KEGG   ORTHOLOGY: K04514Help
Entry
K04514                      KO                                     
Name
ROCK
Definition
Rho-associated protein kinase [EC:2.7.11.1]
Pathway
Chemokine signaling pathway
Vascular smooth muscle contraction
Wnt signaling pathway
TGF-beta signaling pathway
Axon guidance
Focal adhesion
Leukocyte transendothelial migration
Regulation of actin cytoskeleton
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04310 Wnt signaling pathway
    K04514  ROCK; Rho-associated protein kinase
   04350 TGF-beta signaling pathway
    K04514  ROCK; Rho-associated protein kinase
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04514  ROCK; Rho-associated protein kinase
  Cell communication
   04510 Focal adhesion
    K04514  ROCK; Rho-associated protein kinase
 Organismal Systems
  Immune system
   04670 Leukocyte transendothelial migration
    K04514  ROCK; Rho-associated protein kinase
   04062 Chemokine signaling pathway
    K04514  ROCK; Rho-associated protein kinase
  Circulatory system
   04270 Vascular smooth muscle contraction
    K04514  ROCK; Rho-associated protein kinase
  Development
   04360 Axon guidance
    K04514  ROCK; Rho-associated protein kinase
 Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    K04514  ROCK; Rho-associated protein kinase
  Infectious diseases
   05130 Pathogenic Escherichia coli infection
    K04514  ROCK; Rho-associated protein kinase
   05132 Salmonella infection
    K04514  ROCK; Rho-associated protein kinase
   05131 Shigellosis
    K04514  ROCK; Rho-associated protein kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04514  ROCK; Rho-associated protein kinase
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: AGC group
  DMPK family
   K04514  ROCK; Rho-associated protein kinase
Chromosome [BR:ko03036]
 Eukaryotic Type
  Centrosomal proteins
   Kinases and associated factors
    K04514  ROCK; Rho-associated protein kinase
BRITE hierarchy
Genes
HSA: 
6093(ROCK1) 9475(ROCK2)
PTR: 
455326(ROCK1) 470307(ROCK2)
PPS: 
100969111(ROCK2) 100976232(ROCK1)
GGO: 
101154194(ROCK1)
PON: 
MCC: 
698223(ROCK1) 708444(ROCK2)
MMU: 
19877(Rock1) 19878(Rock2)
RNO: 
25537(Rock2) 81762(Rock1)
CFA: 
480181(ROCK1) 482970(ROCK2)
AML: 
FCA: 
101092552 101094501(ROCK2)
BTA: 
282041(ROCK2) 785911(ROCK1)
SSC: 
397445(ROCK2) 397447(ROCK1)
ECB: 
100034056(ROCK1) 100072339
MDO: 
100032706 100618269
SHR: 
100916611(ROCK1) 100916865(ROCK2)
OAA: 
100073941
GGA: 
373970(ROCK1)
MGP: 
100538826 100539446
TGU: 
100221127(ROCK2) 100229794(ROCK1)
ACS: 
100558337 100562729
XLA: 
100301953 394289(rock2)
XTR: 
100493965 100496057
DRE: 
100329779(rock1) 317747(rock2a) 321070(rock2b)
TRU: 
101067715 101068674 101070472
OLA: 
101158388 101159717
BFO: 
BRAFLDRAFT_87816
CIN: 
100176906
SPU: 
579202(ROCK)
DME: 
Dmel_CG9774(rok)
DPO: 
Dpse_GA22026
DAN: 
Dana_GF21023
DER: 
Dere_GG18241
DPE: 
Dper_GL13164 Dper_GL25366 Dper_GL27069
DSE: 
Dsec_GM13385
DWI: 
Dwil_GK25713
DYA: 
Dyak_GE15957
DGR: 
Dgri_GH12095
DMO: 
Dmoj_GI11100
DVI: 
Dvir_GJ15785
AGA: 
AgaP_AGAP000406
AAG: 
AaeL_AAEL005532
CQU: 
CpipJ_CPIJ011538
AME: 
100578506(ROCK2)
NVI: 
100119770(NV12927)
TCA: 
663533
API: 
100164812
PHU: 
Phum_PHUM507390
ISC: 
IscW_ISCW011682
CEL: 
CELE_C10H11.9(let-502)
CBR: 
CBG03960(Cbr-let-502)
BMY: 
Bm1_49370
TSP: 
Tsp_09712
SMM: 
Smp_139800
NVE: 
NEMVE_v1g10896 NEMVE_v1g135014
AQU: 
100641926
MBR: 
MONBRDRAFT_1270
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Ferretti R, Palumbo V, Di Savino A, Velasco S, Sbroggio M, Sportoletti P, Micale L, Turco E, Silengo L, Palumbo G, Hirsch E, Teruya-Feldstein J, Bonaccorsi S, Pandolfi PP, Gatti M, Tarone G, Brancaccio M
  Title
Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis.
  Journal
Dev Cell 18:486-95 (2010)
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