KEGG   ORTHOLOGY: K04459Help
Entry
K04459                      KO                                     
Name
DUSP, MKP
Definition
dual specificity phosphatase [EC:3.1.3.16 3.1.3.48]
Pathway
MAPK signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04459  DUSP, MKP; dual specificity phosphatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  phosphoprotein phosphatase
     K04459  DUSP, MKP; dual specificity phosphatase
    3.1.3.48  protein-tyrosine-phosphatase
     K04459  DUSP, MKP; dual specificity phosphatase
BRITE hierarchy
Genes
HSA: 
11072(DUSP14) 11221(DUSP10) 1843(DUSP1) 1844(DUSP2) 1845(DUSP3) 1846(DUSP4) 1847(DUSP5) 1848(DUSP6) 1849(DUSP7) 1850(DUSP8) 1852(DUSP9) 56940(DUSP22) 80824(DUSP16)
PTR: 
452115(DUSP6) 464497(DUSP4) 465297(DUSP16) 468226(DUSP14) 468271(DUSP3) 469145(DUSP10) 470826(DUSP7) 471742(DUSP1) 738584(DUSP5) 740713(DUSP9) 746336 750495(DUSP22)
PPS: 
100971842(DUSP22) 100974933(DUSP6) 100976729(DUSP5) 100977037(DUSP9) 100978783(DUSP1) 100981920 100982627(DUSP4) 100983333(DUSP2) 100984563(DUSP14) 100988699(DUSP7) 100990230(DUSP3) 100991340(DUSP16) 100995665(DUSP8)
GGO: 
101124273(DUSP8) 101125194(DUSP3) 101127326(DUSP6) 101128460(DUSP14) 101133211(DUSP5) 101136431 101144461(DUSP22) 101145560(DUSP1) 101146122(DUSP16) 101147735(DUSP4) 101150559 101150765(DUSP2) 101154350(DUSP9)
PON: 
100172013(DUSP3) 100435862(DUSP1) 100439949(DUSP22) 100441872(DUSP2) 100444636(DUSP8) 100448820(DUSP16) 100451135(DUSP10) 100455112(DUSP14) 100457966(DUSP5) 100459785 100460640(DUSP4) 100460800(DUSP6) 100939018(DUSP9)
MCC: 
696161(DUSP9) 696332(DUSP16) 698178(DUSP5) 698473 702981(DUSP1) 705056(DUSP10) 705824(DUSP22) 708907(DUSP6) 713686(DUSP3) 714290(DUSP4) 714383(DUSP14) 718442 720960
MMU: 
105352(Dusp22) 13537(Dusp2) 18218(Dusp8) 19252(Dusp1) 235584(Dusp7) 240672(Dusp5) 319520(Dusp4) 56405(Dusp14) 63953(Dusp10) 67603(Dusp6) 70686(Dusp16) 72349(Dusp3) 75590(Dusp9)
RNO: 
114856(Dusp1) 116663(Dusp6) 171109(Dusp5) 293847(Dusp9) 297682(Dusp16) 300980(Dusp7) 311406(Dusp2) 360580(Dusp14) 361242(Dusp22) 361679(Dusp8) 498003(Dusp3) 60587(Dusp4) 63995(Dusp10)
CFA: 
480505(DUSP3) 482594(DUSP6) 482880(DUSP4) 483660(DUSP8) 484742(DUSP7) 486683(DUSP16) 486884(DUSP5) 488673(DUSP10) 489117(DUSP1) 491131(DUSP14) 492240(DUSP9) 606970 611653(DUSP2)
AML: 
FCA: 
101080951(DUSP9) 101082789(DUSP14) 101085448 101088832(DUSP4) 101089691(DUSP22) 101090684(DUSP2) 101091792(DUSP16) 101093416(DUSP1) 101095132 101096697(DUSP10) 101097255(DUSP6) 101098828(DUSP5) 101101624(DUSP7)
BTA: 
100850224 507061(DUSP5) 507294(DUSP14) 515310(DUSP6) 539140(DUSP2) 539175(DUSP1) 540380(DUSP4) 541175(DUSP10) 614306(DUSP9) 615432(DUSP3) 615727(DUSP8) 618644(DUSP16) 785016(DUSP7) 787471(DUSP22)
SSC: 
