KEGG   ORTHOLOGY: K04459Help
Entry
K04459                      KO                                     

Name
DUSP, MKP
Definition
dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]
Pathway
MAPK signaling pathway
Disease
H00255  
Hypogonadotropic hypogonadism
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04459  DUSP, MKP; dual specificity MAP kinase phosphatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     K04459  DUSP, MKP; dual specificity MAP kinase phosphatase
    3.1.3.48  protein-tyrosine-phosphatase
     K04459  DUSP, MKP; dual specificity MAP kinase phosphatase
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   MAPK phosphatases
    K04459  DUSP, MKP; dual specificity MAP kinase phosphatase
BRITE hierarchy
Other DBs
Genes
HSA: 
1844(DUSP2) 1846(DUSP4) 1847(DUSP5) 1848(DUSP6) 1849(DUSP7) 1850(DUSP8) 80824(DUSP16)
PTR: 
452115(DUSP6) 464497(DUSP4) 465297(DUSP16) 470826(DUSP7) 738584(DUSP5) 741723(DUSP2) 746336(DUSP8)
PPS: 
100983333(DUSP2)
GGO: 
101150765(DUSP2)
PON: 
100434673 100441872(DUSP2) 100444636(DUSP8) 100448820(DUSP16) 100457966(DUSP5) 100460640(DUSP4) 100460800(DUSP6)
MCC: 
696332(DUSP16) 698178(DUSP5) 698473(DUSP7) 708907(DUSP6) 714290(DUSP4) 718442(DUSP2) 720960(DUSP8)
MCF: 
102118860(DUSP2)
MMU: 
13537(Dusp2) 18218(Dusp8) 235584(Dusp7) 240672(Dusp5) 319520(Dusp4) 67603(Dusp6) 70686(Dusp16)
RNO: 
116663(Dusp6) 171109(Dusp5) 297682(Dusp16) 300980(Dusp7) 311406(Dusp2) 361679(Dusp8) 60587(Dusp4)
CGE: 
100757670(Dusp2) 100765417(Dusp7)
HGL: 
101702046(Dusp2)
TUP: 
102488964(DUSP7) 102495637(DUSP5)
CFA: 
482594(DUSP6) 483660(DUSP8) 484742(DUSP7) 486683(DUSP16) 486884(DUSP5) 611653(DUSP2)
AML: 
100464243(DUSP8) 100466694(DUSP6) 100468072(DUSP16) 100470219(DUSP4) 100474524(DUSP5) 100479162(DUSP7) 105240775(DUSP2)
FCA: 
101090684(DUSP2)
BTA: 
107131977(DUSP8) 507061(DUSP5) 515310(DUSP6) 539140(DUSP2) 540380(DUSP4) 615727 618644(DUSP16) 785016(DUSP7)
BOM: 
102265023(DUSP2) 102287805(DUSP5)
PHD: 
102325077(DUSP2)
CHX: 
102173395(DUSP2) 102174186(DUSP4)
SSC: 
100157144(DUSP5) 100514374(DUSP4) 100521473(DUSP7) 100620494 100622812(DUSP2) 100622968(DUSP6)
ECB: 
100051565(DUSP6) 100051611(DUSP2) 100058453(DUSP4) 100060559(DUSP7) 100063475(DUSP16) 100068966(DUSP5) 100146958(DUSP8)
MYB: 
102256351(DUSP2)
MDO: 
100013791(DUSP8) 100014655(DUSP6) 100015073(DUSP16) 100020686(DUSP4) 100028017(DUSP5) 100031101(DUSP7) 100033190(DUSP2)
SHR: 
100918580(DUSP8) 100926616(DUSP2)
OAA: 
100074749(DUSP7) 100077401(DUSP16) 100077666 100080443(DUSP6) 100082126(DUSP5)
GGA: 
374272(DUSP6) 395642(DUSP4) 415891(DUSP7) 423890(DUSP5) 431336(DUSP16) 770435(DUSP8)
MGP: 
100541970(DUSP8) 100542108(DUSP6) 100544063(DUSP16) 100545175(DUSP5) 100549821(DUSP4)
CJO: 
