KEGG   ORTHOLOGY: K04515Help
Entry
K04515                      KO                                     

Name
CAMK2
Definition
calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
Pathway
ko04012  ErbB signaling pathway
ko04020  Calcium signaling pathway
ko04024  cAMP signaling pathway
ko04066  HIF-1 signaling pathway
ko04114  Oocyte meiosis
ko04217  Necroptosis
ko04261  Adrenergic signaling in cardiomyocytes
ko04310  Wnt signaling pathway
ko04360  Axon guidance
ko04713  Circadian entrainment
ko04720  Long-term potentiation
ko04722  Neurotrophin signaling pathway
ko04725  Cholinergic synapse
ko04728  Dopaminergic synapse
ko04740  Olfactory transduction
ko04745  Phototransduction - fly
ko04750  Inflammatory mediator regulation of TRP channels
ko04911  Insulin secretion
ko04912  GnRH signaling pathway
ko04916  Melanogenesis
ko04921  Oxytocin signaling pathway
ko04922  Glucagon signaling pathway
ko04925  Aldosterone synthesis and secretion
ko04934  Cushing's syndrome
ko04971  Gastric acid secretion
ko05031  Amphetamine addiction
ko05152  Tuberculosis
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05214  Glioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04310 Wnt signaling pathway
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04066 HIF-1 signaling pathway
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04020 Calcium signaling pathway
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04024 cAMP signaling pathway
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
 Cellular Processes
  Cell growth and death
   04114 Oocyte meiosis
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04217 Necroptosis
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
 Organismal Systems
  Endocrine system
   04911 Insulin secretion
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04922 Glucagon signaling pathway
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04912 GnRH signaling pathway
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04921 Oxytocin signaling pathway
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04916 Melanogenesis
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04925 Aldosterone synthesis and secretion
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
  Digestive system
   04971 Gastric acid secretion
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
  Nervous system
   04725 Cholinergic synapse
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04728 Dopaminergic synapse
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04720 Long-term potentiation
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04722 Neurotrophin signaling pathway
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
  Sensory system
   04745 Phototransduction - fly
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04740 Olfactory transduction
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   04750 Inflammatory mediator regulation of TRP channels
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
