KEGG   ORTHOLOGY: K04514Help
Entry
K04514                      KO                                     

Name
ROCK1
Definition
Rho-associated protein kinase 1 [EC:2.7.11.1]
Pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
Vascular smooth muscle contraction
TGF-beta signaling pathway
Axon guidance
Focal adhesion
Platelet activation
Leukocyte transendothelial migration
Regulation of actin cytoskeleton
Oxytocin signaling pathway
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04350 TGF-beta signaling pathway
    K04514  ROCK1; Rho-associated protein kinase 1
   04024 cAMP signaling pathway
    K04514  ROCK1; Rho-associated protein kinase 1
   04022 cGMP - PKG signaling pathway
    K04514  ROCK1; Rho-associated protein kinase 1
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04514  ROCK1; Rho-associated protein kinase 1
  Cellular commiunity
   04510 Focal adhesion
    K04514  ROCK1; Rho-associated protein kinase 1
 Organismal Systems
  Immune system
   04611 Platelet activation
    K04514  ROCK1; Rho-associated protein kinase 1
   04670 Leukocyte transendothelial migration
    K04514  ROCK1; Rho-associated protein kinase 1
   04062 Chemokine signaling pathway
    K04514  ROCK1; Rho-associated protein kinase 1
  Endocrine system
   04921 Oxytocin signaling pathway
    K04514  ROCK1; Rho-associated protein kinase 1
  Circulatory system
   04270 Vascular smooth muscle contraction
    K04514  ROCK1; Rho-associated protein kinase 1
  Development
   04360 Axon guidance
    K04514  ROCK1; Rho-associated protein kinase 1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04514  ROCK1; Rho-associated protein kinase 1
   05206 MicroRNAs in cancer
    K04514  ROCK1; Rho-associated protein kinase 1
   05205 Proteoglycans in cancer
    K04514  ROCK1; Rho-associated protein kinase 1
  Infectious diseases
   05130 Pathogenic Escherichia coli infection
    K04514  ROCK1; Rho-associated protein kinase 1
   05132 Salmonella infection
    K04514  ROCK1; Rho-associated protein kinase 1
   05131 Shigellosis
    K04514  ROCK1; Rho-associated protein kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04514  ROCK1; Rho-associated protein kinase 1
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: AGC group
  DMPK family [OT]
   K04514  ROCK1; Rho-associated protein kinase 1
Chromosome [BR:ko03036]
 Eukaryotic Type
  Centrosomal proteins
   Kinases and associated factors
    K04514  ROCK1; Rho-associated protein kinase 1
BRITE hierarchy
Genes
HSA: 
6093(ROCK1)
PTR: 
455326(ROCK1)
PPS: 
100976232(ROCK1)
GGO: 
101154194(ROCK1)
PON: 
100432582(ROCK1)
NLE: 
100586590(ROCK1)
MCC: 
698223(ROCK1)
MCF: 
102140851(ROCK1)
CJC: 
100394652(ROCK1)
MMU: 
19877(Rock1)
RNO: 
81762(Rock1)
CGE: 
100770074(Rock1)
NGI: 
103728977(Rock1)
HGL: 
101710589(Rock1)
OCU: 
100009220(ROCK1)
TUP: 
CFA: 
480181(ROCK1)
AML: 
UMR: 
103662842(ROCK1)
FCA: 
PTG: 
BTA: 
785911(ROCK1)
BOM: 
102284712(ROCK1)
PHD: 
CHX: 
OAS: 
SSC: 
397447(ROCK1)
CFR: 
102520724(ROCK1)
BACU: 
LVE: 
ECB: 
100034056(ROCK1)
MYB: 
MYD: 
102757900(ROCK1)
PALE: 
102879861(ROCK1)
MDO: 
SHR: 
100916611(ROCK1)
GGA: 
373970(ROCK1)
MGP: 
APLA: 
101797330(ROCK1)
TGU: 
100229794(ROCK1)
FAB: 
101819345(ROCK1)
PHI: 
102100951(ROCK1)
FPG: 
101913286(ROCK1)
FCH: 
102052286(ROCK1)
CLV: 
ASN: 
102377504(ROCK1)
AMJ: 
PSS: 
102463968(ROCK1)
CMY: 
ACS: 
100558337(rock1)
PBI: 
103059736(ROCK1)
XLA: 
394289(rock2)
XTR: 
100496057(rock1)
DRE: 
100329779(rock1) 321070(rock2b)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102350260(ROCK1)
CMK: 
103183447(rock1)
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
TCA: 
BMOR: 
100529202(rock1)
ISC: 
CEL: 
CELE_C10H11.9(let-502)
CBR: 
CBG03960(Cbr-let-502)
BMY: 
SMM: 
NVE: 
MBR: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Amano M, Nakayama M, Kaibuchi K
  Title
Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity.
  Journal
Cytoskeleton (Hoboken) 67:545-54 (2010)
Reference
  Authors
Ferretti R, Palumbo V, Di Savino A, Velasco S, Sbroggio M, Sportoletti P, Micale L, Turco E, Silengo L, Palumbo G, Hirsch E, Teruya-Feldstein J, Bonaccorsi S, Pandolfi PP, Gatti M, Tarone G, Brancaccio M
  Title
Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis.
  Journal
Dev Cell 18:486-95 (2010)

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