100157144(DUSP5) 100512983 100514374 100517416(DUSP10) 100519006 100521473 100522469(DUSP1) 100620494 100622812 100622968(DUSP6) 100623524
ECB: 
100050108(DUSP10) 100051565(DUSP6) 100051611 100057681 100057759 100058453 100060559 100063475(DUSP16) 100064999 100068966 100069834
MDO: 
100009813 100013795 100014655(DUSP6) 100015073(DUSP16) 100018106(DUSP10) 100020686 100027857 100028017 100028721 100031101(DUSP7) 100031265(DUSP1) 100033190
SHR: 
100915219 100915718(DUSP9) 100918580 100921269(DUSP6) 100923042 100923908(DUSP1) 100926616(DUSP2) 100928829(DUSP16) 100928979(DUSP3) 100930552(DUSP5) 100931495(DUSP14)
OAA: 
100074749 100076090 100076782 100077401(DUSP16) 100077666 100078511 100080443 100081167(DUSP10) 100081987 100082126
GGA: 
374192(DUSP1) 374272(DUSP6) 395642(DUSP4) 417657(DUSP14) 420887(DUSP22) 421340(DUSP10) 423890(DUSP5) 425527(DUSP3) 431336(DUSP16) 768665 770435(DUSP8)
MGP: 
100541970(DUSP8) 100542108 100543333 100543610 100544063(DUSP16) 100545175 100546569 100546582 100546942 100549821
TGU: 
100218546(DUSP14) 100219518(DUSP1) 100222007(DUSP16) 100222847(DUSP6) 100223600(DUSP4) 100226803(DUSP8) 100227773(DUSP10) 100227799(DUSP22) 100229727(DUSP7) 100232346(DUSP3) 100232367(DUSP5)
ACS: 
100551628 100552967 100555344 100557150 100557549 100557967 100558871(dusp6) 100558989 100561811 100562331(dusp8) 100563421 100565011 100567200(dusp16) 100567223 100567888
XLA: 
100505429 380262(dusp1) 398829(dusp6) 443862(dusp22) 444606(dusp14) 444752(dusp5) 495060 495963
XTR: 
100036691(dusp16) 100497288 100498529 448043(dusp1) 496452(dusp22) 548573(dusp5) 548863(dusp4) 733814(dusp7) 733815(dusp6) 779639(dusp14)
DRE: 
100000665 100002272(dusp22b) 100034609 114436(dusp5) 327246(dusp7) 353314(dusp6) 393854(dusp8a) 394146(dusp4) 406340(dusp1) 406523(dusp16) 445057(dusp2) 450040(dusp14)
TRU: 
100137150(dusp6) 101061126 101061562 101063158 101065665 101068137 101069624 101071863 101072053 101072874 101073776 101074284 101078614 101079172
OLA: 
101157459 101158099 101158832 101161478 101162227 101163358 101164462 101166402 101167166 101172819 101173264 101173794
BFO: 
BRAFLDRAFT_124221 BRAFLDRAFT_222288 BRAFLDRAFT_236700 BRAFLDRAFT_261371 BRAFLDRAFT_57405 BRAFLDRAFT_58757
CIN: 
100182135 100183860 778580(dusp8.16)
SPU: 
579231 582330 584461 586673 589648 763415
DME: 
Dmel_CG10089 Dmel_CG14080(Mkp3) Dmel_CG15528 Dmel_CG7850(puc)
DPO: 
Dpse_GA10063 Dpse_GA12750 Dpse_GA13785 Dpse_GA20632
DAN: 
Dana_GF10784 Dana_GF10970 Dana_GF16206 Dana_GF16724
DER: 
Dere_GG11968 Dere_GG13428 Dere_GG13761 Dere_GG23159
DPE: 
Dper_GL13480 Dper_GL20790 Dper_GL24256
DSE: 
Dsec_GM12185 Dsec_GM14895 Dsec_GM23703 Dsec_GM24587
DSI: 
Dsim_GD12305 Dsim_GD12655 Dsim_GD17377 Dsim_GD18513
DWI: 
Dwil_GK12504 Dwil_GK13421 Dwil_GK14377 Dwil_GK17106
DYA: 
