KEGG ORTHOLOGY: K04441

ORTHOLOGY: K04441

Entry

K04441 KO

Name

P38

Definition

p38 MAP kinase [EC:2.7.11.24]

Pathway

ko04010	MAPK signaling pathway
ko04011	MAPK signaling pathway - yeast
ko04370	VEGF signaling pathway
ko04380	Osteoclast differentiation
ko04620	Toll-like receptor signaling pathway
ko04621	NOD-like receptor signaling pathway
ko04622	RIG-I-like receptor signaling pathway
ko04660	T cell receptor signaling pathway
ko04664	Fc epsilon RI signaling pathway
ko04670	Leukocyte transendothelial migration
ko04722	Neurotrophin signaling pathway
ko04723	Retrograde endocannabinoid signaling
ko04728	Dopaminergic synapse
ko04912	GnRH signaling pathway
ko04914	Progesterone-mediated oocyte maturation
ko05014	Amyotrophic lateral sclerosis (ALS)
ko05120	Epithelial cell signaling in Helicobacter pylori infection
ko05131	Shigellosis
ko05132	Salmonella infection
ko05133	Pertussis
ko05140	Leishmaniasis
ko05142	Chagas disease (American trypanosomiasis)
ko05145	Toxoplasmosis
ko05152	Tuberculosis
ko05160	Hepatitis C
ko05164	Influenza A
ko05169	Epstein-Barr virus infection
ko05205	Proteoglycans in cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04441  P38; p38 MAP kinase
   04011 MAPK signaling pathway - yeast
    K04441  P38; p38 MAP kinase
   04370 VEGF signaling pathway
    K04441  P38; p38 MAP kinase
Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K04441  P38; p38 MAP kinase
   04621 NOD-like receptor signaling pathway
    K04441  P38; p38 MAP kinase
   04622 RIG-I-like receptor signaling pathway
    K04441  P38; p38 MAP kinase
   04660 T cell receptor signaling pathway
    K04441  P38; p38 MAP kinase
   04664 Fc epsilon RI signaling pathway
    K04441  P38; p38 MAP kinase
   04670 Leukocyte transendothelial migration
    K04441  P38; p38 MAP kinase
  Endocrine system
   04912 GnRH signaling pathway
    K04441  P38; p38 MAP kinase
   04914 Progesterone-mediated oocyte maturation
    K04441  P38; p38 MAP kinase
  Nervous system
   04728 Dopaminergic synapse
    K04441  P38; p38 MAP kinase
   04723 Retrograde endocannabinoid signaling
    K04441  P38; p38 MAP kinase
   04722 Neurotrophin signaling pathway
    K04441  P38; p38 MAP kinase
  Development
   04380 Osteoclast differentiation
    K04441  P38; p38 MAP kinase
Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    K04441  P38; p38 MAP kinase
  Neurodegenerative diseases
   05014 Amyotrophic lateral sclerosis (ALS)
    K04441  P38; p38 MAP kinase
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04441  P38; p38 MAP kinase
   05132 Salmonella infection
    K04441  P38; p38 MAP kinase
   05131 Shigellosis
    K04441  P38; p38 MAP kinase
   05133 Pertussis
    K04441  P38; p38 MAP kinase
   05152 Tuberculosis
    K04441  P38; p38 MAP kinase
   05164 Influenza A
    K04441  P38; p38 MAP kinase
   05160 Hepatitis C
    K04441  P38; p38 MAP kinase
   05169 Epstein-Barr virus infection
    K04441  P38; p38 MAP kinase
   05145 Toxoplasmosis
    K04441  P38; p38 MAP kinase
   05140 Leishmaniasis
    K04441  P38; p38 MAP kinase
   05142 Chagas disease (American trypanosomiasis)
    K04441  P38; p38 MAP kinase
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     K04441  P38; p38 MAP kinase
Protein kinases [BR:ko01001]
Serine/threonine protein kinases: CMGC group
  MAPK family
   K04441  P38; p38 MAP kinase

