiation
    K04440  JNK; c-Jun N-terminal kinase
  Aging
   04212 Longevity regulating pathway - worm
    K04440  JNK; c-Jun N-terminal kinase
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04440  JNK; c-Jun N-terminal kinase
   05231 Choline metabolism in cancer
    K04440  JNK; c-Jun N-terminal kinase
   05210 Colorectal cancer
    K04440  JNK; c-Jun N-terminal kinase
   05212 Pancreatic cancer
    K04440  JNK; c-Jun N-terminal kinase
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K04440  JNK; c-Jun N-terminal kinase
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K04440  JNK; c-Jun N-terminal kinase
   04931 Insulin resistance
    K04440  JNK; c-Jun N-terminal kinase
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04440  JNK; c-Jun N-terminal kinase
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04440  JNK; c-Jun N-terminal kinase
   05132 Salmonella infection
    K04440  JNK; c-Jun N-terminal kinase
   05131 Shigellosis
    K04440  JNK; c-Jun N-terminal kinase
   05133 Pertussis
    K04440  JNK; c-Jun N-terminal kinase
   05152 Tuberculosis
    K04440  JNK; c-Jun N-terminal kinase
   05164 Influenza A
    K04440  JNK; c-Jun N-terminal kinase
   05161 Hepatitis B
    K04440  JNK; c-Jun N-terminal kinase
   05160 Hepatitis C
    K04440  JNK; c-Jun N-terminal kinase
   05168 Herpes simplex infection
    K04440  JNK; c-Jun N-terminal kinase
   05169 Epstein-Barr virus infection
    K04440  JNK; c-Jun N-terminal kinase
   05145 Toxoplasmosis
    K04440  JNK; c-Jun N-terminal kinase
   05142 Chagas disease (American trypanosomiasis)
    K04440  JNK; c-Jun N-terminal kinase
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00688  MAPK (JNK) signaling
     K04440  JNK; c-Jun N-terminal kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     K04440  JNK; c-Jun N-terminal kinase
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: CMGC group
  MAPK family [OT]
   K04440  JNK; c-Jun N-terminal kinase
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
5599(MAPK8) 5601(MAPK9) 5602(MAPK10)
PTR: 
450445(MAPK8) 461358(MAPK10) 462336(MAPK9)
PPS: 
100982480(MAPK8) 100984173(MAPK10) 100990080(MAPK9)
GGO: 
PON: 
100174482(MAPK10) 100437424(MAPK8) 100459133(MAPK9)
NLE: 
100581677(MAPK9) 100602081(MAPK10) 100605285(MAPK8)
MCC: 
699736(MAPK10) 711115(MAPK8) 715782(MAPK9)
MCF: 
102118497(MAPK9) 102121272(MAPK10) 102126339(MAPK8)
RRO: 
104668007(MAPK10) 104676194(MAPK9) 104678447(MAPK8)
CJC: 
100387686(MAPK9) 100390109(MAPK10) 100392721(MAPK8)
MMU: 
26414(Mapk10) 26419(Mapk8) 26420(Mapk9)
RNO: 
116554(Mapk8) 25272(Mapk10) 50658(Mapk9)
CGE: 
100754361(Mapk10) 100764964(Mapk9) 100771734(Mapk8)
NGI: 
103735023(Mapk8) 103748972(Mapk10) 103749366(Mapk9)
HGL: 
101698286(Mapk9) 101712980(Mapk10) 101715259(Mapk8)
OCU: 
100337999(MAPK10) 100342664(MAPK9) 100346929(MAPK8)
TUP: 
102472233(MAPK8) 102475730(MAPK10) 102497095(MAPK9)
CFA: 
474652(MAPK9) 477746(MAPK8) 478464(MAPK10)
AML: 
100477600(MAPK9) 100477951(MAPK10) 100482196(MAPK8)
UMR: 
103667893(MAPK8) 103676947(MAPK10) 103679990(MAPK9)
FCA: 
101084765(MAPK9) 101091310(MAPK8) 101101463(MAPK10)
PTG: 
102950880(MAPK8) 102959159(MAPK10) 102963096(MAPK9)
BTA: 
534125(MAPK9) 537631(MAPK10) 539941(MAPK8)
BOM: 
102266960(MAPK9) 102272421(MAPK10) 102277976(MAPK8)
PHD: 
102323252(MAPK9) 102334117(MAPK8) 102344390(MAPK10)
CHX: 
