KEGG ORTHOLOGY: K04500

ORTHOLOGY: K04500

Entry

K04500                      KO

Symbol

SMAD2

Name

mothers against decapentaplegic homolog 2

Pathway

map04110

Cell cycle

map04144

Endocytosis

map04218

Cellular senescence

map04350

TGF-beta signaling pathway

map04371

Apelin signaling pathway

map04390

Hippo signaling pathway

map04550

Signaling pathways regulating pluripotency of stem cells

map04659

Th17 cell differentiation

map04926

Relaxin signaling pathway

map04933

AGE-RAGE signaling pathway in diabetic complications

map05142

Chagas disease

map05166

Human T-cell leukemia virus 1 infection

map05200

Pathways in cancer

map05205

Proteoglycans in cancer

map05210

Colorectal cancer

map05212

Pancreatic cancer

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

map05321

Inflammatory bowel disease

map05415

Diabetic cardiomyopathy

Disease

H00020

Colorectal cancer

H00800

Loeys-Dietz syndrome

H02199

Congenital heart defects, multiple type

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    K04500  SMAD2; mothers against decapentaplegic homolog 2
   04390 Hippo signaling pathway
    K04500  SMAD2; mothers against decapentaplegic homolog 2
   04371 Apelin signaling pathway
    K04500  SMAD2; mothers against decapentaplegic homolog 2
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04500  SMAD2; mothers against decapentaplegic homolog 2
  09143 Cell growth and death
   04110 Cell cycle
    K04500  SMAD2; mothers against decapentaplegic homolog 2
   04218 Cellular senescence
    K04500  SMAD2; mothers against decapentaplegic homolog 2
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K04500  SMAD2; mothers against decapentaplegic homolog 2
09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K04500  SMAD2; mothers against decapentaplegic homolog 2
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K04500  SMAD2; mothers against decapentaplegic homolog 2
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04500  SMAD2; mothers against decapentaplegic homolog 2
   05205 Proteoglycans in cancer
    K04500  SMAD2; mothers against decapentaplegic homolog 2
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04500  SMAD2; mothers against decapentaplegic homolog 2
   05212 Pancreatic cancer
    K04500  SMAD2; mothers against decapentaplegic homolog 2
   05225 Hepatocellular carcinoma
    K04500  SMAD2; mothers against decapentaplegic homolog 2
   05226 Gastric cancer
    K04500  SMAD2; mothers against decapentaplegic homolog 2
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04500  SMAD2; mothers against decapentaplegic homolog 2
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K04500  SMAD2; mothers against decapentaplegic homolog 2
  09163 Immune disease
   05321 Inflammatory bowel disease
    K04500  SMAD2; mothers against decapentaplegic homolog 2
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K04500  SMAD2; mothers against decapentaplegic homolog 2
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04500  SMAD2; mothers against decapentaplegic homolog 2

Other DBs

GO:

0070410

Genes

HSA:	4087(SMAD2)

PTR:	455407(SMAD2)

PPS:	100980706(SMAD2)

GGO:	101154310(SMAD2)

PON:	100173357(SMAD2)

NLE:	100589735(SMAD2)

HMH:	116468563(SMAD2)

MCC:	697581(SMAD2)

MCF:	101925163(SMAD2)

MTHB:

126941494

MNI:	105489370(SMAD2)

CSAB:

103222457(SMAD2)

CATY:

105592520(SMAD2)

PANU:

101004882(SMAD2)

TGE:	112611391(SMAD2)

MLEU:

105531149(SMAD2)

RRO:	104657832(SMAD2)

RBB:	108519603(SMAD2)

TFN:	117063928(SMAD2)

PTEH:

111539679(SMAD2)

CANG:

105517011(SMAD2)

CJC:	100396826(SMAD2)

SBQ:	101040653(SMAD2)

CIMI:

108305119(SMAD2)

CSYR:

103255534

MMUR:

105860538(SMAD2)

LCAT:

123621890(SMAD2)

PCOQ:

105808878(SMAD2)

OGA:	100960336(SMAD2)

MMU:	17126(Smad2)

MCAL:

110284497(Smad2)