107311338(DUSP6)
TGU: 
100222007(DUSP16) 100222847(DUSP6) 100223600(DUSP4) 100226803(DUSP8) 100229727(DUSP7) 100232367(DUSP5)
FAB: 
101810587(DUSP6)
PHI: 
102111436(DUSP6)
FPG: 
101922044(DUSP6)
ACS: 
XLA: 
100505429 108695998(dusp5.L) 108712239(dusp4.L) 108712565(dusp16.S) 108714619(dusp7.L) 398254(dusp1.S) 398829(dusp6.L) 444752(dusp5.S) 495060 495963
XTR: 
100036691(dusp16) 548573(dusp5) 548863(dusp4) 733814(dusp7) 733815(dusp6)
DRE: 
114436(dusp5) 327246(dusp7) 353314(dusp6) 393854(dusp8a) 394146(dusp4) 406523(dusp16) 445057(dusp2)
TRU: 
MZE: 
101484664(dusp2)
OLA: 
101157459(dusp2)
XMA: 
LCM: 
102358462(DUSP2)
BFO: 
CIN: 
100183860 778580(dusp8.16)
SPU: 
DME: 
DPO: 
AGA: 
AAG: 
CQU: 
AME: 
411820(Mkp3)
NVI: 
TCA: 
CEL: 
CBR: 
CBG02372(Cbr-vhp-1) CBG05704(Cbr-lip-1)
BMY: 
TSP: 
LGI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
AT2G04550(IBR5)
ALY: 
GMX: 
MTR: 
OSA: 
4330549(OJ1008_D06.16) 4340847(P0414E10.1)
BDI: 
SBI: 
SORBI_04g029700(SORBIDRAFT_04g029700)
ZMA: 
100285381(GRMZM2G045404)
SMO: 
CRE: 
VCN: 
SCE: 
YBR276C(PPS1)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0B07490(NCAS0B07490)
NDI: 
NDAI_0B04820(NDAI0B04820)
TPF: 
TPHA_0I02700(TPHA0I02700)
TBL: 
TBLA_0F01370(TBLA0F01370)
TDL: 
TDEL_0D01800(TDEL0D01800)
KAF: 
KAFR_0C04160(KAFR0C04160)
PPA: 
DHA: 
PIC: 
PGU: 
LEL: 
CTP: 
COT: 
CDU: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
MGR: 
NHE: 
VAL: 
SSL: 
BFU: 
ANI: 
AFM: 
AOR: 
AOR_1_498094(AO090120000287)
ANG: 
ANI_1_1242164(An18g03040)
AFV: 
ACT: 
NFI: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
ZTR: 
TML: 
CNE: 
CNB: 
CGI: 
PPL: 
LBC: 
CCI: 
SCM: 
UMA: 
MGL: 
PGR: 
MBR: 
DDI: 
EHI: 
EHI_048550(107.t00002) EHI_053090(4.t00016) EHI_059820(101.t00013) EHI_079260(183.t00006)
EDI: 
ACAN: 
TET: 
PTM: 
TPS: 
GTT: 
VG: 
1733121(IIV6gp119) 22974500(ORF-133) 3431532(ORF-140_ptp2) 5364480(N318L) 5470864(Z219L) 5659340(B430L) 5660091(C378L) 918420(A305L) 951809(ptp2)
 » show all
TaxonomyVtaxonomyKoalaUniProt
Reference
  Authors
Bermudez O, Pages G, Gimond C
  Title
The dual-specificity MAP kinase phosphatases: critical roles in development and cancer.
  Journal
Am J Physiol Cell Physiol 299:C189-202 (2010)
Reference
  Authors
Keyse SM
  Title
Dual-specificity MAP kinase phosphatases (MKPs) and cancer.
  Journal
Cancer Metastasis Rev 27:253-61 (2008)
Reference
  Authors
Kondoh K, Nishida E
  Title
Regulation of MAP kinases by MAP kinase phosphatases.
  Journal
Biochim Biophys Acta 1773:1227-37 (2007)
Reference
  Authors
Patterson KI, Brummer T, O'Brien PM, Daly RJ
  Title
Dual-specificity phosphatases: critical regulators with diverse cellular targets.
  Journal
Biochem J 418:475-89 (2009)

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