KEGG   ORTHOLOGY: K04456Help
Entry
K04456                      KO                                     

Name
AKT
Definition
RAC serine/threonine-protein kinase [EC:2.7.11.1]
Pathway
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Tight junction
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Neurotrophin signaling pathway
Cholinergic synapse
Dopaminergic synapse
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Adipocytokine signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Carbohydrate digestion and absorption
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Disease
H00027  
Ovarian cancer
H00420  
Familial partial lipodystrophy (FPL)
H00539  
PTEN hamartoma tumor syndrome (PHTS)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04015 Rap1 signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04010 MAPK signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04012 ErbB signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04370 VEGF signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04630 Jak-STAT signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04668 TNF signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04066 HIF-1 signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04068 FoxO signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04024 cAMP signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04022 cGMP - PKG signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04151 PI3K-Akt signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04152 AMPK signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04150 mTOR signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K04456  AKT; RAC serine/threonine-protein kinase
  Cellular commiunity
   04510 Focal adhesion
    K04456  AKT; RAC serine/threonine-protein kinase
   04530 Tight junction
    K04456  AKT; RAC serine/threonine-protein kinase
 Organismal Systems
  Immune system
   04611 Platelet activation
    K04456  AKT; RAC serine/threonine-protein kinase
   04620 Toll-like receptor signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04660 T cell receptor signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04662 B cell receptor signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04664 Fc epsilon RI signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04666 Fc gamma R-mediated phagocytosis
    K04456  AKT; RAC serine/threonine-protein kinase
   04062 Chemokine signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
  Endocrine system
   04910 Insulin signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04920 Adipocytokine signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04915 Estrogen signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04914 Progesterone-mediated oocyte maturation
    K04456  AKT; RAC serine/threonine-protein kinase
   04917 Prolactin signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
   04919 Thyroid hormone signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04456  AKT; RAC serine/threonine-protein kinase
  Digestive system
   04973 Carbohydrate digestion and absorption
    K04456  AKT; RAC serine/threonine-protein kinase
  Nervous system
   04725 Cholinergic synapse
    K04456  AKT; RAC serine/threonine-protein kinase
   04728 Dopaminergic synapse
    K04456  AKT; RAC serine/threonine-protein kinase
   04722 Neurotrophin signaling pathway
    K04456  AKT; RAC serine/threonine-protein kinase
  Development
   04380 Osteoclast differentiation
    K04456  AKT; RAC serine/threonine-protein kinase
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04456  AKT; RAC serine/threonine-protein kinase
   05205 Proteoglycans in cancer
    K04456  AKT; RAC serine/threonine-protein kinase
   05210 Colorectal cancer
    K04456  AKT; RAC serine/threonine-protein kinase
   05212 Pancreatic cancer
    K04456  AKT; RAC serine/threonine-protein kinase
   05214 Glioma
    K04456  AKT; RAC serine/threonine-protein kinase
   05221 Acute myeloid leukemia
    K04456  AKT; RAC serine/threonine-protein kinase
   05220 Chronic myeloid leukemia
    K04456  AKT; RAC serine/threonine-protein kinase
   05218 Melanoma
    K04456  AKT; RAC serine/threonine-protein kinase
   05211 Renal cell carcinoma