  Development
   04360 Axon guidance
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
  Environmental adaptation
   04713 Circadian entrainment
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   05205 Proteoglycans in cancer
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
   05214 Glioma
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
  Substance dependence
   05031 Amphetamine addiction
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
  Endocrine and metabolic diseases
   04934 Cushing's syndrome
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
  Infectious diseases
   05152 Tuberculosis
    K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.17  Ca2+/calmodulin-dependent protein kinase
     K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CAMK group
  CAMK2 family
   K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II
BRITE hierarchy
Other DBs
GO: 0004683
Genes
HSA: 815(CAMK2A) 816(CAMK2B) 817(CAMK2D) 818(CAMK2G)
PTR: 461445(CAMK2D) 462189(CAMK2A) 738167(CAMK2B) 738330(CAMK2G)
PPS: 100973727(CAMK2A) 100982179(CAMK2G) 100983859(CAMK2D) 100986246(CAMK2B)
GGO: 101134676(CAMK2D) 101136547(CAMK2G) 101148194(CAMK2B) 101153594(CAMK2A)
PON: 100172212(CAMK2A) 100433531(CAMK2B) 100436747(CAMK2D) 100462386(CAMK2G)
NLE: 100580290(CAMK2D) 100591995(CAMK2B) 100597007(CAMK2G) 100600165(CAMK2A)
MCC: 702504(CAMK2D) 705980(CAMK2G) 706977(CAMK2B) 710540(CAMK2A)
MCF: 101865637(CAMK2G) 101866326(CAMK2D) 101926613(CAMK2B) 102126681(CAMK2A)
CSAB: 103215984(CAMK2G) 103226136(CAMK2B) 103236144(CAMK2D) 103244792(CAMK2A)
RRO: 104669984(CAMK2G) 104670410(CAMK2A) 104671146(CAMK2B) 104676623(CAMK2D)
RBB: 108512486(CAMK2D) 108516884(CAMK2G) 108529387 108532044(CAMK2A) 108544005
CJC: 100390938(CAMK2A) 100391424 100397956(CAMK2D) 100405903(CAMK2G) 100410352(CAMK2B)
SBQ: 101031635(CAMK2G) 101038342(CAMK2D) 101041452(CAMK2A) 101041781 101052251(CAMK2B)
MMU: 108058(Camk2d) 12322(Camk2a) 12323(Camk2b) 12325(Camk2g)
RNO: 103693838(NEWGENE_621802) 171140(Camk2g) 24245(Camk2b) 24246(Camk2d) 25400(Camk2a)
CGE: 100752268 100763272(Camk2g) 100765253(Camk2a) 100769205(Camk2b)
NGI: 103734983(Camk2b) 103736933(Camk2g) 103743264(Camk2d) 103747079(Camk2a)
HGL: 101711305(Camk2d) 101713923(Camk2g) 101718749(Camk2b) 101722229(Camk2a)
OCU: 100101556(CAMK2G) 100101557(CAMK2D) 100341507(CAMK2A) 100342451(CAMK2B)
TUP: 102472689(CAMK2B) 102482912(CAMK2D) 102494625(CAMK2A) 102503259(CAMK2G)
CFA: 482687 489050(CAMK2G) 610764(CAMK2D) 612941(CAMK2A)
AML: 100466256(CAMK2D) 100474459(CAMK2G) 100475467(CAMK2A) 100478243(CAMK2B)
UMR: 103661761(CAMK2D) 103664598(CAMK2A) 103668027(CAMK2G) 103674683(CAMK2B)
ORO: 101367567(CAMK2G) 101375584(CAMK2D) 101375944(CAMK2A) 101384300(CAMK2B)
FCA: 101084342(CAMK2A) 101098090(CAMK2G) 101098221(CAMK2D) 101098615(CAMK2B)
PTG: 102950197(CAMK2D) 102957556(CAMK2G) 102964851(CAMK2B) 102966494(CAMK2A)
AJU: 106968235(CAMK2B) 106970983(CAMK2G) 106977318(CAMK2D) 106985400(CAMK2A)
BTA: 282162(CAMK2G) 525416(CAMK2B) 530719(CAMK2A) 532713(CAMK2D)