Dyak_GE20058 Dyak_GE22525 Dyak_GE23417 Dyak_GE25849
DGR: 
Dgri_GH12630 Dgri_GH16683 Dgri_GH16949 Dgri_GH18324 Dgri_GH18398
DMO: 
Dmoj_GI11369 Dmoj_GI11370 Dmoj_GI11809 Dmoj_GI23305 Dmoj_GI23389
DVI: 
Dvir_GJ10384 Dvir_GJ11624 Dvir_GJ13512 Dvir_GJ24161
AGA: 
AgaP_AGAP004353 AgaP_AGAP006593 AgaP_AGAP012237 AgaP_AGAP012243
AAG: 
AaeL_AAEL001110 AaeL_AAEL001145 AaeL_AAEL010411 AaeL_AAEL014391
CQU: 
CpipJ_CPIJ005712 CpipJ_CPIJ005718 CpipJ_CPIJ007427
AME: 
408844(puc)
NVI: 
100121751(NV13973)
TCA: 
659125 660318 662837 664002
API: 
100163569 100164369 100168996 100574429
PHU: 
Phum_PHUM046720 Phum_PHUM280810 Phum_PHUM490910 Phum_PHUM601600
ISC: 
IscW_ISCW007877 IscW_ISCW011863 IscW_ISCW016177 IscW_ISCW021412
CEL: 
CELE_C04F12.8(C04F12.8) CELE_F08B1.1(vhp-1)
CBR: 
CBG02372(Cbr-vhp-1) CBG03773 CBG05704(Cbr-lip-1)
BMY: 
Bm1_21370 Bm1_22010 Bm1_47545
TSP: 
Tsp_11906 Tsp_12613
SMM: 
Smp_034500 Smp_038530 Smp_136040 Smp_169960
NVE: 
NEMVE_v1g124302 NEMVE_v1g234224 NEMVE_v1g81300 NEMVE_v1g92609
HMG: 
100213163 100214438
TAD: 
TRIADDRAFT_14780 TRIADDRAFT_19907 TRIADDRAFT_60150
AQU: 
100632228 100637025
ATH: 
AT2G04550(IBR5)
ALY: 
ARALYDRAFT_899261(IBR5)
GMX: 
100806021 100808721
MTR: 
MTR_5g084720
CSV: 
101211000 101223386
RCU: 
RCOM_0511150
POP: 
POPTR_732365
VVI: 
100249965
OSA: 
4330549 4340847
DOSA: 
Os02t0720300-01(Os02g0720300) Os06t0308100-01(Os06g0308100)
BDI: 
100842961 100843241
SBI: 
SORBI_04g029700(SORBIDRAFT_04g029700) SORBI_10g011780(SORBIDRAFT_10g011780)
ZMA: 
100285227(umc21) 100285381
SMO: 
SELMODRAFT_25589 SELMODRAFT_36025
PPP: 
PHYPADRAFT_106219
CRE: 
CHLREDRAFT_190432(DSP7)
VCN: 
VOLCADRAFT_77506
UMA: 
UM02303.1
MBR: 
MONBRDRAFT_8130
NGR: 
NAEGRDRAFT_33056 NAEGRDRAFT_77806
DPP: 
DICPUDRAFT_10471
EHI: 
EHI_048550(107.t00002) EHI_053090(4.t00016) EHI_059820(101.t00013) EHI_079260(183.t00006)
EDI: 
EDI_231530 EDI_259890
TET: 
TTHERM_00046430 TTHERM_00189500 TTHERM_00250870 TTHERM_00697520
PTM: 
GSPATT00005903001
TPS: 
THAPSDRAFT_31200
PIF: 
PITG_13732
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Bermudez O, Pages G, Gimond C
  Title
The dual-specificity MAP kinase phosphatases: critical roles in development and cancer.
  Journal
Am J Physiol Cell Physiol 299:C189-202 (2010)
Reference
  Authors
Keyse SM
  Title
Dual-specificity MAP kinase phosphatases (MKPs) and cancer.
  Journal
Cancer Metastasis Rev 27:253-61 (2008)
Reference
  Authors
Kondoh K, Nishida E
  Title
Regulation of MAP kinases by MAP kinase phosphatases.
  Journal
Biochim Biophys Acta 1773:1227-37 (2007)
Reference
  Authors
Patterson KI, Brummer T, O'Brien PM, Daly RJ
  Title
Dual-specificity phosphatases: critical regulators with diverse cellular targets.
  Journal
Biochem J 418:475-89 (2009)
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