MPAH:

110332834(Smad2)

RNO:	29357(Smad2)

MCOC:

116087365(Smad2)

ANU:	117719725(Smad2)

MUN:	110550301(Smad2)

CGE:	100771578(Smad2)

MAUA:

101831324(Smad2)

PROB:

127234906(Smad2)

PLEU:

114694883(Smad2)

MORG:

121438761(Smad2)

MFOT:

126507311

AAMP:

119814613(Smad2)

NGI:	103727836(Smad2)

HGL:	101714203(Smad2)

CPOC:

100726958(Smad2)

CCAN:

109700302

DORD:

105987654(Smad2)

DSP:	122104270(Smad2)

PLOP:

125364233(Smad2)

NCAR:

124965420

MMMA:

107139517(Smad2)

OCU:

100359137

OPI:	101529841(SMAD2)

TUP:	102499541(SMAD2)

GVR:	103595293(SMAD2)

CFA:	480144(SMAD2)

CLUD:

112647773(SMAD2)

VVP:	112918856(SMAD2)

VLG:	121484675(SMAD2)

NPO:	129508622(SMAD2)

AML:	100467069(SMAD2)

UMR:	103663939(SMAD2)

UAH:	113253394(SMAD2)

UAR:	123787367(SMAD2)

ELK:

111142395

LLV:

125081717

MPUF:

101691860(SMAD2)

MNP:	132023610(SMAD2)

MLK:	131811852(SMAD2)

NVS:	122902898(SMAD2)

ORO:	101385419(SMAD2)

EJU:	114204964(SMAD2)

ZCA:	113913242(SMAD2)

MLX:	118004611(SMAD2)

NSU:	110577095(SMAD2) 110583310

LWW:	102730764(SMAD2)

FCA:	101087179(SMAD2)

PYU:	121032957(SMAD2)

PCOO:

112868176(SMAD2)

PBG:	122470746(SMAD2)

PVIV:

125148749(SMAD2)

LRUF:

124517096

PTG:	102971687(SMAD2)

PPAD:

109275745(SMAD2)

PUC:

125914628

AJU:

106972947

HHV:	120229672(SMAD2)

BTA:	516010(SMAD2)

BOM:	102286495(SMAD2)

BBUB:

102406564(SMAD2)

BBIS:

104989326(SMAD2)

CHX:	102188455(SMAD2)

OAS:	101114231(SMAD2)

BTAX:

128067292(SMAD2)

ODA:	120881010(SMAD2)

CCAD:

122425874(SMAD2)

MBEZ:

129549831(SMAD2)

SSC:	100155304(SMAD2)

CFR:	102508588(SMAD2)

CBAI:

105074009(SMAD2)

CDK:	105097587(SMAD2)

VPC:	102538474(SMAD2)

BACU:

103005078(SMAD2)

BMUS:

118906922(SMAD2)

LVE:	103069124(SMAD2)

OOR:	101278299(SMAD2)

DLE:	111180276(SMAD2)

PCAD:

102978015(SMAD2)

PSIU:

116738762(SMAD2)

NASI:

112407460(SMAD2)

ECB:	100033843(SMAD2)

EPZ:	103548562(SMAD2)

EAI:	106831216(SMAD2)

MYB:	102256193(SMAD2)

MYD:	102758819(SMAD2)

MMYO:

118662725(SMAD2)

MLF:	102429768(SMAD2)

PKL:	118707412(SMAD2)

MNA:	107546622(SMAD2)

DRO:	112322688(SMAD2)

SHON:

118978461(SMAD2)

AJM:	119063624(SMAD2)

PDIC:

114506330(SMAD2)

PHAS:

123826060(SMAD2)

MMF:	118618734(SMAD2)

PPAM:

129078704(SMAD2)

HAI:	109388212(SMAD2)

RFQ:	117011743(SMAD2)

PALE:

102893928(SMAD2)

PGIG:

120585764(SMAD2)

PVP:	105292640(SMAD2)

RAY:	107512663(SMAD2)

MJV:	108400736(SMAD2)

TOD:	119243064(SMAD2)

SARA:

101547889(SMAD2)

SETR:

126020080(SMAD2)

LAV:	100663495(SMAD2)

TMU:

101348656

ETF:	101642964(SMAD2)

DNM:	101429090(SMAD2)

MDO:	100014493(SMAD2)

GAS:	123237729(SMAD2)

SHR:	100914956(SMAD2)

AFZ:

127543521

PCW:	110207982(SMAD2)

GGA:	395247(SMAD2Z) 769000(SMAD2W)

PCOC:

116231370(SMAD2)

CJO:	107305704(SMAD2)

TPAI:

128074324(SMAD2)

LMUT:

125686954(SMAD2)

NMEL:

110389836(SMAD2)

APLA:

101803787 101805334(SMAD2)

ACYG:

106037327 125179633

CATA:

118254572(SMAD2)

AFUL:

116500445(SMAD2)

TGU:	100225108(SMAD2) 116806871

LSR:	110473205(SMAD2)

SCAN:

103820639(SMAD2) 103824734

PMOA:

120513693(SMAD2)

OTC:	121346084(SMAD2)

PRUF:

121357871

GFR:	102040865 102044404(SMAD2)

FAB:	101818681(SMAD2)

OMA:	130265087(SMAD2)

PHI:	102100805(SMAD2)

PMAJ:

107198156(SMAD2)

CCAE:

111941053(SMAD2)

CCW:	104695695(SMAD2)

CBRC:

103620409 103622031(SMAD2)

ETL:	114058469(SMAD2) 114067837

ZAB:

102065531

ACHL:

103809583 103809640

SVG:	106865043(SMAD2)

MMEA:

130574534(SMAD2)

HRT:	120764834 120765388(SMAD2)

FPG:	101918546(SMAD2)

FCH:	102059402(SMAD2)

CLV:	102085910(SMAD2)

EGZ:	104134175(SMAD2)

PCRI:

104034862(SMAD2)

PLET:

104622665(SMAD2)

EHS:	104516400(SMAD2)

PCAO:

104046813(SMAD2)

ACUN:

113489639(SMAD2)

TALA:

104361429(SMAD2)

PADL:

103916021(SMAD2)

AFOR:

103898213(SMAD2)

ACHC:

115336932(SMAD2)

HALD:

104322122(SMAD2)

HLE:	104841375(SMAD2)

AGEN:

126036392

GCL:

127027686

CCRI:

104157677(SMAD2)

CSTI:

104555523

CMAC:

104481715(SMAD2)

BREG:

104631251(SMAD2)

FGA:	104082329(SMAD2)

GSTE:

104250830

LDI:	104343998(SMAD2)

MNB:	103776919 103781455

OHA:	104335579(SMAD2)

NNT:

104399512

SHAB:

115619142 115619623(SMAD2)

DPUB:

104301321(SMAD2)

PGUU:

104469004

CPEA:

104394605 104395034

AVIT:

104269454(SMAD2)

CVF:	104291926(SMAD2)

RTD:	128902009 128902618

CUCA:

104063566(SMAD2)

TEO:	104374688(SMAD2)

BRHI:

104493505

AAM:	106497650(SMAD2)

AROW:

112978607(SMAD2)

NPD:	112947301(SMAD2)

TGT:	104564687 104575154

DNE:	112994477(SMAD2)

SCAM:

104138497(SMAD2)

ASN:	102370509(SMAD2)

AMJ:	102564903(SMAD2)

CPOO:

109307739(SMAD2)

GGN:	109298011(SMAD2)

PSS:	102457921(SMAD2)

CMY:	102940642(SMAD2)

CCAY:

125636648(SMAD2)

DCC:	119855698(SMAD2)

CPIC:

101939963(SMAD2)

TST:	117879187(SMAD2)

CABI:

116835549(SMAD2)

MRV:	120408025(SMAD2)

ACS:	100554929(smad2)

ASAO:

132766861(SMAD2)

PVT:	110085053(SMAD2)

SUND:

121921670(SMAD2)

PBI:

103058841

CTIG:

120317890

TSR:

106551732

PGUT:

117655967(SMAD2)

APRI:

131192146(SMAD2)

PTEX:

113445546(SMAD2)

VKO:	123023962(SMAD2)

PMUA:

114606122(SMAD2)

PRAF:

128423642(SMAD2)

ZVI:	118077093(SMAD2)

HCG:	128344917(SMAD2)

GJA:	107118628(SMAD2)

STOW:

125436221(SMAD2)

EMC:	129334390(SMAD2)

XLA:	399442(smad2.L) 432023(smad2.S)

XTR:	496586(smad2)

NPR:	108786433(SMAD2)

RTEM:

120926551(SMAD2)

BBUF:

120992261(SMAD2)

BGAR:

122924840(SMAD2)

MUO:	115462866(SMAD2)

GSH:	117355800(SMAD2)

DRE:	30639(smad2)

SRX:	107738844 107743055

SANH:

107653131 107667259(smad2)

SGH:	107558710(smad2)

CCAR:

109062884 109062952

CAUA:

113054041 113109436 113109601

CGIB:

127966259 128021490

PTET:

122352813(smad2)

LROH:

127172601(smad2)

OMC:	131547906(smad2)

PPRM:

120482166(smad2)

RKG:	130076575(smad2)

MAMB:

125258281(smad2)

CIDE:

127520704

MASI:

127432353 127433145

TROS:

130546549(smad2)

TDW:	130411392(smad2)

MANU:

129447399(smad2)

IPU:

108277249

IFU:	128620319(smad2)

PHYP:

113544066(smad2)

SMEO:

124393264(smad2)

TFD:	113639291(smad2)

TVC:	132862990(smad2)

AMEX:

103025750(smad2)

CMAO:

118824416(smad2)

EEE:	113590822(smad2)

CHAR:

105912572(smad2)

TRU:

101072871

TFS:

130525690

TNG:	GSTEN00021584G001

LCO:

TBEN:

CGOB:

PGEO:

GACU:

117536909(smad2)

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

MZE:

ONL:	100693777 100710325

OAU:	116322660 116324976(smad2)

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:	107098523(smad2) 107098778

CTUL:

GMU:

NFU:

KMR:

ALIM:

106513591(smad2) 106527493

NWH:

AOCE:

MCEP:

CSEM:

POV:	109626315(smad2) 109633657

SSEN:

HHIP:

HSP:

SMAU:

LCF:	108878489(smad2)

SDU:

111228088

SLAL:

111648020 111655756(smad2)

XGL:	120804852 120806316(smad2)

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

MALB:

BSPL:

SJO:

SASA:

STRU:

OTW:	112248205 112263143

OMY:	101268919 101867532

OGO:	124034501 124036100

ONE:	115111387 115139828

OKI:	109877018 109895715(smad2)

OKE:	118358127 118392988

SALP:

111957603 111973863

SNH:	120053749 120063104

CCLU:

121550213 121584646

ELS:

105014505

SFM:	108936291(smad2) 108938101

PKI:	111842093(smad2) 111856558

AANG:

118237532(smad2)

LOC:	102689511(smad2)

PSPA:

121303852 121314339(smad2)

ARUT:

117421319(smad2)

PSEX:

120533041(smad2)

LCM:	102360430(SMAD2)

CMK:	103187354(smad2)

RTP:	109914262(smad2)

CPLA:

122563388(smad2)

HOC:	132830054(smad2)

LERI:

129711150(smad2)

SCLV:

120348023

» show all

Reference

PMID:8752209

Authors

Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, Kim H, Tsui LC, Bapat B, Gallinger S, Andrulis IL, Thomsen GH, Wrana JL, Attisano L

Title

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma.

Journal

Cell 86:543-52 (1996)
DOI:10.1016/S0092-8674(00)80128-2

Sequence

[hsa:4087]

All links

Ontology (2)   
   KEGG BRITE (1)   
   GO (1)   
Pathway (40)   
   KEGG PATHWAY (40)   
Disease (3)   
   KEGG DISEASE (3)   
Gene (2251)   
   KEGG GENES (429)   
   KEGG MGENES (45)   
   RefGene (1773)   
   OC (4)   
Literature (1)   
   PubMed (1)   
All databases (2297)   

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