BOM: 102271451(CAMK2A) 102279381(CAMK2G) 102280002 102281822(CAMK2B)
BIU: 109553698(CAMK2G) 109557541(CAMK2B) 109560236(CAMK2D) 109562200(CAMK2A)
PHD: 102318078(CAMK2G) 102327803(CAMK2D) 102332764(CAMK2A) 102344159(CAMK2B)
CHX: 102175934(CAMK2D) 102176762(CAMK2B) 102185084(CAMK2A) 102185715(CAMK2G)
OAS: 101108884(CAMK2G) 101113850(CAMK2D) 101118870(CAMK2B) 443453(CAMK2A)
SSC: 100516166(CAMK2B) 100626014(CAMK2A) 397394(CAMK2G) 397674(CAMK2D)
CFR: 102506589(CAMK2B) 102512557(CAMK2A) 102521522(CAMK2D) 102522167(CAMK2G)
CDK: 105089916(CAMK2D) 105092345(CAMK2B) 105092453(CAMK2G) 105098484(CAMK2A)
BACU: 102999844(CAMK2G) 103003341(CAMK2B) 103012734(CAMK2D) 103018247(CAMK2A)
LVE: 103072903(CAMK2G) 103075213(CAMK2B) 103081366(CAMK2A) 103088458(CAMK2D)
OOR: 101269181(CAMK2D) 101271879(CAMK2A) 101281498(CAMK2G) 101287513(CAMK2B)
ECB: 100064138(CAMK2G) 100071654(CAMK2A) 100072618(CAMK2D) 100146368(CAMK2B)
EPZ: 103549121(CAMK2A) 103549465(CAMK2G) 103549616(CAMK2D) 103554952(CAMK2B)
EAI: 106822866(CAMK2B) 106838495(CAMK2A) 106843233(CAMK2D) 106843543(CAMK2G)
MYB: 102252254(CAMK2D) 102255052 102257317(CAMK2A) 102260966(CAMK2B) 102262365(CAMK2G)
MYD: 102764742(CAMK2A) 102765684(CAMK2D) 102773049(CAMK2G)
HAI: 109372542(CAMK2G) 109373019(CAMK2B) 109375001(CAMK2A) 109390284(CAMK2D)
RSS: 109437754(CAMK2D) 109446985 109447347(CAMK2B) 109448744(CAMK2A) 109454815(CAMK2G)
PALE: 102880869(CAMK2D) 102888385(CAMK2A) 102888982(CAMK2B) 102896030(CAMK2G)
LAV: 100653927(CAMK2G) 100658516(CAMK2B) 100663321(CAMK2D) 104846071(CAMK2A)
MDO: 100010898(CAMK2G) 100011784(CAMK2D) 100024521(CAMK2B) 100028973(CAMK2A)
SHR: 100913975(CAMK2D) 100915634 100916233(CAMK2G) 100918427(CAMK2B) 100934917(CAMK2A)
OAA: 100074083(CAMK2D) 100079279(CAMK2A) 100089453(CAMK2G)
GGA: 374174(CAMK2B) 374175(CAMK2A) 422688(CAMK2D) 423737(CAMK2G)
MGP: 100541354(CAMK2D) 100541823(CAMK2G) 100550458(CAMK2A)
CJO: 107313595(CAMK2D) 107315812(CAMK2G) 107320147(CAMK2A) 107323605(CAMK2B)
APLA: 101801648(CAMK2D) 101802013 101802786(CAMK2A) 101804017(CAMK2G)
ACYG: 106032824(CAMK2A) 106033089(CAMK2G) 106038617(CAMK2D)
TGU: 100219415(CAMK2D) 100220435(CAMK2A) 100226008(CAMK2G) 100228031(CAMK2B)
GFR: 102031855(CAMK2D) 102036854(CAMK2G) 102040653(CAMK2A) 102041076(CAMK2B)
FAB: 101806876(CAMK2D) 101810626(CAMK2A) 101812759(CAMK2G) 101817363(CAMK2B)
PHI: 102104310(CAMK2B) 102104633(CAMK2G) 102108054(CAMK2D) 102112061(CAMK2A)
PMAJ: 107203083(CAMK2D) 107206815(CAMK2G) 107210746(CAMK2A) 107213806 109022933
CCW: 104683185(CAMK2B) 104689694(CAMK2A) 104696844(CAMK2D) 104697948(CAMK2G)
FPG: 101914593(CAMK2D) 101915367(CAMK2G) 101918953(CAMK2A) 101923748(CAMK2B)
FCH: 102051471(CAMK2D) 102052104(CAMK2A) 102057655(CAMK2G) 102057671(CAMK2B)
CLV: 102083707(CAMK2B) 102086515(CAMK2G) 102090258(CAMK2D) 102095946(CAMK2A)
EGZ: 104123272(CAMK2A) 104129105(CAMK2G) 104135961
AAM: 106491995(CAMK2D) 106493448(CAMK2A) 106494574(CAMK2B) 106498878(CAMK2G)
ASN: 102369083(CAMK2B) 102372048(CAMK2A) 102376749(CAMK2G) 102382581(CAMK2D)
