KEGG   ORTHOLOGY: K04500Help
Entry
K04500                      KO                                     

Name
SMAD2_3
Definition
mothers against decapentaplegic homolog 2/3
Pathway
FoxO signaling pathway
Cell cycle
Endocytosis
TGF-beta signaling pathway
Hippo signaling pathway
Adherens junction
Chagas disease (American trypanosomiasis)
HTLV-I infection
Pathways in cancer
Colorectal cancer
Pancreatic cancer
Inflammatory bowel disease (IBD)
Disease
H00020  
Colorectal cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04350 TGF-beta signaling pathway
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   04390 Hippo signaling pathway
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   04068 FoxO signaling pathway
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  Cell growth and death
   04110 Cell cycle
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  Cell communication
   04520 Adherens junction
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   05210 Colorectal cancer
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   05212 Pancreatic cancer
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  Immune diseases
   05321 Inflammatiory bowel disease (IBD)
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  Infectious diseases
   05166 HTLV-I infection
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   05142 Chagas disease (American trypanosomiasis)
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
4087(SMAD2) 4088(SMAD3)
PTR: 
455407(SMAD2) 748161(SMAD3)
PPS: 
100980706(SMAD2) 100993322(SMAD3)
GGO: 
PON: 
100173357(SMAD2) 100448249(SMAD3)
MCC: 
697581(SMAD2) 711355(SMAD3)
MCF: 
MMU: 
17126(Smad2) 17127(Smad3)
RNO: 
25631(Smad3) 29357(Smad2)
CGE: 
HGL: 
101713378(Smad3) 101714203(Smad2)
TUP: 
102473158(SMAD3) 102499541(SMAD2)
CFA: 
480144(SMAD2) 610902(SMAD3)
AML: 
FCA: 
101087179(SMAD2) 101101387(SMAD3)
BTA: 
515125(SMAD3) 516010(SMAD2)
BOM: 
102282627(SMAD3) 102286495(SMAD2)
PHD: 
102323907(SMAD2) 102333447(SMAD3)
CHX: 
102169293(SMAD3) 102188455(SMAD2)
SSC: 
100155304(SMAD2) 397260(SMAD3)
CFR: 
102508588(SMAD2)
ECB: 
100033843(SMAD2) 100033845(SMAD3)
MYB: 
102256193(SMAD2) 102259468(SMAD3)
MDO: 
100014493(SMAD2) 100018703(SMAD3)
SHR: 
100914956(SMAD2) 100923201(SMAD3)
OAA: 
100073364(SMAD2)
GGA: 
395132(SMAD3) 395247(SMAD2)
MGP: 
TGU: 
100225108(SMAD2)
FAB: 
101806307(SMAD3) 101818681(SMAD2)
PHI: 
102100805(SMAD2) 102110827(SMAD3)
APLA: 
FPG: 
101918546(SMAD2) 101924726(SMAD3)
FCH: 
102053568(SMAD3) 102059402(SMAD2)
CLV: 
102085910(SMAD2) 102095468(SMAD3)
ASN: 
102370509(SMAD2)
PSS: 
102449871(SMAD3) 102457921(SMAD2)
ACS: 
100554929(smad2)
XLA: 
378633(smad3) 399442(mad2) 432023(smad2)
XTR: 
493272(smad3) 496586(smad2)
DRE: 
30639(smad2) 58092(smad3a)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102356317(SMAD3) 102360430(SMAD2)
BFO: 
CIN: 
100178575 778756(smad2/3b)
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
412601(SMAD3)
NVI: 
100114895(Smox)
BMOR: 
API: 
PHU: 
BMY: 
LOA: 
TSP: 
NVE: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
Reference
  Authors
Chen YG
  Title
Endocytic regulation of TGF-beta signaling.
  Journal
Cell Res 19:58-70 (2009)

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