Other DBs

GO:

0008339

Genes

HSA:	1432(MAPK14) 5600(MAPK11) 5603(MAPK13) 6300(MAPK12)
PTR:	450161(MAPK14) 462644(MAPK13) 747077(MAPK12)
PPS:	100980937(MAPK11) 100981268(MAPK12) 100982544(MAPK13) 100983649(MAPK14)
GGO:	101134492(MAPK12) 101134843(MAPK11) 101148438(MAPK13) 101152640(MAPK14)
PON:	100437263(MAPK12) 100449269(MAPK14) 100449853(MAPK13)
MCC:	715745(MAPK12) 715794(MAPK11) 718976 719085
MMU:	19094(Mapk11) 26415(Mapk13) 26416(Mapk14) 29857(Mapk12)
RNO:	29513(Mapk13) 60352(Mapk12) 689314(Mapk11) 81649(Mapk14)
CFA:	403856(MAPK14) 607019(MAPK11) 607023(MAPK12) 612821(MAPK13)
AML:	100465223 100465476 100480235 100480483
FCA:	101081149(MAPK12) 101081396(MAPK11) 101101135(MAPK14)
BTA:	512943(MAPK12) 534492(MAPK14) 535327(MAPK13) 618906(MAPK11)
SSC:	100156630(MAPK14) 574062(MAPK12)
ECB:	100056239 100056278 100063532(MAPK14)
MDO:	100010279 100010891 100026324(MAPK14) 100028821
SHR:	100925013(MAPK14) 100925447(MAPK13) 100928729(MAPK12) 100928990(MAPK11)
OAA:	100078507 100091330 100093026
GGA:	417739(MAPK11) 421183(MAPK14) 769763(MAPK12) 771145(MAPK13)
MGP:	100540259 100540416 100546830 100546983(MAPK13)
TGU:	100218485 100225101(MAPK11) 100227852 100227993(MAPK12)
ACS:	100563538 100563731(mapk11) 100567479 100567676(mapk14)
XLA:	100329215(p38-beta) 379992(mapk14) 398592(mapk12) 494669(mapk11) 735153
XTR:	100101766(mapk11) 100144715(mapk13) 100145045(mapk12) 448296(mapk14) 549834(mapk12)
DRE:	100002318(mapk13) 266756(mapk14b) 30681(mapk12a) 415185(mapk11) 557810(mapk12b) 562552(fc89f08) 65237(mapk14a)
TRU:	101062695 101064045 101074026 101074428
OLA:	101154993 101159668 101160731 101162042 101171243 101172944 101175696
BFO:	BRAFLDRAFT_166018 BRAFLDRAFT_93656
CIN:	778927(p38)
SPU:	577728
DME:	Dmel_CG33338(p38c) Dmel_CG5475(Mpk2) Dmel_CG7393(p38b)
DPO:	Dpse_GA18909 Dpse_GA20320 Dpse_GA26003 Dpse_GA26518
DAN:	Dana_GF18893 Dana_GF18894 Dana_GF23057
DER:	Dere_GG12369 Dere_GG12370 Dere_GG23876
DPE:	Dper_GL21224 Dper_GL24141
DSE:	Dsec_GM15179 Dsec_GM23508 Dsec_GM23509
DSI:	Dsim_GD18318 Dsim_GD18319 Dsim_GD23919
DWI:	Dwil_GK11930 Dwil_GK18192
DYA:	Dyak_GE10824 Dyak_GE10825 Dyak_GE18678
DGR:	Dgri_GH11110 Dgri_GH19092
DMO:	Dmoj_GI18232 Dmoj_GI23428
DVI:	Dvir_GJ14531 Dvir_GJ18140
AAG:	AaeL_AAEL008379
CQU:	CpipJ_CPIJ002174
AME:	411915(p38b)
NVI:	100114440(P38mapk)
