KEGG   ORTHOLOGY: K04500Help
Entry
K04500                      KO                                     

Name
SMAD2_3
Definition
mothers against decapentaplegic homolog 2/3
Pathway
FoxO signaling pathway
Cell cycle
Endocytosis
TGF-beta signaling pathway
Hippo signaling pathway
Adherens junction
Signaling pathways regulating pluripotency of stem cells
Chagas disease (American trypanosomiasis)
HTLV-I infection
Pathways in cancer
Colorectal cancer
Pancreatic cancer
Inflammatory bowel disease (IBD)
Disease
H00020  
Colorectal cancer
H00800  
Loeys-Dietz syndrome (LDS)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04350 TGF-beta signaling pathway
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   04390 Hippo signaling pathway
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   04068 FoxO signaling pathway
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  Cell growth and death
   04110 Cell cycle
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  Cellular commiunity
   04520 Adherens junction
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   04550 Signaling pathways regulating pluripotency of stem cells
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   05210 Colorectal cancer
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   05212 Pancreatic cancer
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  Immune diseases
   05321 Inflammatiory bowel disease (IBD)
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  Infectious diseases
   05166 HTLV-I infection
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   05142 Chagas disease (American trypanosomiasis)
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
4087(SMAD2) 4088(SMAD3)
PTR: 
455407(SMAD2) 748161(SMAD3)
PPS: 
100980706(SMAD2) 100993322(SMAD3)
GGO: 
PON: 
100173357(SMAD2) 100448249(SMAD3)
MCC: 
697581(SMAD2) 711355(SMAD3)
MCF: 
MMU: 
17126(Smad2) 17127(Smad3)
RNO: 
25631(Smad3) 29357(Smad2)
CGE: 
100759220(Smad3) 100771578(Smad2)
HGL: 
101713378(Smad3) 101714203(Smad2)
TUP: 
102473158(SMAD3) 102499541(SMAD2)
CFA: 
480144(SMAD2) 610902(SMAD3)
AML: 
FCA: 
101087179(SMAD2) 101101387(SMAD3)
PTG: 
102971687(SMAD2) 102971888(SMAD3)
BTA: 
515125(SMAD3) 516010(SMAD2)
BOM: 
102282627(SMAD3) 102286495(SMAD2)
PHD: 
102323907(SMAD2) 102333447(SMAD3)
CHX: 
102169293(SMAD3) 102188455(SMAD2)
OAS: 
101114231(SMAD2) 443169(SMAD3)
SSC: 
100155304(SMAD2) 397260(SMAD3)
CFR: 
102508588(SMAD2) 102523073(SMAD3)
BACU: 
103005078(SMAD2) 103019152(SMAD3)
LVE: 
103069124(SMAD2) 103085090(SMAD3)
ECB: 
100033843(SMAD2) 100033845(SMAD3)
MYB: 
102256193(SMAD2) 102259468(SMAD3)
MYD: 
102758819(SMAD2) 102769241(SMAD3)
PALE: 
102893928(SMAD2) 102895268(SMAD3)
MDO: 
100014493(SMAD2) 100018703(SMAD3)
SHR: 
100914956(SMAD2) 100923201(SMAD3)
OAA: 
100073364(SMAD2) 100085963(SMAD3)
GGA: 
395132(SMAD3) 395247(SMAD2)
MGP: 
TGU: 
100225108(SMAD2) 100228359(SMAD3)
FAB: 
101806307(SMAD3) 101818681(SMAD2)
PHI: 
102100805(SMAD2) 102110827(SMAD3)
APLA: 
FPG: 
101918546(SMAD2) 101924726(SMAD3)
FCH: 
102053568(SMAD3) 102059402(SMAD2)
CLV: 
102085910(SMAD2) 102095468(SMAD3)
ASN: 
102370509(SMAD2) 102379863(SMAD3)
AMJ: 
102564680(SMAD3) 102569331(SMAD2)
PSS: 
102449871(SMAD3) 102457921(SMAD2)
CMY: 
ACS: 
100554929(smad2)
PBI: 
103058841(SMAD2) 103067237(SMAD3)
XLA: 
378633(smad3) 399442(mad2) 432023(smad2)
XTR: 
493272(smad3) 496586(smad2)
DRE: 
30639(smad2) 58092(smad3a)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102356317(SMAD3) 102360430(SMAD2)
CMK: 
103187354(smad2) 103189587(smad3)
BFO: 
CIN: 
100178575 778756(smad2/3b)
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
412601(SMAD3)
NVI: 
100114895(Smox)
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
BMY: 
LOA: 
TSP: 
NVE: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Lin X, Duan X, Liang YY, Su Y, Wrighton KH, Long J, Hu M, Davis CM, Wang J, Brunicardi FC, Shi Y, Chen YG, Meng A, Feng XH
  Title
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling.
  Journal
Cell 125:915-28 (2006)
  Sequence
[hsa:4087 4088]

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