    K04456  AKT; RAC serine/threonine-protein kinase
   05215 Prostate cancer
    K04456  AKT; RAC serine/threonine-protein kinase
   05213 Endometrial cancer
    K04456  AKT; RAC serine/threonine-protein kinase
   05222 Small cell lung cancer
    K04456  AKT; RAC serine/threonine-protein kinase
   05223 Non-small cell lung cancer
    K04456  AKT; RAC serine/threonine-protein kinase
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K04456  AKT; RAC serine/threonine-protein kinase
  Infectious diseases
   05152 Tuberculosis
    K04456  AKT; RAC serine/threonine-protein kinase
   05166 HTLV-I infection
    K04456  AKT; RAC serine/threonine-protein kinase
   05162 Measles
    K04456  AKT; RAC serine/threonine-protein kinase
   05164 Influenza A
    K04456  AKT; RAC serine/threonine-protein kinase
   05161 Hepatitis B
    K04456  AKT; RAC serine/threonine-protein kinase
   05160 Hepatitis C
    K04456  AKT; RAC serine/threonine-protein kinase
   05169 Epstein-Barr virus infection
    K04456  AKT; RAC serine/threonine-protein kinase
   05145 Toxoplasmosis
    K04456  AKT; RAC serine/threonine-protein kinase
   05142 Chagas disease (American trypanosomiasis)
    K04456  AKT; RAC serine/threonine-protein kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04456  AKT; RAC serine/threonine-protein kinase
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: AGC group
  AKT family
   K04456  AKT; RAC serine/threonine-protein kinase
BRITE hierarchy
Genes
HSA: 
10000(AKT3) 207(AKT1) 208(AKT2)
PTR: 
100609583(AKT3) 456035(AKT2) 740898(AKT1)
PPS: 
100969217(AKT3) 100969444(AKT1) 100991804(AKT2)
GGO: 
101124923(AKT1) 101137723(AKT2) 101138019(AKT3)
PON: 
100448114(AKT3) 100454279(AKT2)
MCC: 
697747(AKT1) 700591(AKT2) 714717(AKT3)
MCF: 
102132744(AKT2) 102142406(AKT1) 102144461(AKT3)
MMU: 
11651(Akt1) 11652(Akt2) 23797(Akt3)
RNO: 
24185(Akt1) 25233(Akt2) 29414(Akt3)
CGE: 
100752454(Akt3) 100768351(Akt2) 100769460(Akt1)
HGL: 
101700695(Akt1) 101701289(Akt3) 101719164(Akt2)
TUP: 
102472172(AKT2) 102474297(AKT3) 102492771(AKT1)
CFA: 
442964(AKT3) 449021(AKT2) 490878(AKT1)
AML: 
FCA: 
100499544(AKT2) 101087931(AKT1) 101092818(AKT3)
PTG: 
102952603(AKT3) 102954757(AKT2)
BTA: 
100137872(AKT3) 280991(AKT1) 534923(AKT2)
BOM: 
102265427(AKT3) 102275199(AKT2) 102283212(AKT1)
PHD: 
102333230(AKT3) 102339842(AKT2)
CHX: 
100860904(AKT1) 102174051(AKT3) 102187521(AKT2)
SSC: 
100126861(AKT1) 100127478(AKT2) 100513811(AKT3)
CFR: 
102503460(AKT2) 102515350(AKT3)
BACU: 
103002026(AKT3) 103004139(AKT2) 103013147(AKT1)
LVE: 
103068921(AKT3) 103076365(AKT1) 103084975(AKT2)
ECB: 
100054961(AKT3) 100061130(AKT1) 100064671(AKT2)
MYB: 
102251050(AKT1) 102254191(AKT2) 102254864(AKT3)
MYD: 
102772266(AKT3) 102773065(AKT2)
PALE: 
102879337(AKT3) 102885144(AKT1) 102898305(AKT2)
MDO: 
100014564(AKT2) 100019947(AKT1) 100027373(AKT3)
SHR: 
OAA: 
GGA: 
395928(AKT1) 421497(AKT3)
MGP: 
TGU: 
100217811(AKT3) 100232504(AKT1)
FAB: 
101814876(AKT1) 101819472(AKT3)
PHI: 
102104813(AKT1) 102112828(AKT3)
APLA: 
101800458(AKT1) 101801994(AKT2) 101804556(AKT3)
FPG: 
101910975(AKT1) 101918846(AKT3) 101918868(AKT2)
FCH: 
102050094(AKT3) 102055811(AKT1) 102060018(AKT2)
CLV: 
ASN: 
102372104(AKT1) 102388207(AKT2) 102388514(AKT3)
AMJ: 
102558879(AKT3) 102564996(AKT1) 102574794(AKT2)
PSS: 
102448379(AKT3) 102453850(AKT1)
CMY: 
102929975(AKT3) 102939884(AKT1) 102947630(AKT2)
ACS: 
PBI: 
103055559(AKT2) 103058510(AKT3) 103061866(AKT1)
XLA: 
379783(akt2) 399170(akt1) 432172(MGC78893)
XTR: 
100144709(akt2) 100490038(akt1)
DRE: 
100149794(akt3) 101910198(akt1) 378972(akt2) 403146(akt2l) 560549(akt3a)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102346546(AKT3) 102359272(AKT2) 102359797(AKT1)
CMK: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
413430(Akt1)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG09565(Cbr-akt-1)
BMY: 
LOA: 
TSP: 
SMM: 
HMG: 
100210496(akt3)
TAD: 
AQU: 
CCP: 
MBR: 
ACAN: 
PTI: 
PIF: 
NGR: 
TVA: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Carnero A
  Title
The PKB/AKT pathway in cancer.
  Journal
Curr Pharm Des 16:34-44 (2010)
Reference
  Authors
Liao Y, Hung MC
  Title
Physiological regulation of Akt activity and stability.
  Journal
Am J Transl Res 2:19-42 (2010)

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