100861087(MAPK8) 102170408(MAPK9) 102182774(MAPK10)
OAS: 
101116201(MAPK8) 101120665(MAPK10) 101120826(MAPK9)
SSC: 
100521736(MAPK10) 396609(MAPK9) 396610(MAPK8)
CFR: 
102503577(MAPK8) 102509448(MAPK10) 102518561(MAPK9)
BACU: 
102997603(MAPK8) 103007019(MAPK9) 103008728(MAPK10)
LVE: 
103078792(MAPK10) 103084630(MAPK8) 103087676(MAPK9)
ECB: 
100051798(MAPK8) 100052608(MAPK10) 100057961(MAPK9)
MYB: 
102246292(MAPK8) 102259984(MAPK9) 102263026(MAPK10)
MYD: 
102764416(MAPK8) 102772062(MAPK9) 102772884(MAPK10) 102775351(MAPK10)
PALE: 
102885064(MAPK10) 102890689(MAPK9) 102892777(MAPK8)
MDO: 
100028089(MAPK9) 100618895(MAPK10)
SHR: 
100924267(MAPK9) 100928480(MAPK10) 100930815(MAPK8)
OAA: 
100073424(MAPK9) 100076033(MAPK8) 100082590(MAPK10)
GGA: 
395983(MAPK9) 422592(MAPK10) 423778(MAPK8)
MGP: 
100541011(MAPK9) 100542628(MAPK10) 100547737(MAPK8)
CJO: 
107313439(MAPK10) 107315851(MAPK8) 107320159(MAPK9)
APLA: 
101793594(MAPK8) 101799011(MAPK9) 101799776(MAPK10)
TGU: 
100218416 100220867(MAPK8) 100223519(MAPK10) 100225285(MAPK9)
GFR: 
102036009(MAPK8) 102043222(MAPK9) 102043776(MAPK10)
FAB: 
101809052(MAPK10) 101817339(MAPK8) 101819306(MAPK9)
PHI: 
102099159(MAPK10) 102106744(MAPK9) 102114724(MAPK8)
CCW: 
104689594(MAPK9) 104696634(MAPK8) 104697227(MAPK10)
FPG: 
101917138(MAPK10) 101921076(MAPK9) 101924129(MAPK8)
FCH: 
102047380(MAPK8) 102054176(MAPK10) 102055660(MAPK9)
CLV: 
102085027(MAPK9) 102085840(MAPK10) 102087983(MAPK8)
AAM: 
106493457(MAPK9) 106496655(MAPK10) 106497812(MAPK8)
ASN: 
102374542(MAPK10) 102376040(MAPK9) 102376154(MAPK8)
AMJ: 
102566087(MAPK10) 102570366(MAPK8) 102570628(MAPK9)
PSS: 
102453224(MAPK9) 102459702(MAPK8) 102460734(MAPK10)
CMY: 
102932835(MAPK10) 102934812(MAPK9) 102935187(MAPK8)
ACS: 
100558211(mapk10) 100561907(mapk8) 100565814(mapk9)
PBI: 
103049456(MAPK10) 103059296(MAPK9) 103060996(MAPK8) 103066640
GJA: 
XLA: 
379876(mapk8)
XTR: 
100170194(mapk8) 779515(mapk10)
DRE: 
100149273(mapk9) 562720(mapk8a) 569698(mapk10) 65236(mapk8b)
TRU: 
101067839(mapk10) 101070190(mapk8) 101073575 101078548(mapk9)
MZE: 
101476882(mapk9) 101477577(mapk8) 101480702 101486303(mapk10)
OLA: 
101157952(mapk9) 101158978 101164997(mapk8) 101168799(mapk10)
XMA: 
LCM: 
102351693(MAPK9) 102351958(MAPK10) 102357573(MAPK8)
CMK: 
103180867(mapk10) 103183732(mapk9) 103185857(mapk8)
BFO: 
CIN: 
778660(jnk)
SPU: 
SKO: 
DME: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD22289(Dsim_GD22289)
DWI: 
DYA: 
Dyak_GE26274(dyak_GLEANR_983)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
409286(bsk)
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
663836(bsk)
BMOR: 
PXY: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG05733(Cbr-jnk-1)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8137421
  Authors
Derijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ
  Title
JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain.
  Journal
Cell 76:1025-37 (1994)
  Sequence
[hsa:5599]
Reference
  Authors
Miotto B, Struhl K
  Title
JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress.
  Journal
Mol Cell 44:62-71 (2011)
  Sequence
[hsa:5599]
Reference
  Authors
Kawasaki M, Hisamoto N, Iino Y, Yamamoto M, Ninomiya-Tsuji J, Matsumoto K
  Title
A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons.
  Journal
EMBO J 18:3604-15 (1999)
  Sequence

DBGET integrated database retrieval system