KEGG   ORTHOLOGY: K04500Help
Entry
K04500                      KO                                     

Name
SMAD2_3
Definition
mothers against decapentaplegic homolog 2/3
Pathway
FoxO signaling pathway
Cell cycle
Endocytosis
TGF-beta signaling pathway
Hippo signaling pathway
Adherens junction
Signaling pathways regulating pluripotency of stem cells
AGE-RAGE signaling pathway in diabetic complications
Chagas disease (American trypanosomiasis)
HTLV-I infection
Pathways in cancer
Colorectal cancer
Pancreatic cancer
Inflammatory bowel disease (IBD)
Module
M00680  
TGF-beta signaling
M00681  
Activin signaling
Disease
H00020  
Colorectal cancer
H00800  
Loeys-Dietz syndrome (LDS)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04350 TGF-beta signaling pathway
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   04390 Hippo signaling pathway
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   04068 FoxO signaling pathway
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  Cell growth and death
   04110 Cell cycle
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  Cellular community - eukaryotes
   04520 Adherens junction
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   04550 Signaling pathways regulating pluripotency of stem cells
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   05210 Colorectal cancer
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   05212 Pancreatic cancer
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  Immune diseases
   05321 Inflammatiory bowel disease (IBD)
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  Infectious diseases
   05166 HTLV-I infection
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   05142 Chagas disease (American trypanosomiasis)
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00680  TGF-beta signaling
     K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
    M00681  Activin signaling
     K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
4087(SMAD2) 4088(SMAD3)
PTR: 
455407(SMAD2) 748161(SMAD3)
PPS: 
100980706(SMAD2) 100993322(SMAD3)
GGO: 
PON: 
100173357(SMAD2) 100448249(SMAD3)
NLE: 
100583279(SMAD3) 100589735(SMAD2)
MCC: 
697581(SMAD2) 711355(SMAD3)
MCF: 
101925163(SMAD2) 102146086(SMAD3)
CSAB: 
103222457(SMAD2) 103245436(SMAD3)
RRO: 
104657832(SMAD2) 104662580(SMAD3)
CJC: 
100393808(SMAD3) 100396826(SMAD2)
SBQ: 
101039593(SMAD3) 101040653(SMAD2)
MMU: 
17126(Smad2) 17127(Smad3)
RNO: 
25631(Smad3) 29357(Smad2)
CGE: 
100759220(Smad3) 100771578(Smad2)
NGI: 
103727836(Smad2) 103736807(Smad3)
HGL: 
OCU: 
100346303(SMAD3) 100359137(SMAD2)
TUP: 
102473158(SMAD3) 102499541(SMAD2)
CFA: 
480144(SMAD2) 610902(SMAD3)
AML: 
100467069(SMAD2) 100479304(SMAD3)
UMR: 
103663939(SMAD2) 103679154(SMAD3)
FCA: 
101087179(SMAD2) 101101387(SMAD3)
PTG: 
102971687(SMAD2) 102971888(SMAD3)
BTA: 
515125(SMAD3) 516010(SMAD2)
BOM: 
102282627(SMAD3) 102286495(SMAD2)
PHD: 
102323907(SMAD2) 102333447(SMAD3)
CHX: 
102169293(SMAD3) 102188455(SMAD2)
OAS: 
101114231(SMAD2) 443169(SMAD3)
SSC: 
100155304(SMAD2) 397260(SMAD3)
CFR: 
102508588(SMAD2) 102523073(SMAD3)
BACU: 
103005078(SMAD2) 103019152(SMAD3)
LVE: 
103069124(SMAD2) 103085090(SMAD3)
ECB: 
100033843(SMAD2) 100033845(SMAD3)
MYB: 
102256193(SMAD2) 102259468(SMAD3)
MYD: 
102758819(SMAD2) 102769241(SMAD3)
PALE: 
102893928(SMAD2) 102895268(SMAD3)
LAV: 
100663495(SMAD2) 100677673(SMAD3)
MDO: 
100014493(SMAD2) 100018703(SMAD3)
SHR: 
100914956(SMAD2) 100923201(SMAD3)
OAA: 
100073364(SMAD2) 100085963(SMAD3)
GGA: 
395132(SMAD3) 395247(SMAD2)
MGP: 
100544037(SMAD3)
CJO: 
107305704(SMAD2) 107318915(SMAD3)
APLA: 
TGU: 
100225108(SMAD2) 100228359(SMAD3)
GFR: 
FAB: 
101806307(SMAD3) 101818681(SMAD2)
PHI: 
102100805(SMAD2) 102110827(SMAD3)
CCW: 
104683877(SMAD3) 104695695(SMAD2)
FPG: 
101918546(SMAD2) 101924726(SMAD3)
FCH: 
102053568(SMAD3) 102059402(SMAD2)
CLV: 
102085910(SMAD2) 102095468(SMAD3)
AAM: 
106487670(SMAD3) 106497650(SMAD2)
ASN: 
102370509(SMAD2) 102379863(SMAD3)
AMJ: 
102564680(SMAD3) 102564903(SMAD2)
PSS: 
102449871(SMAD3) 102457921(SMAD2)
CMY: 
ACS: 
100554929(smad2) 100562178(smad3)
PBI: 
103058841(SMAD2) 103067237(SMAD3)
GJA: 
107105564(SMAD3) 107118628(SMAD2)
XLA: 
378633(smad3.L) 399442(mad2) 432023(smad2.S)
XTR: 
493272(smad3) 496586(smad2)
DRE: 
30639(smad2) 58092(smad3a)
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
102356317(SMAD3) 102360430(SMAD2)
CMK: 
103187354(smad2) 103189587(smad3)
BFO: 
CIN: 
100178575 778756(smad2/3b)
SPU: 
SKO: 
100313734(Smad2/3)
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD24642(Dsim_GD24642)
DWI: 
DYA: 
Dyak_GE17479(dyak_GLEANR_18805)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
412601(SMAD3)
BIM: 
BTER: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
100114895(Smox)
TCA: 
BMOR: 
DPL: 
PXY: 
API: 
PHU: 
DPX: 
ISC: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
NVE: 
ADF: 
107337755(AdiSmad2/3)
HMG: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8673135
  Authors
Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B
  Title
Mad-related genes in the human.
  Journal
Nat Genet 13:347-9 (1996)
  Sequence
[hsa:4087 4088]

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