API:	100169493
PHU:	Phum_PHUM390460
ISC:	IscW_ISCW021966
CEL:	CELE_B0218.3(pmk-1) CELE_F42G8.3(pmk-2)
CBR:	CBG01554(Cbr-pmk-2) CBG01555(Cbr-pmk-1)
BMY:	Bm1_31785
TSP:	Tsp_03128
NVE:	NEMVE_v1g180219
HMG:	100212645
TAD:	TRIADDRAFT_50163
AQU:	100638502
SCE:	YLR113W(HOG1)
AGO:	AGOS_AGR048C
ERC:	Ecym_4266
KLA:	KLLA0F20053g
LTH:	KLTH0G12738g
PPA:	PAS_chr1-3_0232
VPO:	Kpol_543p55
ZRO:	ZYRO0D06182g
CGR:	CAGL0M11748g
NCS:	NCAS_0C03380(NCAS0C03380)
NDI:	NDAI_0G02700(NDAI0G02700)
TPF:	TPHA_0A01630(TPHA0A01630)
TBL:	TBLA_0H01330(TBLA0H01330)
TDL:	TDEL_0F04290(TDEL0F04290)
KAF:	KAFR_0B02980(KAFR0B02980)
DHA:	DEHA2E20944g
PIC:	PICST_54431
PGU:	PGUG_05033
LEL:	LELG_01317
CAL:	CaO19.8514(HOG1) CaO19.895(HOG1)
CTP:	CTRG_01181
CDU:	CD36_18080(HOG1)
COT:	CORT_0A11180
YLI:	YALI0E25135g
CLU:	CLUG_01883
NCR:	NCU07024
SMP:	SMAC_09127(os2)
PAN:	PODANSg3754
TTT:	THITE_2082381
MTM:	MYCTH_2309838
MGR:	MGG_01822
FGR:	FG09612.1
NHE:	NECHADRAFT_58353
VAL:	VDBG_04396
SSL:	SS1G_07590
BFU:	BC1G_03001
ANI:	AN1017.2 AN4668.2
NFI:	NFIA_012610
AFM:	AFUA_1G12940
AOR:	AOR_1_1044194
ANG:	ANI_1_492064(An07g03980) ANI_1_826074(An08g05850)
AFV:	AFLA_099500
ACT:	ACLA_022520
PCS:	Pc13g11680
CIM:	CIMG_05915
CPW:	CPC735_025180
PBL:	PAAG_00535
URE:	UREG_04432
TVE:	TRV_02393
AJE:	HCAG_08451
PNO:	SNOG_13296
PTE:	PTT_10964
ZTR:	MYCGRDRAFT_76502(MgHog1)
TML:	GSTUM_00005852001
SPO:	SPAC24B11.06c(sty1)
CNE:	CNC06590
CNB:	CNBC0610
CGI:	CGB_C0630C
PPL:	POSPLDRAFT_125584
LBC:	LACBIDRAFT_187188
CCI:	CC1G_00577
SCM:	SCHCODRAFT_72648
UMA:	UM02357.1
MGL:	MGL_0949
PGR:	PGTG_04715
MBR:	MONBRDRAFT_14615 MONBRDRAFT_2871 MONBRDRAFT_39353

» show all

Reference

PMID:20626350

Authors

Cuadrado A, Nebreda AR

Title

Mechanisms and functions of p38 MAPK signalling.

Journal

Biochem J 429:403-17 (2010)

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Ontology (5)   
   KEGG BRITE (4)   
   GO (1)   
Pathway (56)   
   KEGG PATHWAY (56)   
Drug (6)   
   KEGG DRUG (6)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (369)   
   KEGG GENES (229)   
   KEGG DGENES (17)   
   KEGG EGENES (65)   
   KEGG MGENES (58)   
Protein sequence (173)   
   UniProt (173)   
Literature (1)   
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All databases (611)   

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