KEGG   ORTHOLOGY: K04492Help
Entry
K04492                      KO                                     

Name
LEF1
Definition
lymphoid enhancer-binding factor 1
Pathway
Wnt signaling pathway
Hippo signaling pathway
Adherens junction
Melanogenesis
Pathways in cancer
Colorectal cancer
Endometrial cancer
Prostate cancer
Thyroid cancer
Basal cell carcinoma
Acute myeloid leukemia
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Module
M00677  
Wnt signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04310 Wnt signaling pathway
    K04492  LEF1; lymphoid enhancer-binding factor 1
   04390 Hippo signaling pathway
    K04492  LEF1; lymphoid enhancer-binding factor 1
 Cellular Processes
  Cellular commiunity
   04520 Adherens junction
    K04492  LEF1; lymphoid enhancer-binding factor 1
 Organismal Systems
  Endocrine system
   04916 Melanogenesis
    K04492  LEF1; lymphoid enhancer-binding factor 1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05210 Colorectal cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05216 Thyroid cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05221 Acute myeloid leukemia
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05217 Basal cell carcinoma
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05215 Prostate cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05213 Endometrial cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
  Cardiovascular diseases
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K04492  LEF1; lymphoid enhancer-binding factor 1
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00677  Wnt signaling
     K04492  LEF1; lymphoid enhancer-binding factor 1
Transcription factors [BR:ko03000]
 Eukaryotic Type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    K04492  LEF1; lymphoid enhancer-binding factor 1
BRITE hierarchy
Genes
HSA: 
51176(LEF1)
PTR: 
461425(LEF1)
PPS: 
100995847(LEF1)
GGO: 
101140253(LEF1)
PON: 
100447785(LEF1)
NLE: 
100593051(LEF1)
MCC: 
695776(LEF1)
MCF: 
CJC: 
100399759(LEF1)
MMU: 
16842(Lef1)
RNO: 
161452(Lef1)
CGE: 
100761200(Lef1)
NGI: 
103742515(Lef1)
HGL: 
101711023(Lef1)
OCU: 
100352691(LEF1)
TUP: 
102474621(LEF1)
CFA: 
478507(LEF1)
AML: 
100465982(LEF1)
UMR: 
103661728(LEF1)
FCA: 
101088077(LEF1)
PTG: 
102970026(LEF1)
BTA: 
535399(LEF1)
BOM: 
102266946(LEF1)
PHD: 
102341699(LEF1)
CHX: 
OAS: 
780521(LEF-1)
SSC: 
100170126(LEF1)
CFR: 
102510619(LEF1)
BACU: 
103020844(LEF1)
LVE: 
103068879(LEF1)
ECB: 
100072938(LEF1)
MYB: 
102255910(LEF1)
MYD: 
102767379(LEF1)
PALE: 
102886933(LEF1)
MDO: 
100011783(LEF1)
SHR: 
OAA: 
GGA: 
395865(LEF1)
MGP: 
APLA: 
101792052(LEF1)
TGU: 
100228376(LEF1)
FAB: 
101821185(LEF1)
PHI: 
102109576(LEF1)
FPG: 
101917929(LEF1)
FCH: 
102050307(LEF1)
CLV: 
102084626(LEF1)
ASN: 
102385539(LEF1)
AMJ: 
102560337(LEF1)
PSS: 
102456780(LEF1)
CMY: 
102930185(LEF1)
ACS: 
100556215(lef1)
PBI: 
103064656(LEF1)
XLA: 
100337575(lef-1) 398238(lef1)
XTR: 
100493178(lef1)
DRE: 
30701(lef1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
HRO: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Arce L, Yokoyama NN, Waterman ML
  Title
Diversity of LEF/TCF action in development and disease.
  Journal
Oncogene 25:7492-504 (2006)

DBGET integrated database retrieval system