AMJ: 102562159(CAMK2G) 102564631(CAMK2B) 102570318(CAMK2D) 106736808(CAMK2A) 109286050
PSS: 102445881(CAMK2D) 102452528(CAMK2G) 102461772(CAMK2A) 102463425
CMY: 102932986(CAMK2B) 102935217(CAMK2D) 102935773(CAMK2G) 102938664(CAMK2A)
CPIC: 101933671(CAMK2B) 101939367(CAMK2A) 101952653(CAMK2D) 101952899(CAMK2G)
ACS: 100552004(camk2d) 100554504(camk2b) 100562492(camk2g) 100563784(camk2a)
PVT: 110077789(CAMK2G) 110083899 110084335(CAMK2B) 110086082(CAMK2A)
PBI: 103054335(CAMK2A) 103062746(CAMK2B) 103063596(CAMK2D) 103065234(CAMK2G)
GJA: 107110299 107117391(CAMK2B) 107122036 107123332(CAMK2A)
XLA: 108696257 108712641 380508(camk2g.S) 397789(camk2b.L) 398376 399160(camk2d.S) 399284(camk2a.S)
XTR: 100101771(camk2a) 100135023(camk2d) 100135711(camk2g) 780379(camk2b)
NPR: 108785601(CAMK2B) 108785806(CAMK2A) 108792205 108798063 108804479(CAMK2G)
DRE: 436815(camk2d2) 445208(camk2d1) 550436(camk2a) 562064(camk2b1) 791855(camk2g1) 793359(camk2g2) 798222(camk2b)
IPU: 108255499 108260541 108263497(camk2g) 108267517(camk2d1) 108273829 108277079(camk2b) 108278566(CAMK2A)
LCM: 102346458(CAMK2G) 102355499(CAMK2D) 102360076 102360263(CAMK2B) 102361646(CAMK2A)
CMK: 103180901(camk2d) 103181591(camk2g) 103187823 103188234(camk2a) 103190417
CIN: 100181678(camk2d)
SPU: 105437783 373512(camk-ii)
APLC: 110977564
SKO: 100371971(CAMK2D)
DME: Dmel_CG18069(CaMKII)
DSI: Dsimw501_GD28701(Dsim_GD28701)
MDE: 101888482
AAG: 5578710
AME: 551691(Camkii)
BIM: 100745387
BTER: 100648089
SOC: 105205626
AEC: 105148855
ACEP: 105625869
PBAR: 105433286
HST: 105185279
CFO: 105254953
LHU: 105669204
PGC: 109859326
NVI: 100122555
TCA: 655266
DPA: 109534487
BMOR: 100462731(CaMKII)
PMAC: 106715049
PRAP: 110999070
PXY: 105391166
API: 100161639
ZNE: 110832661
FCD: 110842877
TUT: 107359488
CEL: CELE_K11E8.1(unc-43)
CBR: CBG04391(Cbr-unc-43)
CRG: 105341112
MYI: 110448224
LAK: 106174951
SHX: MS3_01904
HMG: 100200906
CSAT: 104763565
CPAP: 110807774
CIT: 102612908
TCC: 18603213
DZI: 111307405
EGR: 104432530
GMX: 100776088
VAR: 108345147
CAM: 101512514
ADU: 107465518
AIP: 107619439
LJA: Lj0g3v0048319.1(Lj0g3v0048319.1) Lj5g3v1341920.1(Lj5g3v1341920.1)
PXB: 103931816
CSV: 101210072
CMO: 103483595
MCHA: 111015644
RCU: 8268212
JCU: 105632131
HBR: 110636345
NTA: 107779231
NTO: 104094984
SIND: 105158459
OEU: 111371229
DCR: 108206052
BVG: 104891102
AOF: 109820488
SPAR: SPRG_14823
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Illario M, Cavallo AL, Bayer KU, Di Matola T, Fenzi G, Rossi G, Vitale M
  Title
Calcium/calmodulin-dependent protein kinase II binds to Raf-1 and modulates integrin-stimulated ERK activation.
  Journal
J Biol Chem 278:45101-8 (2003)
DOI:10.1074/jbc.M305355200
  Sequence
[hsa:815]
Reference
PMID:2543961
  Authors
Hanley RM, Payne ME, Cruzalegui F, Christenson MA, Means AR
  Title
Sequence of the cDNA for the alpha subunit of calmodulin kinase II from mouse brain.
  Journal
Nucleic Acids Res 17:3992 (1989)
  Sequence
[mmu:12322]

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